Science
NIH budget cuts threaten the future of biomedical research — and the young scientists behind it
Over the last several months, a deep sense of unease has settled over laboratories across the United States. Researchers at every stage — from graduate students to senior faculty — have been forced to shelve experiments, rework career plans, and quietly warn each other not to count on long-term funding. Some are even considering leaving the country altogether.
This growing anxiety stems from an abrupt shift in how research is funded — and who, if anyone, will receive support moving forward. As grants are being frozen or rescinded with little warning and layoffs begin to ripple through institutions, scientists have been left to confront a troubling question: Is it still possible to build a future in U.S. science?
On May 2, the White House released its Fiscal Year 2026 Discretionary Budget Request, proposing a nearly $18-billion cut from the National Institutes of Health. This cut, which represents approximately 40% of the NIH’s 2025 budget, is set to take effect on Oct. 1 if adopted by Congress.
“This proposal will have long-term and short-term consequences,” said Stephen Jameson, president of the American Assn. of Immunologists. “Many ongoing research projects will have to stop, clinical trials will have to be halted, and there’ll be the knock-on effects on the trainees who are the next generation of leaders in biomedical research. So I think there’s going to be varied and potentially catastrophic effects, especially on the next generation of our researchers, which in turn will lead to a loss of the status of the U.S. as a leader in biomedical research.“
In the request, the administration justified the move as part of its broader commitment to “restoring accountability, public trust, and transparency at the NIH.” It accused the NIH of engaging in “wasteful spending” and “risky research,” releasing “misleading information,” and promoting “dangerous ideologies that undermine public health.”
National Institutes of Health.
(NIH.gov)
To track the scope of NIH funding cuts, a group of scientists and data analysts launched Grant Watch, an independent project that monitors grant cancellations at the NIH and the National Science Foundation. This database compiles information from public government records, official databases, and direct submissions from affected researchers, grant administrators, and program directors.
As of July 3, Grant Watch reports 4,473 affected NIH grants, totaling more than $10.1 billion in lost or at-risk funding. These include research and training grants, fellowships, infrastructure support, and career development awards — and affect large and small institutions across the country. Research grants were the most heavily affected, accounting for 2,834 of the listed grants, followed by fellowships (473), career development awards (374) and training grants (289).
The NIH plays a foundational role in U.S. research. Its grants support the work of more than 300,000 scientists, technicians and research personnel, across some 2,500 institutions and comprising the vast majority of the nation’s biomedical research workforce. As an example, one study, published in the Proceedings of the National Academy of Sciences, found that funding from the NIH contributed to research associated with every one of the 210 new drugs approved by the U.S. Food and Drug Administration between 2010 and 2016.
Jameson emphasized that these kinds of breakthroughs are made possible only by long-term federal investment in fundamental research. “It’s not just scientists sitting in ivory towers,” he said. “There are enough occasions where [basic research] produces something new and actionable — drugs that will save lives.”
That investment pays off in other ways too. In a 2025 analysis, United for Medical Research, a nonprofit coalition of academic research institutions, patient groups and members of the life sciences industry, found that every dollar the NIH spends generates $2.56 in economic activity.
A ‘brain drain’ on the horizon
Support from the NIH underpins not only research, but also the training pipeline for scientists, physicians and entrepreneurs — the workforce that fuels U.S. leadership in medicine, biotechnology and global health innovation. But continued American preeminence is not a given. Other countries are rapidly expanding their investments in science and research-intensive industries.
If current trends continue, the U.S. risks undergoing a severe “brain drain.” In a March survey conducted by Nature, 75% of U.S. scientists said they were considering looking for jobs abroad, most commonly in Europe and Canada.
This exodus would shrink domestic lab rosters, and could erode the collaborative power and downstream innovation that typically follows discovery. “It’s wonderful that scientists share everything as new discoveries come out,” Jameson said. “But, you tend to work with the people who are nearby. So if there’s a major discovery in another country, they will work with their pharmaceutical companies to develop it, not ours.”
