Science
NIH cuts put medical research at risk, scientists say, raising concerns at UC and elsewhere
Each year, the National Institutes of Health gives billions of dollars to the University of California to pay for research into cancer, Alzheimer’s, Parkinson’s, heart disease, diabetes and other diseases it has been at the forefront of studying for decades.
But a drastic cut to NIH funding under the Trump administration set to take place Monday has caused alarm among UC leaders and many medical researchers, who said the move would “jeopardize America’s research preeminence.”
Speaking to The Times since the cuts were announced Friday night, UC medical researchers expressed concerns about the future of their labs and lifesaving endeavors — as have others at universities and academic medical centers nationwide.
The NIH said late Friday that it would slash by more than half so-called “indirect funding” — overhead for research supplies, building maintenance, utilities, support staff and other costs — that institutions receive as part of medical research grants.
Beginning Monday, NIH-sponsored indirect funding will be capped at 15% of grants, down from 57% that many UCLA research projects receive and the 64% given at UC San Francisco, which has the highest rate in the UC system.
In its X post on the change Friday, the NIH shared a graphic that compared the indirect funding rates for Harvard, Yale and Johns Hopkins with their multibillion-dollar endowments. The highest among them, Harvard, was 69%.
The NIH’s move would save roughly $4 billion a year in tax dollars, the post stated. The agency said that more than a quarter of its $35 billion in research funding last year went to overhead. As a comparison, it cited private foundations, including the Chan Zuckerberg Initiative and the Gates Foundation, saying their overhead costs are 15% or lower.
“The United States should have the best medical research in the world,” the NIH said in guidance posted to its website. “It is accordingly vital to ensure that as many funds as possible go towards direct scientific research costs rather than administrative overhead.”
University researchers said the money, despite being labeled “indirect funding,” is essential to their work and pays to keep lifesaving science going — from ensuring the proper storage of biological samples to keeping alive animals for medical trials. They also contend that private foundations do not have to follow the same rules in how they categorize spending, saying it is unfair to compare overheads between the two.
Republicans argue that the costs are superfluous, part of bloated spending of taxpayer funds that President Trump has appointed Elon Musk to pare down.
Scientists point out that universities have already been paying a greater share for research costs. Data from the National Center for Science and Engineering Statistics show that, since 1980, the federal slice of research support at universities has gone down 12% while university payments have gone up 11%.
Cuts could ‘imperil’ UC medical research
The NIH is the largest funder of UC research, providing $2.6 billion in the last academic year — 62% of the university’s federal awards of more than $4.2 billion.
In a statement, UC said that the “new administration guidance would imperil this vital support and jeopardize America’s research preeminence.”
“These time-honored university partnerships have led to some of the most powerful and impactful research discoveries in human history,” the statement said. “Life-saving treatments for cancer, diabetes, heart attacks, and strokes, including in children, and new technologies and industries that translate into hundreds of thousands of well-paying jobs are all at risk. America is first in research, but its dominance is not assured.”
On Saturday, UC officials were still analyzing the effect of the NIH move, and were in contact with UC lawyers, researchers and administrators on how to respond.
In an email to his science faculty after the NIH announcement, a UCLA dean said: “As with many announcements over the last several weeks, this no doubt causes significant anxiety. Please know that the leadership at UCLA and across the UC is working to understand the implications.”
White House defends move
The White House defended its action, saying in an email blast to media outlets Saturday that “the NIH did not announce any cuts to actual research.” It cited Vinay Prasad, a professor of epidemiology and biostatistics and medicine at UC San Francisco, who praised the NIH move on his blog.
The cut “might even mean more science. Less money spent on the administration is more money to give out to actual scientists,” wrote Prasad. “I am shocked to see researchers crying about how much money the university gets — it means more grants can be given per cycle.”
Several other UC researchers, many who had just applied for grant renewals after a recent application pause or were in the midst of assembling grant proposals, said they were stunned.
