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Popular weight-loss medications linked to hidden side effects, study finds

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Popular weight-loss medications linked to hidden side effects, study finds

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In a sweeping analysis of more than 400,000 Reddit posts, researchers have revealed some little-known GLP-1 side effects.

GLP-1 receptor agonists — such as semaglutide (Ozempic and Wegovy), and tirzepatide (Mounjaro and Zepbound) — have been most commonly associated with gastrointestinal side effects, such as nausea, vomiting, diarrhea and constipation.

A new study published in Nature Health, however, uncovered some overlooked effects.

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University of Pennsylvania researchers used artificial intelligence to analyze more than five years of Reddit posts from more than 67,000 people taking the popular drugs for diabetes or weight loss.

While clinical trials are still the “gold standard,” the researchers noted that Reddit community feedback reflects a different population.

GLP-1 receptor agonists — such as semaglutide (Ozempic and Wegovy), and tirzepatide (Mounjaro and Zepbound) — have been most commonly associated with gastrointestinal side effects, such as nausea, vomiting, diarrhea and constipation. (iStock)

“People often use medications differently than they’re prescribed, so it’s also important to look at real-world usage, which can diverge from usage in a clinical trial,” lead researcher Neil Sehgal, a PhD student at the University of Pennsylvania, told Fox News Digital. “So there are many possible reasons we’re seeing signals that the trials may have missed.”

Overlooked effects

Nearly half of the users reported one or more side effects. The most common were nausea, vomiting and constipation, which aligned with what clinical trials found, according to Sehgal.

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“We’re almost certainly capturing a skewed slice of the full picture.”

“We did notice a few side effects that have not previously been reported for these drugs,” he told Fox News Digital. 

“For example, about 4% of users who described side effects reported menstrual irregularities. Other Redditors described unusual temperature-related symptoms, like chills or hot flashes.”

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Nearly 13% of users also experienced psychiatric symptoms, such as anxiety, depression and insomnia. More than 5% also complained of abdominal pain, acid reflux, headache and dizziness.

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“Fatigue was also the second most commonly reported symptom overall, but has met relatively few reporting thresholds in existing trials,” Seghal noted. “This gap between what patients are self-reporting online and what gets captured in trials is really what motivated this whole line of work.”

Clinical context

Dr. Sue Decotiis, a New York City-based board-certified weight-loss physician, noted that many of the reported symptoms, such as disorientation and fatigue, are most likely due to dehydration and hypoglycemia (low blood sugar).

“People often use medications differently than they’re prescribed, so it’s also important to look at real-world usage, which can diverge from usage in a clinical trial,” the lead researcher said. (iStock)

“Patients should be carefully monitored using a structured protocol that ensures proper nutrition and adequate hydration, ideally under the direct supervision of a physician experienced in metabolism and weight loss,” Decotiis, who was not involved in the study, told Fox News Digital. 

“Additionally, body composition analysis can help identify issues such as muscle loss, excessive water loss or insufficient fat loss.”

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A significant concern, according to the doctor, is that many individuals are accessing these medications through online platforms or without receiving appropriate medical care. 

“In my experience treating thousands of patients with various GLP-1 medications, complications are rare and typically occur only when patients are noncompliant,” she added.

Study limitations

As the data came from Reddit users, who tend to be younger, primarily male and mostly based in the U.S., it may not represent everyone taking these medications, the researchers noted.

“In my experience treating thousands of patients with various GLP-1 medications, complications are rare and typically occur only when patients are noncompliant,” a weight-loss doctor shared. (iStock)

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“And even within Reddit, the people who post about their side effects are probably not typical of everyone on the medication,” Sehgal said. “If you had a good experience, you’re less likely to be writing about it online. So we’re almost certainly capturing a skewed slice of the full picture.”

The researchers also noted that the study can’t prove the drug caused the reported symptoms.

