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Slow cognitive decline with flavonols, study says | CNN

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Slow cognitive decline with flavonols, study says | CNN

Editor’s Be aware: Join CNN’s Eat, However Higher: Mediterranean Type. Our eight-part information exhibits you a scrumptious expert-backed consuming life-style that can enhance your well being for all times.



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Consuming extra flavonols, antioxidants discovered in lots of greens, fruits, tea and wine, might sluggish your price of reminiscence loss, a brand new research finds.

The cognitive rating of individuals within the research who ate essentially the most flavonols declined 0.4 models per decade extra slowly than those that ate the fewest flavonols. The outcomes held even after adjusting for different components that may have an effect on reminiscence, corresponding to age, intercourse and smoking, in response to the research just lately revealed in Neurology, the medical journal of the American Academy of Neurology.

“It’s thrilling that our research exhibits making particular weight loss plan decisions might result in a slower price of cognitive decline,” mentioned research creator Dr. Thomas Holland, an teacher within the division of inner drugs at Rush College Medical Middle in Chicago, in a press release.

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“One thing so simple as consuming extra vegetables and fruit and consuming extra tea is a straightforward means for folks to take an energetic function in sustaining their mind well being.”

Flavonols are cytoprotective, which means they shield cells, together with neurons, so it’s believable there may very well be a direct impression on cognition, mentioned Dr. David Katz, a specialist in preventive and life-style drugs and diet who was not concerned within the research.

“However they’re additionally a marker of upper consumption of vegetables and fruit — which is sweet for the mind as a result of it’s good for each important organ, and the organism as a complete,” Katz mentioned in an e mail.

“They might even be a marker of higher total weight loss plan high quality, and even larger well being consciousness. People who find themselves extra well being aware might do issues to protect their cognition, or possibly being extra well being aware is a by-product of higher cognition.”

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Crops include over 5,000 flavonoid compounds, which play roles in producing cell development, combating environmental stress and attracting bugs for pollination.

Flavonols, a kind of flavonoid, have been proven in animal and a few human research to scale back irritation, a serious set off for persistent illness, and are wealthy sources of antioxidants. Antioxidants fight free radicals, “extremely unstable molecules which can be naturally fashioned while you train and when your physique converts meals into vitality,” in response to the Nationwide Middle for Complementary and Integrative Well being, a part of the Nationwide Institutes of Well being.

Probably the most frequent flavonols, quercetin, has proven promise in decreasing the onset of colorectal most cancers and different cancers, in response to research. Onions include the very best ranges — decrease ranges may be present in broccoli, blueberries, cauliflower, curly kale, leeks, spinach and strawberries.

One other frequent flavonol, kaempferol, seems to inhibit the expansion of most cancers cells whereas preserving and defending regular cells. Good sources of kaempferol are onions, asparagus and berries, however the richest plant sources are spinach, kale and different inexperienced leafy greens, in addition to herbs corresponding to chives, dill and tarragon.

A 3rd main participant is myricetin, which has been studied in rodents for blood sugar management and the discount of tau, a protein that causes the hallmark tangles of Alzheimer’s and different dementia. Spinach and strawberries include excessive ranges of myricetin, however honey, black currants, grapes and different fruits, berries, greens, nuts and tea are additionally good sources.

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The final group of flavonols, isorhamnetin, might shield towards cardiovascular and neurovascular illness along with anti-tumor and anti inflammatory advantages. Good sources of isorhamnetin are pears, olive oil, wine and tomato sauce.

You will discover a full record of the flavonoid content material of assorted vegetables and fruit right here.

The brand new research requested 961 folks with a median age of 81 and no indicators of dementia to fill out a meals questionnaire annually for seven years. As well as, the members underwent annual cognitive and reminiscence checks and had been quizzed on their time spent being bodily and mentally energetic.

Individuals had been divided into teams primarily based on their each day consumption of flavonols. The bottom consumption was about 5 milligrams a day; the very best 15 milligrams a day — equal to a couple of cup of darkish leafy greens, the research famous. (For comparability, the typical flavonol consumption in US adults is about 16 to twenty milligrams per day, in response to the research.)

The research appeared on the impression of the 4 main flavonols — kaempferol, quercetin, myricetin and isorhamnetin — on the speed of cognitive decline over the seven years.

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The best impression was discovered with kaempferol: Individuals who ate the very best quantities of meals with kaempferol confirmed a 0.4 models per decade slower price of cognitive decline in contrast with those that ate the fewest, in response to the research.

Myricetin was subsequent: Individuals who ate essentially the most meals with myricetin had a 0.3 models per decade slower price of cognitive decline in contrast with the bottom consuming group. Individuals who ate essentially the most meals with quercetin confirmed a 0.2 models per decade slower price of cognitive decline.

Dietary isorhamnetin had no impression, the research discovered.

Regardless of the obvious positives, research on the impression of flavonols on human well being have been inconclusive -— primarily as a result of many are observational and can’t present a direct trigger and impact. That applies to the Neurology research as nicely, in response to its authors.

