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Arizona Cardinals at Buffalo Bills: Predictions, picks and odds for NFL Week 1 game

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Arizona Cardinals at Buffalo Bills: Predictions, picks and odds for NFL Week 1 game


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The Buffalo Bills have won four straight AFC East titles, but their streak could be in jeopardy in 2024. The departure of star receiver Stefon Diggs opens up the possibility for regression from quarterback Josh Allen. Couple that with the fact that the team’s No. 2 receiver Gabe Davis also split town, and there is plenty reason to feel uneasy about this team’s offensive capabilities this season.

At the very least, the Bills return standout tight end Dalton Kincaid as well as late-season breakout receiver Khalil Shakir. The team also added second-round receiver Keon Coleman to the fold as well. If James Cook can continue holding down their backfield, the Bills could still boast one of the most effective offenses in the league.

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Their opponent this week will be the Arizona Cardinals, who have a lot to look forward to on offense. Kyler Murray, Trey McBride, James Conner, and Marvin Harrison Jr. should be spectacular but the team’s defense lacks the same high-end potential. While this team could have the offensive firepower to surprise some people, it would take a massive improvement on the other side of the ball for them to compete for a Super Bowl.

PROP TALK: These are the best prop bets for NFL games this week 

Cardinals vs. Bills odds, moneyline, over/under

The Bills are favorites to defeat the Cardinals, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Bills (-6.5)
  • Moneyline: Bills (-300); Cardinals (+240)
  • Over/under: 48

Not interested in this game? Our guide toNFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

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FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

NFL Week 1 odds, predictions and picks

Ravens vs. Chiefs | Packers vs. Eagles | Jaguars vs. Dolphins | Steelers vs. Falcons | Vikings vs. Giants | Panthers vs. Saints | Patriots vs. Bengals | Titans vs. Bears | Cardinals vs. Bills | Texans vs. Colts | Raiders vs. Chargers | Broncos vs. Seahawks | Commanders vs. Buccaneers | Cowboys vs. Browns | Rams vs. Lions | Jets vs. 49ers

Lorenzo Reyes: Bills 25, Cardinals 23

I think Buffalo may struggle a bit on offense this season. Josh Allen may feel the pressure of needing to create more, given the loss of Stefon Diggs, and this could prompt carelessness with the ball. That has long been a problem for Buffalo, which should still win this game. Still, I think it’s a closer affair with the Cardinals’ improved roster.

Tyler Dragon: Bills 27, Cardinals 20

Not much is expected of Kyler Murray and the Cardinals this season. Cardinals rookie wideout Marvin Harrison Jr. is a player to watch. Arizona will play teams tough, but they lack talent across the board. The Bills lost plenty of veteran leaders over the offseason, Stefon Diggs. Josh Allen is going to have to elevate Buffalo’s offense the way franchise quarterbacks are expected.

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Safid Deen: Bills 26, Cardinals 16

Josh Allen has some new teammates to get used to, but he’s still one of the best offensive players in the sport. He’ll be able to gut out a win against Kyler Murray and Arizona.

Richard Morin: Bills 23, Cardinals 15

A still-getting-to-know-you Bills offense combined with a sleepy Cardinals team playing on the East Coast is a recipe for a slow game. I think the Bills get it done, but it will produce questions of whether they have the offense to be a legitimate AFC contender in 2024.

MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024? 



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Arizona State could push Big 12 title chase to final weekend

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Arizona State could push Big 12 title chase to final weekend


TEMPE, AZ (AP/AZFamily) — The Arizona State Sun Devils are set for a huge matchup this weekend when they host the BYU Cougars at Mountain America Stadium.

Saturday’s game in Tempe will have massive implications in the Big 12 Conference with multiple teams chasing a title game appearance.

A win over the 14th-ranked Cougars would massively boost title game hopes for the 21st-ranked Sun Devils. Ticket prices have been soaring for the highly anticipated conference game.

