Health
Some cancer patients could avoid surgery with innovative new therapy
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An experimental drug has shown promise in fighting a hard-to-treat form of bladder cancer known as BCG-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC).
BCG (Bacillus Calmette-Guérin) is an immunotherapy drug that is often the first-line treatment for certain early-stage bladder cancers.
The new drug, TAR-200 — which was evaluated in a trial sponsored and conducted by Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson — may offer a less invasive alternative to bladder removal surgery.
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TAR-200 is a small, drug-releasing device placed directly into the bladder through a simple outpatient procedure, without general anesthesia, according to the study press release.
Once inserted, it slowly releases the chemotherapy drug gemcitabine over several weeks.
Researchers say the new bladder-inserted device could spare patients from losing their bladder entirely. (iStock)
“Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said study lead Sia Daneshmand, M.D., director of urologic oncology with Keck Medicine of USC, in a press release.
“The findings of the clinical trial are a breakthrough in how certain types of bladder cancer might be treated, leading to improved outcomes and saved lives.”
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Bladder cancer is the fourth most common cancer in men and the 11th most common cancer in women.
According to the Urology Care Foundation, non-muscle-invasive bladder cancer is found in the tissue that lines the inner surface of the bladder.
“Bladder cancer is one of the 10 most common cancers worldwide, yet treatment options have remained largely unchanged for over 40 years.”
High-risk NMIBC carries a greater chance of coming back after treatment. This study aimed to find an option for patients whose cancer recurred even after standard therapy.
“The standard treatment plan for these patients was surgery to remove the bladder and surrounding tissue and organs, which has many health risks and may negatively impact patients’ quality of life,” said Daneshmand.
This new therapy could eventually allow some patients to avoid that procedure.
Trial results showed that many patients stayed cancer-free for more than two years. (iStock)
All participants in the study had high-risk NMIBC that did not respond to the standard immunotherapy drug BCG. The study was split into multiple groups who tested different combinations of drugs and treatment methods.
In one group, patients received TAR-200 once every three weeks for about six months, followed by maintenance treatments every 12 weeks for up to two years.
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Among 85 patients in this group, 82.4% showed no detectable signs of cancer after treatment. In that group, 52.9% remained cancer-free at one year, and many stayed cancer-free for more than two years without needing additional therapy.
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In another group of patients with a less aggressive type of early-stage bladder cancer, early disease-free survival rates were 85.3% at six months and 81.1% at nine months. Overall, 94% were able to keep their bladders.
The clinical trial results were published earlier this year in the Journal of Clinical Oncology.
The TAR-200 device delivers gemcitabine directly to the bladder, keeping the drug where it’s needed most. (iStock)
The researchers emphasized that this is still mid-stage (Phase 2b) data. Longer-term, larger trials and regulatory reviews are still needed before the treatment could become standard care.
“Because the study didn’t include a traditional comparison (no randomized control arm), we can’t definitively say how TAR-200 stacks up against other treatments in a fair head-to-head way,” the researchers wrote.
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Patients in this study are a specific subset (BCG-unresponsive and eligible for bladder preservation) and may not represent all bladder-cancer cases.
“Also, follow-up time remains relatively short and the number of patients modest, meaning we don’t yet know how long the benefits will last or how they apply to larger, more diverse groups of people,” the researchers added.
Health
Your daily coffee habit may be quietly reshaping your gut and mood, study finds
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Coffee may do more than keep you going: It could have a noticeable impact on your digestive health, even if you drink decaf.
Researchers from APC Microbiome Ireland found that habitual coffee consumption alters the trillions of microbes living in the digestive tract, creating a chemical feedback loop that directly influences mood, stress levels and cognitive sharpness.
The study followed 62 participants to determine how coffee interacts with the microbiome. The group included 31 coffee drinkers and 31 non-coffee drinkers who went through a series of psychological tests and kept detailed journals about their diet and coffee consumption.
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The researchers defined “coffee drinkers” as those consuming three to five cups daily, a range the European Food Safety Authority deems safe and moderate.
After people stopped drinking coffee for two weeks and then started drinking it again, the bacteria in their digestive systems behaved differently than the non-drinkers, according to a press release.
“It’s a complex dietary factor that interacts with our gut microbes, our metabolism and even our emotional well-being.” (iStock)
“Coffee is more than just caffeine,” study author John Cryan, principal investigator at APC Microbiome Ireland, said in a statement.
“It’s a complex dietary factor that interacts with our gut microbes, our metabolism and even our emotional well-being.”
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The coffee drinkers were found to have higher levels of specific beneficial bacteria, such as Eggertella and Cryptobacterium curtum.
These microbes play a vital role in releasing gastric acids and creating bile, both of which help the body eliminate harmful bacteria and manage inflammation, the researchers noted.
The non-caffeine components of coffee, like polyphenols and antioxidants, may be doing the heavy lifting for mental health. (iStock)
Both caffeinated and decaf drinkers reported lower levels of perceived stress, depression and impulsivity. This suggests that the non-caffeine components of coffee, like polyphenols and antioxidants, are doing the heavy lifting for mental health.
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However, the two types of brew offer different perks. Caffeinated coffee was specifically linked to reduced anxiety and better focus, while decaf was shown to lead to significant improvements in learning and episodic memory.
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Researchers believe these cognitive gains in decaf drinkers may be tied to better sleep quality and increased physical activity.
Caffeinated coffee was specifically linked to reduced anxiety and better focus, while decaf led to significant improvements in learning and episodic memory. (iStock)
The study’s findings are limited by a small sample size, which may not accurately represent the diverse microbiome profiles found across different global populations.
