San Diego, CA
UC San Diego Receives $7.35 million for Scripps Center for Oceans and Human Health
The University of California San Diego was awarded $7.35 million in funding from the National Science Foundation (NSF) and the National Institutes of Health (NIH) for a multidisciplinary program to advance understanding of marine contaminants and nutrients in a changing climate, and to ensure that safe and healthy seafood is available and accessible to all people.
The funding, to be awarded over five years, will enable the re-establishment of the Scripps Center for Oceans and Human Health as one of four new nationwide centers focused on understanding how ocean-related exposures affect people’s health.
The center brings together experts from UC San Diego’s Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, and the School of Biological Sciences, as well as NOAA’s California Sea Grant and the Southwest Fisheries Science Center. Its multidisciplinary research team will explore the sources, fates and potential toxicity of human-made and natural chemicals in the ocean, and further study their environmental distribution and movement through the marine food web.
“The Scripps Center for Oceans and Human Health will bring together a range of scientific disciplines to advance of our understanding of seafood security to ensure we maintain our access to safe and healthy seafood,” said Bradley Moore, professor of marine chemistry at Scripps Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, who will serve as center director. “Scientific discoveries are the first of many steps to ensuring seafood safety, and to help with the process, the center will also have a focus on community engagement to work with fishers, chefs, non-profits, and the public at large to bridge scientific discovery with the community.”
The team will look at health benefits from nutrients like selenium and omega-3 fatty acids, and examine toxic heavy metals like methylmercury and organic pollutants like polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), and how concentrations may be impacted in a changing climate. PCBs are industrial chemicals banned in the U.S. in 1979, and PBDEs are a class of fire retardant chemicals that can be both human made and occur naturally in the ocean.
“The ocean is absorbing more than 90% of excess heat caused by human activity, which is causing habitat migration and compression, low oxygen zones, and biodiversity loss,” said Margaret Leinen, vice chancellor for marine sciences at UC San Diego and director of Scripps Oceanography. “It’s important to understand how these changes may impact seafood security, given that three billion people consume seafood globally each year. UC San Diego is uniquely positioned to bring together leaders across oceanography, biomedical and human health sciences, and community engagement experts to bridge the science to society.”
The center will focus on three primary research endeavors and include a large community engagement program:
Climate change impacts on the human intake of seafood micronutrients and contaminants
Led by Scripps Oceanography marine biogeochemist Amina Schartup and biological oceanographer Anela Choy, this project aims to understand how nutrients and contaminants like methylmercury and other chemicals are bioaccumulating in the marine food web. Schartup and Choy will also develop models to simulate the cycling of methylmercury and PCBs, and potential human exposure, under different climate change scenarios.
In 2019, Schartup led novel research that found warming oceans could lead to an increase in methylmercury in popular seafood, including cod, Atlantic bluefin tuna and swordfish. Her findings attributed the increases to corresponding changes to food web dynamics.
“Habitat change such as fish leaving or fish joining an ecosystem means a new food source has entered the ecosystem of a region,” said Schartup. “We’ll be looking at if those ocean changes are potentially going to impact contaminants or micronutrient levels in these animals.”
San Diego, CA
Machado's walk-off lifts Padres to 10-inning comeback victory over Cards
Here’s some instant reaction from the Padres’ wild 3-2 victory
San Diego, CA
Padres come back, walk off with win over Cardinals to split series
It seemed like the same tired story.
Instead, it was the same thriller.
The Padres pushed their offensive lethargy as long as possible without paying for it Sunday, tying the game with two outs in the ninth inning on Nick Castellanos’ two-run homer and then celebrating after Manny Machado’s sacrifice fly in the 10th inning gave them a 3-2 victory over the Cardinals.
“Getting it done,” Machado said.
That’s it. That is all they are doing.
And at what is essentially the quarter mark of the season, the Padres are 24-16 and tied with the Dodgers atop the National League West.
The shocking component of their having the major leagues’ fifth-best record is that the Padres rank in the bottom three among MLB’s 30 teams in batting average and OPS.
They split with the Cardinals despite having 14 hits, their fewest in a four-game series in franchise history. Their 61 hits over their past 10 games are the fewest in a stretch that long since 2019, and they are 5-5 in those games.
