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A new approach to a Covid-19 nasal vaccine shows early promise | CNN

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A new approach to a Covid-19 nasal vaccine shows early promise | CNN



CNN
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Scientists in Germany say they’ve been in a position to make a nasal vaccine that may shut down a Covid-19 an infection within the nostril and throat, the place the virus will get its first foothold within the physique.

In experiments in hamsters, two doses of the vaccine – which is made with a reside however weakened type of the coronavirus that causes Covid-19 – blocked the virus from copying itself within the animals’ higher airways, attaining “sterilizing immunity” and stopping sickness, a long-sought purpose of the pandemic.

Though this vaccine has a number of extra hurdles to clear earlier than it will get to a physician’s workplace or drug retailer, different nasal vaccines are in use or are nearing the end line in medical trials.

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China and India each rolled out vaccines given by the nasal tissues final fall, although it’s not clear how effectively they could be working. Research on the effectiveness of those vaccines have but to be revealed, leaving a lot of the world to wonder if this strategy to safety actually works in folks.

The US has reached one thing of a stalemate with Covid-19. Even with the darkest days of the pandemic behind us, tons of of People are nonetheless dying day by day because the an infection continues to simmer within the background of our return to regular life.

So long as the virus continues to unfold amongst folks and animals, there’s at all times the potential for it mutate right into a extra contagious or extra damaging model of itself. And whereas Covid infections have change into manageable for many wholesome folks, they could nonetheless pose a hazard to susceptible teams such because the aged and immunocompromised.

Researchers hope next-generation Covid-19 vaccines, which purpose to close down the virus earlier than it ever will get an opportunity to make us sick and finally forestall the unfold of an infection, may make our latest resident respiratory an infection much less of a risk.

A technique scientists try to do this is by boosting mucosal immunity, beefing up immune defenses within the tissues that line the higher airways, proper the place the virus would land and start to contaminate our cells.

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It’s a bit like stationing firefighters beneath the smoke alarm in your own home, says research creator Emanuel Wyler, a scientist on the Max Delbruck Heart for Molecular Medication within the Helmholtz Affiliation in Berlin.

The immunity that’s created by photographs works all through the physique, but it surely resides primarily within the blood. Which means it could take longer to mount a response.

“If they’re already on web site, they’ll instantly remove the hearth, but when they’re like 2 miles away, they first must drive there, and by that point, one-third of the home is already in full flames,” Wyler stated.

Mucosal vaccines are additionally higher at priming a unique sort of first responder than injections do. They do a greater job of summoning IgA antibodies, which have 4 arms to seize onto invaders as a substitute of the 2 arms that the y-shaped IgG antibodies have. Some scientists assume IgA antibodies could also be much less choosy about their targets than IgG antibodies, which makes them higher outfitted to take care of new variants.

The brand new nasal vaccine takes a brand new strategy to a really outdated thought: weakening a virus so it’s not a risk after which giving it to folks so their immune techniques can study to acknowledge and battle it off. The primary vaccines utilizing this strategy date to the 1870s, towards anthrax and rabies. Again then, scientists weakened the brokers they had been utilizing with warmth and chemical substances.

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The researchers manipulated the genetic materials within the virus to make it more durable for cells to translate. This method, referred to as codon pair deoptimization, hobbles the virus so it may be proven to the immune system with out making the physique sick.

“You would think about studying a textual content … and each letter is a unique font, or each letter is a unique measurement, then the textual content is way more durable to learn. And that is principally what we do in codon pair deoptimization,” Wyler stated.

Within the hamster research, which had been revealed Monday within the journal Nature Microbiology, two doses of the reside however weakened nasal vaccine created a a lot stronger immune response than both two doses of an mRNA-based vaccine or one which makes use of an adenovirus to ferry the vaccine directions into cells.

The researchers assume the reside weakened vaccine most likely labored higher as a result of it intently mimics the method of a pure an infection.

