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Pig kidney functions inside donated body for record 2 months

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Pig kidney functions inside donated body for record 2 months

Dozens of doctors and nurses silently lined the hospital hallway in tribute: For a history-making two months, a pig’s kidney worked normally inside the brain-dead man on the gurney rolling past them.

The dramatic experiment came to an end Wednesday as surgeons at NYU Langone Health removed the pig kidney and returned the donated body of Maurice “Mo” Miller to his family for cremation.

It marked the longest a genetically modified pig kidney has ever functioned inside a human, albeit a deceased one. And by pushing the boundaries of research with the dead, the scientists learned critical lessons they’re preparing to share with the Food and Drug Administration -– in hopes of eventually testing pig kidneys in the living.

PIG KIDNEY WORKS IN BODY OF BRAIN-DEAD MAN FOR OVER A MONTH, A GIANT STEP IN ANIMAL-HUMAN ORGAN TRANSPLANTS

“It’s a combination of excitement and relief,” Dr. Robert Montgomery, the transplant surgeon who led the experiment, told The Associated Press. “Two months is a lot to have a pig kidney in this good a condition. That gives you a lot of confidence” for next attempts.

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Montgomery, himself a recipient of a heart transplant, sees animal-to-human transplants as crucial to ease the nation’s organ shortage. More than 100,000 people are on the national waiting list, most who need a kidney, and thousands will die waiting.

So-called xenotransplantation attempts have failed for decades — the human immune system immediately destroyed foreign animal tissue. What’s new: Trying pigs genetically modified so their organs are more humanlike.

The family of Maurice “Mo” Miller stands next to his body at NYU Langone Health in New York on Sep. 12, 2023. On Wednesday, the dramatic experiment of transplanting a pig organ into Miller successfully ended. (AP Photo/Shelby Lum)

Some short experiments in deceased bodies avoided an immediate immune attack but shed no light on a more common form of rejection that can take a month to form. Last year, University of Maryland surgeons tried to save a dying man with a pig heart –- but he survived only two months as the organ failed for reasons that aren’t completely clear. And the FDA gave Montgomery’s team a list of questions about how pig organs really perform their jobs compared to human ones.

Montgomery gambled that maintaining Miller’s body on a ventilator for two months to see how the pig kidney worked could answer some of those questions.

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“I’m so proud of you,” Miller’s sister, Mary Miller-Duffy, said in a tearful farewell at her brother’s bedside this week.

Miller had collapsed and was declared brain-dead, unable to donate his organs because of cancer. After wrestling with the choice, Miller-Duffy donated the Newburgh, New York, man’s body for the pig experiment. She recently got a card from a stranger in California who’s awaiting a kidney transplant, thanking her for helping to move forward desperately needed research.

“This has been quite the journey,” Miller-Duffy said as she and her wife Sue Duffy hugged Montgomery’s team.

PIG ORGAN TRANSPLANTS BEING TESTED ON DEAD HUMAN BODIES

On July 14, shortly before his 58th birthday, surgeons replaced Miller’s own kidneys with one pig kidney plus the animal’s thymus, a gland that trains immune cells. For the first month, the kidney worked with no signs of trouble.

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But soon after, doctors measured a slight decrease in the amount of urine produced. A biopsy confirmed a subtle sign that rejection was beginning –- giving doctors an opportunity to tell if it was treatable. Sure enough, the kidney’s performance bounced back with a change in standard immune-suppressing medicines that patients use today.

“We are learning that this is actually doable,” said NYU transplant immunologist Massimo Mangiola.

The researchers checked off other FDA questions, including seeing no differences in how the pig kidney reacted to human hormones, excreted antibiotics or experienced medicine-related side effects.

“It looks beautiful, it’s exactly the way normal kidneys look,” Dr. Jeffrey Stern said Wednesday after removing the pig kidney at the 61-day mark for closer examination.

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The next steps: Researchers took about 180 different tissue samples –- from every major organ, lymph nodes, the digestive tract –- to scour for any hints of problems due to the xenotransplant.

Experiments in the deceased cannot predict that the organs will work the same in the living, cautioned Karen Maschke, a research scholar at the Hastings Center who is helping develop ethics and policy recommendations for xenotransplant clinical trials.