“It sucks; we need to hit; Machado said. “I mean, you know, look, it’s obvious. We’re not hitting. It’s obvious, but we’re getting things done, man.”
Sunday was the Padres’ 12th victory this season in which the decisive run was scored in the seventh inning or later. That is exactly half their victories.
It was their fourth walk-off victory, their second in extra innings. It was the seventh time that a run scored in their final offensive half-inning decided a victory.
So it is no small thing to proffer that Sunday was possibly their most dramatic triumph. Because it was possibly their most unlikely one.
Not only were they a strike away from defeat, but they began the ninth inning having gotten two hits all day.
The Cardinals took a 2-0 lead in the fourth inning on their first two hits off Walker Buehler — a single by Alec Burleson and a home run by Jordan Walker with two outs. Buehler pitched six innings, allowing just one more hit before Ron Marinaccio worked two scoreless innings.
But the Padres were unable to make anything of their seven at-bats with runners in scoring position over the first eight innings. They had walked five times but had just Jackson Merrill’s third-inning single and Xander Bogaerts’ fourth-inning double to that point.
“Really good teams find ways to win games when they’re not doing their best,” Gavin Sheets said. “… We’re not clicking on all cylinders by any means. And I don’t think any of us would say that he’s on a roll right now, but we’re getting hits in a timely fashion and it’s someone different every night.”
Almost.
The Padres have game-winning RBIs from 10 different players. They have go-ahead RBIs from 13 of the 14 position players who have been on their roster this season. Sunday was Castellanos’s third game-tying RBI.
His home run, on the ninth pitch of his at-bat against Cardinals closer Riley O’Brien, was something of a clinic by a veteran hitter who is in his first season as a role player.
Castellenos, who entered the game as a pinch-hitter in the seventh inning and remained in right field, came to the plate with Bogaerts at first base with two outs.
Bogaerts’ single leading off the inning had been followed by two strikeouts, and Castellanos fell behind 0-2 before working the count full and then sending a 99 mph sinker on the inner edge of the plate almost to the ribbon scoreboard fronting the second level of seats beyond left field.
“The first pitch started, and I was probably looking to do what I did,” he said. “And then I ended up getting 0-2 and chasing. After that, just took a deep breath and tried to shorten up as much as possible and just compete. Just find a way on base. And then found myself in a full account and was able to get the job done.”
It was the first home run allowed by O’Brien this season.
With closer Mason Miller not available after throwing 29 pitches over 1⅓ innings on Saturday, Jeremiah Estrada got the first two outs of the 10th. With runners on first and second, Adrian Morejón entered the game and got an inning-ending pop out on his first pitch.
Gordon Graceffo was on the mound for the Cardinals, and Ramón Laureano was the Padres’ automatic runner in the 10th. The Cardinals intentionally walked Merrill at the start before Fernando Tatis Jr. whittled a 1-2 count into a walk to load the bases.
The game was over one pitch later, when Machado sent a fastball to right-center field and Laureano slid across the plate well in front of right fielder Jordan Walker’s throw.
It was a somewhat subdued but still enthusiastic celebration along the first-base line, as teammates bounced around Machado.
“It’s hard to win a game like that,” Padres manager Craig Stammen said. “Their pitchers pitched great, and they’re bringing in one of the best closers in the game. And we just stuck with it. It just speaks to how those guys believe in themselves and how they believe in what we’ve got going on as a team.”
San Diego, CA
It’s ‘trust, but verify’ for new AI spine surgery system
On a recent morning, Dr. Joseph Osorio arrived in the operating room ready to sink six surgical screws into his patient’s spine, and he did not seem remotely nervous that their placement and size had been recommended by artificial intelligence software.
Osorio was the first neurosurgeon on the West Coast to begin using Medtronic’s new “Stealth AXiS” surgical robotic system, conducting a spinal fusion procedure to treat degenerative scoliosis at Jacobs Medical Center in La Jolla by anchoring two small custom-shaped metal rods across three vertebrae in his patient’s lower spine.
The process started with a CT scan, identifying the segment of spine that needed reinforcement. A program analyzed the resulting three-dimensional image, using an AI model trained on information from previous successful surgeries, not just where screws should go, but also the best path for their insertion.
Board-certified with thousands of such surgeries in his past, having completed a fellowship at Columbia University after a surgical residency at UC San Francisco, Osorio is well-qualified to make these calls with zero help from technology. So, why bother using an algorithm to plan these crucial, but routine details?
