Health
AI could predict whether cancer treatments will work, experts say: ‘Exciting time in medicine'
A chemotherapy alternative called immunotherapy is showing promise in treating cancer — and a new artificial intelligence tool could help ensure that patients have the best possible experience.
Immunotherapy, first approved in 2011, uses the cancer patient’s own immune system to target and fight cancer.
While it doesn’t work for everyone, for the 15% to 20% who do see results, it can be life-saving.
WHAT IS ARTIFICIAL INTELLIGENCE (AI)?
Like any medication, immunotherapy has the potential for adverse side effects — which can be severe for some.
Studies show that some 10% to 15% of patients develop “significant toxicities.”
A chemotherapy alternative called immunotherapy is showing promise in treating cancer — and a new artificial intelligence tool could help ensure that patients have the best possible experience. (iStock)
Headquartered in Chicago, GE HealthCare — working in tandem with Vanderbilt University Medical Center (VUMC) in Nashville, Tennessee — has created an AI model that’s designed to help remove some of the uncertainties surrounding immunotherapy.
Over the five years it’s been in development, the AI model was trained on thousands of patients’ electronic health records (EHRs) to recognize patterns in how they responded to immunotherapy, focusing on safety and effectiveness.
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“The model predicts which patients are likely to derive the benefit from immunotherapy versus those patients who may not,” said Jan Wolber, global digital product leader at GE HealthCare’s pharmaceutical diagnostics segment, in an interview with Fox News Digital.
“It also predicts which patients have a likelihood of developing one or more significant toxicities.”
When pulling data from the patient’s health record, the model looks at demographic information, preexisting diagnoses, lifestyle habits (such as smoking), medication history and more.
Immunotherapy, which was first approved in 2011, uses the cancer patient’s immune system to target and fight cancer. (iStock)
“All of these data are already being collected by the patient’s oncologist, or they’re filling out a form in the waiting room ahead of time,” said Travis Osterman, a medical oncologist and associate chief medical information officer at Vanderbilt University Medical Center, in an interview with Fox News Digital.
(Osterman is working with Wolber on the development of the AI model.)
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“We’re not asking for additional blood samples or complex imaging. These are all data points that we’re already collecting — vital signs, diagnoses, lab values, those sorts of things.”
In a study, the AI model showed 70% to 80% accuracy in predicting patients’ responses to immunotherapies, according to an article published in the Journal of Clinical Oncology Clinical Cancer Informatics.
“While the models are not perfect, this is actually a very good result,” Wolber said. “We can implement those models with very little additional effort because there are no additional measurements required in the clinic.”
‘Natural progression’
This type of technology is “a natural progression of what we’ve been doing in medicine for a very long time,” Osterman said.
“The only difference is, instead of surveying patients, we’re taking the entirety of the medical record and looking for risk factors that contribute to an outcome,” he said in an interview with Fox News Digital.
The AI model was trained on thousands of patients’ electronic health records to recognize patterns in how they responded to immunotherapy, focusing on safety and effectiveness. (iStock)
With immunotherapy, there is generally a lower response rate than with chemotherapy, Osterman noted — but some patients have “incredible responses” and ultimately become cancer-free.
“I would be horrified to know that one of my patients that I didn’t give immunotherapy to could have been one of the tremendous responders,” he told Fox News Digital.
Conversely, Osterman noted that in rare cases, immunotherapy can have some serious side effects.
“I would be horrified to know that one of my patients that I didn’t give immunotherapy to could have been one of the tremendous responders.”
“I would say about half of patients don’t have any side effects, but for those who do, some of them are really life-altering,” he said.
“We don’t want to miss anyone, but we also don’t want to harm anyone.”
At the core of the AI project, Osterman said, is the ability to “put all the information into the exam room,” so the oncologist can counsel the patient about the risks and benefits of this particular therapy and make the best, most informed decision about their care.
Combining technology and human expertise
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the AI model’s development but commented on its potential.
“AI models are emerging that are helping to manage responses to cancer treatments,” he told Fox News Digital.