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“To be clear, we can’t say for certain whether these drugs are causing menstrual irregularities,” Sehgal said. “Patients on Reddit aren’t going to self-report every symptom they have, and they may also report things that aren’t actually linked to the medications. So it’s important to treat this as hypothesis-generating signals and do more research.”

The researchers noted that the study can’t prove the drug caused the reported symptoms. (iStock)

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The study also didn’t include GLP-1 dosage, duration of the medication and symptoms, or other health conditions the users experienced. There is also the chance that the AI tools misunderstood meanings or context, the researchers noted.

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The results must be confirmed with more rigorous research, Sehgal said. “That’s how we’ll get real answers about prevalence and causality, which social media data alone can’t provide.” 

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“These are signals, not conclusions – but I do think it’s always worth talking to your doctor about anything unexpected you’re experiencing while on a new medication, even if you’re not sure if it’s related,” he advised. “So if something feels off, say something.”

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Tick bite ER visits hit highest seasonal level in years as doctors warn of disease surge

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Tick bite ER visits hit highest seasonal level in years as doctors warn of disease surge

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Tick bite-related ER visits are at their highest seasonal levels since 2017 across most U.S. regions, raising concerns about increased Lyme disease and other tick-borne illnesses.

That’s according to recent data from the Centers for Disease Control and Prevention’s Tick Bite Tracker, which monitors weekly emergency department visits associated with tick bites across the country.

For every 100,000 ER visits, approximately 71 were related to tick bites in April 2026, compared to a historical seasonal average of roughly 30 per 100,000.

DOCTORS REVEAL KEY SIGNS OF LYME DISEASE AS TICK SEASON INTENSIFIES ACROSS US

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Some of the highest rates of tick-based ER visits were among children younger than 10 years and adults between 70 and 79 years.

A close-up shows a parasitic mite in motion on a human fingertip, highlighting the potential for disease transmission such as encephalitis. (iStock)

“Over the past three decades, the geographic range of the blacklegged tick has expanded significantly, and with it, the risk of Lyme disease and other Ixodes-transmitted infections,” Dr. Steven Goldberg, a family medicine physician who practices urgent care and family medicine at UofLHealth in Louisville, Kentucky, told Fox News Digital.

‘RABBIT FEVER’ CASES RISING IN US AS CDC WARNS OF ZOONOTIC BACTERIAL DISEASE

“The Ohio River Valley region is one of the most striking examples — Lyme disease cases in Ohio have increased roughly 10-fold over the past decade, likely driven by the convergence of Northeastern and Upper Midwestern tick populations meeting in that corridor.”

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States like Virginia and West Virginia, as well as areas south of the traditional endemic zone, are reporting increasing tick abundance and disease cases, the doctor noted.

“Over the past three decades, the geographic range of the blacklegged tick has expanded significantly.”

“The lone star tick is also expanding its range northward beyond its traditional stronghold in the Southeast, which means diseases like ehrlichiosis and alpha-gal syndrome are appearing in regions where clinicians may not yet be thinking about them,” he warned.

Some climate studies predict that the blacklegged tick’s suitable habitat could expand by over 200% by the end of the century, Goldberg noted, including into Canada and across the central and southern U.S.

What’s driving the spike?

“Warmer, wetter conditions allow ticks to survive in habitats that previously would have been too cold,” said Dr. Suraj Saggar, chief of infectious disease at Holy Name Medical Center in Teaneck, New Jersey. “Milder winters also extend the lifespan of both ticks and the animals they feed on, accelerating tick reproduction and shortening their life cycles.”

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Areas that historically experienced longer, colder winters or significant snow cover are now more hospitable to ticks, the doctor noted.

COPPERHEAD SNAKE BITE LEAVES MAYOR’S WIFE IN ‘EXCRUCIATING PAIN,’ HE REVEALS

“As temperatures rise and precipitation patterns change, ticks are able to spread northward and thrive in new ecosystems,” he said. 

Another contributing factor is increased land development and human expansion into wooded and grassy areas, as well as reforestation of formerly agricultural land.

