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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients

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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients


On a quiet plot of land in rural New Mexico, Jeff Deming feels like he’s really living, once again.

“Mentally, it’s day and night,” he said.

He’s able to do the things that make him happy, like woodworking, despite living with Parkinson’s Disease.

“Physically, I feel better than I did 2-3 years ago,” he said.

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Deming credits the treatment he received during a first-of-its-kind clinical study he participated in at the University of California, San Francisco: Psilocybin therapy for people with Parkinson’s Disease.

“This is very cliché, but it truly gave me my life back,” he said.

Psilocybin is a naturally occurring psychedelic compound found in ‘magic mushrooms.’ When administered in controlled, clinical research settings, it has shown promise in treating depression and anxiety, both of which are mood symptoms associated with Parkinson’s that are linked to a faster physical decline.

“The neurodegeneration that is happening isn’t just impacting motor circuitry – it’s impacting a lot of brain circuitry. That creates this huge burden of symptoms that we often overlook and don’t talk about enough, maybe,” said Dr. Ellen Bradley, of UCSF. “We were really surprised by how well this trial went.”

Bradley and a team of researchers at UCSF are trying to figure out how Psilocybin may help treat mood dysfunction and more in those living with the neurodegenerative disease.

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“This is a first step, and now we’ve opened the door to being able to really investigate the effects of Psilocybin for people with Parkinson’s,” she said.

12 patients participated in this first-round study, which involved a first and second course of Psilocybin treatment.

“We had folks do a lower dose of Psilocybin – a 10 mg dose initially – and monitored them for a couple of weeks to see how that went,” Bradley said. “If it did go well, if we didn’t have safety concerns, then they were eligible for the full therapeutic dose of 25 mg.”

All 12 patients were able to complete both courses of treatment without reporting any serious side effects, according to Bradley.

“We want to find out not just does Psilocybin therapy work, but if it does, how does it work? That mechanistic piece is so important,” she said. “Can it change the brain’s ability to adapt to its environment and to rewire itself?”

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While there were no serious adverse effects reported, every patient didn’t have the same life-changing experience as Deming says he experienced. Though many did report their motor and cognitive functions improved afterwards, per Bradley.

“We don’t have a reason to believe that this is a treatment that is going to be a good fit for every patient. That is never really our expectation in medicine. But our goal is to figure out when is it the right treatment and how much for which patient,” Bradley said.

Bradley says her team is scaling up their work and are in the process of recruiting for a larger study, due to the success with the initial research.

“That was really exciting just to see that promising safety profile in this initial pilot. That kind of gives us a green light to go forward with more in-depth research,” she said. “We really desperately need new treatments for Parkinson’s. It’s a very quickly growing disease that’s becoming more and more prevalent in our population, so, we really feel like we have to be investigating every possible route that could mean new treatments for patients.”

Two years removed from his controlled Psilocybin dosing, Deming says he feels better now than he did when he received his initial diagnosis four years ago.

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“Something about this experience just freed everything back up so I could think again, I could dream again,” he said.

He’d like to see more research into psychedelic therapies for a range of conditions, with the hopes that more people will be able to reclaim the reins of life, as he has.

“There’s been such a stigma against the research with it,” he said. “It is definitely worth looking more closely at.”
 

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What’s Worth More Than Cash in San Francisco Real Estate? Anthropic Stock

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What’s Worth More Than Cash in San Francisco Real Estate? Anthropic Stock


Few things are more valuable in the Bay Area than real estate. In San Francisco, the median house price is now over $2 million. Last month, at least seven houses in the city sold for $1 million over the asking price, and buyers regularly offer to pay in cash or waive contingencies to stay competitive. Yet there is one thing that remains even more valuable than a house, and possibly more valuable than money itself: stock in Anthropic or OpenAI.

Last week, 160 Noe Street, an Edwardian home in San Francisco’s desirable Duboce Triangle neighborhood, was listed for sale at $2.9 million—or the equivalent amount in Anthropic or OpenAI shares, as based on those companies’ current valuations. Rachel Swann, the listing agent, says she was inspired to set these unusual terms after meeting several Anthropic employees at an open house for a different property. “These people have a lot of paper wealth, but they don’t always have the liquidity to do things they want,” Swann says. Some of these employees were expecting to come into as much as $50 million from their Anthropic shares, and wondered if they could use that as leverage to buy a house, according to Swann. “This kept coming up over and over again.”

Swann’s listing is unconventional, but not singular. In April, an investment banker named Storm Duncan offered to exchange his Mill Valley home and an adjacent parcel of land for Anthropic shares. And in May, Vijay Chattha, who owns an agency that does PR for tech companies, listed his Healdsburg home for $2.5 million, or $2 million in Anthropic stock. “I want to sell my house, and I want to invest in Anthropic,” Chattha says. “Why not combine the two?

Chattha’s house—a three bed, three bath with a pool and a bocce court in a part of Sonoma County that abuts some of the region’s most famous wineries—also comes with coveted short-term rental status, allowing the owner to list it on platforms like Airbnb. Only a handful of properties in Healdsburg come with that status, and only about a dozen come up for sale in a given year.

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Chattha is offering a $500,000 discount to Anthropic employees because he believes the value of Anthropic shares will grow faster than any other investment, and his vacation home in wine country is the best bargaining chip he has to try to access them. “If you look at Anthropic’s growth last year, it’s insane,” he says, noting the $380 billion valuation the company claimed in February. “Now they’re raising at $965 billion. That’s three X in like three months.” He added that he was open to exchanging the house for shares in Anthropic, but not OpenAI, because he prefers using Anthropic’s products.