“All my research will be shut down if this goes through. There is no other way to say it. It will be done,” said Beate Ritz, a professor and vice chair of the epidemiology department at UCLA who has received at least $1 million a year for more than a decade from the NIH to research environmental pollution, Parkinson’s and Alzheimer’s. “It’s not my salary. I get paid by the state to teach. But it is the cost of much of everything else.”
What is being cut
Indirect costs cover items outside of salaries, travel, supplies and other direct expenses. The indirect costs are negotiated between the university and the federal government — typically every three or four years for UC campuses — which is why the change surprised scientists.
Gina Poe, a neurobiology professor in UCLA’s David Geffen School of Medicine, said she feared that her decades of research into memory, sleep and post-traumatic stress syndrome were threatened.
Poe explained how her grant works. She receives $250,000 a year from the NIH to pay five undergraduate and graduate research assistants, among other expenditures, including rats and mice. This does not include her indirect funding.
With UCLA’s indirect cost rate of 57%, at first glance, it appears Poe would receive an additional $142,500 in such funding. But she said the math is more complicated and she gets much less.
The federal government, Poe said, deducts certain costs from the grant before it calculates indirect funding levels. Major equipment costs, tuition awards to students and more are not included. In the end, her NIH indirect funding totals an additional $114,000, which mostly goes to UCLA and to the university’s life sciences division to cover facilities costs and other expenditures.
Among the budget items indirect funding pays for: workers who care for rats and mice, feeding them and cleaning their cages. It also pays for medicine and veterinarian visits.
Under the new NIH formula, Poe’s indirect funding allowance would be minimal.
“The only way left for me to make up that money is to move my work to a private company, for UCLA to raise tuition to cover extra costs or to apply to private foundations where the competition is going to increase significantly for funding,” Poe said.
Vivek Shetty, a UCLA professor of oral and maxillofacial surgery and biomedical engineering and former Academic Senate chair, expressed concerns that U.S. research power could be diminished.
“America’s global leadership in science and technology wasn’t built on genius alone. It relied heavily on infrastructure and systems that allowed universities to transform ideas into innovations. Cripple that infrastructure, and the next medical or AI advancement will happen elsewhere — taking with it not just jobs and prestige, but also the economic vitality and societal progress that innovation brings,” Shetty said.
The funding change has hit a particular nerve at universities since Trump’s inauguration. Many administrators have felt under the microscope from a president who has spoken out against what he describes as “Marxist” universities overrun with leftists.
Last month, UC officials raised concerns after a temporary NIH pause on research grant reviews. Trump’s executive orders have also targeted diversity, equity and inclusion programs — including in federal grants and programming. On Wednesday he signed an executive order designed to ban transgender athletes from participating in women’s or girls’ sporting events.
Times Staff Writer Corinne Purtill contributed to this story.
Science
Commentary: My toothache led to a painful discovery: The dental care system is full of cavities as you age
I had a nagging toothache recently, and it led to an even more painful revelation.
If you X-rayed the state of oral health care in the United States, particularly for people 65 and older, the picture would be full of cavities.
“It’s probably worse than you can even imagine,” said Elizabeth Mertz, a UC San Francisco professor and Healthforce Center researcher who studies barriers to dental care for seniors.
Mertz once referred to the snaggletoothed, gap-filled oral health care system — which isn’t really a system at all — as “a mess.”
But let me get back to my toothache, while I reach for some painkiller. It had been bothering me for a couple of weeks, so I went to see my dentist, hoping for the best and preparing for the worst, having had two extractions in less than two years.
Let’s make it a trifecta.
My dentist said a molar needed to be yanked because of a cellular breakdown called resorption, and a periodontist in his office recommended a bone graft and probably an implant. The whole process would take several months and cost roughly the price of a swell vacation.
I’m lucky to have a great dentist and dental coverage through my employer, but as anyone with a private plan knows, dental insurance can barely be called insurance. It’s fine for cleanings and basic preventive routines. But for more complicated and expensive procedures — which multiply as you age — you can be on the hook for half the cost, if you’re covered at all, with annual payout caps in the $1,500 range.
