Health
What are GLP-3s? Meet the new generation of weight-loss drugs with three key ingredients
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GLP-1 has become a popular buzzword in the weight-loss community — but now some are touting “GLP-3s,” claiming they are taking obesity medications to the next level.
GLP-1 (glucagon-like peptide-1) medications work by mimicking a naturally occurring hormone in the body that helps regulate blood sugar and appetite.
The informal term “GLP-3” refers to a new triple-agonist drug that targets three hormones: GLP-1, GIP (glucose-dependent insulinotropic polypeptide, another naturally occurring hormone released by the gut after eating) and glucagon receptors. The most advanced example is retatrutide by Eli Lilly, according to clinical trial outcomes.
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The New England Journal of Medicine published results from a 2023 phase 2 retatrutide trial for obesity, revealing “substantial reductions in body weight” after 48 weeks of treatment.
A 12 mg once-weekly injection led to a 24.2% weight reduction, and participants continued to drop pounds after the 48-week trial period.
GLP-1 (glucagon-like peptide-1) medications work by mimicking a naturally occurring hormone in the body that helps regulate blood sugar and appetite. (iStock)
Side effects were reportedly similar to GLP-1 medications, most commonly including gastrointestinal complications like nausea, vomiting and diarrhea. Heart rate increases were noted, depending on the dose.
How it’s different
Retatrutide mimics three natural hormones found in the body, compared to GLP-1s that simulate just one hormone, according to a report by GoodRx pharmacists.
GIP and GLP-1 hormones signal the pancreas to release insulin after eating, while slowing digestion to help initiate feelings of fullness.
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These hormones target the area of the brain that regulates appetite and influences food cravings, the report noted.
The third hormone, glucagon, speeds up metabolism and helps the body break down fat cells for energy. That hormone also tells the liver to make new sugar, which is kept in check by GIP and GLP-1 activity, preventing blood sugar spikes.
Participants in the phase 3 trial saw an average weight loss of 71.8 pounds. (iStock)
“This added metabolism boost can add to and complement GIP’s and GLP-1’s actions. And that’s why it seems to provide significant weight loss,” the GoodRx website states. “If approved, retatrutide will be the first in a new class of medications.”
Eli Lilly announced results from its phase 3 trial TRIUMPH-4 in December, testing retatrutide’s effect on weight loss and other health conditions.
“We believe retatrutide could become an important option for patients with significant weight loss needs and certain complications.”
Participants with obesity and knee arthritis who took a 12-mg dose of retatrutide saw an average weight loss of 71.8 lbs (28.7%) at 68 weeks.
“For retatrutide, the findings from TRIUMPH-4 are encouraging, and with seven additional phase 3 readouts expected in 2026, we believe retatrutide could become an important option for patients with significant weight loss needs and certain complications, including knee osteoarthritis,” a Lilly spokesperson said in a statement to Fox News Digital.
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The drug also reduced Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores by an average of 75.8%, marking “significant improvements” in comfort level and physical function.
More than one in eight patients reported being “completely free” from knee pain at the end of the trial, according to a press release from Lilly.
Participants with obesity and knee arthritis who took a 12-mg dose of retatrutide saw an average weight loss of 71.8 lbs (28.7%) at 68 weeks. (iStock)
Seven additional phase 3 trials for retatrutide are expected to wrap up in 2026. The drug could see FDA approval in 2027, according to GoodRx.
The Lilly spokesperson noted that there have been no studies comparing retatrutide to GLP-1 treatments due to “differences in study design and patient populations.”
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Despite limited data availability on the drug, the medication could also be applied to treat other conditions like type 2 diabetes, kidney disease, cardiovascular risk reduction and metabolic dysfunction, according to GoodRx and other experts.
Fox News senior medical analyst Dr. Marc Siegel noted that Lilly’s Zepbound and Mounjaro already target two metabolic pathways — GLP-1 and GIP — which work together to promote weight loss, reduce hunger and inflammation, improve insulin function and slow digestion.