The real estate listings come at a time when investors are salivating at the record-high valuations of Anthropic and OpenAI, and even those considered wealthy by Bay Area standards are feeling FOMO about the affluence that could come from these companies’ debuts on the stock market. (On Monday, Anthropic submitted paperwork for its initial public offering; OpenAI is also reportedly preparing to file in the coming months.) Despite the unprecedented valuations of these companies, many people believe their stock prices will only go up, and that anyone who gets a piece now could win the jackpot.

People are clamoring to buy equity in OpenAI and Anthropic on the secondary market, leading to a frenzy of transactions that may or may not be legitimate. As a result, Anthropic updated its policy around “unauthorized Anthropic stock sales” this spring, which notes that “if someone purports to sell Anthropic shares without proper board approval, that transaction is invalid.” A spokesperson for Anthropic pointed back to this policy when asked about the possibility of exchanging company shares for real estate.



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Live Updates: San Francisco Primary Election 2026

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Live Updates: San Francisco Primary Election 2026


Welcome to our running tally of Election Night results. Or, as this is California, well beyond tonight, as results continue to trickle in.

The first batch of results should arrive at 8:45 p.m., with three more to follow tonight. The Department of Elections has the breakdown.

San Francisco is voting in three special elections, for District 2 and District 4 supervisors and for a Board of Education member. Both supervisor races are referendums on housing, especially District 2, while the main backdrop of the D4 race is all the hot feelings around the fate of the Sunset Dunes Park (nee Great Highway).

The winners of all three special races will have to compete again in November for their seats.

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Keeping it local, SF is also voting on four ballot measures. Prop A is for a bond to pay for an emergency water-system. B is for term limits. C and D are dueling measures related to the “overpaid CEO” tax. (Links go to our reporting on each race or issue; or click here for our Election 2026 page.)

Vote local, think national: Which two candidates will advance to the November election to replace Nancy Pelosi?

Statewide races include the primaries for governor, education superintendent, lieutenant governor, and much more.

Polls close soon. If you haven’t voted yet, find your polling station here.

Tuesday, June 2, 5:40 p.m.

Two and a half hours until our polls close. Before we go down the local rabbit hole, a reminder that other states have primary action today: New Jersey, Iowa, New Mexico, South Dakota, and Montana.

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Why does it take so long to get results in California? CalMatters has you covered on that story. We shouldn’t expect a call tonight on the governor’s race.

The last big election was November 5, 2024. (Remember?) Ten days later, there were still races to call in San Francisco.


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So if you’re waiting for the pundits (and maybe even us) to tell you What It All Means, you might have to wait a while.



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San Francisco voters to decide on dueling measures on Top Executive Pay Tax changes

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San Francisco voters to decide on dueling measures on Top Executive Pay Tax changes


San Francisco voters weighed in Tuesday on two competing measures that seek to change the Top Executive Pay Tax, with one of the measures also including a change to the Gross Receipts Tax.

Should both measures pass, the one with the most votes will take effect, according to the propositions’ legal text.

Currently, the measures state that most businesses with San Francisco gross receipts up to $5 million are exempt from the Gross Receipts Tax. And businesses that use more than half of their city payroll for in-house administrative and management services pay an Administrative Office Tax instead of a Gross Receipts Tax.

The Top Executive Pay Tax is a tax some large businesses pay if their highest-paid managerial employee earns more than 100 times the median pay of their San Francisco employees. Businesses that have city gross receipts up to $5 million and are not subject to the Administrative Office Tax are exempt.

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Proposition C

Proposition C states it would increase the number of businesses that could be exempt from the Gross Receipts Tax and would stop any further increases to the “Top Executive Pay Tax” after a final rate bump.

The proposed measure says it would raise the Gross Receipts Tax exemption ceiling to $7.5 million. The $7.5 million ceiling would also apply to the Top Executive Pay Tax exemption.

As for changes to the Top Executive Pay Tax, Proposition C states it would implement the 2028 tax rate increase in 2027, but then stop any future increases.

Supporting Proposition C are Rodney Fong, CEO of the San Francisco Chamber of Commerce, and Chris Wright, senior vice president of Advance SF, an organization of companies, which includes Bank of America, OpenAI, Waymo, the SF Giants CEO and others.

Fong and Wright, in their argument for the measure, say giving businesses more tax breaks would help keep more employees on payroll and would give companies the ability to “contribute to city services in a predictable and balanced way.”

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Critics of Proposition C, such as the San Francisco Tenants Union, slam the measure as “billionaire-backed” and argue it would kill the Top Executive Pay Tax and would hand out more tax breaks to businesses at a time when the city is in a budget deficit and faces cuts to essential services.

Proposition D

Proposition D also seeks to change the Top Executive Pay Tax, which is collected from some large businesses where the highest-paid managerial employee earns more than 100 times the median compensation paid to other employees.

If approved, the measure would change the calculation of the tax using the compensation of all employees, not just employees based in San Francisco. Top Executive Pay Tax rates would also be increased for San Francisco gross receipts and payroll.

Supporters have billed the measure as a way to counteract federal cuts to Medicaid. A report by the City Controller’s Office said the measure could result in $250 million to $300 million in additional revenue.

“Proposition D is the solution to our budget deficit. It asks large corporations — not small businesses, not working families — to contribute a little more,” supporters said in the city’s official voter guide.

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The measure has the backing of most of the Board of Supervisors, along with labor unions and Rep. Nancy Pelosi.

Opponents, including Mayor Daniel Lurie and state Sen. Scott Wiener, have argued Proposition D would negatively impact the city’s recovery following the COVID-19 pandemic. 

“San Francisco is already one of the most expensive cities in the country to live and do business. Adding extreme and unpredictable tax increases risks driving employers away just as we are trying to bring jobs, workers, and foot traffic back downtown,” said Supervisor Matt Dorsey in the city’s voter guide.



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