A number of randomized managed trials — the scientific gold customary — have proven advantages related to flavonols for controlling blood sugar in kind 2 diabetes and bettering cardiovascular well being, in response to the Linus Pauling Institute, house to the Micronutrient Info Middle, a web based database for diet info.

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It’s not identified whether or not these advantages are long run, the institute mentioned, and no clear impression has been proven for most cancers prevention or cognitive safety.

“There are different bioactives that will contribute to the noticed outcomes,” Katz mentioned. “Supplemental research are required to isolate flavonoid results totally.”

There’s additionally a draw back to assuming a well being impression with out the required research to again it up, mentioned Dr. Christopher Gardner, a analysis professor of medication and director of the Vitamin Research Analysis Group at Stanford College.

“You’ll be able to rely on Individuals wanting the advantages of vegetation however not eager to eat them,” he mentioned in an e mail.

“(What) if folks learn the headline and rush out and purchase bottled (extracted) flavonols as an alternative of consuming complete plant meals, and it seems it wasn’t simply the flavonols, however the package deal deal of the whole lot in these vegetation (as an alternative).”

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Skydance sweetens Paramount bid with $3bn cash infusion

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Skydance sweetens Paramount bid with $3bn cash infusion

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Skydance and Shari Redstone’s holding company are offering a $3bn investment in Paramount in an effort to win support for a complex merger that has frustrated investors and led to the departure of the Hollywood group’s chief executive.

The offer, which includes $2bn in cash to common shareholders, came as Paramount chief executive Bob Bakish resigned on Monday, raising new questions about the future of the Hollywood group behind The Godfather

Redstone said on Monday: “The board and I thank Bob for his many contributions over his long career . . . we wish him all the best.”

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Redstone and Paramount’s board, which she chairs, have been trying to agree a deal to merge the company with David Ellison’s Skydance, the production company backed by his billionaire father, Larry Ellison, as well as RedBird Capital and KKR. 

Under the latest terms of the deal, Skydance would buy Redstone’s National Amusements for less than $2bn, not as much as previously discussed between the two sides, said people briefed about the matter.

Those people added that Paramount would then merge with Skydance, valuing Ellison’s company at about $5bn in an all-stock deal. The combination would value the existing common shares of Paramount about 30 per cent above its current trading share price.

The Ellison-led consortium would also invest a further $3bn in the combined company, the people said. Two-thirds of the investment would pay cash to holders of common shares by buying back their stock, with the remainder used to reduce Paramount’s debt.

Shareholders would have the option to either sell their shares in Paramount or keep the stock of the combined company, or a combination of the two, as the buyback would be limited to a maximum amount of $2bn. Paramount’s Class B common shares have a current market capitalisation of about $7bn.

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Paramount has a dual-class shareholding structure. Redstone’s NAI controls nearly 80 per cent of voting rights, but holds only 10 per cent of equity ownership. Many Paramount shareholders baulked at a previously proposed merger structure, which they argued would benefit Redstone at the cost of common shareholders. 

Redstone would remain an investor in the combined Paramount-Skydance, a move that aims to show her conviction that the Ellison-led group would turn round the fortunes of Paramount, which has struggled to compete with larger rivals such as Netflix in an expensive “streaming war”.

“There will be more alignment between [Redstone’s] interest and shareholders than before,” said one person familiar with the arrangement.

The Paramount board has set up a special committee to evaluate the plan.  

Paramount on Monday said a team of three executives — George Cheeks, Chris McCarthy and Brian Robbins — would replace Bakish, establishing an “office of the CEO”.

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Bakish, who had worked at the company and its predecessor Viacom for a quarter of a century, had previously been an ally of Redstone, who promoted him to chief executive of Viacom in 2016. But their relationship has deteriorated in recent months, according to several people familiar with the matter.

Bakish was paid a total of $31.5mn in 2023, according to a regulatory filing. 

Private equity group Apollo, in partnership with rival studio Sony, is also preparing to bid on Paramount as soon as this week, according to people familiar with the situation. Paramount recently rejected Apollo’s $26bn all-cash offer, and four members of the Paramount board have since withdrawn their names for re-election in June.

Paramount on Monday reported a net loss of $554mn on $7.7bn in revenue in the first quarter. The company did not take questions on its earnings call, which lasted less than 10 minutes.

“There’s no dressing this up — looks like a car crash with clear divisions among key stakeholders,” said analyst Paolo Pescatore at PP Insights.

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“The latest chapter in this ongoing saga looks to be taking another turn for the worse.”

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Oregon winners of historic $1.3 billion Powerball jackpot revealed

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Oregon winners of historic $1.3 billion Powerball jackpot revealed

The winners of Oregon’s largest-ever lottery jackpot — and the eighth-largest lottery win in the history of the United States — are Laiza Liem Chao, 55, of Milwaukie, and Cheng Saephan, 46, and Duanpen Saephan, 37, of Portland.

The Oregon Lottery announced their names with great fanfare in Salem on Monday.

“First, I want to thank God for giving me this beautiful prize,” said Cheng Saephan, the only winner to attend the official announcement at Oregon Lottery headquarters in Salem.

