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Oregon study finds no clear link between mRNA vaccines and sudden cardiac deaths in young people

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Oregon study finds no clear link between mRNA vaccines and sudden cardiac deaths in young people


In a recent study published in the Morbidity and Mortality Weekly Report (MMWR), a group of researchers investigated the association between messenger Ribonucleic Acid (mRNA) coronavirus disease 2019 (COVID-19) vaccination and sudden cardiac death in Oregon residents aged 16–30 years between June 2021 and December 2022.

Study: Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine — Oregon, June 2021–December 2022. Image Credit: wacomka / Shutterstock

Background 

In December 2020, the Food and Drug Administration (FDA) authorized two mRNA COVID-19 vaccines, initially allocated to healthcare workers and long-term care residents in the United States (U.S.) and later to older adults and those with high-risk conditions, before including healthy young individuals. By April 2021, all Oregonians aged ≥16 were eligible. Shortly afterward, reports emerged of myocarditis, especially in young males, with incidences estimated at 2.13 per 100,000, rising to 10.69 among young males in Israel. These cases were generally mild, with quick recoveries post-hospitalization. Despite no fatal myocarditis reports in Oregon to the Vaccine Adverse Event Reporting System (VAERS), sudden deaths among young athletes raised concerns, necessitating further research to clarify any vaccine linkage.

About the study 

Under Oregon law, each death must have a completed death certificate maintained in a system that meets the data-quality standards set by the Centers for Disease Control and Prevention’s (CDC) ‘s National Center for Health Statistics, including rigorous quality assurance reviews. Although there is no independent verification for the completeness of death certificate reporting, data on Oregon residents who die outside the state are also gathered through interstate agreements. Additionally, the ALERT Immunization Information System (IIS), which serves as Oregon’s comprehensive immunization registry, required mandatory reporting of all COVID-19 vaccinations during the pandemic.

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In an effort to examine the occurrence of sudden cardiac deaths possibly related to recent COVID-19 vaccination, researchers analyzed Oregon’s death certificate database. They focused on identifying individuals aged 16-30 who died between June 1, 2021, and December 31, 2022, and whose cause of death included terms such as “sudden death,” asystole,” “cardiac arrest,” “unknown,” “undetermined,” or “pending,” “arrhythmia,” and “myocarditis.” For those cases where a cardiac cause was likely, the team cross-referenced with the ALERT IIS to check if the deceased had received an mRNA COVID-19 vaccine within 100 days before their death. The analysis also considered gender differences in the findings. This investigation was carried out by the Oregon Health Authority, which stated that the activity was not research but was conducted in accordance with federal law and state policy.

Study results 

During the period from June 2021 to December 2022, in Oregon, a total of 1,292 deaths were recorded among individuals aged 16 to 30 years, with males comprising 72% (925) and females 28% (367) of the deceased.

For the male decedents, none of the death certificates identified vaccination as either an immediate or contributing cause of death. COVID-19 was mentioned as a cause in 17 (2%) of the male deaths. The majority of male deaths, 842 (91%), were attributed to noncardiac causes or other conditions. However, in 66 (7%) of the cases, excluding a cardiac cause was not possible based on the information on the death certificates. Within this subset, vaccination records were available for 58 (88%), with 24 (41%) having received at least one dose of an mRNA COVID-19 vaccine. Of these 24, two deaths occurred within 100 days post-vaccination. The first involved a male who died from congestive heart failure 21 days after vaccination, with contributing conditions including hypertension, obesity, diabetes, and sleep apnea. The second case, recorded 45 days post-vaccination, was labeled as an undetermined natural cause, with toxicology reports negative for common illegal substances but positive for prescribed medications. The medical examiner could not definitively link or rule out the vaccine as a contributing factor.

Among the female decedents, similarly, no death certificate cited vaccination as a cause. COVID-19 was noted in 13 (4%) cases. The majority, 319 (87%), had noncardiac reasons listed on their death certificates. For the remaining 35 (10%), where a cardiac cause could not be excluded, vaccination records were available for 30 (86%), and 16 (53%) had received at least one mRNA COVID-19 vaccine dose. Only one female, who died four days after receiving her vaccine dose, had her death recorded as natural, with the immediate cause being undetermined but related to chronic respiratory failure due to mitral stenosis.

