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NIH selects Dr. Jeanne Marrazzo to succeed Fauci as top infectious disease expert

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NIH selects Dr. Jeanne Marrazzo to succeed Fauci as top infectious disease expert

The National Institutes of Health has selected Dr. Jeanne Marrazzo as the new director of the National Institute of Allergy and Infectious Diseases.

Marrazzo, who is currently the director of the Division of Infectious Diseases at the University of Alabama at Birmingham, succeeds Dr. Anthony Fauci as the nation’s top infectious disease expert. Fauci stepped down from his role last December after more than 50 years of government service. He had held the position since 1984. 

Since his retirement, Dr. Hugh Auchincloss Jr. has been serving as acting director.

Marrazzo is expected to begin her role at NIAID in the fall, overseeing the institute’s $6.3 billion budget as well as its research and response to infectious disease outbreaks.

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Dr. Jeanne Marrazzo, a research scientist at the University of Alabama at Birmingham, was named Wednesday, Aug. 2, 2023, to succeed Dr. Anthony Fauci as director of the National Institute of Allergy and Infectious Diseases. (Lexi Coon/UAB Photo via AP)

“Dr. Marrazzo brings a wealth of leadership experience from leading international clinical trials and translational research, managing a complex organizational budget that includes research funding and mentoring trainees in all stages of professional development,” Dr. Lawrence Tabak, acting director for the NIH, said in a statement. “I look forward to welcoming Dr. Marrazzo to the NIH leadership team. I also want to extend my gratitude to Hugh Auchincloss, Jr., M.D., for serving as acting director of NIAID after longtime director Anthony S. Fauci, M.D., stepped down in December 2022.”

The NIH said Marrazzo’s research has focused specifically on sexually transmitted diseases and the prevention of HIV infection. Science reported that the 61-year-old will be the first openly gay director of an NIH institute.

She was the recipient of the American Sexually Transmitted Diseases Association’s Distinguished Career Award, the highest recognition of contributions to research and mentoring in the field.

In addition, Marrazzo has been a principal investigator on NIH grants continuously since 1997 and has served frequently as a peer reviewer and advisory committee member. 

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The National Institutes of Health, March 9, 2001, in Bethesda, Maryland. (Mark Wilson/Newsmakers)

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She is a fellow of the American College of Physicians and of the Infectious Diseases Society of America and is board certified in infectious disease. 

Marrazzo also has chaired the American Board of Internal Medicine Council, and the ABIM Infectious Disease Specialty Board.

She holds a bachelor’s degree in biology from Harvard University, an M.D. from Thomas Jefferson University and a master of public health in epidemiology from the University of Washington.

Marrazzo declined to be interviewed until she’s officially at NIH.

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Dr. Anthony Fauci

Former NIAID director Dr. Anthony Fauci (Saul Loeb/AFP via Getty Images)

Fauci told The Washington Post he did not have a close relationship with Marrazzo and was not involved in her selection, but applauded the search committee. 

“She’s an experienced infectious-disease person; she’s very well-liked,” he told the outlet.

“Sometimes, my sticking with data and facts generated a lot of antagonism on the part of people with extreme views,” Fauci said. “She will likely face that.… I believe she will be up to it as long as she stays anchored in science and evidence, and in keeping an open mind.”

Dr. Carlos del Rio, interim dean of the Emory University School of Medicine and president of the Infectious Diseases Society of America, said in a release that Marrazzo is an “exceptional infectious diseases physician, leader, mentor and scientist” and that the society looks forward to working with her. 

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Reaction to the appointment on social media has been varied. 

The Associated Press contributed to this report.

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).

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Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).

TO REDUCE CANCER RISK, SKIP THE ALCOHOL, REPORT SUGGESTS

“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research. (iStock)

“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”

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Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.

Addiction expert warns of risks

There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.

“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.

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Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli. 

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The more someone drinks — both in volume and frequency — the higher the risk, he warned.

