Science
Cancer’s New Face: Younger and Female
More Americans are surviving cancer, but the disease is striking young and middle-aged adults and women more frequently, the American Cancer Society reported on Thursday.
And despite overall improvements in survival, Black and Native Americans are dying of some cancers at rates two to three times higher than those among white Americans.
These trends represent a marked change for an illness that has long been considered a disease of aging, and which used to affect far more men than women.
The shifts reflect declines in smoking-related cancers and prostate cancer among older men and a disconcerting rise in cancer in people born since the 1950s.
Cancer is the second leading cause of death in the United States, but the leading cause among Americans under 85. The new report projects that some 2,041,910 new cases will occur this year and that 618,120 Americans will die of the disease.
Six of the 10 most common cancers are on the rise, including cancers of the breast and the uterus. Also on the rise are colorectal cancers among people under 65, as well as prostate cancer, melanoma and pancreatic cancer.
“These unfavorable trends are tipped toward women,” said Rebecca L. Seigel, an epidemiologist with the American Cancer Society and the report’s first author.
“Of all the cancers that are increasing, some are increasing in men, but it’s lopsided — more of this increase is happening in women.”
Women are also being diagnosed at younger ages. Cancer rates are rising among women under 50 (so-called early-onset cancer), as well as among women 50 to 64.
Despite increases in some early-onset cancers, like colorectal cancer and testicular cancer, “overall rates are flat in men under 50 and decreasing in those 50 to 64,” Ms. Seigel said.
Several other troubling trends are outlined in the report. One is an increase in new cases of cervical cancer — a disease widely viewed as preventable in the United States — among women 30 to 44.
The incidence of cervical cancer has plummeted since the mid-1970s, when Pap smear screening to detect precancerous changes became widely available. But recent surveys have found many women are postponing visits to their gynecologists.
A Harris Poll survey of over 1,100 U.S. women last year found that 72 percent said they had put off a visit with their doctor that would have included screening; half said they didn’t know how frequently they should be screened for cervical cancer.
(The current recommendation is a bit complicated: Get a Pap smear every three years starting at age 21, or a combined Pap smear and test for the human papillomavirus, which can cause cervical cancer, every five years.)
Another disturbing trend started in 2021 when, for the first time, lung cancer incidence in women under 65 surpassed the incidence in men: 15.7 cases per 100,000 women under 65, compared with 15.4 per 100,000 in men.
Lung cancer has been declining over the past decade, but it has decreased more rapidly in men. Women took up smoking later than men and took longer to quit.
There have also been upticks in smoking in people who were born after 1965, the year after the surgeon general first warned that cigarettes cause cancer.
Smoking continues to be the leading cause of preventable death in the United States, accounting for almost 500 cancer deaths daily in 2025, mostly from lung cancer, the American Cancer Society said.
“There is growing concern that e-cigarettes and vaping may contribute to this burden in the future, given their carcinogenic potential and wide popularity,” the report said.
Breast cancer rates have also been inching up for many years, increasing by about 1 percent a year between 2012 and 2021. The sharpest rise has been seen in women under 50, and there have been steep increases among Hispanic American, Asian American and Pacific Islander women.
The increases are driven by detection of localized tumors and certain cancers fueled by hormones.
Some of the rise results from changing fertility patterns. Childbearing and breastfeeding protect against breast cancer, but more American women are postponing childbirth — or are choosing not to bear children at all.
Other risk factors include genetics, family history and heavy drinking — a habit that has increased in women under 50. In older women, excess body weight may play a role in cancer risk.
Uterine cancer is the only cancer for which survival has actually decreased over the past 40 years, the A.C.S. said.
Death rates are also rising for liver cancer among women, and for cancers of the oral cavity for both sexes.
Pancreatic cancer has been increasing in incidence among both men and women for decades. It is now the third leading cause of cancer death. As with many other cancers, obesity is believed to contribute.
Little progress has been made in the understanding and treatment of pancreatic cancer. Death rates have been rising since record-keeping started, rising to 13 per 100,000 in men and 10 per 100,000 in women today, up from about five per 100,000 in both men and women in the 1930s.
The lack of progress has frustrated many scientists and physicians. The cancer is often fairly advanced when diagnosed, and the five-year survival rate is only 13 percent.
