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Deadly cancer type linked to obesity and high stress levels

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Deadly cancer type linked to obesity and high stress levels

Obesity and stress could magnify the risk of one of the most aggressive types of cancer, a new study suggests.

Researchers at University of California Los Angeles (UCLA) found that stress-related neurotransmitters and obesity-related hormones activated CREB (cyclic AMP response element-binding protein), which was shown to promote the growth of cancer cells in the pancreas.

In the study, mice that ate a high-fat diet were more likely to develop precancerous lesions. When stress levels were also raised through social isolation, the lesions grew even more.

EXPERIMENTAL VACCINE FOR COMMON CANCER SHOWS POTENTIAL IN CLINICAL TRIAL

The stress-related cancer risk was more pronounced in female mice.

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Based on these findings, the researchers suggested exploring the use of existing medications to reduce the risk of obesity- and stress-related cancers. 

Obesity and stress could magnify the risk of one of the most aggressive types of cancer, a new study suggests. (iStock)

“Since β-adrenergic receptors play a crucial role in stress-related cancer growth, commonly used beta-blockers, which are drugs prescribed for high blood pressure, could be repurposed to help mitigate these effects,” a press release stated.

Pancreatic cancer is one of the deadliest types in the U.S., with a five-year survival rate of just 13%.

PANCREATIC CANCER PATIENT SURVIVAL DOUBLED WITH HIGH DOSE OF COMMON VITAMIN, STUDY FINDS

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One of the biggest challenges with the disease is that it’s often detected at a late stage when the disease is already advanced, according to Dr. Robert Den, a radiation oncologist, professor of radiation oncology, and chief medical officer at Alpha Tau Medical in Israel.

“Unlike some other cancers, there are no effective early screening tools, so by the time a patient is diagnosed, treatment options are often limited,” Den, who was not involved in the study, told Fox News Digital.

Woman getting diagnosis

“Unlike some other cancers, there are no effective early screening tools, so by the time a patient is diagnosed, treatment options are often limited.” (iStock)

The study reinforces the strong connection between the mind and body as it related to cancer development, Den said.

“Stress and its associated pathways can exacerbate disease progression, and we know that obesity fuels certain cancers, potentially impacting a patient’s response to treatment,” he said.

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“In this case, we’re seeing evidence that stress and obesity may contribute to the worsening of pancreatic cancer, which has major implications for both prevention and treatment strategies.”

Maintaining a heart-healthy diet and eating in moderation are essential, Den noted — not just for cancer prevention but for overall health. 

pancreatic cancer 3D rendering

Pancreatic cancer is one of the deadliest types in the U.S., with a five-year survival rate of just 13%. (iStock)

“Exercise is particularly crucial in addressing both obesity and stress,” he said. “Staying active is not only beneficial for physical health, but also an excellent way to reduce stress.”

Mindfulness can also play a key role in reducing cancer risk, the doctor advised.

      

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“Spending time outdoors can also improve both mental and physical well-being, so I always encourage patients to find ways to be active, connect with nature and prioritize their overall wellness,” he said.

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Regarding pancreatic cancer treatment, Den noted that there have been some advancements in chemotherapy and surgical techniques, but “there hasn’t yet been a breakthrough.”

“Most immunotherapies, which have been revolutionary in other cancers, have not shown the same promise in pancreatic cancer,” he said. 

People doing yoga

“Spending time outdoors can also improve both mental and physical well-being, so I always encourage patients to find ways to be active, connect with nature and prioritize their overall wellness,” an oncologist said. (iStock)

“The key challenge is finding ways to help patients who are not candidates for surgery, as surgery remains the best line of defense.”

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Fox News Digital reached out to the study researchers for comment.

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The Best Weight-Loss Pills for Women Over 50: Safe, Effective Options

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Paralyzed man with ALS is third to receive NeuraLink implant, can type with brain

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Paralyzed man with ALS is third to receive NeuraLink implant, can type with brain

Brad Smith, an Arizona husband and father with ALS, has become the third person to receive Neuralink, the brain implant made by Elon Musk’s company.

He is also the first ALS patient and the first non-verbal person to receive the implant, he shared in a post on X on Sunday.

“I am typing this with my brain. It is my primary communication,” Smith, who was diagnosed in 2020, wrote in the post, which was also shared by Musk. He went on to thank Musk.

