Health
Are peptides the fountain of youth? Doctors warn hype may outpace science
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Peptide therapy has gained popularity as a potential health and longevity booster, but experts are warning of cautions and limitations.
Peptides are short chains of amino acids that act as messengers involved in processes like metabolism, growth and immune function, according to Cleveland Clinic.
Some peptides have shown potential in helping with skin health, metabolism, muscle recovery and immunity, although research is limited, experts say.
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“‘Peptides’ is a broad umbrella that includes everything from well-studied, FDA-approved therapies to experimental compounds marketed for anti-aging with limited human data,” Dr. Brad Younggren, a board-certified physician and CEO and co-founder of Circulate Health in Seattle, Washington, told Fox News Digital.
Injectable GLP-1 diabetes and weight-loss drugs are a common form of peptides, he noted.
Peptides are short chains of amino acids that act as messengers involved in processes like metabolism, growth and immune function. (iStock)
“Most people now more widely understand the positive impact this peptide can have on human healthspan,” Younggren said. “Peptides have broad targets across human physiology, and each one must be explored independently.”
Other common types of peptides help with growth hormone production, healing and tissue repair, skin and hair health, immune regulation, and cardiovascular and blood pressure regulation.
Are peptides the fountain of youth?
Despite some claims of peptides extending lifespan, Younggren cautioned that no longevity therapy or treatment should be considered a “fountain of youth.”
“The science is promising in specific areas, but the category as a whole is not a single, proven longevity solution,” he said. “Peptides may be useful tools in select clinical contexts, but claims of universal rejuvenation are ahead of the evidence.”
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Ben Perez, the biomedical technology specialist at Pure Tested Peptides in Pennsylvania, noted that some people have seen benefits in recovery, immunity and tissue repair, while others have reported positive outcomes related to sleep, lean body mass and recovery time.
However, while peptides show promise, he said some suggested results may be “overly optimistic.”
Despite some claims of peptides extending lifespan, one expert cautioned that no longevity therapy or treatment should be considered a “fountain of youth.” (iStock)
“Some are anti-aging related and assist with cellular repair, release of growth hormones and metabolic functions,” Perez, who oversees quality control of research peptides, told Fox News Digital. “However, the results can be inconsistent, and the assertions are usually greater than the supportive research.”
Side effects
Each type of peptide can be associated with its own potential side effects, experts say.
Growth hormone–related therapies, particularly those that act on the growth hormone (GH)–IGF-1 axis, can affect multiple hormone pathways and carry risks such as fluid retention, insulin resistance, headaches and joint symptoms, as well as changes in blood pressure or lipid levels, according to Dr. Anant Vinjamoori, M.D., a Harvard-trained physician and chief longevity officer at Superpower.
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“The pathways in the study of peptides are complex and can lead to imbalances in the hormones of the body,” Perez said. “Other negative outcomes can be localized inflammation at the injection site and other reactions.”
“Endocrine disorders, autoimmune disorders and history of cancer are further reasons to be more careful.”
“Selling unproven, miracle-promising or supplement-peddling products with little accountability or third-party testing is a dangerous red flag.”
The most reliable way to receive peptide therapy is through injection, according to Vinjamoori, as some oral forms can be “under-absorbed” or may rely on added ingredients that can cause side effects.
“‘Safe’ is less about the route and more about the molecule, dose, purity and monitoring,” he told Fox News Digital.
“Most peptides have an extremely strong track safety record based on the data we do have — but there is still much that we do not know.”
Approval and regulation
Some peptides are FDA-approved for specific conditions, including GLP-1s and growth-hormone stimulators. These may be prescribed off-label in some contexts, although risks and benefits vary and evidence may be limited, according to experts.
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There are also some peptides that are not FDA-approved. “Many ‘fitness’ peptides discussed online are in early clinical phases or used only in research settings,” Vinjamoori noted.
“[Peptides] should be approached as a combination of lifestyle measures that contribute to better healthspan,” one expert said. (iStock)
Perez warned that peptides have little to no regulation in many countries, which means online vendors may sell fake, poor-quality or dangerous products.
“Selling unproven, miracle-promising or supplement-peddling products with little accountability or third-party testing is a dangerous red flag,” he said.
Starting safely
For those considering peptides, Vinjamoori recommends watching out for the following red flags.
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- Sourcing issues: Non-pharmacy “research chemicals,” lack of third-party testing or unclear labeling
- Overblown claims: Promises of rapid muscle gain or fat loss with no training changes
- Too many compounds: Stacking multiple substances without clear targets or bloodwork
- Lack of oversight: No clinician, baseline labs, or plan for cycling or stopping
“The most effective longevity care is proactive, personalized, and grounded in biomarkers and scientific evidence,” Younggren added. “It should be approached as a combination of lifestyle measures that contribute to better healthspan.”