At UCLA, Dr. Antoni Ribas has already started to see the ripple effects. “One of my senior scientists was on the job market,” Ribas said. “She had a couple of offers before the election, and those offers were higher than anything that she’s seen since. What’s being offered to people looking to start their own laboratories and independent research careers is going down — fast.”
In addition, Ribas, who directs the Tumor Immunology Program at the Jonsson Comprehensive Cancer Center, says that academia and industry are now closing their door to young talent. “The cuts in academia will lead to less positions being offered,” Ribas explained. “Institutions are becoming more reluctant to attract new faculty and provide startup packages.” At the same time, he said, the biotech industry is also struggling. “Even companies that were doing well are facing difficulties raising enough money to keep going, so we’re losing even more potential positions for researchers that are finishing their training.”
This comes at a particularly bitter moment. Scientific capabilities are soaring, with new tools allowing researchers to examine single cells in precise detail, probe every gene in the genome, and even trace diseases at the molecular level. “It’s a pity,” Ribas said, “Because we have made demonstrable progress in treating cancer and other diseases. But now we’re seeing this artificial attack being imposed on the whole enterprise.”
Without federal support, he warns, the system begins to collapse. “It’s as if you have a football team, but then you don’t have a football field. We have the people and the ideas, but without the infrastructure — the labs, the funding, the institutional support — we can’t do the research.”
For graduate students and postdoctoral fellows in particular, funding uncertainty has placed them in a precarious position.
“I think everyone is in this constant state of uncertainty,” said Julia Falo, a postdoctoral fellow at UC Berkeley and recording secretary of UAW 4811, the union for workers at the University of California. “We don’t know if our own grants are going to be funded, if our supervisor’s grants are going to be funded, or even if there will be faculty jobs in the next two years.”
She described colleagues who have had funding delayed or withdrawn without warning, sometimes for containing flagged words like “diverse” or “trans-” or even for having any international component.
The stakes are especially high for researchers on visas. As Falo points out for those researchers, “If the grant that is funding your work doesn’t exist anymore, you can be issued a layoff. Depending on your visa, you may have only a few months to find a new job — or leave the country.”
A graduate student at a California university, who requested anonymity due to the potential impact on their own position — which is funded by an NIH grant— echoed those concerns. “I think we’re all a little on edge. We’re all nervous,” they said. “We have to make sure that we’re planning only a year in advance, just so that we can be sure that we’re confident of where that funding is going to come from. In case it all of a sudden gets cut.”
The student said their decision to pursue research was rooted in a desire to study rare diseases often overlooked by industry. After transitioning from a more clinical setting, they were drawn to academia for its ability to fund smaller, higher-impact projects — the kind that might never turn a profit but could still change lives. They hope to one day become a principal investigator, or PI, and lead their own research lab.
Now, that path feels increasingly uncertain. “If things continue the way that they have been,” they said. “I’m concerned about getting or continuing to get NIH funding, especially as a new PI.”
Still, they are staying committed to academic research. “If we all shy off and back down, the people who want this defunded win.”
Rallying behind science
Already, researchers, universities and advocacy groups have been pushing back against the proposed budget cut.
On campuses across the country, students and researchers have organized rallies, marches and letter-writing campaigns to defend federal research funding. “Stand Up for Science” protests have occurred nationwide, and unions like UAW 4811 have mobilized across the UC system to pressure lawmakers and demand support for at-risk researchers. Their efforts have helped prevent additional state-level cuts in California: in June, the Legislature rejected Gov. Gavin Newsom’s proposed $129.7-million reduction to the UC budget.
Earlier this year, a coalition of public health groups, researchers and unions — led by the American Public Health Assn. — sued the NIH and Department of Health and Human Services over the termination of more than a thousand grants. On June 16, U.S. District Judge William Young ruled in their favor, ordering the NIH to reinstate over 900 canceled grants and calling the terminations unlawful and discriminatory. Although the ruling applies only to grants named in the lawsuit, it marks the first major legal setback to the administration’s research funding rollback.
Though much of the current spotlight (including that lawsuit) has focused on biomedical science, the proposed NIH cuts threaten research far beyond immunology or cancer. Fields ranging from mental health to environmental science stand to lose crucial support. And although some grants may be in the process of reinstatement, the damage already done — paused projects, lost jobs and upended career paths — can’t simply be undone with next year’s budget.
