Health
With ‘How to Change Your Mind,’ Taking a Trip With Michael Pollan

In late 2012, the best-selling writer and journalist Michael Pollan (“The Omnivore’s Dilemma”) was at a cocktail party in Berkeley, Calif. Amongst his fellow diners was a distinguished developmental psychiatrist, in her 60s, who spoke at some size a couple of latest LSD journey. This pricked up Pollan’s ears.
His first thought, as he shared throughout a latest video interview: “Folks like that are taking LSD?” The psychiatrist went on to elucidate that the drug gave her a greater understanding of the best way kids suppose.
“Her speculation,” Pollan stated, “was that the results of psychedelics, LSD in that case, give us a style of what baby consciousness can be like — this type of 360-degree taking-in of data, not notably centered, fascinated by every thing.”
Pollan had already heard about medical trials through which medical doctors had been giving most cancers sufferers psilocybin to assist them take care of their worry of demise. Now, he was actually interested in psychedelic remedy. That curiosity turned an article in The New Yorker (“The Journey Therapy,” 2015). The article turned a e book, “Find out how to Change Your Thoughts” (2019).
And now the e book has change into a four-part Netflix collection of the identical identify, which debuted Tuesday. Pollan is an govt producer (together with the Oscar-winning filmmaker Alex Gibney) and the first on-camera presence.
A considerate and wide-ranging take a look at psychedelic remedy, the collection is grounded in accounts of their centuries-long sacramental use and of their uneasy historical past in trendy society, particularly in the USA. Specifically, it focuses on 4 substances — LSD, mescaline, MDMA (generally known as Ecstasy or Molly) and psilocybin (the energetic ingredient in magic mushrooms) — and the methods through which they’re getting used to deal with sufferers with maladies together with post-traumatic stress dysfunction, dependancy, despair, anxiousness and obsessive-compulsive dysfunction.
A kind of sufferers is Lori Tipton, a New Orleans lady who endured a Job-like run of sick fortune. Her brother died of an overdose. Her mom murdered two individuals after which killed herself; Tipton discovered the our bodies. She was raped by an acquaintance. Not surprisingly, she developed extreme PTSD.
“I actually felt like I couldn’t entry pleasure in my life, even when it was proper in entrance of me,” Tipton stated in a video interview. She thought of suicide continuously. When she heard a couple of medical trial for MDMA, held in 2018, she figured she had nothing to lose.
I can relate to a few of this. A couple of years again I used to be identified with PTSD and medical despair after my life accomplice, Kate, was identified with a terminal mind illness and died about 18 months later, in 2020. I didn’t have a lot curiosity in dwelling. Operating out of choices, my physician prescribed me a weekly routine of esketamine, which is a detailed relative of the dissociative hallucinogen ketamine.
Like many, I had experimented with hallucinogens, together with mushrooms and LSD, in my youth. I used to be partying, not searching for. I by no means deliberate to return there. However the remedy began serving to me virtually instantly.
Pollan, 67, by no means did the youthful experimenting. Identified primarily as an knowledgeable in vegetation and wholesome consuming — his newest e book, “That is Your Thoughts on Crops,” comes out in paperback on July 19 — he got here to psychedelics late in life. He was too younger to indulge within the Summer season of Love, and by the Nineteen Seventies, the struggle on medicine and anti-LSD hysteria had quashed what had been a fertile interval of scientific analysis within the ’50s.
However as soon as he started learning, and experimenting, he turned a convert relatively rapidly.
“At this age typically it’s essential to be shaken out of your grooves,” he says within the Netflix collection. “We now have to consider these substances in a really cleareyed manner and throw out the inherited desirous about it and ask, ‘What is that this good for?’”
Tall and bald with the construct of a swimmer, Pollan is not any Timothy Leary — he isn’t asking anybody to drop out — and the medical trials described and proven in “Find out how to Change Your Thoughts” shouldn’t be confused with Ken Kesey’s freewheeling acid exams of the ’60s. Again then, when psychedelics left the laboratory and entered the counterculture, the facility construction freaked out.
“Children had been going to communes, and American boys had been refusing to go to struggle,” Pollan stated. “President Nixon actually believed that LSD was accountable for lots of this, and he could effectively have been proper. It was a really disruptive drive in society, and that’s the reason I believe the media after 1965 turns towards it after being extremely enthusiastic earlier than 1965.”