“The No. 1 reason for delayed dental care,” said Mertz, “is out-of-pocket costs.”
So I wondered if cost-wise, it would be better to dump my medical and dental coverage and switch to a Medicare plan that costs extra — Medicare Advantage — but includes dental care options. Almost in unison, my two dentists advised against that because Medicare supplemental plans can be so limited.
Sorting it all out can be confusing and time-consuming, and nobody warns you in advance that aging itself is a job, the benefits are lousy, and the specialty care you’ll need most — dental, vision, hearing and long-term care — are not covered in the basic package. It’s as if Medicare was designed by pranksters, and we’re paying the price now as the percentage of the 65-and-up population explodes.
So what are people supposed to do as they get older and their teeth get looser?
A retired friend told me that she and her husband don’t have dental insurance because it costs too much and covers too little, and it turns out they’re not alone. By some estimates, half of U.S. residents 65 and older have no dental insurance.
That’s actually not a bad option, said Mertz, given the cost of insurance premiums and co-pays, along with the caps. And even if you’ve got insurance, a lot of dentists don’t accept it because the reimbursements have stagnated as their costs have spiked.
But without insurance, a lot of people simply don’t go to the dentist until they have to, and that can be dangerous.
“Dental problems are very clearly associated with diabetes,” as well as heart problems and other health issues, said Paul Glassman, associate dean of the California Northstate University dentistry school.
There is one other option, and Mertz referred to it as dental tourism, saying that Mexico and Costa Rica are popular destinations for U.S. residents.
“You can get a week’s vacation and dental work and still come out ahead of what you’d be paying in the U.S.,” she said.
Tijuana dentist Dr. Oscar Ceballos told me that roughly 80% of his patients are from north of the border, and come from as far away as Florida, Wisconsin and Alaska. He has patients in their 80s and 90s who have been returning for years because in the U.S. their insurance was expensive, the coverage was limited and out-of-pocket expenses were unaffordable.
“For example, a dental implant in California is around $3,000-$5,000,” Ceballos said. At his office, depending on the specifics, the same service “is like $1,500 to $2,500.” The cost is lower because personnel, office rent and other overhead costs are cheaper than in the U.S., Ceballos said.
As we spoke by phone, Ceballos peeked into his waiting room and said three patients were from the U.S. He handed his cellphone to one of them, San Diegan John Lane, who said he’s been going south of the border for nine years.
“The primary reason is the quality of the care,” said Lane, who told me he refers to himself as 39, “with almost 40 years of additional” time on the clock.
Ceballos is “conscientious and he has facilities that are as clean and sterile and as medically up to date as anything you’d find in the U.S.,” said Lane, who had driven his wife down from San Diego for a new crown.
“The cost is 50% less than what it would be in the U.S.,” said Lane, and sometimes the savings is even greater than that.
Come this summer, Lane may be seeing even more Californians in Ceballos’ waiting room.
“Proposed funding cuts to the Medi-Cal Dental program would have devastating impacts on our state’s most vulnerable residents,” said dentist Robert Hanlon, president of the California Dental Assn.
Dental student Somkene Okwuego smiles after completing her work on patient Jimmy Stewart, 83, who receives affordable dental work at the Ostrow School of Dentistry of USC on the USC campus in Los Angeles on February 26, 2026.
(Genaro Molina / Los Angeles Times)
Under Proposition 56’s tobacco tax in 2016, supplemental reimbursements to dentists have been in place, but those increases could be wiped out under a budget-cutting proposal. Only about 40% of the state’s dentists accept Medi-Cal payments as it is, and Hanlon told me a CDA survey indicates that half would stop accepting Medi-Cal patients and many others will accept fewer patients.
“It’s appalling that when the cost of providing healthcare is at an all-time high, the state is considering cutting program funding back to 1990s levels,” Hanlon said. “These cuts … will force patients to forgo or delay basic dental care, driving completely preventable emergencies into already overcrowded emergency departments.”
Somkene Okwuego, who as a child in South L.A. was occasionally a patient at USC’s Herman Ostrow School of Dentistry clinic, will graduate from the school in just a few months.