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the AI model’s development but weighed in on its potential. “AI models are emerging that are helping to manage responses to cancer treatments,” he said. (Dr. Marc Siegel)
“These can allow for more treatment options and be more predictive of outcome.”
AI models like this one are an example of “the essential future of personalized medicine,” Siegel said, “where each patient is approached differently and their cancer is analyzed and treated with precision using genetic and protein analysis.”
As long as physicians and scientists remain in charge — “not a computer or robot” — Siegel said that “there is no downside.”
Potential limitations
The AI model does carry some degree of limitations, the experts acknowledged.
“The models obviously do not return 100% accuracy,” Wolber told Fox News Digital. “So there are some so-called false positives or false negatives.”
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The tool is not a “black box” that will provide a surefire answer, he noted. Rather, it’s a tool that provides data points to the clinician and informs them as they make patient management decisions.
Osterman pointed out that the AI model uses a “relatively small dataset.”
“We would love to be able to refine our predictions by learning on bigger data sets,” he said.
The tool is not a “black box” that will provide a surefire answer, one of the researchers said; rather, it’s a tool that provides data points to clinicians and informs them as they make patient management decisions. (iStock)
The team is currently looking for partnerships that will enable them to test the AI model in new settings and achieve even higher accuracy in its predictions.
Another challenge, Osterman said, is the need to integrate these AI recommendations into the workflow.
“This is pretty new for us as a health care community, and I think we’re all going to be wrestling with that question,” he said.
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Looking ahead, once the AI model has achieved the necessary regulatory approvals, GE HealthCare plans to make the technology available for widespread use by clinicians — perhaps even expanding to other care areas, such as neurology or cardiology.
There is also the potential to incorporate it into drug development.
“We don’t want to miss anyone, but we also don’t want to harm anyone.”
“One of the things that drug makers struggle with is that some of the agents that may be really useful for some patients could be really toxic for others,” Osterman said.
“If they were able to pick which patients could go into a trial and exclude patients with the highest risk of toxicity, that could mean the difference between that drug being made available or not.”
He added, “If this means that we’re able to help tailor that precision risk to patients, I’m in favor of that.”
Ultimately, Osterman said, “it’s a really exciting time to be in medicine … I think we’re going to look back and regard this as the golden age of AI recommendations. I think they’re probably here to stay.”
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Health
Americans are giving up multivitamins for a different daily health habit, study finds
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Americans are popping more supplements – and fewer multivitamins – than ever before, a new study found.
Research published in JAMA Network Open, led by researchers at Memorial Sloan Kettering Cancer Center in New York and the Harvard T.H. Chan School of Public Health in Boston, looked at 25 years of U.S. dietary supplement use data from 1999 to 2023.
This included more than 63,000 adults over the age of 20 who reported their supplement usage.
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When tracking patterns over time, the analysis revealed that overall supplement use increased from 51% of U.S. adults to 60%. The largest rise – from 62% to 78% – was identified in adults 65 and older.
Supplement use was found to be more common in women, people with a higher income or education, and those with insurance.
Supplement use was found to be more common in women, people with a higher income or education, and those with insurance. (iStock)
During the same period, multivitamin use decreased from 35% to 31%, while intake of vitamins and minerals outside of multivitamins increased.
Some of the largest increases in intake were seen in vitamin D, zinc, magnesium, vitamin B12 and turmeric. Other emerging supplements include ashwagandha, elderberry, collagen, hyaluronic acid, probiotics and prebiotics, according to the research.
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The later post-pandemic period saw an influx of immune support-based products, like zinc and vitamin D (outside of multivitamins).
The rise in supplement use aligns with the longevity movement, as more people seek products tailored to specific health goals, such as immune support, inflammation, gut health, skin health and joint health.
The study only shows that people are taking more supplements, but does not prove that they’re effective for these uses, the researchers noted.