Junk science unfold nonsense about LSD scrambling chromosomes. The drug was made unlawful in California in 1967, after which nationally in 1970. Researchers weren’t forbidden from persevering with their work with psychedelics, however the stigma made such work very uncommon till it re-emerged within the 2000s. In the present day, medical trials are accredited by the F.D.A. and D.E.A.
“From the early ’70s to the early ’90s, there was no accredited psychedelic analysis in human topics,” stated Charles Grob, a professor of psychiatry and pediatrics at U.C.L.A., who has written extensively about psychedelic remedy. “Since then, analysis improvement has re-emerged and slowly advanced, till the previous couple of years when skilled and public curiosity within the matter seems to have exploded.”
Given evolving attitudes, one problem dealing with the filmmakers, together with the administrators Alison Ellwood and Lucy Walker, was the way to depict the psychedelic expertise in a classy manner, with out stumbling into the territory of a ’60s exploitation film.
“We didn’t wish to fall into the lure of utilizing psychedelic visible tropes — wild colours, rainbow streaks, morphing photographs,” Ellwood wrote in an electronic mail. “We wished to maintain the visible type extra private, intimate and experiential. We wished individuals watching the collection who haven’t had their very own psychedelic experiences to have the ability to relate to the visuals.”
One imaginative scene recreates the well-known bicycle journey taken by the Swiss chemist Albert Hofmann, who first synthesized LSD in 1936 however didn’t uncover its psychedelic results till 1943 (unintentionally). Feeling unusual after ingesting 250 micrograms, Hofmann rode his bike in the course of the peak of his journey. In “Find out how to Change Your Thoughts,” we see the buildings round him bend and waver as he rides. The highway beneath him blurs. The tombstones in a graveyard sway.
Tipton’s expertise in her medical MDMA trials was extra managed however no much less profound. The outcomes after three periods, she stated, had been past what she may have imagined.
“Because the periods progressed, I labored with the therapists to stay embodied and absolutely current to my feelings as I recalled a few of the most troublesome experiences of my life,” Tipton stated. “In doing this, I used to be capable of finding a brand new perspective, one which had eluded me for years. And from this place I may discover empathy, forgiveness and understanding for many individuals in my life, however most significantly for myself.”
Her descriptions sounded acquainted. In 2020, I started going to my physician’s workplace as soon as every week to ingest three nasal spray inhalers and sit for 2 hours, pausing solely to have my blood strain taken midway by way of. I didn’t hallucinate, however I discovered myself conversing with Kate as if she had been within the room.
I noticed my grief as one thing separate from my being, one thing extra akin to like than demise. I didn’t establish with my ache in the identical manner.
It was, with out query, a non secular expertise. Then, two hours later, a bit groggy however in any other case again to regular, I used to be able to go dwelling. After a number of such periods, mixed with speak remedy, I began to see a lightweight on the finish of the tunnel. Esketamine is technically not a psychedelic, but it surely had actually modified my thoughts.
It’s protected to say Pollan’s has modified, too. He not too long ago turned a co-founder of the College of California Berkeley Middle for the Science of Psychedelics. A portion of his writer web site now serves as an informational clearinghouse for individuals trying to study extra. Phrase of his effort seems to be spreading. His e book on the topic was name-checked on a latest episode of the HBO Max collection “Hacks.” The Netflix collection has already cracked the streamer’s High 10 in the USA.
Little by little, the nation’s legal guidelines are starting to mirror evolving attitudes. Final yr, Oregon voters accredited a poll initiative that directs the Oregon Well being Authority to license and regulate “psilocybin merchandise and the availability of psilocybin companies.” Colorado seems more likely to vote on an identical initiative this fall.
For Pollan, such efforts strike a private nerve.
“The ego is a membrane between you and the world,” he stated. “It’s defensive and it’s very helpful. It will get quite a bit completed, but it surely additionally stands between us and different issues and offers us this subject-object duality. When the ego is gone, there may be nothing between you and the world.”
“Getting perspective in your ego is one thing you’re employed at in psychotherapy,” he added. “However this occurred for me in the middle of a day, and that’s what’s exceptional about it.”