Doctor holding lung x-ray and woman smoking

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%). (iStock)

“Alcohol is a toxin,” Scioli said. 

“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”

Is there a ‘safe’ amount?

Moderate alcohol use is defined as one drink or less in one day for women. 

For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).

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“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”

“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.

“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”

      

Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”

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“The line between safety and danger is debatable, and is different for each person.”

While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.

alcoholic beverages

Moderate alcohol use is defined as one drink or less in one day for women, and two drinks or fewer for men, per the CDC. (iStock)

Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.

“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.

What needs to change?

The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk. 

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As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.

cancer patient looks out window

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, an expert said. (iStock)

“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said. 

“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”

For more Health articles, visit www.foxnews.com/health

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To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”

Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight


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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

A new drug has been approved for the treatment of schizophrenia in adults.

On Thursday, the U.S. Food and Drug Administration (FDA) approved COBENFY (xanomeline and trospium chloride), an oral medication that is manufactured by Bristol Myers Squibb in New Jersey.

This marks the first new class of medications for the brain disorder in several decades, according to a press release.

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COBENFY is expected to be available in the U.S. in late October, the company noted.

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A new drug has been approved for the treatment of schizophrenia in adults. (iStock)

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb, in the press release.

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Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors.

It often causes hallucinations, delusions, disordered speech and loss of touch with reality, Mayo Clinic states on its website.

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COBENFY

COBENFY (xanomeline and trospium chloride) is an oral medication that is manufactured by Bristol Myers Squibb in New Jersey. (Bristol Myers Squibb)

The disorder can also lead to lack of emotional expression, lack of motivation, cognitive dysfunction and social withdrawal.

Approximately 2.8 million people in the U.S. and 24 million people globally are living with schizophrenia.

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The disorder has traditionally been treated with antipsychotic medications, but around 40% of patients do not respond to treatments and 60% experience “inadequate improvement” in symptoms or “intolerable side effects,” studies have shown.

COBENFY

COBENFY is expected to be available in the U.S. in late October, the company noted. (Bristol Myers Squibb)

COBENFY works differently than the currently available schizophrenia medications.

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“Due to its heterogeneous nature, schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies,” said Rishi Kakar, MD, chief scientific officer and medical director at Segal Trials and investigator in the drug’s clinical trials, in the release. 

“Schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies.”

“The approval of COBENFY is a transformative moment in the treatment of schizophrenia because, historically, medicines approved to treat schizophrenia have relied on the same primary pathways in the brain.”

“By leveraging a novel pathway, COBENFY offers a new option to manage this challenging condition.”

Bristol Myers Squibb

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb. (iStock)

Sam Clark, founder and CEO at Terran Biosciences — a biotech company that develops treatments and technologies for neurological and psychiatric diseases in New York City — commented on the new approval in a statement sent to Fox News Digital.

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“I am excited that the FDA has just approved [COBENFY] as a treatment for patients with schizophrenia, marking a big leap forward in the psychiatry space,” he said. 

      

“These patients live with a difficult disease, and this drug with a novel mechanism of action will surely make a significant impact,” Clark continued. 

“We look forward to seeing the renaissance continue as this approval paves the way for future breakthroughs and novel patient-focused therapeutics.”

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The approval follows three phases of clinical trials in which COBENFY was shown to result in a “statistically significant improvement in illness.”

schizophrenia split

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors and often causes hallucinations and delusions. (iStock)

In terms of safety, the medication’s most common side effects during clinical trials were nausea, indigestion, vomiting, diarrhea, constipation, hypertension, abdominal pain, accelerated heart rate, dizziness and gastroesophageal reflux disease, the release stated.

Patients with certain existing medical conditions may experience other, more serious risks.

For more Health articles, visit www.foxnews.com/health

People should discuss potential complications with a doctor before starting the medication.

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Fox News Digital reached out to Bristol Myers Squibb and the Schizophrenia & Psychosis Action Alliance requesting comment.

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