“As temperatures rise and precipitation patterns change, ticks are able to spread northward and thrive in new ecosystems,” an expert said.  (iStock)

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“The recovery and expansion of white-tailed deer populations — critical hosts for adult blacklegged ticks — has been a major driver,” Goldberg added. “Deer density is positively associated with Lyme disease incidence. Small mammal communities, particularly white-footed mice that serve as key reservoir hosts for Borrelia burgdorferi, also play a central role.”

Tick-borne diseases

Tick bites are known to transmit numerous illnesses, the most widespread of which is Lyme disease, a bacterial infection.

“Lyme disease cases alone have increased roughly two- to threefold over the past 20 years,” Saggar said. Approximately 476,000 Americans are diagnosed and treated for Lyme disease each year, per CDC surveillance data.

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Also common are anaplasmosis and ehrlichiosis, two different types of bacterial infections, according to the doctor. Tick bites can also cause babesiosis, a malaria-like parasitic disease that infects and destroys red blood cells.

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“Another growing concern is alpha-gal syndrome, a condition in which a (lone star) tick bite triggers a serious allergic reaction to red meat,” Saggar said. “In rare cases, people have died from anaphylactic reactions linked to alpha-gal syndrome following a tick bite.”

Some common symptoms of tick-borne illness include fever, chills, fatigue, headaches, muscle aches and joint pain. (iStock)

Ticks can also transmit viruses, including the Powassan virus, which can cause severe neurologic injury.

“Powassan virus disease is arguably the most concerning emerging tick-borne infection,” said Goldberg, who is also chief medical officer at HealthTrack. “It’s transmitted by the same blacklegged tick that carries Lyme disease, but unlike Lyme, it can be transmitted within minutes of tick attachment.”

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Powassan can cause severe encephalitis with a roughly 10% to 15% fatality rate, and more than half of survivors have lasting neurological deficits, Goldberg noted.

In the Rocky Mountain states, the Rocky Mountain wood tick (Dermacentor andersoni) transmits Rocky Mountain spotted fever and Colorado tick fever.

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“In the Southeast and South-Central U.S., the lone star tick (Amblyomma americanum) drives a different set of concerns: ehrlichiosis, tularemia, and two emerging viral threats — Heartland virus and Bourbon virus,” said Goldberg.

Symptoms to watch for

Some common symptoms of tick-borne illness include fever, chills, fatigue, headaches, muscle aches and joint pain, according to Saggar.

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Another sign is the classic “bull’s-eye” rash associated with Lyme disease, known medically as “erythema migrans.” 

“If you think you have been bitten by a tick, you should seek medical attention if you develop symptoms after a known tick bite or after spending time in tick-prone areas, especially during the spring, summer and fall.” (iStock)

“Because testing can sometimes be falsely negative early in the disease process, doctors may treat patients based on symptoms and exposure history rather than waiting for laboratory confirmation,” Saggar noted. 

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“If you think you have been bitten by a tick, you should seek medical attention if you develop symptoms after a known tick bite or after spending time in tick-prone areas, especially during the spring, summer and fall.”

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Preventing tick bites

As there are no vaccines currently available for any tick-borne disease in the U.S., prevention is the most effective strategy.

Goldberg shared the following recommended prevention strategies.

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  • Use EPA-approved repellents, including DEET, picaridin, IR3535 or oil of lemon eucalyptus on exposed skin. Treat clothing and gear with permethrin (a synthetic insecticide and repellent) or purchase pre-treated clothing.
  • Wear light-colored clothing (to spot ticks more easily), long sleeves and long pants tucked into socks when in wooded or grassy areas.
  • After spending time outdoors, check your entire body, paying special attention to the scalp, behind the ears, armpits, groin and behind the knees, the doctor advised. It’s also recommended to shower within two hours of coming indoors.
  • Tumble-dry clothing on high heat for at least 10 minutes to kill any ticks on clothing.
  • Remove ticks promptly and properly. Using fine-tipped tweezers, grasp the tick as close to the skin as possible, and pull upward with steady, even pressure. Clean the bite area afterward.

