Health
A Single Infusion Could Suppress H.I.V. for Years, Study Suggests
For about a decade, scientists have had remarkable success curing some blood cancers by modifying a patient’s own immune cells to recognize and kill the malignant cells.
That same approach may help control H.I.V., among the wiliest of viruses, scientists will report on Tuesday. After a single infusion of immune cells engineered to recognize the virus, two people in a new study have suppressed their H.I.V. to undetectable levels, one of them for nearly two years.
The data is scheduled to be presented at a gene therapy conference in Boston, but the researchers shared an early copy with The New York Times.
The treatment is years, if not decades, from being widely available, but the study offers what scientists call “proof of concept,” and the tantalizing hope that a single shot could one day offer lifelong relief from H.I.V.
“It is inspiration and a potential road map to get to where we need to go,” said Dr. Steve Deeks, an H.I.V. expert at the University of California, San Francisco, who led the trial.
Other scientists were enthusiastic about the milestone.
“It’s truly amazing that they were able to accomplish this,” said Dr. Hans-Peter Kiem, an oncologist and gene therapy expert at the Fred Hutchinson Cancer Center in Seattle, who was not involved in the study.
H.I.V. requires lifelong control because the virus hides out in deep recesses of the body, and comes roaring back when it sees an opportunity. It also mutates easily to evade its attackers.
More than 40 million people are living with H.I.V. worldwide. About three-fourths of them take daily oral pills to keep the virus in check, and a much smaller proportion now receive injections every month or two. Several companies are developing longer-acting options, including weekly and monthly pills, and shots that could be given just once a year.
But scientists still aspire to develop “functional cures” that would effectively control H.I.V. over a lifetime, even if they do not eliminate it.
“People are really working hard on trying to cure it, and we’re making progress,” said James Riley, an immunologist at the University of Pennsylvania who is also modifying immune cells to control H.I.V.
Since the 1990s, many scientists have tried to modify immune cells called T cells to attack H.I.V., but those efforts were mostly unsuccessful. Some research teams lost interest after the arrival of powerful antiretroviral drugs soon after.
Cancer researchers soldiered on and succeeded in using the approach against blood cancers like leukemia.
“Cancer will always probably be the pioneer in this stuff, because of the incredible unmet medical need,” Dr. Riley said.
In the new study, scientists at Caring Cross, a nonprofit focused on developing affordable immunotherapies, engineered immune cells from each study participant to carry two molecules on the cell surface. Both molecules bind to H.I.V. and kill infected cells, but one also prevents the immune cells from becoming infected.
“It’s this dual nature of targeting — killing and protecting — that we think is the missing piece in terms of how this therapy works,” said Boro Dropulić, the executive director of Caring Cross, who developed the method.
The researchers extracted immune cells from each participant, modified the cells, then injected them back in. The participants stopped taking antiretroviral drugs the day of the infusion.
If a person does not take antiretroviral drugs, their H.I.V. levels typically soar within two weeks. But one person in the trial partially suppressed the virus for 12 weeks before rebounding. Two others were still in remission, 92 and 48 weeks after their infusion.
All three had begun receiving antiretroviral therapy within months of being infected. Three others who had lived with H.I.V. for longer before they were treated did not respond and needed to resume antiretroviral therapy. (A seventh participant showed signs of control seven weeks after infusion.)
Those details may be important. Those who were treated early in infection may have less H.I.V. sequestered in their body. Their immune system may also be less ravaged by the virus, and therefore more likely to rally when infused with the modified cells.
“Three out of three people with early disease doing some degree of control, to me, is the most provocative finding here,” Dr. Deeks said.
The two people with long-term response did show some blips of viral replication that quickly died down. That is to be expected as H.I.V. emerges from its reservoirs and is quashed by the immune cells.
Still, the results were exciting, several experts said.
The numbers in the study are very small but “these n-of-ones are so powerful because they encourage further research,” said Dr. Mike McCune, the head of a division at the Gates Foundation that supports innovation in H.I.V.