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Because the research relied heavily on self-reported data regarding participants’ coffee habits and mood levels, the results are subject to memory errors and subjective bias, the researchers noted.
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The study also did not strictly control for other dietary variables, such as sugar and dairy additives, which could independently influence gut health and cloud the specific impact of the coffee bean itself.
The research was published in the journal Nature Communications.
Health
This Is the Best Time To Eat Breakfast for Weight Loss After 50
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Health
Carrie Ann Inaba shares her struggle to manage hidden, invisible illness: ‘It’s real’
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Longtime “Dancing with the Stars” judge Carrie Ann Inaba is spreading awareness about a condition she’s been living with for decades.
The dancer and TV personality has recently been transparent about her journey with Sjogren’s disease – an autoimmune condition that can start with seemingly small symptoms but has the potential to become debilitating.
Inaba, 58, was rushed to the hospital last week after her condition triggered a medical emergency mid-flight while traveling to New York City.
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In an Instagram post featuring a video of Inaba being transported in an ambulance, she described how she “suddenly felt quite ill.”
“And while it seemed like food poisoning, I also suddenly broke out into a cold sweat, got dizzy and my arms went numb,” she wrote.
“Like many people who live with autoimmune disease, I travel with a health tool kit and am prepared for the worst, but this scared me.”
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In an interview with Fox News Digital, Inaba revealed that she’s been silently struggling with the disease for years, since first developing eye problems when she was younger.
“My eyes were really, really dry and I kept having injuries to my corneas,” she said.
After consulting her ophthalmologist, who brushed off her symptoms, Inaba met with a rheumatologist who directed her to a Sjogren’s specialist.
Carrie Ann Inaba has been a “Dancing with the Stars” judge since the ballroom dance competition’s first season in 2005. (Courtesy of Carrie Ann Inaba)
Following extensive bloodwork and a dry-eye test, Inaba was diagnosed with Sjogren’s disease in 2013 – more than 10 years after she first experienced symptoms.
What is Sjogren’s disease?
Sjogren’s is a chronic, systemic autoimmune disease that can affect different parts of the body. If left untreated, the condition can worsen over time, in some cases causing damage to the lungs, kidneys and other organs, according to medical experts.
An estimated four million people in the U.S. are living with Sjogren’s, 90% of whom are women.
In a survey of more than 3,500 adults living with the disease, 48 different symptoms were reported over the course of a year, per data from Sjout for Sjogren’s.
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Sjogren’s can show up differently for everyone, making it difficult to diagnose.
In Inaba’s case, after the initial dry-eye symptoms, she began suffering from “a lot of pain” in her neck and shoulders. As a dancer, this was difficult to differentiate from the normal aches and pains, she shared. Extreme fatigue was another symptom she experienced.
Carrie Ann Inaba, pictured at the Deadline x Dancing with the Stars 20th Anniversary Portrait Studio in November 2025, was diagnosed with Sjogren’s disease in 2013. (Anthony Avellano/Deadline via Getty Images)
“I had no energy to move forward with things, which is unlike me,” she said. “I’ve always been a go-getter … I was physically active my whole life. And during this chapter, when I was starting to figure out something was wrong, there were all these symptoms, and I didn’t understand how they were related.”
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Other symptoms can include dry mouth, brain fog, anxiety, swollen glands and lymph nodes, skin rashes, fevers and night sweats. People may also notice numbness, tingling or burning in the hands or feet. Internal organ complications can also occur.
Managing the disease
Inaba said she relies on a variety of practices to manage her symptoms, including keeping her eyes and environment moist.
“I always have a lot of drinks. I’m always spraying things in the air to get moisture in the air. I have a humidifier I sleep with,” she told Fox News Digital.
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“I also do lots of meditation and reiki and body work to make sure I don’t get too flared up, because pain is always with me. I live with pain 24/7.”
Inaba said she’s learned how to listen to her body to tap into what it needs, especially taking time to rest surrounding big events.
An infographic displaying symptoms experienced by more than 3,500 U.S. Sjogren’s patients in one year. (Sjoiut for Sjogren’s/sjoutforsjogrens.com)
“I know that more than likely, I might be sick and I might have a few down days afterwards, and it’s worth the risk,” she said. “If I don’t have to be in a crowd, I won’t, because I want to take care of my health and prioritize myself.”
“Don’t let people tell you it’s not real.”
For others who are living with Sjogren’s or experiencing symptoms, Inaba’s advice is to keep “careful track” of the warning signs, to recognize when something doesn’t feel right and to advocate for proper care.
This is the message behind the Sjout for Sjogren’s campaign, an awareness movement that Inaba hopes will help spread more knowledge about the disease and reduce stigma.
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“We want people to respect that it is a complicated systemic autoimmune disease that needs care,” she said. “There is no FDA-approved treatment at this time, so it’s about managing symptoms.”
“It’s important to also have a community – and part of this campaign is about building a community.”
Carrie Ann Inaba appears on “Dancing with the Stars” during the show’s 20th birthday celebration that aired Nov. 11. (Eric McCandless/Disney)
The most important thing Inaba wants people to know about Sjogren’s is that “it’s real.”
“It’s an invisible illness,” she said. “I know when I’m out there doing whatever show I’m doing, you don’t think I’m sick, but I pay a price for doing that.”
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“It’s sometimes a lonely and isolating disease – and so I want people to know they can reach out … I want people to feel confident enough to shout about what they’re going through.”
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She added, “Don’t let people tell you it’s not real. And have patience for the friends who are trying to understand, but can’t quite. Because, most likely, you don’t believe it unless you’re actually experiencing it.”
Fox News Digital’s Stephanie Giang-Paunon contributed to this report.
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