The nasal vaccine additionally previews all the coronavirus for the physique, not simply its spike proteins like present Covid-19 vaccines do, so the hamsters had been in a position to make immune weapons towards a wider vary of targets.

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As promising as all this sounds, vaccine consultants say warning is warranted. This vaccine nonetheless has to move extra exams earlier than it’s prepared to be used, however they are saying the outcomes look encouraging.

“They did a really good job. That is clearly a reliable and considerate group that did this work, and spectacular within the scope of what they did. Now it simply must be repeated,” maybe in primates and definitely in people earlier than it may be broadly used, stated Dr. Greg Poland, who designs vaccines on the Mayo Clinic. He was not concerned within the new analysis.

The research started in 2021, earlier than the Omicron variant was round, so the vaccine examined in these experiments was made with the unique pressure of the coronavirus. Within the experiments, after they contaminated animals with Omicron, the reside however weakened nasal vaccine nonetheless carried out higher than the others, however its skill to neutralize the virus was diminished. Researchers assume it would want an replace.

It additionally must be examined in people, and Wyler says they’re engaged on that. The scientists have partnered with a Swiss firm referred to as RocketVax to begin section I medical trials.

Different vaccines are additional alongside, however the progress has been “sluggish and halting,” Poland stated. Teams engaged on these vaccines are struggling to lift the steep prices of getting a brand new vaccine to market, they usually’re doing it in a setting the place folks are likely to assume the vaccine race has been gained and performed.

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In actuality, Poland stated, we’re removed from that. All it could take is one other Omicron-level shift within the evolution of the virus, and we might be again at sq. one, with no efficient instruments towards the coronavirus.

“That’s silly. We must be growing a pan-coronavirus vaccine that does induce mucosal immunity and that’s long-lived,” he stated.

At the very least 4 nasal vaccines for Covid-19 have reached late-stage testing in folks, in accordance with the World Well being Group’s vaccine tracker.

The nasal vaccines in use in China and India depend on innocent adenoviruses to ferry their directions into cells, though effectiveness knowledge for these has not been revealed.

Two different nasal vaccines are ending human research.

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One, a recombinant vaccine that may be produced cheaply in hen eggs, the identical approach many flu vaccines are, is being put by its paces by researchers at Mount Sinai in New York Metropolis.

One other, just like the German vaccine, makes use of a reside however weakened model of the virus. It’s being developed by an organization referred to as Codagenix. Outcomes of these research, which had been carried out in South America and Africa, might come later this yr.

The German group says it’s eagerly looking forward to the Codagenix knowledge.

“They are going to be essential with a view to know the place whether or not this sort of try is principally promising or not,” Wyler stated.

They’ve purpose to fret. Respiratory infections have proved to be powerful targets for inhaled vaccines.

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FluMist, a reside however weakened type of the flu virus, works moderately effectively in youngsters however doesn’t assist adults as a lot. The reason being considered that adults have already got immune reminiscence for the flu, and when the virus is injected into the nostril, the vaccine largely boosts what’s already there.

Nonetheless, a number of the most potent vaccines such because the vaccine towards measles, mumps and rubella use reside attenuated viruses, so it’s a promising strategy.

One other consideration is that reside vaccines can’t be taken by everybody. Individuals with very compromised immunity are sometimes cautioned towards utilizing reside vaccines as a result of even these very weakened viruses could also be dangerous for them.

“Though it’s strongly attenuated, it’s nonetheless an actual virus,” Wyler stated, so it must be used rigorously.

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Video: Heavy Rains and Wind Wreak Havoc on the West Coast

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Video: Heavy Rains and Wind Wreak Havoc on the West Coast

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Heavy Rains and Wind Wreak Havoc on the West Coast

A series of atmospheric rivers has caused flooding and damage in the Pacific Northwest and Northern California, knocking out power for hundreds of thousands of people.

It just crashed through the front of the house, crashed through the kitchen, and it broke the whole ridge beam. The whole peak of the house is just crushed.

