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Slow cognitive decline with flavonols, study says | CNN

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Slow cognitive decline with flavonols, study says | CNN

Editor’s Be aware: Join CNN’s Eat, However Higher: Mediterranean Type. Our eight-part information exhibits you a scrumptious expert-backed consuming life-style that can enhance your well being for all times.



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Consuming extra flavonols, antioxidants discovered in lots of greens, fruits, tea and wine, might sluggish your price of reminiscence loss, a brand new research finds.

The cognitive rating of individuals within the research who ate essentially the most flavonols declined 0.4 models per decade extra slowly than those that ate the fewest flavonols. The outcomes held even after adjusting for different components that may have an effect on reminiscence, corresponding to age, intercourse and smoking, in response to the research just lately revealed in Neurology, the medical journal of the American Academy of Neurology.

“It’s thrilling that our research exhibits making particular weight loss plan decisions might result in a slower price of cognitive decline,” mentioned research creator Dr. Thomas Holland, an teacher within the division of inner drugs at Rush College Medical Middle in Chicago, in a press release.

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“One thing so simple as consuming extra vegetables and fruit and consuming extra tea is a straightforward means for folks to take an energetic function in sustaining their mind well being.”

Flavonols are cytoprotective, which means they shield cells, together with neurons, so it’s believable there may very well be a direct impression on cognition, mentioned Dr. David Katz, a specialist in preventive and life-style drugs and diet who was not concerned within the research.

“However they’re additionally a marker of upper consumption of vegetables and fruit — which is sweet for the mind as a result of it’s good for each important organ, and the organism as a complete,” Katz mentioned in an e mail.

“They might even be a marker of higher total weight loss plan high quality, and even larger well being consciousness. People who find themselves extra well being aware might do issues to protect their cognition, or possibly being extra well being aware is a by-product of higher cognition.”

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Crops include over 5,000 flavonoid compounds, which play roles in producing cell development, combating environmental stress and attracting bugs for pollination.

Flavonols, a kind of flavonoid, have been proven in animal and a few human research to scale back irritation, a serious set off for persistent illness, and are wealthy sources of antioxidants. Antioxidants fight free radicals, “extremely unstable molecules which can be naturally fashioned while you train and when your physique converts meals into vitality,” in response to the Nationwide Middle for Complementary and Integrative Well being, a part of the Nationwide Institutes of Well being.

Probably the most frequent flavonols, quercetin, has proven promise in decreasing the onset of colorectal most cancers and different cancers, in response to research. Onions include the very best ranges — decrease ranges may be present in broccoli, blueberries, cauliflower, curly kale, leeks, spinach and strawberries.

One other frequent flavonol, kaempferol, seems to inhibit the expansion of most cancers cells whereas preserving and defending regular cells. Good sources of kaempferol are onions, asparagus and berries, however the richest plant sources are spinach, kale and different inexperienced leafy greens, in addition to herbs corresponding to chives, dill and tarragon.

A 3rd main participant is myricetin, which has been studied in rodents for blood sugar management and the discount of tau, a protein that causes the hallmark tangles of Alzheimer’s and different dementia. Spinach and strawberries include excessive ranges of myricetin, however honey, black currants, grapes and different fruits, berries, greens, nuts and tea are additionally good sources.

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The final group of flavonols, isorhamnetin, might shield towards cardiovascular and neurovascular illness along with anti-tumor and anti inflammatory advantages. Good sources of isorhamnetin are pears, olive oil, wine and tomato sauce.

You will discover a full record of the flavonoid content material of assorted vegetables and fruit right here.

The brand new research requested 961 folks with a median age of 81 and no indicators of dementia to fill out a meals questionnaire annually for seven years. As well as, the members underwent annual cognitive and reminiscence checks and had been quizzed on their time spent being bodily and mentally energetic.

Individuals had been divided into teams primarily based on their each day consumption of flavonols. The bottom consumption was about 5 milligrams a day; the very best 15 milligrams a day — equal to a couple of cup of darkish leafy greens, the research famous. (For comparability, the typical flavonol consumption in US adults is about 16 to twenty milligrams per day, in response to the research.)

The research appeared on the impression of the 4 main flavonols — kaempferol, quercetin, myricetin and isorhamnetin — on the speed of cognitive decline over the seven years.

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The best impression was discovered with kaempferol: Individuals who ate the very best quantities of meals with kaempferol confirmed a 0.4 models per decade slower price of cognitive decline in contrast with those that ate the fewest, in response to the research.

Myricetin was subsequent: Individuals who ate essentially the most meals with myricetin had a 0.3 models per decade slower price of cognitive decline in contrast with the bottom consuming group. Individuals who ate essentially the most meals with quercetin confirmed a 0.2 models per decade slower price of cognitive decline.

