Health
Widely prescribed opioid shows minimal pain relief and higher heart risk, study finds
NEWYou can now listen to Fox News articles!
A widely prescribed opioid painkiller showed limited effectiveness and increased risk of negative effects in a new analysis published in BMJ Evidence-Based Medicine.
The study examined tramadol, a common prescription opioid used to treat chronic pain.
Tramadol has historically been perceived as a safer or less addictive opioid, which has contributed to its widespread use in chronic pain treatment, the study authors noted.
PSYCHIATRIST REVEALS HOW SIMPLE MINDSET SHIFTS CAN SIGNIFICANTLY REDUCE CHRONIC PAIN
“Often, we may use tramadol to avoid more addictive drugs like other opioids, though in fact tramadol is a synthetic opioid. It is much milder,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
In the new analysis, researchers used data from 19 randomized clinical trials involving 6,506 adults with conditions including osteoarthritis, chronic low back pain, neuropathic pain and fibromyalgia. All the studies compared tramadol to a placebo treatment.
The level of pain relief associated with tramadol fell below the threshold typically considered clinically important. (iStock)
Overall, tramadol led to a small decrease in pain, but the amount of relief was less than what is usually considered clinically meaningful, the authors reported.
“It is notable how minimal the pain reduction was and how clearly the study highlighted the elevated risk of serious adverse events, even over relatively short trial durations,” Alopi M. Patel, M.D., pain medicine physician at Icahn School of Medicine at Mt. Sinai in New York City, told Fox News Digital. (Patel was not involved in the study.)
MORE PEOPLE TURN TO ACUPUNCTURE FOR BACK PAIN AS STUDY SHOWS RELIEF
Participants receiving tramadol experienced a higher risk of adverse events, both serious and non-serious, compared with those receiving a placebo.
Serious adverse events primarily included cardiovascular events, such as chest pain, coronary artery disease and congestive heart failure. The authors concluded that tramadol likely increases the risk of heart-related issues.
Serious adverse events were primarily driven by cardiovascular outcomes, including chest pain, coronary artery disease and congestive heart failure. (iStock)
The authors concluded that the benefits of tramadol for chronic pain are small and that the harms likely outweigh the benefits. The findings call into question the use of tramadol for chronic pain conditions, they stated.
Study limitations
Most of the trials included in the analysis were short, with treatment periods ranging from two to 16 weeks and follow-up periods from three to 15 weeks.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
This limited the ability to assess long-term outcomes, the researchers acknowledged.
The authors reported that many outcomes had a high risk of bias, which may have exaggerated the apparent benefits and minimized the reported harms.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
The trials involved several different types of chronic pain, but the data were not detailed enough to draw conclusions for any specific condition. This makes it “harder to generalize the findings to specific patient populations,” noted Patel.
Most trials were short in duration and compared tramadol only with a placebo — limiting conclusions about long-term effects and comparisons with other treatments. (iStock)
Though the study has value, Siegel said, “looking at slight increased rates of cancer or heart disease among those on the drug is completely misleading, because it is not controlled for other factors and there is no evidence or hint of causation.”
“You would have to first look at underlying characteristics of that group who took the meds.”
CLICK HERE FOR MORE HEALTH STORIES
The doctor also pointed out that the study “doesn’t compare [tramadol] with full-on opioids like Percocet.”
Experts emphasize that patients should not stop taking tramadol abruptly, as doing so can lead to withdrawal symptoms. Those looking to change their medication should consult a doctor.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
“I recommend that clinicians and patients engage in transparent, shared decision-making that considers tramadol’s modest benefits alongside its risks,” Patel advised.
Fox News Digital reached out to several manufacturers of tramadol requesting comment.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
NEWYou can now listen to Fox News articles!
Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
NEARLY 90% OF AMERICANS AT RISK OF SILENT DISEASE — HERE’S WHAT TO KNOW
As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
SIMPLE NIGHTLY HABIT LINKED TO HEALTHIER BLOOD PRESSURE, STUDY SUGGESTS
“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
MISSING SLEEP MAY TAKE A HIDDEN TOLL ON YOUR BRAIN AND LONGEVITY, RESEARCH REVEALS
“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
HEART DISEASE THREAT PROJECTED TO CLIMB SHARPLY FOR KEY DEMOGRAPHIC
The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
CLICK HERE FOR MORE HEALTH STORIES
The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
Health
The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism
Use left and right arrow keys to navigate between menu items.
Use escape to exit the menu.
Sign Up
Create a free account to access exclusive content, play games, solve puzzles, test your pop-culture knowledge and receive special offers.
Already have an account? Login
Health
‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason
NEWYou can now listen to Fox News articles!
Top stories
→ Some 80-year-olds still have razor-sharp brains — and now scientists know why
→ One father’s nightly bathroom habit was missed sign of common cancer
→ 5 ways to preserve vision as you age, according to an ophthalmologist
SuperAger Ralph Rehbock sits with his wife in his home. (Shane Collins, Northwestern University)
On the lookout
→ Heart disease threat projected to climb sharply for key demographic
→ Heavy snow is recipe for serious heart attack risk, experts say
→ Flu season could linger into spring as doctors warn of second wave
A doctor says the second wave of flu season may be worse than previous years. (iStock)
Conversation starters
→ One type of olive oil has a surprising effect on brainpower in aging adults
→ Common vision issue linked to type of lighting used in homes
→ Some supplements may pose risks for people with diabetes, experts say
Medical advances
→ Alzheimer’s symptoms could be predicted years in advance through one simple test
→ Combination nasal spray vaccine could protect against COVID, flu and pneumonia
→ Weight-loss medications could impact sexual health in unexpected ways
Stat of the week
More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.
CLICK HERE FOR MORE HEALTH STORIES
-
World3 days agoExclusive: DeepSeek withholds latest AI model from US chipmakers including Nvidia, sources say
-
Massachusetts3 days agoMother and daughter injured in Taunton house explosion
-
Montana1 week ago2026 MHSA Montana Wrestling State Championship Brackets And Results – FloWrestling
-
Louisiana5 days agoWildfire near Gum Swamp Road in Livingston Parish now under control; more than 200 acres burned
-
Denver, CO3 days ago10 acres charred, 5 injured in Thornton grass fire, evacuation orders lifted
-
Technology1 week agoYouTube TV billing scam emails are hitting inboxes
-
Technology1 week agoStellantis is in a crisis of its own making
-
Politics1 week agoOpenAI didn’t contact police despite employees flagging mass shooter’s concerning chatbot interactions: REPORT