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Alzheimer's disease could be prevented by antiviral drug already on market

An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers.
NRTIs (nucleoside reverse transcriptase inhibitors) are antivirals that are approved to treat HIV infection, but scientists from UVA Health at the University of Virginia found that patients taking them were less likely to develop the common form of dementia.
There was a roughly 10% annual reduction in the risk of developing Alzheimer’s disease in people taking NRTIs for every year of use of these drugs, according to lead study author Dr. Jayakrishna Ambati, M.D., professor of ophthalmology at UVA, who spoke to Fox News Digital about the finding.
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After coming across another mechanism that could potentially prevent Alzheimer’s, the researchers analyzed 24 years of health insurance data, including 270,000 patients.
The Alzheimer’s risk reduction among patients taking NRTIs was “significant and substantial,” the researchers wrote in the findings, which were published in the journal Alzheimer’s & Dementia.
An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers. (iStock)
Now, the UVA team is calling for clinical trials of NRTIs to gauge their use for treating Alzheimer’s.
Approximately 10 million people worldwide are diagnosed with the common dementia each year.
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“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” Ambati told Fox News Digital.
In addition to keeping the HIV virus from replicating, NRTIs also prevent the activation of inflammasomes, proteins that are involved in the development of Alzheimer’s.

“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” the lead study author told Fox News Digital. (iStock)
“We had previously shown that NRTIs blocked the inflammasome, so it wasn’t altogether surprising that people taking NRTIs might be protecting against this disease,” Ambati noted.
“However, the degree of protection against Alzheimer’s was quite surprising.”
“It is very possible that this drug may be useful in Alzheimer’s prevention.”
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, was not involved in the study but commented on the findings.
“Inflammasomes are intracellular protein complexes that trigger the release of inflammatory cytokines,” he told Fox News Digital. “HIV uses these inflammasomes to fight the immune system.”

Repurposing existing drugs can offer a “promising pathway,” according to an expert from the Alzheimer’s Association. (iStock)
“These chemicals are likely responsible for making Alzheimer’s worse, or for accelerating the process of cognitive decline based on neuro-inflammation.”
Rebecca Edelmeyer, Ph.D., vice president of Scientific Engagement at the Alzheimer’s Association in Chicago, also reviewed the study’s findings, which she called “interesting.”
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“Further research and specifically designed clinical trials are needed to fully understand the potential future use of NRTIs to reduce the risk of Alzheimer’s, but the study highlights the potential role drug repurposing can play in advancing new Alzheimer’s treatments,” she told Fox News Digital.
Repurposing existing drugs can offer a “promising pathway,” according to Edelmayer. As existing drugs’ safety and side effects are often already known, the studies can be quicker and less expensive than with new treatments, she added.
Potential limitations and next steps
The research team acknowledged some limitations of the study.
“Like all retrospective health insurance database studies, the findings of our study are an association between this class of drugs and the development of Alzheimer’s disease,” Ambati told Fox News Digital.
“They don’t necessarily provide a cause and effect — however, the fact that we found this link in multiple databases increases confidence in this result.”
Siegel agreed that the new study is observational, but noted that it takes place over many years.
“It also shows that only this particular HIV drug — inflammasome — dramatically decreases the risk of Alzheimer’s, not the other HIV drugs, including protease inhibitors,” the doctor said.

Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association. (iStock)
“I think this is convincing preliminary evidence that warrants further study,” Siegel added. “It is very possible that this drug may be useful in Alzheimer’s prevention, given the increasing evidence implicating immune dysregulation and inflammation as causes of AD.”
Looking ahead, the researchers have developed a new drug called K9. Like NRTIs, the novel medication blocks inflammasomes, but is “safer and more effective,” according to Ambati.
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“The fact that the new drug reversed memory loss and improved spatial learning in mice further increases confidence in our findings,” he told Fox News Digital.
The UVA team now plans to test K9 in clinical trials for Azheimer’s.

The study author cautioned that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial. (iStock)
Ambati noted that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial.
“If interested, they should be on the lookout for such trials for themselves or loved ones who may be affected,” he advised.
For more Health articles, visit www.foxnews.com/health
Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association.
The UVA study was funded in part by the UVA Strategic Investment Fund and the National Institutes of Health.
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