Polio came for 5-year-old Lynn Lane when she was visiting her grandmother in rural Indiana. Suddenly, her arms and legs became weak, and by the time she got to a hospital in Indianapolis, she was totally paralyzed and in respiratory failure. Lane spent the next several months in an iron lung.

“I don’t really remember too much about that,” Lane, now 73, told me Monday from her home north of Sacramento. “The only memories I really have are mainly at night. You could hear the swooshing of all the iron lungs.”

Lane’s family moved to Northern California a few years after her bout with polio, when she was 8. “That’s when I started noticing I was different than other kids,” she said. “I was in leg braces and had to learn to walk all over again.”

Her parents took her to Shriners Hospital in San Francisco, where she lived on and off for the next eight years.

“It was kind of like a boarding school, except with surgeries,” Lane said. “They did all these muscle and tendon transfers. I think I had maybe 15 to 18 surgeries. They transferred my quads from the front to the back so I could stand.”

In her early 40s, Lane was diagnosed with post-polio syndrome, which afflicts between 25% and 40% of childhood polio survivors. It is similar to chronic fatigue syndrome and can range from mild to debilitating.

“I’m not in a wheelchair yet,” said Lane, who uses leg braces and crutches, “but it’s heading that way.”

The idea that anyone would question the polio vaccine now, she said, “makes me nuts.”

Last week, the New York Times reported that in 2022, Robert F. Kennedy Jr.’s attorney and close advisor Aaron Siri had petitioned the Food and Drug Administration to revoke approval of the polio vaccine in use for the last three decades until its safety can be studied further against an unvaccinated control group. Kennedy, President-elect Donald Trump’s pick for Health and Human Services secretary, is a longtime vaccine skeptic who spouts nonsense about the safety and efficacy of vaccines and a lot of other things. He is, in the view of many medical professionals, a danger to public health.

The Times’ report set off shock waves. Before Jonas Salk developed the first successful polio vaccine in the mid-1950s, the disease killed or paralyzed more than half a million people around the world each year. Many high-profile Americans who suffered from childhood polio, including Senate Republican leader Mitch McConnell and the actor Mia Farrow, immediately condemned the questioning of the vaccine. Kennedy and Trump were forced to reassure Americans that they support the lifesaving treatment.

As Kennedy met with Republican senators to shore up support for his nomination this week, he told reporters that he is “all for” the polio vaccine. Trump, in his first post-election press conference, insisted, “You’re not going to lose the polio vaccine. It’s not going to happen.”

And yet Trump also persisted in promulgating the oft-debunked lie that childhood vaccines are linked to autism, vowing to “look into” the conspiracy theory. Kennedy, he said, will “come back with a report as to what he thinks. We’re going to find out a lot.”

This fear-mongering is unconscionable. We already know a lot. In fact, we know more than a lot.

The autism question has “been studied to death in some ways,” said Richard Pan, a pediatrician and former California state senator who led the successful 2015 campaign to eliminate a “personal belief” exemption from vaccine requirements for the state’s schoolchildren.

“Do we know what causes autism? Not yet,” Pan said. But, he added, we do know what does not cause autism: the measles, mumps and rubella vaccine, which was implicated in a long-since-discredited 1998 paper based on 12 cases by the defrocked English physician Andrew Wakefield.

“What will it take to convince Trump and RFK Jr. that a retracted 12-subject study with fake data was actually wrong?” asked Pan.

In any case, he added, blaming the vaccine is an “ableist” response to autism by some parents. “They don’t want to accept that their child is neurodivergent,” Pan said. “You want to say your child is broken and my life has been ruined and it’s the fault of Big Pharma or whoever.”

People who do not vaccinate their children, he said, are risking the health of the very people they are supposed to protect.

“You are playing with your children’s lives,” he said. “All of these adults have already been vaccinated.”

Although polio has essentially been eradicated in the U.S., it still exists in parts of the world and could certainly make a comeback here if enough people refuse to vaccinate their children. In 2022, the Centers for Disease Control and Prevention reported that an unvaccinated New York man had contracted polio. And earlier this year, amid Israel’s war on Hamas, a 10-month-old child in Gaza contracted the virus, confirming fears about the war’s potential effect on preventable childhood disease.

As for the Kennedy advisor’s petition, Pan said, how could we withhold a potentially lifesaving treatment from children in a control group to test the efficacy of a vaccine that has been used successfully for decades?

“Sometimes a trial cannot be done safely or ethically, “ he said. “Are you willing to volunteer your child into the control group?”

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Three men sought help at clinics or emergency rooms in Los Angeles County over a three-month period this year, each reporting severe diarrhea and a recent history of sexual contact with other men.

Stool cultures revealed that all three were infected with Shigella sonnei, a strain of Shigella bacteria that is resistant to five of the antibiotic classes most commonly prescribed for such infections. But upon further analysis, the UCLA researchers analyzing the samples realized they were looking at something altogether new.

All three cases had a distinct genetic mutation that made the bacteria resistant to yet another class of antibiotics, the cephalosporins, which are often used to treat Shigella infections when other drugs fail.

The strain appears to be unique to Los Angeles and has not been recorded anywhere else, said Dr. Shangxin Yang, a UCLA molecular biologist and clinical microbiologist who is a co-author of the paper describing the find. Although all the patients ultimately recovered, the mutation represents an unsettling new development in a battle against a tiny but hardy foe.

“It’s very alarming,” Yang said. “We are dealing with a very stealthy pathogen, and it’s really successful in spreading in a community.”

