Health
Four Texas residents forever connected by two kidney donations in different cities: 'Superbly timed'
Two hard-to-match transplant patients 250 miles apart started the year of 2024 with shining new hope for long, healthy lives — thanks to the collaboration of two Texas hospitals.
UT Southwestern Medical Center’s Solid Organ Transplant Program in Dallas, Texas, and University Health Transplant Institute in San Antonio worked together to find compatible living kidney donors for their failing patients.
In Dallas, Jorge Mendez, 50, an automotive shop foreman, was in need of a life-saving transplant.
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Mendez was on dialysis — which has a significant impact on not only a person’s quality of life on a daily basis, but also long-term health.
It was important for him to find a transplant before he became too sick for the procedure, according to his doctor.
Rebecca Warden, second from left, volunteered to give a kidney to her mother, 71-year-old Ann Winer of San Antonio, far left. And Svetlana Balmeo Stockdale, 28 (far right), volunteered to give a kidney to her co-worker, Jorge Mendez, 50, standing beside her. (University Health/UT Southwestern)
Mendez’s coworker, Svetlana Balmeo Stockdale, 28, offered to donate a kidney to her friend — but unfortunately she was not a match.
Meanwhile, 250 miles away in San Antonio, 71-year-old Ann Winer was also in dire need of a kidney transplant.
She was on dialysis after waiting almost two years for a kidney donor.
Winer’s biggest obstacle was that she had unusual antibodies that made it very difficult for her to match with a donor, her doctors said.
“A patient’s access to a lifesaving transplant shouldn’t be limited by geographic or organizational boundaries.”
Winer’s daughter, Rebecca Warden, wanted to donate a kidney — but it was not a compatible match.
“Winer would likely have become weaker over time and her condition would have grown worse,” Parsia Vagefi, M.D., the transplant surgeon at UT Southwestern who led the surgical team in Dallas, told Fox News Digital.
“She said she had almost given up hope of receiving a transplant.”
Rebecca Warden, left, volunteered to give a kidney to her mother, 71-year-old Ann Winer of San Antonio, right. Warden was not a match, though, so Winer’s medical team in San Antonio collaborated with another team in Dallas to find a donor swap for their respective patients. (University Health)
The leaders at both institutions began working together to find matches outside their local transplant networks.
After learning that she wasn’t a match for her friend, Stockdale — the intended donor for Mendez — got a surprising phone call.
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“A little while after I was told my kidney wasn’t a match, UT Southwestern called me and they said, ‘You couldn’t donate to Jorge, but we could do a swap with somebody else,’” she said in a statement to Fox News Digital.
As it turned out, Stockdale was a match for Winer, the grandmother in San Diego — and Warden, who had intended to donate to her mother, was a match for Mendez.
Setting the stunning plan into motion
The medical teams in Dallas and San Antonio began plans for a donor swap for their respective patients.
“[After finding the matches], we began discussing, ‘When would we start the surgeries? How would we transport the organs? How would the organs be tracked?’” said Dr. Elizabeth Thomas, transplant surgeon with University Health who led the transplant team in San Antonio, in a comment sent to Fox News Digital.
Jorge Mendez, 50, left, received a replacement for his failing kidney after medical teams in San Antonio and Dallas searched beyond their own networks for compatible living donors for their patients. Shown at right with him and wearing a matching yellow gown, Svetlana Balmeo Stockdale, 28, walks with Mendez after the two underwent surgery at UT Southwestern in Dallas. (UT Southwestern)
Through “carefully choreographed surgical schedules and chartered flights,” the transplant teams ensured that the donated organs would be safely transported and transplanted as quickly as possible, according to a statement from the hospitals.
“[The transport] could be tracked minute by minute in the plane via a tag that was on the box that was used to transport [the kidneys],” Thomas said.
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“It is important because we want to keep the time that the organ is out of the body without blood to a minimum.”
On Aug. 31, 2023, after a day of “superbly timed surgeries and close coordination,” according to the hospitals, Winer and Mendez received the new, functioning kidneys they needed to save their lives.