But they can provide other valuable information, she said. That includes helping to tease out differences between pigs with up to 10 genetics changes that some research teams prefer — and those like Montgomery uses that have just a single change, removal of a gene that triggers an immediate immune attack.

“Why we’re doing this is because there are a lot of people that unfortunately die before having the opportunity of a second chance at life,” said Mangiola, the immunologist. “And we need to do something about it.”

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FDA bans red food dye due to potential cancer risk

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FDA bans red food dye due to potential cancer risk

The U.S. Food and Drug Administration (FDA) has officially banned red dye — called Red 3, or Erythrosine — from foods, dietary supplements and ingested medicines, as reported by the Associated Press on Wednesday.

Food manufacturers must remove the dye from their products by January 2027, while drug manufacturers will have until January 2028 to do so, AP stated. 

Any foods imported into the U.S. from other countries will also be subject to the new regulation.

RED FOOD DYE COULD SOON BE BANNED AS FDA REVIEWS PETITION

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“The FDA is taking action that will remove the authorization for the use of FD&C Red No. 3 in food and ingested drugs,” said Jim Jones, the FDA’s deputy commissioner for human foods, in a statement. 

The U.S. Food and Drug Administration has officially banned red dye — called Red 3, or Erythrosine — from foods, dietary supplements and ingested medicines (iStock)

“Evidence shows cancer in laboratory male rats exposed to high levels of FD&C Red No.3,” he continued. “Importantly, the way that FD&C Red No. 3 causes cancer in male rats does not occur in humans.”

      

The synthetic dye, which is made from petroleum, is used as a color additive in food and ingested drugs to give them a “bright cherry-red color,” according to an online statement from the FDA.

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Red cough syrup

Food manufacturers must remove the dye from their products by January 2027, while drug manufacturers will have until January 2028 to do so. (iStock)

The petition to ban the dye cited the Delaney Clause, which states that the agency cannot classify a color additive as safe if it has been found to induce cancer in humans or animals.

The dye was removed from cosmetics nearly 35 years ago due to potential cancer risk.

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“This is a welcome, but long overdue, action from the FDA: removing the unsustainable double standard in which Red 3 was banned from lipstick but permitted in candy,” said Dr. Peter Lurie, director of the group Center for Science in the Public Interest, which led the petition effort, as reported by AP.

Red Jello

Nearly 3,000 foods are shown to contain Red No. 3, according to Food Scores, a database of foods compiled by the Environmental Working Group. (iStock)

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, applauded the FDA’s ban.

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“It was a long time coming,” he told Fox News Digital. “It’s been more than 30 years since it was banned from cosmetics in the U.S. due to evidence that it is carcinogenic in high doses in lab rats. There needs to be a consistency between what we put on our skin and what we put into our mouths.”

“There needs to be a consistency between what we put on our skin and what we put into our mouths.”

Siegel said he believes the FDA’s decision could be tied to the incoming new head of the Department of Health and Human Services, Robert F. Kennedy Jr.

“They knew it would have happened anyway under RFK Jr.,” he said. “It is already banned or severely restricted in Australia, Japan and the European Union.”

Kid eating sugary cereal

The food additive also “drew kids in” to a diet of empty calories and ultraprocessed foods, one doctor stated. (iStock)

The food additive also “drew kids in” to a diet of empty calories and ultraprocessed foods, Siegel added.

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“It has also been linked to behavioral issues in children, including ADHD.”

Nearly 3,000 foods are shown to contain Red No. 3, according to Food Scores, a database of foods compiled by the Environmental Working Group.

For more Health articles, visit www.foxnews.com/health

The National Confectioners Association provided the below statement to Fox News Digital.

“Food safety is the number one priority for U.S. confectionery companies, and we will continue to follow and comply with FDA’s guidance and safety standards.”

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The petition to remove Red No. 3 from foods, supplements and medications was presented in 2022 by the Center for Science in the Public Interest and 23 other organizations and scientists.

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How Yvette Nicole Brown Lost Weight and Got Her Diabetes Under Control

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