Dietary isorhamnetin had no impression, the research discovered.

Regardless of the obvious positives, research on the impression of flavonols on human well being have been inconclusive -— primarily as a result of many are observational and can’t present a direct trigger and impact. That applies to the Neurology research as nicely, in response to its authors.

A number of randomized managed trials — the scientific gold customary — have proven advantages related to flavonols for controlling blood sugar in kind 2 diabetes and bettering cardiovascular well being, in response to the Linus Pauling Institute, house to the Micronutrient Info Middle, a web based database for diet info.

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It’s not identified whether or not these advantages are long run, the institute mentioned, and no clear impression has been proven for most cancers prevention or cognitive safety.

“There are different bioactives that will contribute to the noticed outcomes,” Katz mentioned. “Supplemental research are required to isolate flavonoid results totally.”

There’s additionally a draw back to assuming a well being impression with out the required research to again it up, mentioned Dr. Christopher Gardner, a analysis professor of medication and director of the Vitamin Research Analysis Group at Stanford College.

“You’ll be able to rely on Individuals wanting the advantages of vegetation however not eager to eat them,” he mentioned in an e mail.

“(What) if folks learn the headline and rush out and purchase bottled (extracted) flavonols as an alternative of consuming complete plant meals, and it seems it wasn’t simply the flavonols, however the package deal deal of the whole lot in these vegetation (as an alternative).”

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Congress avoids a shutdown but leaves 'a big mess' for Trump and Republicans in 2025

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Congress avoids a shutdown but leaves 'a big mess' for Trump and Republicans in 2025

WASHINGTON — Congress struck an 11th-hour deal to avert a government shutdown during the holidays, but in the process, it lengthened an already extensive to-do list for the first year of President-elect Donald Trump’s return to office.

The funding bill keeps the government open until March 14. Even though Republicans will control the White House, the House and the Senate, they’ll again need Democratic votes to stop a shutdown in less than three months.

In addition, Trump’s demand that Congress extend or abolish the debt ceiling to take it off his plate next year failed dramatically. On Wednesday, he threatened electoral primary challenges against “any Republican” who voted to fund the government without dealing with the debt limit. On Friday, 170 House Republicans defied him and did just that.

The turmoil of the week previews the legislative chaos that awaits Washington in the second Trump administration when the incoming president faces a wide range of major deadlines and ambitions.

Sen. Ron Johnson, R-Wis., said Republicans made a mistake by punting funding to March 14, and instead should have approved a stopgap bill through the end of next September to clear their plate for Trump’s agenda.

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“I think it’s kind of stupid,” he said of the new deadline. “Don’t ask me to explain or defend this dysfunction.”

Rep. Andy Barr, R-Ky., said late Friday that the “lesson” of the last few days is: “Unity is our strength. Disunity is the enemy of the conservative cause.”

He advised Trump and his team to avoid such a situation in the future by presenting legislative demands “early” so the GOP can “air out whatever differences there are” well before a deadline.

“The House needs to over-communicate within our various factions,” Barr said. “The House needs to over-communicate with [incoming Senate] Majority Leader [John] Thune, and House and the Senate both need to over-communicate with the administration.”

In the last four days, the communication was particularly poor. A day after Speaker Mike Johnson released an initial bipartisan deal, Trump and his billionaire confidant Elon Musk blew it up. The speaker went through three additional iterations of his plan to prevent a shutdown, ultimately succeeding after nixing Trump’s most consequential — and last-minute — demand.

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“I’m concerned,” said Sen. Gary Peters, D-Mich., who faces re-election in 2026. “Obviously, we’ve seen this kind of chaos for the last two years. So I would fully expect we’ll see that continue in the next two years and probably get even worse.”

On Thursday night, Rep. Derrick Van Orden, R-Wis., downplayed what he called a “disjointed process,” saying it’s a natural way for House Republicans and Trump’s team to understand “how to communicate with each other.”

“It’s going to be awesome. You know why it’s going to be awesome? Because now we know how to work together,” Van Orden said just before Speaker Johnson’s Plan B went down in flames in the House.

Van Orden’s fellow Wisconsinite, Sen. Johnson, was less bullish about smoothly plowing through the early part of the 2025 agenda.

“We got a big mess on our hands, no doubt about it,” Johnson said. “That’s why I’m trying to underpromise and hopefully over-deliver.”

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In addition to another government funding deadline and a debt limit that must be addressed by mid-2025 to avert a calamitous default, Trump and Republicans need to confirm his personnel through the Senate, and they want to pass major party-line bills to beef up immigration enforcement and extend his expiring 2017 tax law.

“It’s not going to be boring,” Sen. Ted Cruz, R-Texas, deadpanned when asked about the tasks facing Congress next year.

