An increasing number of patients are requesting “unvaccinated” blood for transfusions, which can delay care and pose risks to patients’ health, experts warn.

There is no evidence that unvaccinated blood presents any safety benefit, according to a new study published in the journal Transfusion.

There is currently no process for checking whether donated blood comes from vaccinated or unvaccinated donors, experts say.

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Vanderbilt University in Tennessee, which conducted the research, received 15 requests for unvaccinated blood between Jan. 1, 2024, and Dec. 31, 2025. The median age of patients was 17 years old and more than half were children, the university reported.

Thirteen of the patients received blood donated specifically for them by family members, which is known as “direct donation.” This can be risky, because most direct donors are giving blood for the first time, and their donations are more likely to contain “potentially harmful pathogens,” the authors noted. 

“Despite being framed as ‘safer,’ directed donations may paradoxically increase risk.”

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Among the studied patient group, two became much sicker after refusing a standard blood transfusion. 

One patient developed anemia, a condition where the body lacks enough healthy red blood cells to carry adequate oxygen. The other developed hemodynamic shock, a serious condition in which there is insufficient blood flow and oxygen to the body’s tissues, potentially leading to organ failure.

“Despite being framed as ‘safer,’ directed donations may paradoxically increase risk.”

Requests for unvaccinated blood spiked after the approval of COVID-19 vaccines, posing a “recurring challenge for transfusion services and clinicians,” the researchers stated.

“These requests were associated with care delays, escalation and inefficiencies,” they indicated.

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The researchers recommend that health systems create standardized policies to handle these types of requests.

“Regulatory and professional organizations have opposed these non-evidence-based policies, emphasizing that blood centers do not record or convey donor COVID-19 vaccination status and that evidence demonstrates transfusion from vaccinated donors poses no unique risk.”

The Vanderbilt study had some limitations, the researchers noted. It looked at a small number of cases and only included situations where special blood donations made it to the blood bank, so it doesn’t show how often people made this request overall. 

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It also didn’t include cases where concerns were resolved through conversations with doctors or ethics teams, the team noted.

As this was an observational study and not a controlled experiment, it only showed an association and could not prove that refusing standard blood directly caused any specific patient outcomes.

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Several states have introduced proposals aimed at allowing patients to receive blood specifically from donors who have not received COVID-19 vaccines.

In Oklahoma, one such proposal called for the creation of a state-run blood bank dedicated to collecting and distributing blood from unvaccinated donors. Despite these efforts, none of the measures have been enacted into law.

Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the research, but said these types of requests are “part of an ongoing fear culture.”

“It is also very difficult to test for, because the antibodies may be positive from COVID itself as well as the vaccine, and it can be difficult to tell the difference,” he told Fox News Digital.

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The notion that receiving blood from someone who had the vaccine would be harmful is not based on any scientific studies, the doctor reiterated.

“If people want to group up to get blood from other unvaccinated people, I respect that choice, though it will be expensive and will limit options,” Siegel added.

Diane Calmus, vice president of government affairs for America’s Blood Centers in Washington, D.C., said that requests for direct donations are “exceedingly rare” – representing about 0.06% of the U.S. blood supply.

“Requests for unvaccinated blood are something we’ve seen wax and wane since the introduction of the COVID vaccine,” Calmus, who also was not involved in the Vanderbilt study, told Fox News Digital. “The challenge is that there’s no way to tell whether someone’s blood has been vaccinated – there’s no test that exists.”

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Any situation where someone requires a blood transfusion is most likely a “very scary time,” she noted.

“Family members want to be cautious, and this is why it’s so important that people talk to a transfusion medicine-trained doctor,” the expert advised. “These are physicians who have a specialty in blood transfusions … and who can answer those questions that any individual will have.”

Calmus pointed out that it takes some time to facilitate a direct donation, and that there is a specific process in place. 

“Blood has to be prescribed. You can’t just show up at the blood center and say, ‘I would like my sister to donate for me,’” she said. “There needs to be a prescription. It needs to go through the hospital … they need to make sure it is the right blood for the right patient.”

“We need people – vaccinated or not vaccinated – to show up and donate blood, because it is the blood on the shelves that saves lives.”

Calmus emphasized that the U.S. blood supply is “meticulously tracked,” and that there have been no indications of a lack of safety. She also stressed the ongoing need for blood donors.

“We need people – vaccinated or not vaccinated – to show up and donate blood, because it is the blood on the shelves that saves lives.”

Fox News Digital reached out to the Vanderbilt researchers for comment.

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A fatty bulge at the base of the neck — commonly known as a “buffalo hump” — isn’t always just a cosmetic concern, as experts say it can sometimes signal an underlying condition.

As more Americans grapple with poor posture, obesity and chronic conditions requiring long-term medications, experts warn that these factors can contribute to the development of “buffalo humps.” 

There are a range of possible causes and treatments for the commonly misunderstood condition, Health.com recently reported.

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“A buffalo hump is a fullness at the base of the neck or upper back area,” Dr. Dahlia Rice, a Chicago-based plastic surgeon and founder of DMR Aesthetics, told Fox News Digital.

Posture can make a hump appear more pronounced, even if someone does not have much excess fat, Rice said. A forward head posture or rounding of the upper spine can contribute to this effect.

“Depending on the pattern and timing, it could also signal an underlying medical issue,” the expert said.

The condition is often linked to weight, according to Dr. Rachel Mason, a Las Vegas-based plastic surgeon and founder of La Femme Plastic Surgery, though that is not always the case.

“In some cases, it can be associated with medical conditions like Cushing’s syndrome or long-term use of steroids,” she told Fox News Digital.

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“Depending on the pattern and timing, it could signal an underlying medical issue.”

Elevated levels of cortisol — the body’s primary stress hormone — can also lead to fat deposits in the neck and upper back, experts say. Certain medications, including some HIV treatments, may also play a role, according to Health.com.

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Experts emphasize the importance of distinguishing between a true buffalo hump and other conditions. The buffalo hump is often confused with a posture-related “dowager’s hump,” which is caused by spinal curvature rather than fat buildup.

“A true buffalo hump will feel soft and fatty,” Mason said. “Structural, posture-related issues require a completely different approach than fat reduction.”

If the lump appears suddenly, continues to grow or is accompanied by other symptoms, medical evaluation is recommended, according to doctors.

“If it’s paired with fatigue, muscle weakness or changes in blood pressure, patients should seek medical evaluation,” Rice advised.

Mason added that symptoms such as easy bruising, hormonal changes or purple stretch marks could point to an endocrine disorder rather than a cosmetic issue.

Treatment options depend largely on the underlying cause. In cases tied to posture, physical therapy and strengthening exercises may help. When medications are involved, doctors may adjust treatment.

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For patients with localized fat and no underlying condition, cosmetic procedures may be considered.

“Liposuction is often the effective option for contouring this area, as it directly removes excess fat and improves the profile of the upper back and neck,” Mason said, noting that more extensive cases may require surgical removal of dense tissue.

Lifestyle changes — such as maintaining a healthy weight, improving posture and monitoring long-term medication use — may help to manage or reduce the condition, experts say.

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Although a buffalo hump itself is not usually dangerous, untreated underlying conditions can lead to more serious complications, including high blood pressure or sleep issues, according to Health.com.

“Identifying the cause early is important in ensuring the right treatment path is taken,” Mason said.