I first wrote about Okwuego three years ago, after she got an undergrad degree in gerontology, and she told me a few days ago that many of her dental patients are elderly and have Medi-Cal or no insurance at all. She has also worked at a Skid Row dental clinic, and plans after graduation to work at a clinic where dental care is free or discounted.
Okwuego said “fixing the smiles” of her patients is a privilege and boosts their self-image, which can help “when they’re trying to get jobs.” When I dropped by to see her Thursday, she was with 83-year-old patient Jimmy Stewart.
Stewart, an Army veteran, told me he had trouble getting dental care at the VA and had gone years without seeing a dentist before a friend recommended the Ostrow clinic. He said he’s had extractions and top-quality restorative care at USC, with the work covered by his Medi-Cal insurance.
I told Stewart there could be some Medi-Cal cuts in the works this summer.
“I’d be screwed,” he said.
Him and a lot of other people.
steve.lopez@latimes.com
Science
Diablo Canyon clears last California permit hurdle to keep running
Central Coast Water authorities approved waste discharge permits for Diablo Canyon nuclear plant Thursday, making it nearly certain it will remain running through 2030, and potentially through 2045.
The Pacific Gas & Electric-owned plant was originally supposed to shut down in 2025, but lawmakers extended that deadline by five years in 2022, fearing power shortages if a plant that provides about 9 percent the state’s electricity were to shut off.
In December, Diablo Canyon received a key permit from the California Coastal Commission through an agreement that involved PG&E giving up about 12,000 acres of nearby land for conservation in exchange for the loss of marine life caused by the plant’s operations.
Today’s 6-0 vote by the Central Coast Regional Water Board approved PG&E’s plans to limit discharges of pollutants into the water and continue to run its “once-through cooling system.” The cooling technology flushes ocean water through the plant to absorb heat and discharges it, killing what the Coastal Commission estimated to be two billion fish each year.
The board also granted the plant a certification under the Clean Water Act, the last state regulatory hurdle the facility needed to clear before the federal Nuclear Regulatory Commission (NRC) is allowed to renew its permit through 2045.
The new regional water board permit made several changes since the last one was issued in 1990. One was a first-time limit on the chemical tributyltin-10, a toxic, internationally-banned compound added to paint to prevent organisms from growing on ship hulls.
Additional changes stemmed from a 2025 Supreme Court ruling that said if pollutant permits like this one impose specific water quality requirements, they must also specify how to meet them.
The plant’s biggest water quality impact is the heated water it discharges into the ocean, and that part of the permit remains unchanged. Radioactive waste from the plant is regulated not by the state but by the NRC.
California state law only allows the plant to remain open to 2030, but some lawmakers and regulators have already expressed interest in another extension given growing electricity demand and the plant’s role in providing carbon-free power to the grid.
Some board members raised concerns about granting a certification that would allow the NRC to reauthorize the plant’s permits through 2045.
“There’s every reason to think the California entities responsible for making the decision about continuing operation, namely the California [Independent System Operator] and the Energy Commission, all of them are sort of leaning toward continuing to operate this facility,” said boardmember Dominic Roques. “I’d like us to be consistent with state law at least, and imply that we are consistent with ending operation at five years.”
Other board members noted that regulators could revisit the permits in five years or sooner if state and federal laws changes, and the board ultimately approved the permit.
Science
Deadly bird flu found in California elephant seals for the first time
The H5N1 bird flu virus that devastated South American elephant seal populations has been confirmed in seals at California’s Año Nuevo State Park, researchers from UC Davis and UC Santa Cruz announced Wednesday.
The virus has ravaged wild, commercial and domestic animals across the globe and was found last week in seven weaned pups. The confirmation came from the U.S. Department of Agriculture’s National Veterinary Services Laboratory in Ames, Iowa.
“This is exceptionally rapid detection of an outbreak in free-ranging marine mammals,” said Professor Christine Johnson, director of the Institute for Pandemic Insights at UC Davis’ Weill School of Veterinary Medicine. “We have most likely identified the very first cases here because of coordinated teams that have been on high alert with active surveillance for this disease for some time.”