“We need to make progress in specifically understanding what’s driving pancreatic cancers to grow, what treatment will then stave off these cancers, what can prevent it in the first place, and how we can screen for it early,” said Dr. Amy Abernathy, an oncologist who co-founded Highlander Health, which focuses on accelerating clinical research.
Some experts are beginning to acknowledge that environmental exposures may be contributing to early-onset cancer, in addition to the usual suspects: lifestyle, genetics and family history.
“I think that the rise in not just one but a variety of cancers in younger people, particularly in young women, suggests there is something broader going on than variations in individual genetics or population genetics,” said Neil Iyengar, an oncologist at Memorial Sloan Kettering Cancer Center.
“It strongly points to the possibility that environmental exposures and our lifestyles in the U.S. are contributing to the rise of cancers in younger people.”
Public health efforts aimed at reducing risky lifestyle behaviors have focused on people at higher risk and at older Americans, who still bear the brunt of cancer’s burden, he noted.
But the risk factors in young people may be different.
Emerging research hints that maintaining regular sleeping patterns, for example, may also help to prevent cancer, he said.
Lifestyle and behavioral changes can reduce the risk for many cancers, Ms. Siegel said.
“I don’t think people realize how much control they have over their cancer risk,” she said. “There’s so much we can all do. Don’t smoke is the most important.”
Among the others: Maintaining a healthy body weight; not consuming alcohol or consuming in moderation; eating a diet high in fruits and vegetables, and low in red and processed meat; physical activity; and regular cancer screenings.
“There are all these things you can do, but they’re individual choices, so just pick one that you can focus on,” she said. “Small changes can make a difference.”
Science
As mosquitoes go year-round in L.A., a promising fix hits a snag
Residents were supposed to get a respite from the ankle-nipping mosquitoes that fueled a recent surge in dengue fever in Los Angeles County.
Typically, the invasive mosquitoes — called Aedes aegypti — essentially disappear from winter until early May in the region.
Instead, complaints to local agencies tasked with controlling the pests spiked recently.
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“We have not seen them go away altogether like they have in previous years,” said Susanne Kluh, general manager for the Greater Los Angeles County Vector Control District.
Their unusual presence adds to the urgency of work going on in a 40-foot shipping container tucked away in Pacoima. It’s about to transform into a bustling nursery for tens of thousands of mosquitoes.
This May, the district is set for the third year in a row to release legions of sterilized male mosquitoes — which don’t bite — into parts of Sunland-Tujunga.
The last two years were promising, with the female population in two treated neighborhoods plunging by an average of more than 80%.
Yet business owners have signaled they’re not willing to pay to expand it.
That’s thrown uncertainty into officials’ goal of eventually bringing the approach to their whole service area, spanning 36 cities and unincorporated communities.
Steve Vetrone, assistant general manager at the Greater L.A. district.
(Ronaldo Bolanos / Los Angeles Times)
“Unfortunately, that’s going to be a rather expensive endeavor,” said Steve Vetrone, an assistant general manager for the district. “I can tell you right now that’s not something that we can do with our current operating budget.”
A need, an ask and a disappointing answer
Aedes aegypti are a new-ish local fixture. Native to Africa, the black-and-white striped mosquitoes were first detected in California in 2013 and landed in L.A. County the following year.
“Despite our best efforts, they’ve been able to just outpace us, and they’re now in every city and community within our district,” and all of Southern California, Vetrone said. In fact, the low-flying, day-biting mosquitoes are present in nearly half of California’s counties, including Shasta in the far north.
Desperate to find a solution, many are trying the so-called sterile insect technique — including vector control districts serving Orange and San Bernardino counties, as well as the San Gabriel Valley — and “we kind of all hope that this is going to be our silver bullet,” Kluh said.
The idea is fairly simple: unleash sterile males so that they far outnumber wild ones — say, 10 to 1 or even 100 to 1. The goal is for the altered males to mate with females, producing eggs that don’t hatch.
Kluh’s district uses X-rays to sterilize males but there are other methods, such as using genetically modified insects or ones infected with bacteria.
Female mosquitoes are fed different types of blood — pig and cow — to see which leads to the most eggs.