Those on a GLP-1 medication should factor in a multivitamin to counteract the risk of nutrient gaps or deficiencies, an expert recommended. (iStock)
In an interview with Fox News Digital, Los Angeles-based registered dietitian nutritionist Ilana Muhlstein gave her take on the emerging supplement movement.
“I love that people are getting more educated and more intentional – I just wish they were being advised by more doctors and dietitians and less by ‘wellness influencers’ who are likely not doing the due diligence on the quality and efficacy of the supplements they’re promoting,” she said.
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Muhlstein expressed concern that all-in-one-multivitamin use has “slipped,” despite the rise in GLP-1 weight-loss medications.
“A multivitamin is where I think people should start as the foundation to help bridge nutrient gaps, especially for people on a GLP-1 who are eating about 15% to 30% less, and therefore likely consuming 15% to 30% less vitamins and minerals,” she said. “I recommend that everyone on a GLP-1 medication [should] take a multivitamin daily.”
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A daily probiotic, magnesium and vitamin D3 are also “smart for many of us,” the nutritionist added. She also recommends elderberry as an effective supplement for boosting the immune system when fighting a cold.
A nutrition expert cautioned against taking supplements that have not gone through third-party testing for safety and quality. (iStock)
Collagen has also been shown to benefit the skin and joints, which Muhlstein said is “worth considering as we get older.”
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“My real concern is the unregulated market,” she cautioned. “I can’t tell you how many calls I’ve received over the years of people pitching me new supplements … because the margins are high and the market is huge.”
“That’s why I’m extremely picky about what I take and what I recommend to my family and clients.”
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Muhlstein warned against taking a supplement that hasn’t gone through third-party testing for safety and quality.
“The best ones go further and test for pesticides, arsenic and heavy metals, especially for protein powders,” she said. “If a product has many ingredients, I like to see that they do testing on each individual ingredient.”
Health
America’s national parks could add years to your life — here’s how they boost health
Bipartisan push to invest in US national parks
Bret Baier moderates a discussion with Representatives Bruce Westerman (R-AR) and Jared Huffman (D-CA) about the ‘America the Beautiful’ initiative. This bipartisan effort seeks to modernize national parks ahead of America’s 250th anniversary, investing $1.9 billion annually. They emphasize national parks as common ground, beloved by all Americans, and crucial for our shared heritage.
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As the United States celebrates its 250th anniversary, many Americans are taking extra notice of all the things the country has to offer.
One such case is our access to vast wilderness. Today, the nation’s national parks are bustling tourist attractions, but they may also serve as vital resources for public health, experts say.
The most immediate health boost comes from physical movement.
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Guidelines from the Centers for Disease Control and Prevention show that regular physical activity is crucial for reducing obesity, improving sleep quality and lowering the risk of chronic illnesses.
The nation’s public lands include parks, trails and open spaces that encourage outdoor recreation and physical activity.
Beyond physical fitness, national parks contribute to documented mental health benefits. (iStock)
A review by the Community Preventive Services Task Force (CPSTF) found that implementing park, trail and greenway infrastructure directly increases physical activity across communities.
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When people walk, hike or bike through national parks, they are actively lowering their blood pressure, boosting immune function and reducing overall mortality, data shows.
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Beyond physical fitness, national parks may contribute to documented mental health benefits.
Previous research has demonstrated that direct exposure to nature significantly reduces physiological stress, lowers heart rates and decreases levels of stress hormones, like cortisol.
Engaging in educational activities and lifelong learning preserves brain function, improves memory and helps stave off age-related cognitive decline, research shows. (iStock)
This research also shows that natural environments boost attention span, combat mental fatigue and improve cognitive performance.
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Parks also act as natural venues for mindfulness and social connection.
Research shows that practicing mindfulness in quiet outdoor spaces lowers stress and mitigates feelings of loneliness and social isolation.
Research highlights that practicing mindfulness in quiet outdoor spaces lowers stress and mitigates feelings of loneliness and social isolation. (iStock)
Additionally, because parks protect cultural and historical resources, they can inspire lifelong learning.