The doctor confirmed that the new drug, with its third receptor agonist, will further decrease hunger while increasing the feeling of fullness.
More than one in eight patients reported being “completely free” from knee pain at the end of the trial. (iStock)
“The weight loss in clinical trials is even more substantial, and the most likely reason that it decreases orthopedic problems is because of the weight loss — less stress on the joints and the decreased inflammation,” Siegel added.
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The most common side effect of GLP-3s is gastrointestinal symptoms, the doctor confirmed. Rarer side effects may include pancreatitis, gallstones and heart arrhythmia.
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Philip Rabito, M.D., a specialist in endocrinology, weight loss and wellness in New York City, shared in an interview with Fox News Digital that this new class of weight-loss drugs is positioned to “approach bariatric surgery level outcomes” — although it doesn’t come without risks.
“The novel glucagon‑agonist component introduces less‑understood long‑term safety considerations, so it is imperative that patients are followed closely by healthcare professionals experienced with this class of medicines, with cautious, stepwise use, despite the impressive efficacy,” he cautioned.
Health
Jane Seymour, 75, shares how she approaches aging with vitality: ‘Best I can be’
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At 75, Jane Seymour isn’t fighting the years under her belt — she’s leaning into them. The former Bond girl in “Live and Let Die” and star of “Dr. Quinn, Medicine Woman” has a simple outlook on aging: She’s just grateful for the opportunity.
Her perspective shifted radically in her 40s after a near-death experience involving anaphylactic shock, according to an interview the actress did with Women’s Health.
“I remember looking at my body from above and thinking, ‘That’s your vehicle. I am responsible for taking care of this car,’” Seymour recalled.
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The actress shared the following four key habits she uses to navigate her 70s with vitality.
1. Embrace a positive attitude
Seymour’s perspective shifted in her 40s after a near-death experience involving anaphylactic shock, she told Women’s Health. (Michael Loccisano/Getty Images for Elton John AIDS Foundation)
For Seymour, the mental game of aging is just as important as the physical. She said she approaches every day with a sense of optimism, which she describes as “getting up and not giving up.”
In a recent interview with Future of Personal Health, Seymour said that being depressed over lost youth is “redundant.” Instead of mourning the past, she embraces the present.
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“You were 20, and you had whatever that experience was,” she said. “Now, maybe you’re 70, and it’s a whole new world.”
2. Know your body
Seymour’s fitness routine is built on consistency rather than intensity, she shared. The actress aims to work out at least three times a week, but refuses to push herself to the point of injury.
“You were 20, and you had whatever that experience was,” she said. “Now, maybe you’re 70, and it’s a whole new world.” (Jane Seymour/Instagram)
“I listen to my body,” she told Women’s Health. “I’m not going to overdo it.”
Seymour’s workouts focus on strengthening her core, arms and legs. While her preference is the reformer (a Pilates machine), she is highly adaptable.
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When traveling without workout equipment, Seymour said she performs bodyweight exercises, even doing incline press-ups against a kitchen counter.
“I’m not going to pretend I’m 20 when I’m 70,” she said. “I’m going to be the best I can be at the age I am.”
3. Nourish your body
Rather than fighting the natural signs of a life well-lived, Seymour said she views her appearance as a professional asset.
Seymour focuses on a rigorous skincare and nutritional routine to maintain the “vehicle” she was given, she said. (Emma Mcintyre/Getty Images)
“I’m not chasing wrinkles,” she added. “My laugh lines and even my frown lines are useful in my work – they’re part of my toolkit.”
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The actress said she focuses on a rigorous skincare and nutritional routine to maintain the “vehicle” she was given.
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This includes a daily regimen of exfoliation and hydration, alongside a diet rich in fruits and vegetables.
“I’m going to be the best I can be at the age I am.”
When her filming schedule makes fresh meals difficult, Seymour supplements with antioxidant blends to ensure there are “no nutritional gaps,” aiming for a holistic balance that allows her to “think sharper and move stronger.”