Cheng Saephan, his wife and Chao already have been paid, the couple and their friend splitting the $422,309,193.97 that remained of the $1.326 billion prize after state and federal taxes, lottery spokesperson Melanie Mesaros said. They opted for the one-time payout rather than the 30-year annuity, which also brought the amount down.

Cheng Saephan, who was born in Laos and moved to the United States from Thailand in 1994, said he is especially grateful that he will be able to provide a comfortable life for his family, which includes two children he has with his wife. As for himself, he doesn’t believe he’ll have that much time to enjoy his winnings because he is in the midst of battling cancer. He was first diagnosed in 2016, he said. His most recent chemotherapy treatment was a week ago.

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“How am I going to have time to spend all of this money?” Cheng Saephan said.

Cheng Saephan said he, his wife and their friend Chao bought 20 lottery tickets for $200. For several months before the big win he said he felt like he was going to win something — but he expected no more than several million, he said, not a jackpot in excess of $1 billion. He plans to buy a house with the money, he said.

He used to be a machinist working on airplane parts, he said.

Cheng Saephan said he told his friend and co-winner Chao about the big win over the phone. He asked her what she was doing and she said she was driving to work.

“You don’t have to work now,” Cheng Saephan said he told her.

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A man at the Salem event who identified himself as Cheng Saephan’s pastor said Saephan agreed to send him on missionary trips to Thailand, Laos and possibly China.

The historic winning Powerball ticket was sold at a Plaid Pantry convenience store in Northeast Portland. The store will get a $100,000 bonus for selling the winning ticket, the Oregon Lottery said.

“I want to offer my heartfelt congratulations to the Saephans and Ms. Chao on this historic win,” Oregon Lottery Director Mike Wells said in a statement. “Not only is the prize life-changing for the three of them and their families, it’s also a huge win for the state.”

— Fedor Zarkhin is a breaking news and enterprise reporter with a focus on crime. Reach him at 971-373-2905; fzarkhin@oregonian.

Our journalism needs your support. Subscribe today to OregonLive.com.

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Sticky German inflation curbs investors’ ECB rate cut expectations

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Sticky German inflation curbs investors’ ECB rate cut expectations

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German inflation rose slightly more than forecast in April on the back of strong food and energy prices in Europe’s largest economy, curbing investors’ hopes of a string of interest rate cuts this year.

Consumer prices in Germany increased 2.4 per cent in the year to April, rising from 2.3 per cent a month earlier, according to EU harmonised data released by the federal statistical agency Destatis on Monday. Economists polled by Reuters had expected a flat reading.

However, excluding underlying energy and food prices, Destatis reported core inflation had fallen from 3.3 per cent to 3 per cent.

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With Spain reporting a similar uptick in headline inflation coupled with a cooling of core price growth, the German figures chipped away at investors’ confidence about the extent of European Central Bank rate cuts this year.

The uptick in German inflation was “a good reminder of how difficult the last mile of bringing inflation sustainably back to 2 per cent will be for the ECB”, said Carsten Brzeski, an economist at ING.

Government bond yields, which move inversely to their prices, rose slightly on the news as investors trimmed their bets that the ECB will start cutting rates in just over a month. Despite the rise, Germany’s benchmark 10-year bond yield was still down almost 5 basis points at 2.53 per cent.

Senior ECB policymakers have said they are likely to cut rates for the first time in five years at their next policy meeting on June 6 as long as wages and price pressures keep cooling in line with their forecasts for inflation to drop to the bank’s 2 per cent target by next year.

A June rate cut by the ECB “still looks like a done deal”, Brzeski said.

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Eurozone inflation is expected to remain flat at 2.4 per cent, while core inflation in the bloc is expected to fall from 2.9 per cent to 2.7 per cent when that data is released on Tuesday.

Any overshoot could cause traders to doubt whether the ECB will start cutting rates in June, especially after hotter than forecast US inflation prompted them to reduce bets on the scale of Federal Reserve easing this year.

Recent business and consumer surveys show the eurozone economy is tentatively emerging from its recent stagnation and data on Tuesday is expected to show gross domestic product in the region expanded at a quarterly rate of 0.2 per cent in the three months to March.

But despite economic activity improving, most economists expect the fact that Easter was in March rather than April this year to lower airfare and package holiday prices in the past month, bringing down eurozone services inflation for the first time in six months.

The earlier Easter seemed to contribute to lower German services inflation, which fell back to 3.4 per cent, having accelerated to 3.7 per cent in March.

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Ralph Solveen, an economist at Commerzbank, predicted that German inflation would rise later this year “as companies in the service sectors in particular will pass on the massive rise in wage costs to their customers”.

Destatis said energy prices fell 1.2 per cent in April — a much smaller annual decline than the drop of 2.7 per cent recorded in March — while food prices rose 0.5 per cent after falling the previous month.

Spain’s statistics office said rising gas and food prices — after the removal of government subsidies — helped to push up its inflation rate to 3.4 per cent in April, compared with 3.3 per cent a month earlier. But core inflation, excluding energy and fresh food, slowed from 3.3 per cent to 2.9 per cent.

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