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According to the data, engaging in educational activities and lifelong learning preserves brain function, improves memory and helps stave off age-related cognitive decline.
The National Park Service was established in 1916 to conserve the nation’s natural and historic resources for future generations, according to the organization.
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Today, that mission has expanded, as parks are recognized not only for their scenic and cultural value, but also the opportunities they provide for recreation and physical activity.
Health
Doctors thought man had brain cancer — they found live tapeworms instead
Screwworm outbreak threat to US livestock, prompts USDA action
Agriculture Secretary Brooke Rollins discusses USDA’s response to the New World Screwworm outbreak in Texas and New Mexico, assuring safe food supply on ‘The Bottom Line.’ VI LONG DEK: Agriculture Secretary Brooke Rollins addresses the alarming resurgence of New World Screwworm in Texas and New Mexico, emphasizing USDA’s aggressive containment efforts. She confirms the food supply remains safe while highlighting the administration’s focus on domestic fertilizer production, investing billions in new plants and infrastructure projects. Rollins celebrates 250 years of American agriculture and its vital role in national security.
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Doctors thought a 60-year-old man had metastatic brain cancer after scans revealed multiple tumors – but further testing revealed a shocking diagnosis.
The Spanish man, who was not named, was found to have a parasitic tapeworm larvae lodged in his brain — a case of neurocysticercosis, a parasitic infection of the central nervous system caused by the pork tapeworm (Taenia solium).
The patient, a lifelong resident of Castellón, Spain, had not traveled to any regions where the disease is endemic, according to the case report published in the CDC journal Emerging Infectious Diseases.
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The man had initially come to the hospital after suffering two weeks of progressive headaches and mild behavioral changes.
Radiologic findings from a study of autochthonous neurocysticercosis brain lesions mimicking metastatic disease. (Emerging Infectious Diseases)
CT scans showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer.
However, whole-body scans, a colonoscopy and specialized imaging failed to identify cancer anywhere in the patient’s body, the case report stated.
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When doctors performed a more detailed MRI, they discovered several fluid-filled cysts in the brain, some of which contained the head of a tapeworm. A blood test confirmed the diagnosis of neurocysticercosis.
The man was treated with a combination of albendazole and praziquantel (two antiparasitic medications), as well as corticosteroids to reduce inflammation. He successfully recovered with no complications, according to the case report.
CT scans (not pictured) showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer. (iStock)
The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier.
The exposure may have occurred while working a construction job with migrant coworkers from regions where neurocysticercosis is endemic.
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People can catch the pork tapeworm in two different ways. Eating undercooked infected pork usually leads to an intestinal tapeworm, but accidentally swallowing the parasite’s eggs — typically through food or water contaminated with feces — can send the larvae into the bloodstream, where they may form cysts in the brain and other organs. This can cause the disease the patient in the case report acquired.
A photomicrograph shows histopathologic features in a brain tissue specimen from a case of neurocysticercosis caused by the pork tapeworm Taenia solium. The image documents pathological changes associated with this parasitic infection. (Smith Collection/Gado/Getty Images)
As this was just a single case, the source of transmission could not be proven, the researchers acknowledged, and the findings cannot be generalized to a wider population. The report shows that there is a possibility of local transmission in non-endemic settings, but cannot establish how often this occurs.
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In the United States, less than 2% of neurocysticercosis cases are considered domestically acquired, according to the case report.
A prior systematic review identified only 18 confirmed locally acquired cases in Western Europe between 1990 and 2011.
The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier. (Associated Press)
In some cases, NCC can cause serious symptoms, including seizures, stroke, neurological deficits and cognitive decline.
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“Our case emphasizes that the absence of travel history should not preclude NCC from the differential diagnosis of multiple ring-enhancing brain lesions, even in regions where metastatic cancer is statistically much more likely,” the researchers concluded in the case study.
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Detecting the worms earlier could have prevented “unnecessary invasive oncologic procedures and led to prompt, targeted antiparasitic therapy,” they added.
Fox News Digital reached out to the researchers for comment.
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