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Conclusions 

To summarize, data from 40 U.S. healthcare systems from January 2021 to January 2022 showed that cardiac complications were significantly more common after COVID-19 infection than post-mRNA vaccination for those aged ≥5 years. In Oregon, from June 2021 to December 2022, of 1,292 deaths among residents aged 16-30, none were definitively linked to cardiac causes shortly after vaccination. During this period, 979,289 vaccine doses were administered to this group. Among 30 COVID-19-attributed deaths, only three had received the vaccine. Nationwide, vaccination is credited with preventing about 3.2 million deaths in its first two years.

Journal reference:

  • Liko J, Cieslak PR. Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine — Oregon, June 2021–December 2022. MMWR Morb Mortal Wkly Rep (2024), DOI: 10.15585/mmwr.mm7314a5, https://www.cdc.gov/mmwr/volumes/73/wr/mm7314a5.htm



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Flavored tobacco ban clears Oregon court hurdle

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Flavored tobacco ban clears Oregon court hurdle


The Oregon Court of Appeals has upheld a Washington County ordinance barring the sale of flavored tobacco products, in a ruling that could have ramifications for a similar ban in Multnomah County.

Wednesday’s ruling reversed a 2022 decision from Washington County Circuit Judge Andrew Erwin, who said the county had the power to regulate how sales are made but that only the state had the authority to ban products completely.



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Appeals court rejects climate change lawsuit by young Oregon activists against US government

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Appeals court rejects climate change lawsuit by young Oregon activists against US government


SEATTLE – A federal appeals court panel on Wednesday rejected a long-running lawsuit brought by young Oregon-based climate activists who argued that the U.S. government’s role in climate change violated their constitutional rights.

The 9th U.S. Circuit Court of Appeals previously ordered the case dismissed in 2020, saying that the job of determining the nation’s climate policies should fall to politicians, not judges. But U.S. District Judge Ann Aiken in Eugene, Oregon, instead allowed the activists to amend their lawsuit and last year ruled the case could go to trial.

Acting on a request from the Biden administration, a three-judge 9th Circuit panel issued an order Wednesday requiring Aiken to dismiss the case, and she did. Julia Olson, an attorney with Our Children’s Trust, the nonprofit law firm representing the activists, said they were considering asking the 9th Circuit to rehear the matter with a larger slate of judges.

“I have been pleading for my government to hear our case since I was ten years old, and I am now nearly 19,” one of the activists, Avery McRae, said in a news release issued by the law firm. “A functioning democracy would not make a child beg for their rights to be protected in the courts, just to be ignored nearly a decade later. I am fed up with the continuous attempts to squash this case and silence our voices.”

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The case — called Juliana v. United States after one of the plaintiffs, Kelsey Juliana — has been closely watched since it was filed in 2015. The 21 plaintiffs, who were between the ages of 8 and 18 at the time, said they have a constitutional right to a climate that sustains life. The U.S. government’s actions encouraging a fossil fuel economy, despite scientific warnings about global warming, is unconstitutional, they argued.

The lawsuit was challenged repeatedly by the Obama, Trump and Biden administrations, whose lawyers argued the lawsuit sought to direct federal environmental and energy policies through the courts instead of through the political process. At one point in 2018, a trial was halted by U.S. Supreme Court Chief Justice John Roberts just days before it was to begin.

Another climate lawsuit brought by young people was successful: Early this year the Montana Supreme Court upheld a landmark decision requiring regulators to consider the effects of greenhouse gas emissions before issuing permits for fossil fuel development.

That case was also brought by Our Children’s Trust, which has filed climate lawsuits in every state on behalf of young plaintiffs since 2010.

Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.

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Federal cannabis reclassification could bring pharmaceutical companies to Oregon’s marijuana industry

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Federal cannabis reclassification could bring pharmaceutical companies to Oregon’s marijuana industry


The Biden administration is moving to reclassify cannabis as a Schedule III drug, which would remove the plant from the “most dangerous” list and recognize that it has medical uses.