There’s also the question of Musk’s role after his part in scuttling the original bipartisan funding deal raised hackles across Capitol Hill.

“A lot of people on both sides of the aisle are deeply disturbed by a billionaire threatening people if they don’t vote the right way,” Rep. Debbie Dingell, D-Mich., said.

The tumult of the last week “foretells something very ominous about next year,” Rep. Gerry Connolly, D-Va., said after the House vote, noting that the Republican majority in the lower chamber will be even smaller next year.

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“I think we’re in for a lot of turbulence on the Republican side of the House because of the instability and chaos and disruption that Trump embraces,” Connolly said.

He also wondered whether Republicans will be able to elect a speaker on Jan. 3 with a wafer-thin majority; it took 15 rounds of voting to elect a speaker at the beginning of the last Congress and some hard-right Republicans are wobbly on Speaker Johnson after his handling of the shutdown threat this week.

“So I leave very unsettled tonight in terms of what we just experienced,” Connolly said before the House adjourned for the holidays. “I think it’s very ominous, and it is portentous.”

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US House votes through last-gasp bill to keep government open

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US House votes through last-gasp bill to keep government open

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The US House passed a stop-gap funding measure with just hours to spare on Friday, paving the way for Congress to avert a government shutdown after days of fighting on Capitol Hill.

The bill that passed the House did not include any change to the debt ceiling, defying Donald Trump’s call for the mechanism to be scrapped or increased.

But the measure gained bipartisan support in the chamber, with Democrats joining Republicans to pass the bill 366-34 just after 6pm in Washington — six hours before the deadline.

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The Democratic controlled Senate must now vote on the law before it heads to the desk of President Joe Biden, who will support the legislation, according to the White House press secretary.

Enacting the bill will end a week of volatility in Washington as Trump and his ally Elon Musk flexed their influence over hardline Republicans, pushing them to reject what they said were “giveaways” to Democrats.

Before the bill passed on Friday, Musk expressed his continued disdain for the bill: “So is this a Republican bill or a Democrat bill?”

The measure passed was House Speaker Mike Johnson’s third attempt to get a deal through the chamber after Trump torpedoed the first bipartisan agreement earlier in the week.

The new bill was almost identical to Johnson’s second one, but stripped out any move to raise or suspend the debt ceiling, despite Trump’s demands. It extends government funding at current levels, and provides aid for natural disaster relief and farmers.

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Johnson said after the bill passed that he had been in “constant contact” with Trump and spoken to Musk shortly before the vote and received their blessing.

Trump “knew exactly what we were doing and why and, and this is a good outcome for the country. I think he certainly is happy about this outcome as well”, he told reporters on Capitol Hill.

Johnson said he asked Musk: “‘Hey, you want to be Speaker of the House?’ . . . He said, ‘this may be the hardest job in the world’. It is.”

The passage in the House marked a victory for Johnson, who had vowed earlier in the day that the US would “not have a government shut down”.

A shutdown would temporarily close parts of the government and suspend pay for federal employees. Previous government shutdowns have forced hundreds of thousands of federal workers to be furloughed.

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Democrats also claimed victory, with House minority leader Hakeem Jeffries saying his party “stopped extreme Maga Republicans from shutting down the government”.

He added: “House Democrats have successfully stopped the billionaire boys club, which wanted a $4tn blank cheque by suspending the debt ceiling.”

Trump’s looming presence over the debate has been the biggest complicating factor in frantic negotiations to find a last-minute deal.

But as soon as the vote began, Musk changed his tune, saying that Johnson “did a good job here, given the circumstances. It went from a bill that weighed pounds to a bill that weighed ounces. Ball should now be in the Dem court.”

Democrats, angry that the earlier bipartisan deal was ditched, have blamed Musk for inserting himself in the process this week, triggering more turmoil in Congress just ahead of the US holiday season.

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“At the behest of the world’s richest man who no one voted for, the US Congress has been thrown into pandemonium,” said Democrat Rosa DeLauro about Musk on Thursday.

Some top Republicans also appeared to criticise the interventions by Trump and Musk.

“I don’t care to count how many times I’ve reminded . . . our House counterparts how harmful it is to shut the government down and how foolish it is to bet your own side won’t take the blame for it,” Mitch McConnell, the outgoing Senate Republican leader, said on Friday.

“That said, if I took it personally every time my advice went unheeded, I probably wouldn’t have spent as long as I have in this particular job.”

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What a government shutdown could mean for your holiday travel plans

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What a government shutdown could mean for your holiday travel plans

Holiday travelers wait in line to check their bags at the JetBlue terminal at Boston’s Logan Airport on Friday.

Charles Krupa/AP


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Charles Krupa/AP

With Christmas and Hanukkah just days away, millions of Americans are packing their bags and preparing to hit the road. Meanwhile, Congress is trying — so far unsuccessfully — to find a way to continue funding the government.