On Aug. 31, 2023, after a day of “superbly timed surgeries and close coordination,” according to the hospitals, Winer and Mendez received the new, functioning kidneys they needed to save their lives. (UT Southwestern/University Health)
“There are various ways you can do the swaps and various reasons to do them … It never gets old,” Dr. Vagefi told Fox News Digital.
Only a quarter of the transplants performed at UT Southwestern are from living donors, but Vagefi said he is hoping to expand that number, as living kidney donations last longer for the recipients.
“It’s really great to participate in it and form a collaboration with others who are working toward the same mission but in a different city,” he said. “We crossed geographic boundaries to help these families.”
Grateful for new hope
Because of the life-saving transplant, Mendez was able to hold his new granddaughter when the baby was born in January.
“It brought tears to my eyes to hold her,” he said in a statement. “Now I can live a little bit longer to spend time with her.”
He later wrote to his donor: “Thank you very much. I owe you the world.”
“I don’t think of it as me saving somebody’s life — I think of it as me giving Jorge’s family members more time with him.”
“I felt like they’d never find a donor for me, but they did,” Winer said.
On a card she sent to her Dallas donor, she wrote: “I will never be able to repay you.”
Stockdale, who had intended to donate to her friend Mendez, shared what being a donor means to her in a statement to Fox News Digital.
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“I don’t think of it as me saving somebody’s life,” she said. “I think of it as me giving Jorge’s family members more time with him.”
“[For Winer], whatever she hasn’t accomplished in life yet that she ultimately wanted to do, I hope she gets to do it. Life’s too short to not live out your wildest dreams.”
Winer, the retired nurse anesthesiologist, later wrote a letter to Stockdale thanking her for the kidney.
Through “carefully choreographed surgical schedules and chartered flights,” the transplant teams ensured that the donated organs would be safely transported and transplanted as quickly as possible, according to the hospitals. (UT Southwestern/University Health)
“Thank you for giving me back my life,” she wrote.
“I thought I would never get a transplant with my weird antibodies, and then you came along. Bless you.”
Warden — Winer’s daughter who had intended to donate to her mother but agreed to donate to Mendez in exchange for her mother receiving a transplant — also expressed her gratitude.
Parsia Vagefi, M.D., is the transplant surgeon at UT Southwestern who led the surgical team in Dallas. (UT Southwestern)
“At the end of the day, I’m happy that I’ve been able to help two people and not just one,” she said in a statement.
Today, both transplant recipients are doing well.
Winer is back at work part-time as a nurse anesthesiologist and is planning to retire at the end of July.
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Mendez has also returned to work. “I feel great,” he said.
Scott Bennett, associate vice president of the Solid Organ Transplant Program at UT Southwestern, said in a press release that “a patient’s access to a lifesaving transplant shouldn’t be limited by geographic or organizational boundaries.”
Dr. Parsia Vagefi of UT Southwestern led the surgical team in Dallas that collaborated with University Health in San Antonio to save two patients with failing kidneys. (UT Southwestern)
“It was rewarding to see the collective can-do spirit of two highly regarded programs collaborate to make it happen,” he added.
A kidney is the organ in the greatest demand for transplant.
A healthy person can live a full life after donating one of their two kidneys, according to experts.
The average life expectancy for someone on dialysis is five to 10 years, according to the National Kidney Foundation.
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Specific bacteria in the gut could predict a person’s risk of developing Parkinson’s disease years before symptoms appear, new research suggests.
Led by researchers from University College London (UCL), an observational study analyzed the gut microbes of 271 patients in the U.K. who had been diagnosed with Parkinson’s.
Also included in the study were 43 carriers of the GBA1 variant, which has been linked to an almost 30 times higher risk of Parkinson’s disease. These participants did not have symptoms of the disease. There was also a control group of 150 healthy participants without the gene.