The utility, he said, is similar to what many are now experiencing when they use AI writing tools. The software can quickly get a person to the neighborhood of what they intend to say.
“You might say, ‘write me a paragraph on this,’ and it’s going to cut down your time, but you might still need to change some words, add a comma, tweak a sentence … that’s essentially what the AI is doing here,” Osorio said.
In this particular case, the AI system’s recommendations for screw length and diameter seemed on point, allowing the army of surgical technicians assisting with the procedure to pull the proper supplies ahead of time. The suggested locations, though, did require minor adjustment.
“It was slight, very slight, I’d say probably, like one or two millimeter adjustments,” Osorio said.
And the AI auto planning feature, he added, is even more useful in situations where a patient’s health insurance company will not pay for a pre-surgical CT scan, meaning that the guiding image must be taken after the patient is already sedated in an operating room on the day of their surgery.

Once a digital surgical plan is created and approved by a qualified surgeon, a surgical robot can use a system of cameras and electromagnetic sensors, registered against each patient’s anatomy with an initial X-ray, to move its arm to each screw location, placing a drilling guide at the exact angle needed to put each anchor in the correct spot. Here, too, AI is at work comparing previously recorded X-rays with real-time sensor data to compensate for any patient movements that may occur.
It is an evolution of Medtronic’s previous “Mazor” robotic spike system, which had already achieved levels of anatomy navigation using sensors and cameras that have reduced the need for X-ray images during surgery. And other medical device companies have launched similar systems, building in AI functions as the entire industry begins to see such augmentation as table stakes to play in a market that has always been as competitive as a high-stakes table in a Las Vegas casino.
Patients may wonder whether this push toward AI guidance is a good thing. After all, this is a technology that has made headlines for its ability to “hallucinate” convincing, but incorrect details.
ECRI, an independent non-profit organization that works to improve patient safety and cost effectiveness in health care, has been watching these systems develop.
In an email, Scott Lucas, ECRI’s vice president of devices, therapeutics and technology, said that the organization does not comment on any individual case or procedure, but has found that AI-enabled systems do have their merits.
“We can say that AI seems to be particularly helpful when it is used to support imaging, planning, navigation and precision in technically demanding procedures such as spine surgery,” Lucas said. “These tools may help surgeons in multiple ways, including tailoring procedures to a patient’s anatomy and improving consistency in implant placement and alignment.”

That said, the executive makes it clear that there is no argument for blind loyalty. In these early days, he argues, AI assistance should be less involved with surgeries, and there must be a clear path that allows surgeons to verify the work that their algorithmic assistants perform.
“Used well, AI may strengthen surgical safety; used without appropriate governance, human oversight, training and monitoring, it could introduce new risks, including overreliance, workflow disruption, planning errors or automation bias,” Lucas said.
Such bias, he added, occurs when a surgeon “fails to recognize when the technology is wrong.”
Osorio said that he believes the checks and balances built into the new system he is now using weekly do give him solid checkpoints to make sure that the machine is not hallucinating. While screw placement calculations will automatically calculate for straightforward placements, those with particularly complicated circumstances, such as anatomy that significantly deviates from the norm, will not proceed.
“If things aren’t lining up perfectly in the image, or they’re getting some feedback, it will just refuse to place a screw in that corridor,” Osorio said. “So, it’s only making recommendations in locations that meet the highest standards, and it still requires the surgeon to validate every level.”
AI is now also involved in the calculations used to move the robotic arm to the correct locations for screw insertions and also to make real-time corrections for any patient movement, Medtronic confirmed by email.
Here too, Osorio said, there are ways to verify that the robot’s calculations are pointing at the correct vertebrae, even though this type of minimally invasive surgery does not expose the target bone before screw insertion.
Surgeons use a bony projection at the back of each vertebra called the spinous process to check the robot’s accuracy, laying a special navigation ring over the landmark to verify that what is showing on the computer’s calculated location screen matches the robot’s arm position.
“A very common statement is ‘trust, but verify’,” Osorio said.
While robotic spine surgery is the latest to begin the process of AI integration, other systems have already made similar moves in knee and hip replacements, urologic procedures, and in some aspects of general surgery.
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