4. Nourish your mind
Perhaps the most profound tool in Seymour’s toolkit, she said, is her commitment to purpose. Inspired by her mother, a survivor of WWII concentration camps, Seymour believes that longevity is tied to how much one gives back to the world.
Seymour, inspired by her mother, a survivor of WWII concentration camps, created Open Hearts Foundation to give back to the community. (Jane Seymour/Instagram)
“My mother always said there’s someone worse off than you, and you can find purpose by helping others – listening and making them feel heard,” she shared.
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This philosophy led Seymour to found the Open Hearts Foundation, a nonprofit that empowers others through grant-making and volunteerism.
“That’s the best way to end the day — knowing it wasn’t wasted.”
Health
The Menopause Diet 5-Day Plan To Lose Weight Helps Women Drop Pounds Fast
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Health
Longevity experts reveal ‘flicker method’ that could help you feel years younger
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The idea that aging is a steady, predictable process is being challenged by a new book, which describes a so-called “flicker stage” where some aspects of aging may briefly reverse.
Stuart Kaplan and Marcus Riley, authors of the book “Your Aging Advantage,” say aging may be more fluid than chronological age alone would suggest. They call this phenomenon the “flicker stage,” just one of seven stages of aging.
The “flicker stage” suggests functional age isn’t fixed, with people shifting between levels of youth and vitality based on lifestyle and mindset, the authors state.
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Periods of feeling significantly younger, followed by times of feeling one’s age, may reflect what the authors describe as the “flicker stage.”
Riley said healthier aging involves “flickering back” to a younger state, noting that while stress or setbacks can make people feel older, those shifts aren’t permanent.
The secret to aging healthier is learning how to “flicker back” to a younger state when life pushes you forward, the authors said. (Milan Markovic/iStock)
“Through positive interventions, we have the ability to flicker back to the stage of age we want to be in … these setbacks or unforeseen circumstances might propel us to a different stage of aging, but we have this ability to flip it back through positive intervention.”
“Aging or growing older is [not] a problem to fix… it’s an opportunity to be seized.”
Riley said this requires identifying personal “flicker triggers” — physical, psychological, social or environmental shifts that help reset one’s pace, such as exercise or renewed social connection.
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Most people already live with a “feels-like” age that doesn’t match their chronological age, said Kaplan, comparing it to a weather report.
“In the summertime, the weatherperson might say it’s 85 degrees outside, but with the humidity, it feels like 95… The feels-like age is the lived age, as compared to the chronological age or the age on your birth certificate.”
The authors suggest that engaging in your community is one way to activate the flicker stage. (iStock)
Focusing on the “lived age” may allow people to intentionally shift into a younger stage, according to the authors.
Instead of “aging in place,” which focuses on where one lives, they suggest focusing on “aging on pace.”
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“It’s more about what’s important to us on a personal level… do we want to stay in employment and work for as long as we can? Do we want to be shifting gears… and pursuing other interests and pastimes that are important to us?” Riley asked.
Kaplan said the common focus on age 65 as a point of decline reflects a socially imposed retirement benchmark, not a biological marker.
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“It comes from the Social Security Act that was created in 1935 in the United States. And here we are 90 years later, and we’re still thinking that 65 is an important age…. We didn’t use the word retirement back then. I mean, have you ever seen a farmer back in the 1800s… that says, ‘Oh, we’re going to retire because Grandpa is now going to be 62 or 65 years old?’”
The flicker effect works best when you stop viewing aging as a “downhill” perspective, the experts said. (iStock)
The flicker effect works best when you stop viewing aging as a “downhill” perspective, Riley and Kaplan said.
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Even after a health setback shifts someone into a later stage, maintaining a positive and active approach may help move them back toward an earlier stage of aging, according to the authors.
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Ultimately, the goal is to stop seeing the passage of time as a problem to be solved, Riley said.
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“Aging or growing older is [not] a problem to fix.… We want the mindset [that] it’s an opportunity to be seized.”
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