(Ronaldo Bolanos / Los Angeles Times)
The technique, while promising, requires time and money.
In California, property owners foot the bill for local mosquito (and other pest) control, with some paying an annual fee called a benefit assessment.
Levying a new fee requires approval from home, apartment and business owners, in accordance with Proposition 218.
To unleash sterile male mosquitoes in a broader swath of the Greater L.A. district, officials are seeking up to $20 a year per single family home. That would be on top of $18.97 that homeowners now pay for the agency’s services.
Last April, the district sent out 50,000 sample ballots to property owners, asking if they’d support the increase.
Only 47% of those returned were in favor.
“Data showed that single family homeowners were pretty supportive, but fewer business owners with larger parcels and potentially higher dues did not see the benefit in the additional expense,” Kluh said in an email.
Business owners might not live in the area, but their vote — if their property spans several acres — is weighted more heavily.
Times readers, commenting on a story from last year about the proposal, responded favorably.
“I hate mosquitos because they love me so much,” one reader said. “I would happily spend $20 to reduce their populations! I probably spend more [than] that on repellent.”
Officials haven’t given up, and plan to send out another round of sample ballots next year.
Kluh already has talking points for businesses in her back pocket: Restaurant owners should have an interest in making outdoor dining more pleasant, while apartment owners could lose revenue if their renters are sickened by an outbreak of Zika, chikungunya or yellow fever — all diseases transmitted by Aedes aegypti, she said.
Making mosquitoes that can’t reproduce
On a recent tour of the Pacoima insectary, Nicolas Tremblay, a senior vector ecologist with the district, whipped out a small container filled with a handful of what looked like vitamins.
But the clear pill cases were filled with about 6,500 mosquito eggs and bovine liver powder.
Nicolas Tremblay, senior vector ecologist, tapes trays to indicate pill capsules filled with mosquito eggs were placed in water.
(Ronaldo Bolanos / Los Angeles Times)
The pills are dropped into trays of water, where the eggs hatch and the larvae feed on the powder. It takes about nine days to go from egg to buzzing adult.
The males are then chauffeured to Garden Grove, where they’re zapped with X-rays. Then they’re driven back and set free the next day.
“It’s crazier around August, September, is when we’ll probably reach our peak production” of up to 72,000 mosquitoes a week, he said. “All these [trays] would be full of water and mosquitoes.”
In 2024, the district launched its pilot, releasing nearly 600,000 sterilized males in two Sunland-Tujunga neighborhoods over about five months.
The population of Aedes aegypti females dropped by an average of 82% compared with a control area.
The stakes became clear that year, when California reported 18 locally acquired dengue cases — a sharp rise from the first-ever cases confirmed the year before.
Last year, the pilot saw similar success, though there was also a natural drop in activity districtwide.
On the recent visit to the insectary, several hundred mosquitoes flew around in white mesh cages, serving as participants in a study to see which blood they prefer — pig or cow.
“We haven’t completed the trials yet, but it seems like they didn’t care,” he said.
One thing scientists already know: Aedes aegypti love biting people.
A highly adaptive foe
The invasive mosquitoes can lay their eggs in tiny amounts of water. A bottle cap or crease in a potato chip bag is fair game.
What’s more, mosquitoes in the Greater L.A. district are resistant to a lot of pesticides.
Now, there might be a new concern. Typically, the invasive mosquitoes go into a type of hibernation every year.
Kluh said it appeared that they may have mutated in a way that allows them to stay active through the winter.
A warming climate has already expanded their season and allowed them to move into formerly inhospitable regions.
Releasing sterilized males involves no pesticides, and also leverages the insect’s biology: Males in lust are adept at finding females.
Many residents are thrilled by the promising tool, but others bristle at the idea of manipulating nature.
“There’s folks that are in favor and then there are folks that are just absolutely opposed because it’s like, ‘You’re playing God,’” Vetrone said.
Science
Record Heat Meets a Major Snow Drought Across the West
At this point in a typical year, as the seasons officially turn from winter to spring, snowpack would still be accumulating across the Mountain West.
But this winter wasn’t typical, even before a heat wave this past week. It was the warmest on record for six Western states. Snow cover is the lowest level on record for the Colorado River Basin, and across much of the rest of the West, there are record or near-record low amounts of snow.
