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Study links even mild Covid-19 to changes in the brain

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Study links even mild Covid-19 to changes in the brain
The research, printed Monday within the journal Nature, is believed to be the biggest of its sort. It discovered that the brains of those that had Covid-19 had a better lack of grey matter and abnormalities within the mind tissue in contrast with those that did not have Covid-19. A lot of these modifications have been within the space of the mind associated to the sense of scent.

“We have been fairly shocked to see clear variations within the mind even with delicate an infection,” lead creator Gwenaëlle Douaud, an affiliate professor of neurosciences on the College of Oxford, informed CNN in an e-mail.

Douaud and her colleagues evaluated mind imaging from 401 individuals who had Covid-19 between March 2020 and April 2021, each earlier than an infection and a mean of 4½ months after an infection. They in contrast the outcomes with mind imaging of 384 uninfected folks related in age, socioeconomics and threat components equivalent to blood strain and weight problems. Of the 401 contaminated folks, 15 had been hospitalized.

The 785 individuals have been between the ages of 51 and 81 and have been all a part of the UK Biobank, an ongoing authorities well being database of 500,000 folks begun in 2012.

Douaud defined that it’s regular for folks to lose 0.2% to 0.3% of grey matter yearly within the memory-related areas of the mind as they age, however within the research analysis, individuals who had been contaminated with the coronavirus misplaced a further 0.2% to 2% of tissue in contrast with those that hadn’t been contaminated.

Along with imaging, the individuals have been examined for his or her government and cognitive perform utilizing the Path Making Take a look at, a instrument used to assist detect cognitive impairments related to dementia and take a look at an individual’s mind processing pace and performance. The researchers discovered that those that had the best mind tissue loss additionally carried out the worst on this examination.

Though the areas of the mind most affected look like associated to the olfactory system, Douaud stated it wasn’t clear why that was the case.

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“For the reason that irregular modifications we see within the contaminated individuals’ brains is likely to be partly associated to their lack of scent, it’s potential that recovering it’d result in these mind abnormalities changing into much less marked over time. Equally, it’s possible that the dangerous results of the virus (whether or not direct, or oblique through inflammatory or immune reactions) lower over time after an infection. One of the best ways to seek out out can be to scan these individuals once more in a single or two years’ time,” she stated.

Douaud added that the researchers anticipate reimaging and testing the individuals in a single or two years.

And whereas the research finds some affiliation between an infection and mind perform, it is nonetheless not clear why. Earlier research have proven folks with vital and repeated lack of scent even have an related lack of grey matter. Nevertheless, this research didn’t consider whether or not folks truly had a lack of scent.

The authors cautioned that the findings have been solely of a second in time however famous that they “elevate the likelihood that longer-term penalties of SARS-CoV-2 an infection may in time contribute to Alzheimer’s illness or different types of dementia.”

The findings have been noticeable, however they weren’t sufficient to trigger alarm, stated Dr. Richard Isaacson, a neurologist and director of the Florida Atlantic College Heart for Mind Well being. Isaacson was not concerned within the research.

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Isaacson stated the findings have been noticeable for clinicians, however he added that the general impression on people was troublesome to find out and might be small. “It is actually exhausting to know the long-term medical impression and high quality of life impression in a state of affairs like this,” he stated.

“The mind could also be affected by different mechanisms equivalent to immune, inflammatory, vascular or psychological/behavioral change however not direct an infection,” stated Dr. Alan Carson, a professor of neuropsychiatry on the Heart for Medical Mind Sciences on the College of Edinburgh, who was not concerned within the research.

“What this research virtually definitely exhibits is the impression, when it comes to neural modifications,” he stated. “However I do not assume it helps us perceive the mechanisms underpinning cognitive change after Covid an infection.”

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The U.S. Is Trying to Deport Mahmoud Khalil, a Legal Resident. Here’s What to Know.

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The U.S. Is Trying to Deport Mahmoud Khalil, a Legal Resident. Here’s What to Know.

The Trump administration invoked an obscure statute over the weekend in moving to deport Mahmoud Khalil, a permanent legal resident of the United States who recently graduated from Columbia University, where he helped lead campus protests against high civilian casualties in Gaza during Israel’s campaign against Hamas.

Mr. Khalil was arrested by immigration officers on Saturday and then sent to a detention center in Louisiana. On Monday, a federal judge in New York, Jesse M. Furman, ordered the federal government not to deport Mr. Khalil while he reviewed a petition challenging the legality of the detention.

Here’s what to know about the administration’s attempt to deport Mr. Khalil.

Mr. Khalil, 30, earned a master’s degree from Columbia’s School of International and Public Affairs in December. He has Palestinian heritage and is married to an American citizen who is eight months pregnant.

At Columbia last spring, Mr. Khali assumed a major role in student-led protests on campus against Israel’s war efforts in Gaza. He described his position as a negotiator and spokesman for Columbia University Apartheid Divest, a pro-Palestinian group.

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The Trump administration did not publicly lay out the legal authority for the arrest. But two people with knowledge of the matter, who spoke on the condition of anonymity to discuss sensitive internal deliberations, said Secretary of State Marco Rubio relied on a provision of the Immigration and Nationality Act of 1952 that gives him sweeping power to expel foreigners.