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How long will Trump’s honeymoon with the stock market last?

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How long will Trump’s honeymoon with the stock market last?

Few were surprised when US stocks jumped after Donald Trump’s decisive victory in the presidential election. Amid widespread assumptions of weeks of uncertainty, a clear result was always likely to prompt an initial relief rally. More unexpected was what has happened since.

The president-elect has nominated a string of hardliners to senior positions, signalling his intent to push ahead with a radical agenda to enact sweeping tariffs and deport millions of illegal immigrants that many economists warn would cause inflation and deficits to spiral upward.

Yet the stock market — the economic barometer most closely watched by the general public, and one often referenced by Trump himself — seems to have shown little sign of concern.

The S&P 500, Wall Street’s benchmark index for large stocks, is still up about 3 per cent since the vote, even after a slight pullback. The main index of small cap stocks is up almost 5 per cent.

The relative cost of borrowing for large companies has also plummeted to multi-decade lows, and speculative assets such as bitcoin have surged.

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Under the surface, not every part of the stock market has been so calm. A Citi-created index of stocks that may be vulnerable to government spending cuts, for example, has tumbled 8 per cent since the election, while healthcare stocks have been hit by the nomination of vaccine sceptic Robert Kennedy Jr to head the health department.

The prospect of inflation arising from tariffs and a tighter labour market has also spooked many in the $27tn Treasury market, with some high-profile groups warning about over-exuberance.

But the contrasting signals raise some key questions for traders and policymakers alike: are equity investors setting themselves up for a fall by ignoring high valuations and potential downsides of Trumponomics, or will they be proved right as gloomy economists once again have to walk back their dire prognoses?

“Any time . . . you get to the point where markets are beyond priced to perfection, you have to be concerned about complacency”, says Sonal Desai, chief investment officer at Franklin Templeton Fixed Income.

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But, she adds, “the reality is you also need to very actively look for triggers for sell-offs, and right now . . . I think the underlying economy is strong and the policies of the incoming administration are unlikely to move that significantly.”


The bull case was on full display at the Wynn resort in Las Vegas this week, where more than 800 investors, bankers and executives were gathered for Goldman Sachs’ annual conference for “innovative private companies”.

With interest rates now trending downward, capital markets specialists had already been preparing for a recovery in stock market listings and mergers and acquisitions activity, but the election result has poured fuel on the fire.

Walter Lundon, a trader, shows off his pro-Trump T-shirt on the floor of the New York Stock Exchange
Walter Lundon, a trader, shows off his pro-Trump T-shirt on the floor of the New York Stock Exchange. Investors believe Trump will follow through on pledges to cut taxes and regulation © Timothy A. Clary/AFP via Getty Images

With Republicans controlling both houses of Congress in addition to the White House, investors are assuming that it will be easy for the Trump administration to fulfil promises to slash corporate taxes and scale back regulation. At the same time, more contentious proposals such as the introduction of tariffs were frequently dismissed by attendees as a “negotiating tactic”.

David Solomon, Goldman chief executive, said at the conference: “The market is basically saying they think the new administration will bring [regulation] back to a place where it’s more sensible.”

One hedge fund manager in attendance sums up the atmosphere more bluntly. “There are lots of giddy investors here getting excited about takeout targets,” he says. “M&A is now a real possibility because of the new administration. That’s been the most exciting [element of Trump’s proposals] . . . I think the mood is better than it’s been in the past four years.”

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The emphasis on tax and deregulation is clear when looking at which sectors have been the biggest winners in the recent market rally: financial services and energy.

The S&P 500 financials sub-index has jumped almost 8 per cent since the vote, while the energy sub-index is up almost 7 per cent. Energy executives have celebrated the president-elect’s pledges to withdraw from the Paris climate agreement and open up federal lands for fracking in pursuit of US “energy dominance”.