That alone would create a challenging year for water managers, who rely on slow and steady snowmelt to feed streams, rivers and reservoirs and meet spring and summer demand for irrigation and drinking water. While rainfall runs off quickly and can more readily evaporate from soil, snowpack serves as a valuable and lasting source of moisture and accounts for a majority of water supplies across the region, as much as 80 percent in some areas.
Current snowpack compared to historical averages
The intense heat wave threatens to make water management all the more challenging.
Much of the thin snowpack was already “ready to melt” before the heat set in, said Jon Meyer, assistant state climatologist at the Utah Climate Center. “This is the nail in the coffin.”
It’s unusual to see the whole West like this, said Leanne Lestak, an associate senior scientist at the University of Colorado Boulder who specializes in mapping snow and how much water it holds.
In early March, Ms. Lestak and her team found that vast majority of the Western United States had less than two-thirds of the amount of snow typical for this time of year, with few exceptions. In Arizona and parts of Nevada, New Mexico and Oregon, snowpack was less than a quarter of what it would usually be.
“The situation is pretty dire,” Dr. Meyer said.
The heat wave is also increasing the already-elevated fire risk across some drought-stricken areas. In Nebraska, drought set the stage for the largest wildfire in state history, which broke out last week and has not yet been contained.
The conditions that led to this year’s low snowpack are unusual, too. Snow droughts often develop from dry weather patterns that starve the West of any significant precipitation during the winter, said Dan McEvoy, a climatologist at the Desert Research Institute and Western Regional Climate Center.
But in many places, it wasn’t necessarily a dry year, he said. Instead, temperatures have been so warm that precipitation has fallen as rain, rather than snow, even at higher elevations.
Many of the mountaintops could still see some more snowfall. But as Cody Moser, a hydrologist with the Colorado Basin River Forecast Center in Salt Lake City, looks ahead to predicting how the spring will go, he doesn’t foresee any significant change in weather patterns. Now he’s expecting peak snowmelt flows to occur earlier than ever recorded in many locations, he said this week.
“I think it’s highly likely we’ve seen peak snowpack,” Mr. Moser said.
Snowpack feeding the Colorado River reaches historic lows
Even after a winter that was the warmest on record for Arizona, New Mexico, Colorado, Utah, Wyoming and Oregon, the heat that set in across much of the West this past week was extreme. Meteorologists said they were expecting to set record highs for the month of March in many locations, and the earliest arrivals of 100-degree temperatures in records that go back more than a century.
Across the Colorado River Basin, even at elevations as high as 10,000 feet, temperatures were forecast to surge into the 50s and 60s Fahrenheit on Friday and Saturday, Mr. Moser said, some 15 to 20 degrees warmer than average.
Relatively light winds and dry air over the region could limit snowmelt to some degree, he said, but the warmth and sunshine may prevent some moisture from ever reaching stream beds, said John Fleck, a water policy expert at the University of New Mexico.
“A lot of it is going to evaporate off before it even has a chance to hit the stream,” Mr. Fleck said.
This heat wave is so extreme that it would only be expected to occur once about every 500 years in the current climate, according to World Weather Attribution, a group of scientists who study links between extreme weather events and climate change.
“These temperatures are completely off the scale for March, and our data shows that they would be virtually impossible in a world without human-caused climate change,” said Ben Clarke, a research associate in extreme weather and climate change at Imperial College London.
In places like the Colorado Front Range, home to the majority of that state’s population, snowpack serves as the largest source of water. For the utility Denver Water, snowpack usually contains significantly more water than its largest surface reservoir, said Taylor Winchell, the agency’s climate adaptation program lead.
Denver Water has enough supply to handle a low-water year, but the snowpack conditions are creating “very high levels of concern,” Mr. Winchell said. The Denver Water Board is poised to officially declare Stage One drought restrictions, asking residents to significantly reduce their outdoor watering. If the snow drought were to repeat for multiple years, the problem could compound and worsen, he said.
The snow drought occurs at a critical time for the larger Colorado River Basin. An agreement among the basin’s seven states over how to divide its water expired at the end of last year, and negotiations to develop a new water plan fell apart last month. (The states are also obligated to share a small portion of the water with Mexico.)
