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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients

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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients


On a quiet plot of land in rural New Mexico, Jeff Deming feels like he’s really living, once again.

“Mentally, it’s day and night,” he said.

He’s able to do the things that make him happy, like woodworking, despite living with Parkinson’s Disease.

“Physically, I feel better than I did 2-3 years ago,” he said.

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Deming credits the treatment he received during a first-of-its-kind clinical study he participated in at the University of California, San Francisco: Psilocybin therapy for people with Parkinson’s Disease.

“This is very cliché, but it truly gave me my life back,” he said.

Psilocybin is a naturally occurring psychedelic compound found in ‘magic mushrooms.’ When administered in controlled, clinical research settings, it has shown promise in treating depression and anxiety, both of which are mood symptoms associated with Parkinson’s that are linked to a faster physical decline.

“The neurodegeneration that is happening isn’t just impacting motor circuitry – it’s impacting a lot of brain circuitry. That creates this huge burden of symptoms that we often overlook and don’t talk about enough, maybe,” said Dr. Ellen Bradley, of UCSF. “We were really surprised by how well this trial went.”

Bradley and a team of researchers at UCSF are trying to figure out how Psilocybin may help treat mood dysfunction and more in those living with the neurodegenerative disease.

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“This is a first step, and now we’ve opened the door to being able to really investigate the effects of Psilocybin for people with Parkinson’s,” she said.

12 patients participated in this first-round study, which involved a first and second course of Psilocybin treatment.

“We had folks do a lower dose of Psilocybin – a 10 mg dose initially – and monitored them for a couple of weeks to see how that went,” Bradley said. “If it did go well, if we didn’t have safety concerns, then they were eligible for the full therapeutic dose of 25 mg.”

All 12 patients were able to complete both courses of treatment without reporting any serious side effects, according to Bradley.

“We want to find out not just does Psilocybin therapy work, but if it does, how does it work? That mechanistic piece is so important,” she said. “Can it change the brain’s ability to adapt to its environment and to rewire itself?”

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While there were no serious adverse effects reported, every patient didn’t have the same life-changing experience as Deming says he experienced. Though many did report their motor and cognitive functions improved afterwards, per Bradley.

“We don’t have a reason to believe that this is a treatment that is going to be a good fit for every patient. That is never really our expectation in medicine. But our goal is to figure out when is it the right treatment and how much for which patient,” Bradley said.

Bradley says her team is scaling up their work and are in the process of recruiting for a larger study, due to the success with the initial research.

“That was really exciting just to see that promising safety profile in this initial pilot. That kind of gives us a green light to go forward with more in-depth research,” she said. “We really desperately need new treatments for Parkinson’s. It’s a very quickly growing disease that’s becoming more and more prevalent in our population, so, we really feel like we have to be investigating every possible route that could mean new treatments for patients.”

Two years removed from his controlled Psilocybin dosing, Deming says he feels better now than he did when he received his initial diagnosis four years ago.

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“Something about this experience just freed everything back up so I could think again, I could dream again,” he said.

He’d like to see more research into psychedelic therapies for a range of conditions, with the hopes that more people will be able to reclaim the reins of life, as he has.

“There’s been such a stigma against the research with it,” he said. “It is definitely worth looking more closely at.”
 

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San Francisco’s Santa Con expected to bring in large crowds, benefit local bars

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San Francisco’s Santa Con expected to bring in large crowds, benefit local bars


For some businesses, Saturday is the most wonderful day of the year as thousands of Santas visit San Francisco watering holes for Santa Con.

But for others, the festive event is more trouble than it’s worth.

Kevin Sully Sullivan and his wife, Deb, met at the Marina Lounge in the 1980s. Sully then went on to work at the bar for 30 years and just two years ago, took over the business from the prior owners.

“We’ve loved this bar for such a long time and it’s a dream come true to actually have our names in it,” Sully said.

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While Sully loves celebrating the holidays and supports Santa Con, he has posted this sign on the door of the Sully’s Marina Lounge, officially making it a Santa-free zone. For him, the extra customers aren’t worth the hassle.

“Some of these bars that encourage it, that participate, they do months of business in one day,” he said. “But many of them have to replace sinks in their restrooms. They get it torn off the wall and toilets that have all kinds of things go wrong.”

On the other hand, Westwood has beefed up its staff and is looking forward to all the Santas coming to town.

“It’s really good,” Kwame Wright said.

“It pumps in a lot of money into the economy,” Westwood said. “Local businesses, we benefit from it as well. So, we’re really happy and we’re excited that we get to host. Santa’s are welcome here.”

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Aside from Halloween, Santa Con is one of the biggest events of the year for Westwood. This place normally has long lines to get in on weekends and it’s expecting an even bigger crowd Saturday. Westwood is taking steps to make sure all the Santas behave.

“Security does really hard work, and we have extra security to make sure everybody is safe,” said Wright.

But for those willing to wait until Christmas for a Santa sighting, Sully says his place will be the place to be.

“It actually ends up being a really nice day here because they know it’s a sanctuary haven from the Santa Con,” Sully said.

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3-alarm fire burns San Francisco Tenderloin residential building

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3-alarm fire burns San Francisco Tenderloin residential building



A large fire burned at a six-story residential building in San Francisco’s Tenderloin District early Friday morning, leaving dozens displaced, officials said.

The fire started at around 3 a.m. at a building on Golden Gate Avenue near Taylor and Market streets, adjacent to the Golden Gate Theatre. The San Francisco Fire Department said the fire started on the top floor and reached three alarms, spreading to the attic and roof of the building. Over 100 firefighters at the scene were able to prevent it from spreading to lower floors and nearby buildings, the department said.