And yet, amid the fear and frustration, there’s still resolve. “I’m floored by the fact that the trainees are still devoted,” Jameson said. “They still come in and work hard. They’re still hopeful about the future.”
Science
July Fourth fireworks may bring ‘hazardous’ air quality to Southern California. What you need to know
L.A.’s love of fireworks makes for a colorful Fourth of July, with dozens of official celebrations and countless illicit explosions expected for the holiday.
But as each sparkler, Roman candle, palm and peony dissipates, it leaves behind a cloud of noxious gases, soot and finely ground toxic metals — some of which ends up in the lungs of revelers and passersby below.
Hazardous levels of air pollution are expected across central and southern Los Angeles County, northern Orange County, and Riverside and San Bernardino counties from 5 p.m. Saturday evening through 3 p.m. Sunday, according to the South Coast Air Quality Management District. Unhealthy air quality is also expected in northern Los Angeles County and southern Orange County.
Pollution levels are expected to build from dusk onward Saturday, as light winds and increased firework activity lead to an increase in smoke, a South Coast AQMD advisory said. Soot and particulates will likely linger through Sunday afternoon before being dispersed by the wind.
Firework-related pollution can trigger coughs, breathing problems, asthma flares and heart attacks, according to Los Angeles County Public Health, and anyone experiencing severe or worsening cardiovascular symptoms like chest pain or difficulty breathing should seek medical attention immediately.
Pyrotechnics set off at home are even more likely to trigger cardiovascular problems, the American Lung Assn. says, as the burst of pollutants takes place closer to the ground.
July 4 and 5 are traditionally two of the worst days of the year for the region’s air quality, according to South Coast AQMD. This year’s celebration comes on the heels of a late June warehouse fire in Boyle Heights that released extraordinary amounts of soot and smoke across the county, on par with pollution generated by the previous year’s wildfires.
To limit negative health effects, the L.A. County public health department recommends avoiding strenuous physical activity and keeping doors and windows closed. As whole house fans and swamp coolers can suck additional pollutants inside, the department recommends using air purifiers or air conditioners as alternatives when possible.
Science
Contributor: Alcohol should be stigmatized like smoking
Few substances are as deeply woven into everyday life as alcohol. It is a fixture at holiday celebrations, work-related social gatherings, sporting events, airports, and brunch or dinner tables. All demonstrate how deeply alcohol has become embedded in social customs and cultural traditions.
Yet alcohol contributes to millions of deaths globally each year and is linked to cancer, liver disease, unintentional accidents, violence and, importantly, dependence and addiction. Despite this, the disconnect between alcohol’s cultural role and its serious health burden is striking. An estimated 2.3 billion people worldwide consume alcohol.
As a physician working in addiction medicine, I regularly care for patients whose alcohol use affects nearly every organ system. It is often not until these patients end up admitted to the hospital that they learn the effects of alcohol on various parts of their body besides their liver.
Newer evidence challenges assumptions about what was long considered “safe drinking.” Even moderate drinking carries risk and is not as harmless as people, including experts, once thought.
Many people associate alcohol risk primarily with addiction or dangerous behaviors such as driving while intoxicated. However, its effects extend far beyond this, into nearly every aspect of a person’s well-being.
While alcohol may transiently improve mood and ease social anxiety, long-term alcohol use can lead to a worsening of mood, cognition and sleep, which can further compound use.
A 2021 literature review found that consuming approximately two standard drinks roughly doubles the odds of sustaining injuries — with or without a vehicle involved. The review also found that heavy episodic (binge) drinking can increase the risk of injury by 50-fold, depending on the amount of alcohol consumed and the type of injury. While alcohol’s effects on the liver are well known, it can also lead to gastrointestinal complications and heart disease
The World Health Organization estimates that 2.6 million deaths each year are attributable to alcohol, accounting for nearly 1 in every 20 deaths worldwide.
While many people recognize the risks of alcohol addiction, people are generally much less aware of the links between alcohol use and cancer risk.