Arizona State Head Coach Kenny Dillingham joined Good Morning Arizona on Thursday to talk about the team’s expectation-busting season. Watch the full interview in the video player at the top of this page.

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Things to watch this week in the Big 12 Conference:

Game of the week

No. 14 BYU (9-1, 6-1 Big 12, No. 14 CFP) at No. 21 Arizona State (8-2, 5-2, No. 21), Saturday, 3:30 p.m. ET (ESPN)

League newcomer Arizona State has a three-game winning streak and BYU is coming off its first loss. The Cougars, after losing at home to Kansas, still control their own destiny in making the Big 12 championship game. They can clinch a spot in that Dec. 7 game as early as Saturday, if they win and instate rival Utah wins at home against No. 22 Iowa State.

Arizona State was picked at the bottom of the 16-team league in the preseason media poll, but already has a five-win improvement in coach Dillingham’s second season.

The undercard

No. 16 Colorado (8-2, 6-1, No. 16 CFP) at Kansas (4-6, 3-4), Saturday, 3:30 p.m. ET (Fox)

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Coach Deion Sanders and the Buffaloes are in prime position to make the Big 12 title game in their return to the league after 13 seasons in the Pac-12. If BYU and Utah win, Colorado would be able to claim the other title game spot with a win over Kansas. The Buffs have a four-game winning streak.

The Jayhawks need another November win over a ranked Big 12 contender while trying to get bowl eligible for the third season in a row. Kansas has won consecutive games over Top 25 teams for the first time in school history, knocking off Iowa State before BYU.

Impact players

Iowa State quarterback Rocco Becht has thrown a touchdown in a school-record 14 consecutive games, while receivers Jayden Higgins and Jaylin Noel both have more than 800 yards receiving. San Jose State is the only other FBS team with a pair of 800-yard receivers. Becht has 2,628 yards and 17 touchdowns passing for the Cyclones (8-2, 5-2), who are still in Big 12 contention.

Inside the numbers

Oklahoma State goes into its home finale against Texas Tech with a seven-game losing streak, its longest since a nine-game skid from 1977-78. The only longer winless streak since was an 0-10-1 season in 1991. This is Mike Gundy’s 20th season as head coach, and his longest losing streak before now was five in a row in 2005, his first season and the last time the Cowboys didn’t make a bowl game. … Baylor plays at Houston for the first time since 1995, the final Southwest Conference season. The Cougars won last year in the only meeting since to even the series 14-14-1. … Eight Big 12 teams are bowl eligible. As many as six more teams could reach six wins.

Repeating 1,000

The Big 12 already has four 1,000-yard rushers, including three who did it last season. UCF’s RJ Harvey is the league’s top rusher (1,328 yards) and top scorer with 21 touchdowns (19 rushing/two receiving). The others with consecutive 1,000-yard seasons are Texas Tech career rushing leader Tahj Brooks (1,184 yards) and Kansas State’s DJ Giddens (1,128 yards). Cam Skattebo with league newcomer Arizona State has 1,074 yards.

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Devin Neal, the career rushing leader at his hometown university, is 74 yards shy of being the first Kansas player with three 1,000-yard seasons. Cincinnati’s Corey Kiner needs 97 yards to reach 1,000 again.

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What BYU coach Kalani Sitake said about Arizona State game

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What BYU coach Kalani Sitake said about Arizona State game


BYU’s stock plummeted this week.

After suffering a 17-13 loss to Kansas — their first loss of the season — the Cougars dropped from No. 6 to No. 14 in the College Football Playoff Rankings and into a tie with Colorado for first place in the Big 12.

And now they’re 3.5-point underdogs to Arizona State (8-2) in arguably the biggest game on the college football schedule this weekend. The winner will be in the pole position for a berth in the Big 12 championship game; the loser will be all but eliminated.

BYU coach Kalani Sitake knows anything can happen in the Big 12, and the Cougars are still very much alive for a berth in the College Football Playoff.