The Russell 2000 index, which measures small cap companies, has also risen faster than the S&P thanks to its heavy weighting towards financial stocks, and a belief that smaller domestically focused companies have more to gain from corporate tax cuts.

Chris Shipley, co-chief investment officer at Fort Washington Investment Advisors, which manages about $86bn, says that “we believe the market has acted rationally since the election”, citing the concentration of gains in areas that could benefit from trends such as deregulation and M&A.

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Even policies that most mainstream economists think would have a negative effect overall — like a sharp increase in tariffs — could ironically boost the relative appeal of US stocks by hitting other countries even harder.

The Europe-wide Stoxx 600 index, for example, has slipped since the election as investors bet the export-dependent region will be heavily hit by any increase in trade tensions. At the same time, the euro has dipped to a two-year low against the dollar.

“The ‘America First’ policy, not surprisingly, will be good for the US versus the rest of the world,” says Kay Herr, US chief investment officer for JPMorgan Asset Management’s global fixed income, currency and commodities team.


The worry among economists and many bond investors, however, is that Trump’s policies could create broader economic problems that would eventually be hard for the stock market to ignore.

Some of Trump’s policies, such as corporate tax cuts, could boost domestic growth. But with the economy already in a surprisingly robust state despite years of worries about a potential recession, some like former IMF chief economist Olivier Blanchard fear an “overheating” that would lead to a resurgence in inflation and a subsequent slowdown.

A shale gas well drilling site in Pennsylvania
A shale gas well drilling site in Pennsylvania. The incoming Trump administration is expected to open up federal lands for fracking in pursuit of US ‘energy dominance’ © Keith Srakocic/AP

Demand-driven inflation could be exacerbated by supply-side pressures if Trump follows through with some of his more sweeping policy pledges.

On the campaign trail, Trump proposed a baseline 10 per cent import tariff on all goods made outside the US, and 60 per cent if they are made in China. Economists generally agree that the cost of tariffs falls substantially on the shoulders of consumers in the country enacting them. Walmart, the largest retailer in the US, warned this week it might have to raise prices if tariffs are introduced.

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Deporting millions of undocumented immigrants, meanwhile, would remove a huge source of labour from the US workforce, driving up wages and reducing the capacity of US companies to supply goods and services.

Economists at Morgan Stanley and Deutsche Bank both predicted this week that Trump’s policies would drag on GDP growth by 2026, and make it harder for the Federal Reserve to bring inflation back to its 2 per cent target.

Tom Barkin, president of the Richmond Fed and a voting member on the rate-setting Federal Open Market Committee, says he understands concerns among the business community about tariffs reigniting inflation, and says the US was “somewhat more vulnerable to cost shocks” than in the past.

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But some investors believe the risks to be minimal. “In our view, the inflationary concerns . . . regarding tariffs are overblown,” says Shipley of Fort Washington.

Fed policymakers have been quick to stress that they will not prejudge any potential policies before they have been officially announced, but bond investors have already scaled back their forecasts for how much the central bank will be able to cut interest rates over the next year.

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Interest rate futures are now pricing in a fall in Fed rates to roughly 4 per cent by the end of 2025, from the current level of 4.5-4.75 per cent. In September, investors were betting they would fall below 3 per cent by then.

Meanwhile, the yield on the 10-year Treasury note, which rises when prices fall, is up about 0.8 percentage points since mid-September to 4.4 per cent. As a consequence, the average rate on a 30-year mortgage is also ticking upward, to near 7 per cent.

“The bond market has been very focused on deficits and fiscal expansion, and the equity market has been focused, it seems, on deregulation and the growth aspect,” says JPMorgan’s Herr. But “at some point, a higher [Treasury yield] is problematic to equities”.

In part, that is because higher bond yields represent an alternative source of attractive returns at much lower risk than stocks. But the more important impact could come from the warning signal a further increase in yields would represent.