The World Health Organization classifies alcohol as a Group 1 carcinogen — the same category as tobacco and asbestos. In 2025, the U.S. surgeon general emphasized that alcohol increases the risk of at least seven cancers, including cancers of the breast, colorectal, liver, oral, esophagus and larynx. An advisory called for updated warning labels.
Yet fewer than half of Americans recognize alcohol as a risk factor for cancer, particularly for cancers such as breast cancer that are not commonly associated with alcohol use.
Throughout the 1990s and early 2000s, observational studies suggested that moderate alcohol consumption might offer cardiovascular benefits. Over the past decade, however, higher-quality studies have challenged these findings, suggesting that much of the apparent benefit may have reflected differences in the health and lifestyles of moderate drinkers rather than a protective effect of alcohol itself.
Current evidence increasingly suggests that even low levels of alcohol may increase cancer risk.
Federal guidelines acknowledge that adults should “consume less alcohol for better overall health.” However, the most recent version of the “Dietary Guidelines for Americans,” updated in January, removed the previous recommendation to limit intake to no more than one drink per day for women and two for men. It also omitted explicit discussion of alcohol’s links to cancer.
These changes have drawn criticism from public health experts, who argue that the revised language plays down the growing evidence of alcohol-related harms and provides less specific guidance to consumers. The current administrator of the Centers for Medicare & Medicaid Services characterized alcohol as a “social lubricant” that brings people together, rather than emphasizing its well-established health risks.
This may be true physiologically, at least temporarily, but obscures the fact that relying on it as a social lubricant can lead to chemical and psychological dependency. In my view, statements to that effect are shortsighted, prioritizing short-term social effects over more insidious and long-term issues, including addiction.
While many dangerous mind-altering substances are hidden from public perception, alcohol is often placed at the center of it – a trend that shows no sign of changing imminently.
Further, large companies often profit from ads that appeal to young people.
Looking back at the history of tobacco smoking provides some helpful insights. In 1965, 42.4% of the U.S. population smoked. By 2022, that figure had dropped to 11.6%.
This steep decline did not happen because of a single intervention, but through decades of accumulating scientific evidence, public education campaigns, warning labels, restrictions on advertising, smoke-free policies, higher tobacco taxes and shifts in social norms. Together, these efforts transformed smoking from a widely accepted social behavior into one broadly recognized as a major health risk and correspondingly, less socially accepted.
Although alcohol consumption has modestly declined in recent years, it remains deeply embedded in social life in ways cigarette smoking no longer is.
People often assume that if a substance is legal, common and widely socially accepted — even encouraged — it must also be safe. But public health history suggests those assumptions can and should change.
Emma Fenske is an addiction medicine fellow and internal medicine physician at Oregon Health & Science University. This article was produced in partnership with the Conversation.
Science
Boyle Heights blaze choked L.A. with astronomical soot pollution
The air near the Lineage refrigerated warehouse fire in Boyle Heights carried astronomically high levels of smoke and soot, surpassing some of the worst air pollution during the Los Angeles County fires in January 2025, according to preliminary data from air officials.
The fire spewed thick black smoke for days. From downtown Los Angeles to the San Gabriel Valley, tens of thousands were enveloped in unhealthful levels of smoke, even as some local officials told residents that the air posed no danger.
As the days wore on, worst off were communities nearest the blaze. On June 19, three days after the facility ignited, a temporary air quality monitoring station at Eastman Elementary in unincorporated East Los Angeles measured an extremely hazardous 755 micrograms per cubic meter of fine particles for more than an hour, according to the South Coast Air Quality Management District.
For comparison, a Caltech air monitor in Pasadena recorded about 650 micrograms per cubic meter during the Eaton fire.
These high levels of fine particles, known as PM 2.5, probably resulted in the surge of residents into local emergency rooms during the fire, according to local health officials. But even now with the smoke gone, people still have not been told what chemicals they were breathing in during the weeklong ordeal.
Michael Jerrett, an environmental health professor at the UCLA Fielding School of Public Health, said his concern is the composition of materials emitted when the building burned.