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“You look at the conference, there’s a lot of parity … anyone has a shot,” Sitake said during his weekly press conference.

Here is a snapshot of what Sitake said ahead of BYU’s game with Arizona State:

Sitake on ASU Coach Kenny Dillingham

“Kenny Dillingham is a really good coach. I have a lot of respect for him and the way he coaches his team. You can tell he’s got a great connection with his players, and he’s a local kid so he’s from that area. He grew up an ASU fan and knows what that program can do. … I think he did it the right way bringing in a lot of local staff. … I know a lot of guys on his coaching staff. They’re really good coaches, good men.

“Looking at the talent that they have, it’s a difficult matchup. You have to be ready. We’re going on the road. We already know the time for that game and that it will be a little better weather than what we have here [in Provo]. Looking forward to the matchup. I think the goal is for us, like we said every week, stay humble, stay hungry and find ways to get better.”

Sitake on ASU Quarterback Sam Leavitt

“Really good player. He comes from a good family. He’s super athletic. He can run, he’s got an accurate arm. I think he’s got a great football IQ. He’s dangerous. He’s got a lot of football to play. I think he he saw some opportunities over there at ASU and you look at him, he’s thriving in it. He’s going to be a difficult matchup for us for sure. But man, it’s good to see good young men that you know are from amazing families get what they want. He’s doing some really cool things and he’s going to be doing really good things for a long time becauase I think he’s only a freshman right now. The sky’s the limit for him. Hopefully we just don’t see that great ‘sky limit’ performance this weekend.”

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Sitake on BYU’s Recent Offensive Struggles

“There’s a fine line between it all … the key to execution is just eliminating the mistakes. There shouldn’t be any mistakes. Whether it’s alignment issues or technique issues or even running the wrong route or not doing the correct assignment. So all that should be cleaned up. But there’s also some room for improvement where you can actually install some stuff. You want to have a foundation of stuff that you’re good at and that you could lean on, but that’s the stuff that everybody knows is coming. So we have to have that and you have to have a little bit of install that gives you the favorable matchup, depending on who you’re going against.”

“That’s what we’re trying to get done. Obviously it’s worked quite a bit, and the offense they’re getting in the red zone. We’ve just got to score touchdowns. It’s hard to get in the red zone and only kick field goals. Even though you have a good kicker like Will Ferrin you’re going to need to score points and score touchdowns and finish the drives. It gives you a little bit more motivation and a little bit more ‘umph’ when you’re trying to get it done, so that’s what we’re focusing on.”

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Five Takeaways: Arizona defense Wednesday press conference (TCU)

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Five Takeaways: Arizona defense Wednesday press conference (TCU)


Fresh off breaking its five-game losing streak last week, Arizona heads back on the road this week to take on one of the most potent passing attacks in the country in TCU.

The Wildcats are coming off one of their most complete defensive performances this past week and figure to be challenged more against the Horned Frogs who head into this week boasting the No. 6 passing offense in the country. They will challenge the banged up Arizona secondary that has had many younger players step into key roles as the season has progressed. We’ve seen improvement across the board from them as they’ve seen more reps on the field.

Here are five takeaways from coach Brett Arce as well as Owen Goss and Dominic Lolesio during Wednesday’s press conference.

Dominic Lolesio getting into the starting lineup

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The injuries continue to pile up on the defensive side of the ball for Arizona that has led to lots of new players stepping into roles they may not have expected to be in at the start of the season.

Redshirt freshman Dominic Lolesio saw the field more last week in what was one of the more complete defensive performances of the season by Arizona. Lolesio recorded five tackles and a 0.5 tackle for loss.

“That’s just the standard,” Lolesio said. “We practice that all week. Our thing is to swarm to the ball and play together and have fun. I mean doing it all week in practice and then being able to go out and do it on Friday felt really good.”

Despite the injuries that have come up for Arizona, the next man up stance remains the same for the team.

“I feel like everyone is just as ready as the next man up,” Lolesio said.

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