STUDY FINDS EVIDENCE OF MICROPLASTICS IN BRAINS AND OTHER ORGANS
Based on fecal samples, more than one-quarter of gut microbes — bacteria and other microorganisms in the digestive tract — were in different amounts for people with Parkinson’s disease compared to healthy individuals, according to a press release.
Non-symptomatic people carrying the Parkinson’s gene also had microbial changes that resembled an “intermediate” stage of the disease, which suggests that microbial changes may happen prior to symptoms emerging.
Specific bacteria in the gut could predict a person’s risk of developing Parkinson’s disease years before symptoms appear, new research suggests. (iStock)
Those who reported eating a more diverse and balanced diet were less likely to have microbiome patterns associated with higher Parkinson’s risk, the researchers found.
The findings, which were published in Nature Medicine, were also seen in over 1,400 participants across the U.K., Korea and Turkey, suggesting that the microbial changes are consistent across different cultures and dietary patterns.
“There is an urgent need to develop treatments that can stop or slow the disease’s progression.”
“Parkinson’s disease is a major cause of disability worldwide, and the fastest growing neurodegenerative disease in terms of prevalence and mortality,” lead author professor Anthony Schapira of the UCL Queen Square Institute of Neurology said in the release.
“There is an urgent need to develop treatments that can stop or slow the disease’s progression.”
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Patients with Parkinson’s are known to have “significant gut abnormalities,” according to Dr. Earnest Lee Murray, a board-certified neurologist at Jackson-Madison County General Hospital in Jackson, Tennessee.
One of those is severe constipation, which can occur several years before tremors and other symptoms.
Those who reported eating a more diverse and balanced diet were less likely to have microbiome patterns associated with higher Parkinson’s risk, the researchers found. (iStock)
“There has long been a theory about the gut-brain axis and whether or not the pathology for Parkinson’s starts in the gut decades before stereotypical features are noted,” Murray, who was not involved in the research, told Fox News Digital.
The neurologist said the study sets the stage for additional research exploring the gut-brain axis theory, which could determine whether early pre-symptomatic treatments could prevent or mitigate the risk of developing Parkinson’s later in life.
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“With an aging population that is living longer, the prevalence of Parkinson’s is increasing significantly, which underscores the importance of studies like this that attempt to prevent this debilitating neurodegenerative disease,” Murray added.
“With an aging population that is living longer, the prevalence of Parkinson’s is increasing significantly,” according to Dr. Earnest Lee Murray. (iStock)
Dr. Aaron Ellenbogen, medical director of the Parkinson’s Disease & Movement Disorders Center at the Michigan Institute for Neurological Disorders, said it is not surprising that a change in the organisms living in the GI tract can be a signature of evolving Parkinson’s pathology.
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“In general, people with GBA mutations tend to have Parkinson’s symptoms evolve in a way that is more consistent with a gut-first presentation,” Ellenbogen, who also was not involved in the study, told Fox News Digital.
Others may experience a different set of symptoms, including loss of sense of smell, before developing signs of motor Parkinson’s disease, he noted.
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“In fact, many of these people don’t develop the symptoms of constipation and REM behavior disorder until later in their disease course,” Ellenbogen said. “These people may actually have a form of Parkinson’s that starts in the brain.”
Potential limitations
There were some limitations to the study, the researchers acknowledged. Because it was observational in design, it could not prove that the microbiome changes directly caused Parkinson’s.
The researchers also noted that not everyone with at-risk microbiome profiles will develop the disease, as other genetic or environmental factors could play a role.
The researchers also noted that not everyone with at-risk microbiome profiles will develop the disease, as other genetic or environmental factors could play a role. (iStock)
Additionally, differences in microbiomes across various populations could skew the results.
“To enable both the research and eventual use of such treatments, we need to develop the means for very early detection of people who will, or likely will, go on to develop the disease,” Schapira said.
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The study was funded by the Michael J. Fox Foundation for Parkinson’s Research and the UK Medical Research Council.
Fox News Digital reached out to the researchers for comment.
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