Smith is completely paralyzed and relies on a ventilator to breathe. He created a video using the brain-computer interface (BCI) to control the mouse on his MacBook Pro, he stated. 

“This is the first video edited with [Neuralink], and maybe the first edited with a BCI,” he said. 

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“Neuralink has given me freedom, hope and faster communication.”

The video was narrated by Smith’s “old voice,” he said, which was cloned by artificial intelligence from recordings before he lost the use of his voice. 

“I want to explain how Neuralink has impacted my life and give you an overview of how it works,” he said.

An Arizona husband and father with ALS has become the third person to receive Neuralink, the brain implant made by Elon Musk’s company. (Getty Images)

ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, according to The ALS Association. 

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Over time, the disease impairs muscle control until the patient becomes paralyzed. ALS is ultimately fatal, with an average life expectancy of three years, although 10% of patients can survive for 10 years and 5% live 20 years or longer.

HOW ELON MUSK’S NEURALINK BRAIN CHIP WORKS

It does not impact cognitive function.

Neuralink, which is about 1.75 inches thick, was implanted in Smith’s motor cortex, the part of the brain that controls body movement.

The implanted device captures neuron firings in the brain and sends a raw signal to the computer.

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Neuralink Elon Musk

Neuralink is made by Elon Musk’s company of the same name. (Getty Images)

“AI processes this data on a connected MacBook Pro to decode my intended movements in real time to move the cursor on my screen,” Smith said.

“Neuralink has given me freedom, hope and faster communication,” he added. “It has improved my life so much. I am so happy to be involved in something big that will help many people.” 

EXPERIMENTAL ALS DRUG COULD OFFER NEW HOPE FOR PATIENTS IF APPROVED, RESEARCHERS SAY

Smith is also a man of faith, saying that he believes God has put him in this position to serve others. 

“I have not always understood why God afflicted me with ALS, but with time, I am learning to trust His plan for me,” he said. 

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“God loves me and my family. He has answered our prayers in unexpected ways. He has blessed my kids and our family. So I’m learning to trust that God knows what he is doing.”

illustration of the human brain

The wireless device was implanted in Smith’s motor cortex, the part of the brain that controls body movement. (iStock)

Smith also said he is grateful that he gets to work with the “brilliant people” at Neuralink and do “really interesting work.”

“Don’t get me wrong, ALS still really sucks, but I am talking about the big picture,” he said. “The big picture is, I am happy.” 

Dr. Mary Ann Picone, medical director of the MS Center at Holy Name Medical Center in Teaneck, New Jersey, applauded Neuralink’s capabilities.

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“This is an amazing development that now the third person to use Neuralink has gained the ability with the use of AI to type with neural thoughts,” Picone, who was not involved in Smith’s care, told Fox News Digital. 

“The now-realized potential of Neuralink is to allow patients with quadriplegia to control computers and mobile devices with their thoughts.” 

What’s next for tech in 2024?

“For every Brad Smith out there, there are hundreds of thousands of other disabled patients awaiting access to this technology,” a neurologist said. (Kurt “CyberGuy” Knutsson)

There are some risks involved with the implant, Picone noted. These include surgical infection, bleeding and damage to the underlying brain tissue.

“But the benefits are that patients who are paralyzed would have the potential to restore personal control over the limbs by using their thoughts,” she said.  

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Dr. Peter Konrad, M.D., Ph.D., chairman of the department of neurosurgery at WVU Rockefeller Neuroscience Institute in West Virginia, called Neuralink a “remarkable demonstration of the power of AI-driven technology.”

“Mr. Smith is an incredible hero for those who are severely disabled from diseases such as ALS,” Konrad, who also was not involved in Smith’s care, told Fox News Digital.

“Mr. Smith is an incredible hero for those who are severely disabled from diseases such as ALS.”

Konrad also spoke of the advancements that have occurred since the past generations of BCI technology.

“It is encouraging to see faster progress being made with neural devices reaching clinical trials in the past five to 10 years,” he said. “However, we are still awaiting development of a BCI device that does not require a team of engineers and experts to customize each and every severely disabled patient with this technology.”

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“For every Brad Smith out there, there are hundreds of thousands of other disabled patients awaiting access to this technology,” he said.

“This video demonstrates the safety of these types of devices — now it’s time to provide larger access to these devices through a new generation of educated physicians, engineers and manufacturers able to deploy this technology.”

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Dance Your Way to Weight Loss: Burn Fat and Have Fun in 30 Minutes!

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