The federal government will begin shutdown operations at midnight on Friday if lawmakers can’t pass a stopgap funding bill before then. That would grind certain services, programming and pay for federal workers to a halt, eventually affecting everyday Americans in all sorts of ways.

Could a government shutdown be the Grinch that spoils holiday travel?

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While many federal employees involved in areas like air travel and border control are considered essential and are expected to keep working, a prolonged shutdown could complicate things.

Here’s what to know about planes, trains, automobiles and more.

Air travel could eventually face disruptions

The Transportation Security Administration (TSA) was already bracing for a busy holiday travel season. It expects to screen more than 39 million passengers at airports nationwide between Dec. 19 and Jan. 2.

A shutdown could throw a wrinkle in travelers’ plans, since the TSA is part of the federal government: the Department of Homeland Security.

TSA Administrator David Pekoske said Thursday that about 59,000 of the agency’s more than 62,000 employees are considered essential and would continue working without pay in the event of the shutdown.

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That’s true — at least in theory.

During a five-week partial government shutdown over the 2018-2019 holiday season, scores of TSA employees — as many as 10% of the nationwide workforce — called in sick, prompting long security lines and shuttered checkpoints at some airports.

Pekoske hinted that similar problems could arise if a shutdown persists.

“While our personnel are prepared to handle high volumes of travelers and ensure safe travel, please be aware that an extended shutdown could mean longer wait times at airports,” he tweeted.

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The Federal Aviation Administration (FAA), which is part of the Department of Transportation, says that more than 12,000 air traffic controllers would continue working without pay in the event of a government shutdown.

Hiring and training would be paused, however, according to its operational guidance. The FAA is already experiencing a shortage of air traffic controllers, which experts say strains the system and can exacerbate delays.

Passengers can monitor flight information online and through their airline.

In addition to the standard tips for packing and security, the TSA says travelers can prepare for potential holiday chaos by placing gifts in bags instead of wrapping them and making a plan for traveling with food — especially if they’re hoping to travel with only carry-on luggage, as many experts recommend.

Roads will be busy 

AAA predicts that 119.3 million people across the country will travel more than 50 miles from home between Saturday and Jan. 1, narrowly breaking a record previously set in 2019.

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It projects that 90% of those travelers — amounting to more than 107 million people — will be making their trip by car. And because both Christmas and New Year’s Day fall on a Wednesday, it warns that traffic is likely to be especially bad on the weekends.

“There’s no set one day that’s going to be the busiest at the airports or the worst on the roads, but it’s going to be those two weekends for sure,” AAA’s Aixa Diaz told NPR’s Morning Edition this week.

That said, AAA has a list of the best and worst times to drive during the holiday period (unsurprisingly, Tuesdays and Wednesdays are the winners). And regardless of timing, it urges drivers to follow posted speed limits, slow down and move over for emergency responders, and drive only when alert.

“Driving on 4-5 hours of sleep is as dangerous as driving with a 0.08 BAC (legal intoxication),” it warns. “Less than 4 hours of sleep? The risk doubles.”

AAA advises avoiding overnight drives, heavy meals, medications that cause drowsiness and alcohol. It encourages drivers to take breaks every two hours or 100 miles, using those pauses to take a 20-30 minute nap or switch drivers if possible.

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Train service is expected to continue 

While Amtrak is a for-profit company, it does receive some funding from federal and state governments. That’s not likely to be disrupted in the event of a government shutdown.

“Passengers planning to travel on Amtrak trains in the Northeast Corridor and across the country in the coming days and weeks can be assured that Amtrak will remain open for business,” Amtrak spokesperson W. Kyle Anderson told NPR over email Friday.

However, Amtrak can’t operate indefinitely without receiving disbursements of funding, the Rail Passengers Association said in a statement this week. It warns that a prolonged shutdown “will degrade service, while also slowing down upgrades being funded by the Bipartisan Infrastructure Law.”

Passport processing and border security will be largely unaffected 

The inspection and law enforcement personnel at Customs and Border Protection are considered essential, meaning that ports of entry will be open and processing of passengers will continue as usual, according to the American Immigration Lawyers Association (AILA).

While Americans still waiting on passport renewals are cutting it close for Christmas, a shutdown is not likely to further prolong that process.

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The State Department’s visa and passport operations are funded by fees and therefore “not normally impacted by a lapse in appropriations,” the AILA explains.

The department’s 2023 contingency plans say that consular operations — both domestically and abroad — will remain “100% operational as long as there are sufficient fees to support operations.”

However, it says access to passport services could be suspended in certain government buildings run by agencies that have been put on pause. Luckily, Americans can now renew their passports online.

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