“For us, what’s important is to make sure that we can go from an n-of-one to an n-of-a-million or more,” he said. “And the only way to do that is to engage companies that know how to make products.”
The foundation has not invested in work that involves removing immune cells and reinfusing them back into the individual. That approach is too invasive and expensive to reach the millions who will need it, Dr. McCune said. But it is actively pursuing scalable options.
Cancer researchers are already showing success altering the immune cells while they are still in the body, which should eventually be cheaper by orders of magnitude.
The direct injections could be produced “for less than $10,000 and then be off-the-shelf, meaning you can have them ready when a patient or person living with H.I.V. comes in,” Dr. Kiem said.
Other groups are working on broadly neutralizing antibodies, rare molecules that can disable a wide range of H.I.V. versions by targeting parts of the virus that do not mutate.
“If we can combine these two approaches, that really may be synergistic and provide a pathway to deliver something close to a functional cure long term,” Dr. Riley said.
Anticipating long-term needs, Caring Cross is working with organizations in Brazil, India and elsewhere to manufacture the products for cancer at much lower costs. The team is also refining the tools and approach for H.I.V. and plans to begin a bigger study later this year.
“This is a first-in-human approach,” Dr. Deeks said. “We often come up with new theories as we do this, and that’s what’s happening as we speak.”
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The Trump administration is taking another look at ending biannual clock changes, with an eye toward making daylight saving time (DST), or the “summer clock,” permanent.
On May 21, the House Energy and Commerce Committee advanced legislation that would make daylight saving time permanent in a 48-1 vote, part of a largely bipartisan push to end twice-yearly clock changes.
Although gaining extra winter evening daylight might seem like a win, health experts say permanent daylight saving time could disrupt people’s natural circadian rhythms.
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In an interview with Fox News Digital, Dr. Wendy Troxel, a licensed clinical psychologist and senior behavioral scientist at RAND based in Utah, said science is being “misconstrued” in this decision.
“Ending the biannual clock change is something most sleep scientists and the public would welcome,” she said. “The disruption of springing forward every March is associated with real, measurable harm — spikes in car crashes, heart attacks and sleep deprivation.”
The Trump administration is taking another look at ending semiannual clock changes, with an eye toward making daylight saving time, or the “summer clock,” permanent. (iStock)
However, Troxel noted, implementing permanent daylight saving time is “not supported by science.” Instead, evidence “strongly supports” permanent standard time, or the “winter clock,” according to the expert.
Major sleep medicine organizations, including the American Academy of Sleep Medicine, have previously supported adopting permanent standard time over permanent daylight saving time.
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“Standard time is more closely aligned with human circadian biology, meaning the relationship between light, darkness and our internal clocks remains intact,” Troxel said.
“Permanent DST simply shifts an hour of morning sunlight to the evening, and there are significant health and safety costs of that trade.”
“Standard time is more closely aligned with human circadian biology,” the expert said. (iStock)
The U.S. attempted permanent DST in the early 1970s, but the plan was aborted in part due to these “morning consequences,” according to the sleep expert.
“Within a year, the law was repealed amid public displeasure with commuting to work and school in the dark and increases in morning car crashes, and with no demonstrable impact on energy savings,” Troxel told Fox News Digital.
Why morning sunlight matters
Human circadian rhythms are primarily “anchored” by morning light, Troxel said. Under permanent DST, most people waking up for work or school would be rising before the sun, which forces a “chronic misalignment between the body’s internal clock and the external world.”
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“You cannot override that biology by simply shifting external clocks forward,” the expert said. “What you get instead is a population that is effectively waking up in the middle of their biological night, every single day.”
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The public has typically supported having more daylight in winter evenings, which could alleviate mental health conditions such as seasonal depression.
Supporters of permanent daylight saving time argue that later evening daylight could encourage outdoor activity, recreation and consumer spending after work or school.
Morning light is “crucial to regulate sleep, [boost] alertness and support mental health,” according to a sleep expert. (iStock)
Troxel agreed that light is a “powerful regulator” for sleep and moods, but noted that not all types have the same benefits.
