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Parkinson’s risk increases with exposure to common chemical, study suggests

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Parkinson’s risk increases with exposure to common chemical, study suggests

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A pesticide commonly used in America’s food supply has been linked to Parkinson’s disease, new research suggests.

A UCLA study published in the journal Springer Nature Link suggests that exposure to chlorpyrifos could increase the risk of the neurological disease.

The chemical is often used on agricultural products like soybeans, fruit and nut trees, broccoli, cauliflower and other row crops, according to the U.S. Environmental Protection Agency.

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The study compared 829 people with Parkinson’s to 824 people without the disease over a 45-year period, focusing on their proximity to chlorpyrifos.

The researchers also conducted mouse experiments, where mice inhaled the pesticide as humans would for 11 weeks. Experiments were also carried out on zebrafish to study cell-level brain damage.

Chlorpyrifos is often used on agricultural products like soybeans, fruit and nut trees, broccoli, cauliflower and other row crops, according to the U.S. Environmental Protection Agency. (iStock)

In humans, the study revealed that long-term exposure to chlorpyrifos led to more than a 2.5 times higher risk of Parkinson’s.

In mice, exposure to the pesticide caused movement problems similar to Parkinson’s symptoms, loss of dopamine-producing neurons, increased brain inflammation and build-up of harmful proteins.

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Zebrafish suffered brain cell death and damage linked to failure in the cell’s “cleanup system,” according to the study press release.

Dr. Jeff Bronstein, director of the Movement Disorders Program at UCLA and professor of neurology and molecular toxicology, noted that previous human studies also suggested an association between chlorpyrifos exposure and Parkinson’s.

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“[We were] surprised that the mechanism of toxicity was apparent in both mice and zebrafish,” he said. “We rarely find such consistent results in different animal models.”

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A researcher commented that the consistency in results between human and animal subjects is “rare.” (iStock)

The researcher emphasized that the association between pesticide exposure and Parkinson’s was “very strong,” and the longer someone was exposed, the higher the risk became.

“People should avoid exposure to CPF and similar pesticides (organophosphates) by not using them in their home, eating organics, and washing fruits and vegetables before eating them,” Bronstein advised.

Study limitations

The study did have some limitations, the researchers acknowledged, primarily that it was observational, meaning it shows an association but cannot prove causation.

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It also estimated exposure based on participants’ locations, and did not measure diet, indoor exposure or personal lifestyle behaviors. Additionally, the results of the animal models can’t be translated directly to humans.

There was also the possibility that chlorpyrifos was used along with other chemicals, which means it could be difficult to measure its specific impact, the study noted.

Chlorpyrifos is used to control different kinds of pests, like termites, mosquitoes and roundworms, among crops. (iStock)

Industry reaction

Chlorpyrifos is used to control different kinds of pests, like termites, mosquitoes and roundworms, among crops, according to the National Pesticide Information Center (NPIC) at Oregon State University.

People can be exposed to the pesticide by breathing it in or by consuming contaminated food or water.

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In 2021, the EPA banned the use of chlorpyrifos on food crops, but a federal appeals court overturned that decision in 2023, allowing its use to resume on some crops while regulators revisit the rule.

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In January 2026, the EPA issued an update outlining plans to move forward with a rule that would ban most uses of chlorpyrifos.

“Chlorpyrifos is subject to registration review, a process required under FIFRA (the Federal Insecticide, Fungicide, and Rodenticide Act) in which registered pesticides are comprehensively evaluated every 15 years against current safety standards and the latest scientific evidence,” the EPA said in a statement sent to Fox News Digital.

“EPA is currently developing a revised human health risk assessment for chlorpyrifos as part of that review, and will consider this study alongside any other relevant submissions,” the agency said in a statement sent to Fox News Digital. (Getty)

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“EPA is currently developing a revised human health risk assessment for chlorpyrifos as part of that review, and will consider this study alongside any other relevant submissions. Where the science calls for stronger protections or tolerance revocations, EPA will act without hesitation and without delay.”

Fox News Digital reached out to several manufacturers of the chemical for comment.

“People should avoid exposure to CPF and similar pesticides.”

Corteva, an Indiana agrichemical company formed in 2019 through the merger of Dow Chemical and DuPont, announced in 2020 that it would end production of chlorpyrifos within the year, citing declining sales.

In April 2022, the German chemical company BASF requested the cancellation of its pesticide registrations for products containing chlorpyrifos. 

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“BASF does not manufacture chlorpyrifos and does not have any pesticide registrations issued by the U.S. EPA for chlorpyrifos-containing products,” the company told Fox News Digital. 

No products from Corteva or BASF were included in the study linking chlorpyrifos to Parkinson’s disease.

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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Intermittent fasting’s real benefit may come after you start eating again

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Intermittent fasting’s real benefit may come after you start eating again

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Research continues to uncover new details on how fasting may help extend life.

A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.

Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.

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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.

The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.

Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)

Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”

“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.

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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”

Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”

Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)

The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.

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“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.

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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”

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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.

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Limitations and cautions

Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.

“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”

The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)

Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”

“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.

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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.

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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.

Anyone considering intermittent fasting should consult with a doctor before starting.

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