The rise in yields is being driven by concerns both about inflation and also higher government debt levels, says Kristina Hooper, chief global market strategist at Invesco. “2024 marks the first year in which the US spends more to service its debt than it spends on its entire defence budget. And that’s not sustainable in my opinion over the longer term, and so we have to worry about the potential for a mini Liz Truss moment.”

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Former UK prime minister Truss’s attempt to introduce billions of pounds of unfunded tax cuts and increased borrowing in 2022 caused a massive sell-off in British government debt that spilled into currency and equity markets.

Demonstrators in New York protests against Trump’s immigration proposals
Demonstrators in New York protest against Trump’s immigration proposals. His plans to deport millions of undocumented immigrants would remove a large chunk from the US workforce © Michael Nigro/Sipa USA via Reuters Connect

The structure and scale of the US Treasury market makes this sort of “bond vigilantism” less likely, strategists and investors stress, but many institutions have begun paying more attention to the possibility.

“Over the next two to four years, do I think that there’s a very serious risk of bond vigilantes coming back? Absolutely. And that’s entirely based on what the multiyear plan will be, and the impact which comes out of it,” says Franklin Templeton’s Desai.


Trump and his advisers have dismissed concerns about their economic agenda, arguing that policies such as encouraging the domestic energy sector will help keep inflation low and growth high.

Even if they do not, several investors in Las Vegas this week suggested that the president-elect’s personal preoccupation with the stock market would help restrain him from the most potentially damaging policies.

“I think Trump and all his donors measure their success and happiness around where the US stock market is,” says the hedge fund manager. “It’s one reason why I’m pretty bullish despite the market being where it is.”

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Economists have also consistently underestimated the resilience of the US economy in recent years. The combination of Trump’s attentiveness and economists’ poor past forecasting means even sceptical investors are wary of betting against the US market.

“There are risks out there,” says Colin Graham, head of multi-asset strategies at Robeco. “If some of the more extreme policies that were talked about during the campaign get implemented, our core view for next year is going to be wrong.

“But what is our biggest risk here? Missing out on the upside. The momentum is very strong.”

Data visualisation by Keith Fray and Chris Giles

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Can Matt Gaetz return to Congress? He says he won’t.

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Can Matt Gaetz return to Congress? He says he won’t.

Gaetz not returning to Congress

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Gaetz on not returning to Congress after dropping out of Trump attorney general consideration

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Former Rep. Matt Gaetz of Florida says he doesn’t intend to return to Congress in January, after resigning from his seat and withdrawing from consideration as U.S. attorney general. 

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Gaetz announced his withdrawal Thursday, citing the distraction his impending nomination was causing, and President-elect Donald Trump soon afterward said former Florida attorney general Pam Bondi would be his new pick for the job. But Gaetz won reelection to his U.S. House seat earlier this month, so there were some questions about whether he was considering a return to Congress in January. 

But Gaetz told conservative personality Charlie Kirk on Friday that he doesn’t intend to go back to Congress, though he vowed to continue to fight for Trump and do “whatever he asks of me.”

“I’m still going to be in the fight, but it’s going to be from a new perch,” Gaetz told Kirk. “I do not intend to join the 119th Congress. … Charlie, I’ve been in an elected office for 14 years. I first got elected to the state house when I was 26 years old, and I’m 42 now, and I’ve got some other goals in life that I’m eager to pursue with my wife and my family, and so I’m going to be fighting for President Trump. I’m going to be doing whatever he asks of me, as I always have. But I think that eight years is probably enough time in the United States Congress.”

But it may not be the end of his political career. Florida Gov. Ron DeSantis, first elected in 2018, will not be running again in 2026, since he’s limited by law to two terms as the state’s chief executive. 

Gaetz stepped down from Congress as the House Ethics Committee was weighing whether to release the report from its yearslong investigation into sexual misconduct and illegal drug use allegations. The committee lacked sufficient votes to release the report earlier this week but will, according to Democratic Rep. Susan Wild of Pennsylvania, reconvene on Dec. 5 to “further consider” the matter. 

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