The snow drought is complicating that work. Snowpack from the river’s Upper Basin, across mountains of Colorado, Utah, New Mexico and Wyoming, accounts for a majority of the river’s natural flow each year. Declining spring precipitation and rising temperatures have caused the Colorado’s flow to decrease by nearly 20 percent over the past quarter century.
Recent forecasts estimated that inflows to Lake Powell, a key reservoir that straddles the Utah-Arizona border, will be the third-smallest on record. The lake’s surface could drop to a critical level for hydroelectric power production by the end of this year, affecting a power grid that serves seven states.
Officials at the Bureau of Reclamation, the federal agency that oversees the Colorado River and its reservoirs, declined to be interviewed but said in a statement they were monitoring hydrologic conditions to guide decisions about how to manage the Colorado River system.
Mr. Fleck said a crisis without precedent could be brewing. While a drought that hit the basin in 2002 was worse, it was relatively more manageable than what the West now faces: “We’re having one of the worst years in many decades, but with no cushion of reservoir storage to fall back on to bail us out.”
Science
New report on L.A. post-fire beach contamination finds something unexpected: good news
Researchers investigating the long-term effects of the 2025 firestorms on L.A.’s beaches have found that rarest of things: good news.
In the year following the Palisades and Eaton fires, levels of harmful metals like lead in coastal sand and seawater have remained far below California’s limits for safe drinking water and the U.S. Environmental Protection Agency’s safety thresholds for aquatic life.
“We’re not seeing any evidence for harm in the ecosystem or harm for human health,” said Noelle Held, a University of Southern California marine biogeochemist and principal investigator for the CLEAN Waters project, which is measuring post-fire water quality.
The Palisades and Eaton fires burned more than 40,000 acres and destroyed at least 12,000 buildings, blanketing the ocean in ash for up to 100 miles offshore. Heavy rains a few weeks later washed the charred remnants of plastics, batteries, cars, chemicals and other potentially toxic material into the sea and up onto beaches via the region’s massive network of storm drains and concrete-lined rivers.
Initial testing by the nonprofit environmental group Heal the Bay in the weeks after the fires documented a spike in lead, mercury and other heavy metals in coastal waters. Concentrations of beryllium, copper, chromium, nickel and lead in particular were significantly above established safety thresholds for marine life, prompting fears for the long-term health of fish, marine mammals and the marine food chain.
For their most recent study, Held’s team analyzed seawater samples collected along multiple locations on five different dates between Feb. 10 and Oct. 17 in 2025, along with sand collected in August.
Seawater lead concentrations were highest in the month after the fire and in October, when the season’s first major rain had just washed months’ worth of urban pollution into the ocean.
Even at their peak, lead levels barely surpassed 1 microgram per liter — well below the U.S. Environmental Protection Agency’s aquatic life safety threshold of 8.1 micrograms per liter.
While levels of iron, manganese and cobalt were higher in sampling locations near the Palisades burn scar than they were in other areas, even there they remain well below concentrations that could pose harm to human or marine life.
For beach sand collected in August, lead levels never topped 14 parts per million at any location, significantly below both the current California residential soil standard of 80 parts per million and the stricter 55 parts per million standard proposed by environmental health researchers.
“This isn’t something we would flag if we were testing your soil in your yard,” Held said.
The recent findings are consistent with water quality tests the State Water Resources Control Board conducted earlier in 2025. A board spokesperson said those found both higher relative concentrations of metals closest to the burn scars and no overall evidence that post-fire pollution poses an ongoing threat to human health.
Yet the need for continued testing remains. Officials struggled to answer questions about post-fire beach safety in part because of a lack of historical data on pollution levels, a pitfall researchers would like to forestall before another disaster arrives.
Future rainstorms could also continue to wash metals into Will Rogers Beach and the Rustic Creek outfall, both of which are near the Palisades burn scar, CLEAN Waters warned.
“Post-fire impacts can change over time, depending on rainfalls, runoffs and sediment movements,” said Eugenia Ermacora, manager of the nonprofit Surfrider Foundation’s L.A. chapter, which has partnered with Held’s team to collect samples. “It’s not just about the fires, but it’s about urbanization and how much our city needs to continue the work of doing testing in the water.”
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