The Biden administration is working towards reclassifying cannabis as a Schedule III drug. If this is successful, cannabis will no longer be considered as one of the “most dangerous” drugs, and its medical benefits will be recognized.

Kristian Foden-Vencil / OPB

Portland attorney Amy Margolis sees the move as a way to get much-needed research on cannabis, but it could also pave the way for big pharmaceutical companies to get involved in the established industry in Oregon.

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Amy Margolis is a Portland attorney specializing in cannabis law and policy.

Amy Margolis is a Portland attorney specializing in cannabis law and policy.

Courtesy Amy Margolis

“They’re the ones who will be legally operating if they follow the final rules produced by the FDA and the standard FDA approval and sales process for pharmaceuticals,” Margolis says. “It certainly injects a concern that now we have real big pharmaceutical interests involved in the cannabis market.”

Margolis runs Margolis Legal, a Portland law firm that works with clients in the cannabis industry. She says this proposal doesn’t do what many in the industry have been advocating for; removal of cannabis from the schedule of illegal drugs entirely.

“I think it’s a remnant of the drug war, ” she says. “I think it’s kind of outdated perspectives on cannabis being a hard drug.”

Margolis spoke with OPB “All Things Considered” host Geoff Norcross:

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Geoff Norcross: Basically speaking, the Biden administration is saying they want to officially recognize that cannabis is not as dangerous as the most dangerous drugs. Isn’t that a good thing?

Amy Margolis: Theoretically, that’s a good thing. We’ve long known that cannabis is not dangerous, should be treated like alcohol, which this does not do. But in theory, yes, that’s a good thing. How it impacts the market? We’re not so sure.

Norcross: Okay, what could happen?

Margolis: So what this did is it sent over the reclassification recommendation to the FDA to essentially rule make around it. And from my perspective, and I think the perspective of many of my peers, this simply opened up a pathway for pharmaceutical companies to get involved in the cannabis industry, whether through the development and sales of pharmaceutical cannabis or through the research component.

Norcross: And what would that mean for the local market, which doesn’t have a lot of big players like the pharmaceutical industry in it?

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Margolis: Other than the DOJ, there was not too much outside interests who might care if prosecutions were happening, who might care if statewide industry is developing. I think the risk for Oregon — and this is sort of a worst-case scenario — is that pharmaceutical companies can now get involved. They’re the ones who will be legally operating if they follow the final rules produced by the FDA and the standard FDA approval and sales process for pharmaceuticals. Now you have a player beyond just the Department of Justice who could have some interest in owning that market. It certainly injects a concern that now we have real big pharmaceutical interests involved in the cannabis market. And they’re the only ones who can lawfully operate.

Norcross: One of the big problems for the cannabis industry here has been the lack of banking services or tax breaks that other businesses get. Would this move by the federal government this week change any of that?

Margolis: I think it remains to be seen. You know, the banking industry will look at this, federal regulators will look at this, and try and decide if this clears up the legality around the state licensed recreational and medical markets. And I do not believe this move by the Biden administration does that. I don’t believe it legalizes on a federal level what is currently happening in this state. And that is, aside from federal legislation, the path forward to safe banking.

Norcross: You touched on this a little bit earlier, that what the federal government could have done was to treat cannabis like it’s alcohol, and let an entirely different federal agency, the ATF, oversee its use and the regulations around it. I’m wondering if the Biden administration may have missed an opportunity to go all the way and just take it off the schedule of drugs entirely.

Margolis: I think “missed an opportunity” is how the industry will view it. I mean, the industry in Oregon and across the country has been advocating for cannabis to be declassified and not reclassified. And I think the Biden administration knows that and instead chose to go this direction. I think it’s a remnant of the drug war and I think it’s kind of outdated perspectives on cannabis being a hard drug. We’ll see if this is maybe the first step, but I’m concerned that, for the federal government, first steps can last a long time.

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Norcross: Do you see any upside for the industry here in Oregon, if cannabis is reclassified in this way?

Margolis: I do think the upside is, you know, we have in the industry been talking about research and cannabis for a long time. And this does open the door to that, which I think will be a positive, even if it’s only a financial benefit to those in the pharmaceutical industry.

Click on the audio player above to hear the whole conversation.



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