“Morning light is crucial to regulate sleep, alertness and support mental health, and this would be sacrificed with permanent daylight saving time,” she noted.
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In some areas of the country, like Utah, Americans wouldn’t see the sunrise until about 9 a.m. in the winter, which some research has linked to higher rates of depression and seasonal mood challenges.
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“More evening light may feel enjoyable, in part because we equate it with lovely summer evenings, but permanent daylight saving time does not mean permanent summer,” Troxel emphasized. “It just means we will get less morning sunlight and more evening sunlight.”
“Exposure to light in the evening further pushes circadian rhythms later, making it more difficult to fall asleep and harder to wake up in the morning.”
Risks for vulnerable groups
Permanent daylight saving time can intensify people’s habit of “bedtime procrastination,” deepen sleep deprivation and contribute to the widespread public health issue of insufficient sleep already identified by the Institute of Medicine, according to Troxel.
Teens are most at risk of mental health complications if permanent DST extends darkness in the morning. (iStock)
Various studies have shown that people typically sleep less in summer compared to winter. Troxel said this is particularly concerning in a society where one in three people are already getting insufficient shuteye.
“This is especially alarming for teenagers, a population the U.S. surgeon general has identified as being in a mental health crisis,” she cautioned.
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For example, a teen waking up at 6:30 a.m. for an 8 a.m. school start time under permanent DST would be rising biologically at 5:30 a.m., Troxel noted, which is “in the middle of their biological night.”
“Framing permanent DST as a fix for seasonal depression gets the science exactly backwards,” she added.
Fox News Digital’s Alex Nitzberg contributed to this report.
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People who quit smoking may reduce their risk of developing dementia later in life, according to new research.
A team of researchers at a university in China analyzed data from more than 32,000 adults over a 25-year period and found that former smokers had a lower risk of dementia compared to people who continued smoking.
The findings were published in the journal Neurology.
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During the study period, researchers documented 5,868 cases of dementia.
Participants who quit smoking during the study had a significantly lower risk of developing dementia than current smokers. Their risk was similar to people who had quit smoking before the study began and those who had never smoked.
New research suggests that quitting smoking may lower the chance of developing dementia later in life. (iStock)
The researchers also found that dementia risk continued to decline the longer a person remained smoke-free, approaching that of never-smokers after about seven years.
The benefits appeared strongest among people who gained little or no weight after quitting.
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“Our findings suggest that quitting smoking may support long-term brain health, but they also highlight that what happens after quitting matters,” lead researcher Hui Chen said in a statement.
The reduction in dementia risk was most pronounced among people who experienced little or no weight gain after they stopped smoking. (iStock)
Zaid Fadul, a Harvard-trained physician and chief medical officer of Bespoke Concierge MD who was not involved in the research, said the findings add to growing evidence that quitting smoking can help protect long-term brain health.
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“The key takeaway is that the brain appears to benefit from smoking cessation at virtually any stage,” Fadul told Fox News Digital.
“Smoking contributes to chronic inflammation, oxidative stress, and damage to blood vessels that supply the brain, all of which are associated with cognitive decline and dementia risk.”
Fadul said the findings should encourage smokers who may feel it is too late to quit.
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“Importantly, it is rarely ‘too late’ to quit,” he said.
“While earlier cessation offers the greatest benefit, the body and brain begin recovering soon after smoking stops.”
Experts say it is almost never too late to quit smoking, as the body and brain start to recover soon after a person stops, although quitting earlier provides the greatest health benefits. (iStock)
Improvements in circulation, reduced inflammation and better cardiovascular health can help preserve cognitive function later in life, according to Fadul.
“Every year without tobacco is a step toward lowering future dementia risk and improving overall health,” he said.
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While the findings were encouraging, the study does have limitations.
Researchers identified an association between quitting smoking and a lower risk of dementia, but the study was not designed to prove that ending smoking directly prevents the condition.
Other health, lifestyle and environmental factors may have also influenced participants’ outcomes.
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Fox News Digital reached out to the researchers for further comment.
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