Approximately 476,000 Americans are diagnosed and treated for Lyme disease each year, per CDC data.

“The longer a tick is attached, the higher the risk of disease transmission — for Lyme disease, transmission generally requires at least 36 hours of attachment,” Goldberg said. “The Powassan virus can be transmitted much more quickly.”

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How Author Mary Kay Andrews, 71, Lost 65 Lbs. Microdosing GLP-1 Meds

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How Author Mary Kay Andrews, 71, Lost 65 Lbs. Microdosing GLP-1 Meds


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How Microdosing a GLP-1 Helped Mary Kay Andrews Lose Weight




















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What to know about thyroid cancer prognosis following Pam Bondi’s diagnosis

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What to know about thyroid cancer prognosis following Pam Bondi’s diagnosis

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Former Attorney General Pam Bondi was diagnosed with thyroid cancer shortly after leaving the Department of Justice last month, according to a report.

Bondi, 60, who left her role at the Justice Department in early April, underwent treatment and is recovering, a source stated.

The thyroid is a gland located in the neck. It makes hormones that are then secreted into the blood, which help the body “use energy, stay warm and keep the brain, heart, muscles and other organs working as they should,” according to the American Thyroid Association.

PAM BONDI DIAGNOSED WITH THYROID CANCER WEEKS AFTER DEPARTING AS TRUMP’S ATTORNEY GENERAL: REPORT

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Thyroid cancer is relatively uncommon compared to other cancers. Even so, as of 2023, more than one million people in the U.S. are living with the disease.

The National Cancer Institute (NCI) predicts that there will be an estimated 45,260 new cases in 2026.

Former Attorney General Pam Bondi was diagnosed with thyroid cancer shortly after leaving the Department of Justice last month. (Alex Wong/Getty Images)

Risk factors and symptoms

While more common in women, thyroid cancer can affect both sexes. Those with a family history may be more likely to develop it, as well as those between the ages of 25 and 65. Exposure to radiation is also a risk factor, according to the National Cancer Institute.

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Signs of thyroid cancer may include lumps or swelling in the neck, trouble breathing, trouble swallowing, hoarseness and pain when swallowing, per the above source. Anyone experiencing these symptoms should seek medical attention.

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If thyroid cancer is suspected, a doctor can diagnose it in several ways. A laryngoscopy is a procedure where the doctor checks the voice box with a mirror or laryngoscope — a thin, tube-like instrument with a light and lens, per NCI.

Signs of thyroid cancer may include lumps or swelling in the neck and trouble breathing. (iStock)

Blood hormone studies – where a blood sample is checked to measure hormone levels – can also reveal indicators of thyroid cancer. Ultrasounds and CAT scans are then used to check for tumors in the body.

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Treatment options

Surgery, radiation, chemotherapy and hormone therapy are the main ways doctors treat thyroid cancer. A new type of therapy, immunotherapy, is being tested in clinical trials.

“Surgery is the primary therapy, followed by regular surveillance and thyroid hormone replacement,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.

Bondi, 60, who left her role at the Justice Department in early April, underwent treatment and is recovering, according to a source. (Roberto Schmidt/AFP via Getty Images)

If the thyroid must be completely removed, patients will take hormones to replace the gland’s natural function.

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“Radioactive iodine is added in extensive or more aggressive cases,” Siegel said, but noted that it is “usually not needed.”

The thyroid gland is located in the neck. It makes hormones that are then secreted into the blood, which help the body use energy. (iStock)

Survival rates

The prognosis for thyroid cancer is generally positive and depends heavily on how the cancer responds to treatment, according to NCI.

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Some types are much milder and slower-growing than others. Doctors will also consider the stage of the cancer’s progression.

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The best-case scenario is when a surgeon can completely remove the tumor during surgery. Doctors will also factor in whether this is a brand-new diagnosis or if the cancer has returned after previous treatment.

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