Two years ago, the U.S. Centers for Disease Control began tracking a sharp rise in cases of extensively drug-resistant (XDR) shigellosis — infections by particular strains of Shigella bacteria that are impervious to most antibiotics.

The Los Angeles County Department of Public Health reported 45 cases of XDR shigellosis in 2023, up from just five in 2021. The antibiotic-resistant infection causes diarrhea, nausea and stomach cramping and is spreading primarily among men who have sex with other men.

The number of cases detected this year declined somewhat from the 2023 peak, with 30 such infections reported in the county.

But Shigella sonnei, the parent strain of the new ultra-resistant bug discovered at UCLA, remains a tricky pathogen for multiple reasons, Yang said.

For one, many infections are either asymptomatic or relatively mild, allowing people to pass the disease to others without realizing they are sick.

It’s a tough bacteria to grow in the lab, which makes it harder for pathologists to identify which particular strain they’re dealing with, he added. And without being able to identify which bacteria is sickening the patient and prescribe the appropriate treatment, the duration of the infection — and period in which it can be spread to other people — is prolonged.

“What we found is probably only a fraction of what’s really in the community,” Yang said.

Most shigellosis patients, even those infected with drug-resistant strains, will get better on their own without a need for antibiotics, said Dr. Daniel Uslan, an infectious disease specialist at UCLA and a co-author of the paper.

But for patients with compromised immune systems, these infections can lead to serious complications that can’t be easily cured. One of the three patients identified in the recent paper, a 62-year-old man with a history of HIV/AIDS and hepatitis C, was ill enough to be admitted to the intensive care unit with septic shock. He was ultimately treated successfully with meropenem, an antibiotic used sparingly as a last line of defense against infections resistant to other medications.

“This is not a cause for panic. It’s a cause for caution and alarm,” Uslan said.

More broadly, the appearance of a new drug-resistant bacteria is a troubling development in the fight against “superbugs,” or pathogens resistant to most available antibiotics.

A study in the medical journal Lancet this year found that without new medications, “superbug” infections could kill nearly 2 million people a year in 2050 — a 67.5% increase from the 1.14 million lives lost this way in 2021.

An additional 8.22 million will die of causes related to those infections in 2050, according to a study from the Global Research on Antimicrobial Resistance Project.

In June, the World Health Organization warned that far too few new antibiotics are in the global development pipeline, and the ones that are there fall far short of the innovation required to vanquish the most dangerous microbes.

“The discovery of any extensively antibiotic-resistant bacteria is alarming, especially in cities like Los Angeles,” said Henry Skinner, chief executive of the AMR Action Fund, which invests in antimicrobial drugs.

“The bacterium detailed in this report is resistant to some of our most widely used antibiotics, including ciprofloxacin and azithromycin — medicines that tens of thousands of patients depend on daily,” he said. “With so few new antibiotics in development, it’s very concerning to learn that an XDR strain of Shigella may be gaining a foothold in the U.S.”

The Biden administration said Tuesday it was offering Pacific Gas & Electric a record $15-billion loan guarantee to help the utility upgrade its transmission lines, which have been blamed in causing wildfires, and make other improvements to meet fast-rising energy use.

The commitment, which still must be finalized, would help PG&E expand hydropower generation and battery storage, the utility said in a release. The money would also help PG&E extend its transmission system to connect with new clean energy facilities.

“Investments in a clean and resilient grid for Northern and Central California will have significant returns for our customers in safety, reliability and economic growth,” said Patti Poppe, the company’s chief executive.

The company said the loan would come with a lower interest rate than what it could otherwise obtain and save customers as much as $1 billion over the years.

“We would pass along savings from our lower cost of debt to our customers as we work to modernize the grid and stabilize customer bills,” said Lynsey Paulo, a PG&E spokesperson.

Electric rates at the utility have soared by 56% over the last three years, according to a new report by the Public Advocate’s Office at the state Public Utilities Commission, more than either Southern California Edison or San Diego Gas & Electric.

This year, PG&E hiked rates four times. The company’s rate requests must be approved by the utilities commission, whose members are appointed by Gov. Gavin Newsom and confirmed by the state Senate, which is controlled by a supermajority of Democrats.

Last year, the company recorded $2.2 billion in profits — an increase of almost 25% over the year before.

Paulo said the company was now trying to keep average annual residential gas and electric bill increases within 2% to 4% through 2026.

The announcement of the federal loan drew skeptics on Tuesday.

“This loan is less a solution for California’s energy future and more a bailout for PG&E,” said Ken Cook, president of the Environmental Working Group, a nonprofit advocacy group. “Somebody must repay it, and it certainly won’t be the company’s shareholders or executives.”

The Biden administration has been hurrying to release more money from the 2022 Inflation Reduction Act before President-elect Donald Trump takes office in January.

The loan guarantee is the biggest commitment to date from the Department of Energy’s Loan Programs Office. The money would be provided to PG&E in installments over several years. Loan office officials must approve the projects it pays for.

Federal officials said the company must still satisfy certain technical, legal, environmental and financial conditions before the loan is funded.

In 2019, Pacific Gas & Electric announced a $13.5-billion settlement for several Northern California wildfires sparked by its equipment that killed dozens of people and destroyed thousands of homes and businesses. Those fires included one that nearly destroyed the town of Paradise in 2018, the deadliest in state history.

The company had filed for bankruptcy earlier that year. It reorganized and emerged from bankruptcy in July 2020.