Multiple people were rescued and self-evacuated, and a total of 45 residents were displaced, but there were no injuries, the department said. Two cats were also rescued, one that was treated by medics at the scene and another cared for by Animal Control.

Evacuated residents were provided temporary shelter at the corner of Golden Gate and Jones Street aboard a Muni bus. The Red Cross and other city agencies were called in to assist the displaced residents, the department said.

The fire was contained by 5:30 a.m., and firefighters remained on the scene for several hours. The cause of the fire was not immediately known.

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San Francisco firefighters to retire uniforms linked to cancer

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San Francisco firefighters to retire uniforms linked to cancer


San Francisco firefighters are finally getting the protective gear they were promised after years’ long research revealed certain chemicals used in traditional firefighter uniforms can cause cancer.

“What none of us could have known is that some of the very gear designed to protect us was quietly harming us,” said San Francisco Fire Chief Dean Crispen, who spoke alongside dozens of first responders on Thursday as he announced the city’s $3.6 million plan to provide protective equipment to all frontline firefighters by the end of the year.  “This is a joyous occasion for our city.”

San Francisco Fire Chief Dean Crispen was flanked by the mayor, state and local lawmakers, and dozens of first responders on Thursday when detailing the city’s plans to provide new, non-PFAS uniforms to frontline firefighters across San Francisco.

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The San Francisco fire department, the tenth largest in the nation, has already distributed the redesigned gear to about 80 of its firefighters and hopes to have all 1,100 of its new uniforms in use within the next three weeks – that’s enough protective equipment to provide one uniform to each of the city’s frontline firefighters.  While city leaders hope to eventually purchase a second set of gear, San Francisco firefighters will, for now, need to wash their new gear before returning to work or continue to rely on their old uniform as a backup.

“Public safety relies on the people who stand between danger and our residents,” Mayor Lurie told the crowd during Thursday’s announcement.  “Firefighter health must always be at the center of our decisions.”

San Francisco’s efforts stem from a first-in-the-nation ban that local lawmakers passed last year, which requires the city to outfit firefighters with new uniforms by July 2026. Over the years, studies have shown the jackets and pants firefighters across America have long relied on to keep safe during emergencies are made with materials proven to cause cancer. 

These so-called “PFAS” materials, often referred to as ‘forever chemicals’ because of their reluctance to breakdown, have long been used to bolster the reliability of firefighter clothing by helping to repel flammable liquids and reduce temperatures, even in extreme heat.  Researchers, however, have found the compounds to be harmful when absorbed through skin. While the precise level of PFAS exposure for firefighters and the associated health risks are still being studied, the compounds have been linked to cancer and other negative health effects impacting cholesterol levels and the immune system, according to the Centers for Disease Control and Prevention (CDC).

PFAS aside, the inherit health risks of firefighting, including prolonged exposure to smoke and ash, led the World Health Organization to deem the occupation a “carcinogen.”  Yet, some fear the very safety uniforms firefighters have come to rely on for protection could also be making them sick. 

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Female firefighters in San Francisco are six times more likely to develop cancer compared to the national average, according to the San Francisco Firefighters Cancer Prevention Foundation.

Female firefighters in San Francisco are six times more likely to develop cancer compared to the national average, according to the San Francisco Firefighters Cancer Prevention Foundation.

In San Francisco, female firefighters have a six times higher rate of breast cancer than the national average, according to the San Francisco Firefighters Cancer Prevention Foundation. More than 400 firefighters in San Francisco have been lost to cancer over the past 20 years, according to the city’s fire department.

“The cost of inaction is measured in funerals,” said Stephen Gilman, who represents the local chapter of the International Association of Fire Fighters (IAFF). “The reward of action is measured in lives saved.”


The cost of inaction is measured in funerals.

Stephen Gilman, International Assoc. of Fire Fighters (IAFF)


While materials laced with PFAS have been shown to pose safety risks, so has fire gear that has been manufactured without it.  Last year, the NBC Bay Area Investigative Unit reported on research from North Carolina State University that found non-PFAS fire equipment to be less breathable and more flammable than traditional uniforms made with PFAS.

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“We don’t want to just trade one hazard for another,” Dr. Bryan Ormand told the Investigative Unit back in May 2024.  “We’re introducing a potential hazard for flammability on the fire scene where firefighters didn’t have that before.”

The San Francisco Board of Supervisors is scheduled to vote Tuesday on a city-wide ban of what are known as ‘PFAS’ or ‘forever chemicals,’ but replacement options still aren’t widely available and those that are seem be raising new safety concerns. Senior Investigator Bigad Shaban reports.

Milliken & Company, the textile firm that made the material for San Francisco’s latest uniforms, said the new type of gear “meets or exceeds” all industry standards for “breathability and thermal protection.” 

“We refused to trade one hazard for another,” Marcio Manique, senior vice president and managing director of Milliken’s apparel business, noted in a written statement.

“It meets the strictest performance standards without adding weight or compromising breathability – giving firefighters exactly what they asked for.”

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We refused to trade one hazard for another

Marcio Manique, senior vice president and managing director of Milliken’s apparel business


In San Francisco, the new gear underwent a 90-day test trial with 50 of the city’s own firefighters.

“What we did was we actually went through a really comprehensive testing process,” Chief Crispen told the Investigative Unit.  “It went to the lab and received testing and everything came back great, so we feel strongly about this product.”


Contact The Investigative Unit

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