The provision says that any “alien whose presence or activities in the United States the Secretary of State has reasonable ground to believe would have potentially serious adverse foreign policy consequences for the United States is deportable.”

That is not very clear.

Mr. Rubio reposted a Homeland Security Department statement that accused Mr. Khalil of having “led activities aligned to Hamas.” But officials have not accused him of having any contact with the terrorist group, taking direction from it or providing material support to it.

Rather, the administration’s rationale is that the protests that Mr. Khalil played a key part in were antisemitic and created a hostile environment for Jewish students at Columbia, the people with knowledge of the matter said. Mr. Rubio’s argument, they said, is that the United States’ foreign policy includes combating antisemitism across the globe and that Mr. Khali’s residency in the nation undermines that policy objective.

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President Trump said Mr. Khalil’s case was “the first arrest of many to come.”

But a lawful permanent resident, or green card holder, is protected by the Constitution, which includes First Amendment free-speech rights and Fifth Amendment due-process rights. The Trump administration’s efforts to deport Mr. Khalil under the I.N.A. provision are likely to face a constitutional challenge, several legal experts said.

There is little precedent for deporting a legal permanent resident based on the provision of the 1952 law that gives the State Secretary a broad power to do so on foreign-policy grounds.

A lawyer for Mr. Khalil, Amy Greer, said her client would “vigorously” challenge the Trump administration’s actions in court. On Monday, Judge Furman, of the Federal District Court in Manhattan, scheduled a hearing for two days later after barring the Trump administration from deporting Mr. Khalil “to preserve the court’s jurisdiction.”

Since 2023, Mr. Trump has repeatedly vowed to revoke visas of international students who participate in pro-Palestinian protests and criticize Israel’s war efforts.

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At a rally in Iowa on Oct. 16, 2023, Mr. Trump declared that “in the wake of the attacks on Israel, Americans have been disgusted to see the open support for terrorists among the legions of foreign nationals on college campuses. They’re teaching your children hate.”

He added: “Under the Trump administration, we will revoke the student visas of radical, anti-American and antisemitic foreigners at our colleges and universities, and we will send them straight back home.”

At a speech in Las Vegas on Oct. 28 of that year, Mr. Trump said that “we’ll terminate the visas of all of those Hamas sympathizers, and we’ll get them off our college campuses, out of our cities and get them the hell out of our country.” And at a Nov. 8, 2023, campaign stop in Florida, he said he would “quickly cancel the student visas of all Hamas sympathizers on college campuses, which have been infested with radicalism.”

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OpenAI strikes $12bn deal with CoreWeave

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OpenAI strikes bn deal with CoreWeave

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OpenAI has forged a near-$12bn contract with CoreWeave and will take a stake in the cloud computing provider, boosting the group ahead of its expected $35bn public listing.

The ChatGPT maker has signed a five-year deal in which CoreWeave will supply computing power to train and run OpenAI’s artificial intelligence models, said two people with knowledge of the deal. OpenAI is looking to expand beyond a reliance on Microsoft, its biggest partner, for its computing needs.

The Financial Times last week reported Microsoft had walked away from a planned deal with CoreWeave because of the cloud computing provider’s delivery issues. That decision was a blow to the New Jersey-based company, which this month filed for a New York initial public offering in which it will seek to raise about $4bn.

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OpenAI’s new $11.9bn contract helps fill that void, and could lead to it outspending Microsoft, which accounted for 62 per cent of CoreWeave’s revenues last year, according to public disclosures. Microsoft has agreed to spend $10bn on CoreWeave’s services by 2030.

As part of OpenAI’s agreement with CoreWeave, the AI company will also get a $350mn equity stake in the group at the time of the IPO, said one person with knowledge of the plans.

CoreWeave, which was founded in 2017 as a cryptocurrency mining operation, pivoted to offering cloud services for technology companies to build and train AI models using Nvidia’s high-performing graphics processing units (GPUs). The group has amassed more than 250,000 of Nvidia’s AI GPUs, making it among the chipmaker’s biggest customers.

OpenAI’s deal with the company is its latest effort to boost and diversify the computing power it has available.

Sam Altman, the company’s co-founder and chief executive, has argued infrastructure will be vital in the race to build cutting-edge AI models. Microsoft chief executive Satya Nadella, meanwhile, recently raised concerns about an “overbuild” of computing capacity as Big Tech giants pour hundreds of billions of dollars into data centres.

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OpenAI has also partnered with SoftBank on a potential $500bn data centre effort dubbed ‘Stargate’ in recent months, and struck data centre agreements with Oracle.

OpenAI and CoreWeave declined to comment. Reuters first reported OpenAI had signed a contract with CoreWeave.

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Menendez brothers face resentencing hurdles with new L.A. district attorney

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Menendez brothers face resentencing hurdles with new L.A. district attorney
Menendez brothers face resentencing hurdles with new L.A. district attorney – CBS Texas

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The Menendez brothers are facing challenges in their bid for resentencing due to a new district attorney in Los Angeles County.

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