“These contain many particularly toxic components,” Jerrett said, “and we know little about how these mixtures affect health.”
There is no completely safe level of fine particulate pollution, he noted, meaning higher concentrations are always worse.
During the 2025 L.A. County fires, local air officials announced that several monitors downwind had detected elevated levels of brain-damaging lead and cancer-causing arsenic from toxic paint and construction materials used in older homes.
The Lineage warehouse, built in 2018, is likely to contain different materials of concern. Thick insulation foam required for a massive refrigeration operation, solar panels and refrigerants were burned, leaving many residents on edge.
Even though three public agencies conducted air monitoring, the picture is still murky.
“[Public officials] are speaking with a lot of confidence but not a lot of information,” said mark! Lopez, a community organizer with East Yard Communities for Environmental Justice. “We’ve gotten in the room with folks to discuss where the gaps lie and where assumptions are being made. And I think they are realizing these agencies supposed to protect our air and our health aren’t as reliable as they thought they were.”
In response to the Boyle Heights fire, the South Coast air district deployed a mobile monitoring vehicle to screen for toxic substances in the community near the fire, according to Nahal Mogharabi, a spokesperson for the air district. It found increased levels of bromine, a chemical commonly found in fire retardant, and chlorine, often released from burning plastic. Both were below short-term health-based exposure thresholds.
Toxic metals, including lead and arsenic, were not elevated, according to air district data.
“That was the reassuring piece, that they were not picking up any of the metals,” said Dr. Nichole Quick, chief medical advisor for the Los Angeles County Department of Public Health. “But … that smoke is unhealthy. “You don’t want to be breathing it, regardless.”
The U.S. Environmental Protection Agency set up air monitors around the perimeter of the facility to test for toxic air contaminants, has the results and has not made them public. Julia Giarmoleo, an EPA spokesperson, said the monitors did not detect elevated metals, but would not provide a copy of the data without a federal records request.
The Los Angeles Fire Department’s hazardous material team also tested for ammonia, which is used in refrigeration, and hydrogen fluoride, a toxic chemical that could be released by burning lithium-ion batteries and solar panels.
Fire officials previously said they measured low levels of hydrogen fluoride on the second day of the fire. But the department would not answer questions about its air monitoring. It also told a reporter to submit a public records request.
It remains unclear whether any agency has tested for hydrogen cyanide or isocyanates, highly toxic gases that could be released from burning chemical-laden insulating foam inside the building.
“The real issue is what monitoring has not been done to protect the fence-line community from the air toxics,” said Jane Williams, executive director of California Communities Against Toxics.
Without the EPA or LAFD data, what is known of the smoke’s toxicity rests on the air district’s mobile monitoring.
Jerrett, the UCLA researcher, said that is not ideal for understanding the kind of plume released by the Boyle Heights fire, which rapidly changed direction with the wind.
“This can in some instances lead to levels that look low, but they are resulting from a mismatch between the location of the vehicle and the plume,” he said.
The Boyle Heights blaze, similar to the Eaton and Palisades fires, has revealed the region’s air monitoring can’t always tell people what they’ve been exposed to in a disaster.
“We do need a better monitoring system in place,” he said.
Local officials are now shifting their focus to the rancid odors from millions of pounds of rotting food in the ruined wing of the warehouse. Decomposing food can release hydrogen sulfide, a toxic gas synonymous with landfills and garbage. Lineage hired contractors who are measuring this noxious gas and other pollution. Their data indicate they have not detected hydrogen sulfide.
As Lineage workers haul the rotting food to local landfills, they are using deodorizing mist and have discussed using shrink wrapping to suppress the stench and minimize issues for nearby homes.
At this point, the odors are believed to be an inconvenience rather than a public health threat, according to Quick, the county medical advisor. She said running air purifiers may help to reduce odors indoors.
“It’s very important for folks to understand that the odors themselves do not indicate any dangerous levels of toxins, mold, bacteria, and so forth,” Quick said. “But the odors are a public nuisance.”
The air district is still encouraging residents to report odors to its online complaint system or by calling (800) 288-7664.
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