Anyone interested in peptides should consult a physician to ensure that they receive a safe product and that it is used appropriately. (iStock)
Perez emphasized the importance of starting conservatively. “Understand the science, know the source and get medical guidance,” he advised. “Peptide therapy isn’t one-size-fits-all; it’s nuanced and still evolving.”
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While peptides may address issues that fall outside the reach of conventional medicine, Perez said, the supporting clinical data is still being developed.
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“Excessive use can lead to a decrease in their therapeutic effects and may cause adverse reactions, so more is not necessarily better,” he cautioned.
Anyone interested in peptides should consult with a physician to ensure that they receive a safe product and that it is used appropriately.
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Reducing your risk of cancer death may be as simple as taking brief breaks for physical activity throughout the day, according to a new observational study.
The study, led by researchers from the University of Glasgow studying the association between cancer and prolonged sedentary behavior, found that participants who regularly interrupted prolonged sitting with physical activity had a lower risk of cancer death.
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“This study adds to growing evidence that prolonged sedentary behavior is an independent health risk,” Dr. Georgia Spear, chief of breast imaging at Northwestern Medicine, told Fox News Digital.
“While it does not prove that sitting causes cancer, it suggests that long, uninterrupted periods of sitting are associated with a higher risk of cancer mortality,” Spear explained. “The findings reinforce existing public-health recommendations that regular movement throughout the day is an important component of cancer prevention.”
Prolonged sedentary periods are associated with increased risk of cancer death, researchers observed. (iStock)
The researchers monitored 91,292 volunteer participants in the U.K. who wore movement-tracking devices on their wrists for seven days to track their sedentary habits. The scientists followed the volunteers’ health outcomes over the course of about 12 years.
The researchers defined prolonged sedentary behavior as any bout that lasted “at least 30 minutes and during which at least 90% of the time was sedentary.”
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They defined interrupted sitting as sessions that lasted fewer than 30 minutes or were interrupted by brief periods of physical activity.
Each additional hour per day of prolonged sedentary behavior was associated with a 10% higher risk of cancer death, the researchers reported in their study, published by PLOS Medicine.
Light physical activity, including household chores, such as ironing, are associated with reduced cancer death risk. (iStock)
Replacing one hour of sitting each day with light activity was associated with a 12% lower risk of cancer death. Replacing 30 minutes with moderate activity was linked to an 8% lower risk, and replacing just five minutes with vigorous activity was associated with a 22% lower risk.
The researchers classified light physical activity as walking at a low speed and performing household chores, such as ironing a shirt or washing dishes.
These findings should be interpreted with caution, the researchers wrote, “because the study cannot prove causality.”
The volunteers may not represent the wider population, they noted, “and the activity monitor captured behavior only during a limited period without showing the context of sedentary behavior, such as work, television viewing or driving.”
Spear said that existing research has linked sedentary behavior to obesity, diabetes, cardiovascular disease and several cancers.
Breaking up periods of sitting or reclining with physical activity is key to reducing the risk of cancer death, researchers found. (iStock)
“What is notable here is the finding that how people sit appears to matter, not just the total amount,” she said. “Breaking up sitting with regular movement may provide measurable health benefits.”
According to Spear, other simple lifestyle strategies can be highly effective at reducing cancer-death risk.
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“Stand and move every 30 to 60 minutes, take short walking breaks, including after meals, use the stairs, walk during phone calls and incorporate light activity throughout the day,” she recommended.
“Combined with regular exercise, maintaining a healthy weight, limiting alcohol, not smoking and staying current with recommended cancer screening, these habits can help reduce the risk of breast cancer and other chronic diseases.”
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A simple lifestyle adjustment could potentially slow down the body’s biological aging process, according to new research.
The study, published in the journal Aging, investigated how a diet change and easy exercise regimen affected men between the ages of 50 and 74 over a three-month period.
Researchers designed a clinical trial involving 48 overweight men in Japan. Over a 12-week period, half of the participants followed a strictly structured wellness routine, while the other half maintained their usual habits.
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For the intervention group, the routine required consuming 100 grams of plain yogurt every day.
This group also received individualized dietary counseling that advised them to curb overeating, avoid excessive snacking and cut out sugary drinks.
A simple lifestyle adjustment could potentially slow down the body’s biological aging process, according to new research. (iStock)
They were also instructed to walk or use a stepper machine for roughly 30 minutes a day, at least three days each week.
To measure the impact of these changes, the scientists collected blood samples from all participants before and after the study, and also analyzed DNA for chemical changes that act as indicators of cellular age.
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Specifically, they used a measurement tool called DunedinPACE. Rather than assessing a person’s chronological age in years, this tool calculates the precise rate at which an individual’s body is currently aging.