Since last week, when researchers began noticing neurological and respoiratory signs of the disease in some animals, 30 seals have died, said Roxanne Beltran, a professor of ecology and evolutionary biology at UC Santa Cruz. Twenty-nine were weaned pups and the other was an adult male. The team has so far confirmed the virus in only seven of the dead pups.
Infected animals often have tremors convulsions, seizures and muscle weakness, Johnson said.
Beltran said teams from UC Santa Cruz, UC Davis and California State Parks monitor the animals 260 days of the year, “including every day from December 15 to March 1” when the animals typically come ashore to breed, give birth and nurse.
The concerning behavior and deaths were first noticed Feb. 19.
“This is one of the most well-studied elephant seal colonies on the planet,” she said. “We know the seals so well that it’s very obvious to us when something is abnormal. And so my team was out that morning and we observed abnormal behaviors in seals and increased mortality that we had not seen the day before in those exact same locations. So we were very confident that we caught the beginning of this outbreak.”
In late 2022, the virus decimated southern elephant seal populations in South America and several sub-Antarctic Islands. At some colonies in Argentina, 97% of pups died, while on South Georgia Island, researchers reported a 47% decline in breeding females between 2022 and 2024. Researchers believe tens of thousands of animals died.
More than 30,000 sea lions in Peru and Chile died between 2022 and 2024. In Argentina, roughly 1,300 sea lions and fur seals perished.
At the time, researchers were not sure why northern Pacific populations were not infected, but suspected previous or milder strains of the virus conferred some immunity.
The virus is better known in the U.S. for sweeping through the nation’s dairy herds, where it infected dozens of dairy workers, millions of cows and thousands of wild, feral and domestic mammals. It’s also been found in wild birds and killed millions of commercial chickens, geese and ducks.
Two Americans have died from the virus since 2024, and 71 have been infected. The vast majority were dairy or commercial poultry workers. One death was that of a Louisiana man who had underlying conditions and was believed to have been exposed via backyard poultry or wild birds.
Scientists at UC Santa Cruz and UC Davis increased their surveillance of the elephant seals in Año Nuevo in recent years. The catastrophic effect of the disease prompted worry that it would spread to California elephant seals, said Beltran, whose lab leads UC Santa Cruz’s northern elephant seal research program at Año Nuevo.
Johnson, the UC Davis researcher, said the team has been working with stranding networks across the Pacific region for several years — sampling the tissue of birds, elephant seals and other marine mammals. They have not seen the virus in other California marine mammals. Two previous outbreaks of bird flu in U.S. marine mammals occurred in Maine in 2022 and Washington in 2023, affecting gray and harbor seals.
The virus in the animals has not yet been fully sequenced, so it’s unclear how the animals were exposed.
“We think the transmission is actually from dead and dying sea birds” living among the sea lions, Johnson said. “But we’ll certainly be investigating if there’s any mammal-to-mammal transmission.”
Genetic sequencing from southern elephant seal populations in Argentina suggested that version of the virus had acquired mutations that allowed it to pass between mammals.
The H5N1 virus was first detected in geese in China in 1996. Since then it has spread across the globe, reaching North America in 2021. The only continent where it has not been detected is Oceania.
Año Nuevo State Park, just north of Santa Cruz, is home to a colony of some 5,000 elephant seals during the winter breeding season. About 1,350 seals were on the beach when the outbreak began. Other large California colonies are located at Piedras Blancas and Point Reyes National Sea Shore. Most of those animals — roughly 900 — are weaned pups.
It’s “important to keep this in context. So far, avian influenza has affected only a small proportion of the weaned at this time, and there are still thousands of apparently healthy animals in the population,” Beltran said in a press conference.
Public access to the park has been closed and guided elephant seal tours canceled.
Health and wildlife officials urge beachgoers to keep a safe distance from wildlife and keep dogs leashed because the virus is contagious.
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