The men who consumed the probiotic yogurt, adjusted their diets and exercised showed a statistically significant reduction in their pace of aging compared to the control group, the researchers said.
The anti-aging benefits cannot be attributed to any single component on its own due to the variety in the study, the researchers noted. (iStock)
On average, the speed of their biological aging slowed by approximately 2.2%. This reduction is roughly comparable to the slowing of biological aging observed in a previous two-year U.S. study, in which participants reduced their daily calorie intake by 25%.
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This reduction in aging speed happened independently of weight loss , meaning it did not directly correlate with changes in the participants’ body mass index or the exact number of exercise sessions they logged.
The researchers also recorded a noticeable improvement in a specific DNA marker that is linked to kidney function.
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Because this study combined three distinct factors — probiotics, diet and exercise — the authors concluded that the anti-aging benefits cannot be attributed to any single component. Instead, the slowed aging rate appears to be the result of a combined effect.
The reduction in aging speed happened independently of weight loss, the study found. (iStock)
The researchers also acknowledged clear limitations of the study, including its small sample size and short duration. Also, the participant pool was restricted to overweight men of a single nationality.
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More research is needed to determine whether these short-term biological shifts can translate into permanent, long-term health benefits, the study stated.
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The simple act of noting how fast your heart is beating while you’re at rest may be the key to measuring your overall health.
Resting heart rate is defined by Mayo Clinic as the number of times your heart beats each minute while you’re awake, calm and not moving.
A normal resting heart rate ranges from 60 to 100 beats per minute for adults. A slower resting heart rate means the heart does not have the work as heard to pump blood through the body — something typical of someone who is more fit.
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Athletes who are very fit may have a resting heart rate closer to 40 beats per minute, according to Mayo Clinic.
Your resting heart rate can vary due to a variety of factors, including age, physical activity levels, sleep health, smoking, cardiovascular disease, high cholesterol, diabetes, stress, anxiety, hormones, body type and certain medications.
A normal resting heart rate ranges from 60 to 100 beats per minute for adults, according to medical experts. (iStock)
But a resting heart rate that’s often too high or too low may signal a health issue.
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A high resting heart rate, even if it’s slight, is usually a sign that something else may be going on in the body, such as anemia, an infection or a thyroid problem, according to Cleveland Clinic.
A high resting heart rate, even if it’s slight, is usually a sign that something else may be going on in the body. (iStock)
If your heart rate is regularly above 100 beats per minute, this is a sign to talk with your heart care provider.
The same advice applies if you are not a trained athlete and your resting heart rate is frequently below 60 beats per minute.
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Talk to your doctor if other symptoms such as fainting, dizziness or shortness of breath occur.
How to measure your heart rate
You can check your own heart rate by tracking your pulse on your wrist or neck. The best time of day to measure resting heart rate is first thing in the morning, says Mayo Clinic.
Place your index and middle fingers inside the wrist below the thumb, to feel the radial artery; or, do so on the side of the neck, to feel the carotid artery.
Place your index and middle fingers on the side of the neck, to feel the carotid artery — and count how many beats per minute. (iStock)
Count the number of times your pulse beats in 15 seconds, then multiply this number by four to calculate beats per minute.
Wearable devices can also detect and track resting heart rate, although this may not always be accurate.
How to lower your heart rate
If your resting heart rate is higher than normal, there are a few ways to work toward lowering it.
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Vigorous exercise is “the best way” to lower your resting heart rate and increase the heart’s aerobic capacity and max heart rate, according to Harvard.
For those who don’t exercise regularly, it’s important to work your way up in difficulty when following a new workout routine.
Vigorous exercise is “the best way” to lower your resting heart rate, Harvard Health says. But it’s vital to work your way up carefully. (iStock)
Some medications, such as beta blockers, can also lower heart rate. In the same way, managing stress through holistic methods such as meditation or yoga can also help.
Cleveland Clinic also recommends cutting back on harmful substances such as drugs and alcohol, which can dehydrate you and raise your heart rate.
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Adequate sleep can also help bring your heart rate down, in addition to maintaining a healthy weight.
Cardiologist Tamanna Singh, M.D., shared with Cleveland Clinic that lowering your heart rate takes time as various lifestyle changes kick in.
Managing stress through holistic methods such as meditation or yoga can help lower your resting heart rate,
“Just like building your biceps and triceps, it takes time for your heart to become stronger,” the doctor said.
Singh recommended focusing on heart rate patterns rather than dialing in on just the number.
Take note of how your heart rate changes after eating certain foods, when you’re dehydrated or after you’ve begun a new exercise or stress management routine.
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“If you notice that your heart rate is consistently over 100, mention it to your doctor, especially if you’ve tried making lifestyle changes and they don’t seem to be working,” she said.
“Your resting heart rate isn’t the be-all, end-all of your health, but it’s definitely a marker that you should pay attention to.”
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