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Alzheimer's disease could be prevented by antiviral drug already on market

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Alzheimer's disease could be prevented by antiviral drug already on market

An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers.

NRTIs (nucleoside reverse transcriptase inhibitors) are antivirals that are approved to treat HIV infection, but scientists from UVA Health at the University of Virginia found that patients taking them were less likely to develop the common form of dementia.

There was a roughly 10% annual reduction in the risk of developing Alzheimer’s disease in people taking NRTIs for every year of use of these drugs, according to lead study author Dr. Jayakrishna Ambati, M.D., professor of ophthalmology at UVA, who spoke to Fox News Digital about the finding.

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After coming across another mechanism that could potentially prevent Alzheimer’s, the researchers analyzed 24 years of health insurance data, including 270,000 patients.

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The Alzheimer’s risk reduction among patients taking NRTIs was “significant and substantial,” the researchers wrote in the findings, which were published in the journal Alzheimer’s & Dementia.

An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers. (iStock)

Now, the UVA team is calling for clinical trials of NRTIs to gauge their use for treating Alzheimer’s.

Approximately 10 million people worldwide are diagnosed with the common dementia each year.

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“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” Ambati told Fox News Digital. 

In addition to keeping the HIV virus from replicating, NRTIs also prevent the activation of inflammasomes, proteins that are involved in the development of Alzheimer’s.

“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” the lead study author told Fox News Digital. (iStock)

“We had previously shown that NRTIs blocked the inflammasome, so it wasn’t altogether surprising that people taking NRTIs might be protecting against this disease,” Ambati noted. 

“However, the degree of protection against Alzheimer’s was quite surprising.”

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“It is very possible that this drug may be useful in Alzheimer’s prevention.”

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, was not involved in the study but commented on the findings.

“Inflammasomes are intracellular protein complexes that trigger the release of inflammatory cytokines,” he told Fox News Digital. “HIV uses these inflammasomes to fight the immune system.”

Repurposing existing drugs can offer a “promising pathway,” according to an expert from the Alzheimer’s Association. (iStock)

“These chemicals are likely responsible for making Alzheimer’s worse, or for accelerating the process of cognitive decline based on neuro-inflammation.”

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Rebecca Edelmeyer, Ph.D., vice president of Scientific Engagement at the Alzheimer’s Association in Chicago, also reviewed the study’s findings, which she called “interesting.”

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“Further research and specifically designed clinical trials are needed to fully understand the potential future use of NRTIs to reduce the risk of Alzheimer’s, but the study highlights the potential role drug repurposing can play in advancing new Alzheimer’s treatments,” she told Fox News Digital. 

Repurposing existing drugs can offer a “promising pathway,” according to Edelmayer. As existing drugs’ safety and side effects are often already known, the studies can be quicker and less expensive than with new treatments, she added.  

Potential limitations and next steps

The research team acknowledged some limitations of the study.

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“Like all retrospective health insurance database studies, the findings of our study are an association between this class of drugs and the development of Alzheimer’s disease,” Ambati told Fox News Digital.

“They don’t necessarily provide a cause and effect — however, the fact that we found this link in multiple databases increases confidence in this result.”

Siegel agreed that the new study is observational, but noted that it takes place over many years.

“It also shows that only this particular HIV drug — inflammasome — dramatically decreases the risk of Alzheimer’s, not the other HIV drugs, including protease inhibitors,” the doctor said.

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Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association.  (iStock)

“I think this is convincing preliminary evidence that warrants further study,” Siegel added. “It is very possible that this drug may be useful in Alzheimer’s prevention, given the increasing evidence implicating immune dysregulation and inflammation as causes of AD.”

Looking ahead, the researchers have developed a new drug called K9. Like NRTIs, the novel medication blocks inflammasomes, but is “safer and more effective,” according to Ambati.

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“The fact that the new drug reversed memory loss and improved spatial learning in mice further increases confidence in our findings,” he told Fox News Digital.

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The UVA team now plans to test K9 in clinical trials for Azheimer’s.

The study author cautioned that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial.  (iStock)

Ambati noted that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial. 

“If interested, they should be on the lookout for such trials for themselves or loved ones who may be affected,” he advised.

For more Health articles, visit www.foxnews.com/health

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Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association. 

The UVA study was funded in part by the UVA Strategic Investment Fund and the National Institutes of Health.

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take


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I Tried the Viral Gelatin Weight-Loss Recipe: Does It Really Work?




















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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Medicare fraud is a multibillion-dollar problem that government officials say threatens both taxpayer dollars and Americans’ personal identities.

In a July 6 interview with Fox News Digital at the Great American State Fair in Washington, D.C., Dr. Mehmet Oz warned that every dollar stolen through Medicare fraud is a dollar taxpayers lose – a problem that has worsened since the COVID pandemic.

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz, who is the administrator of the Centers for Medicare & Medicaid Services. “And just to put this in perspective, we think it’s about $100 billion a year.”

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Medicare fraud can include billing for services that were never provided, overcharging for medical equipment, using stolen patient or doctor information, or performing unnecessary procedures, according to the U.S. Government Accountability Office.

CMS administrator Dr. Mehmet Oz is pictured on stage at the Great American State Fair in Washington, D.C., on July 6, 2026. (Angelica Stabile/Fox News Digital)

As the Trump administration ramped up efforts to combat fraud, CMS reported $41.9 billion in Medicare program integrity savings in 2025, up 59% from $26.3 billion in 2024.

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Medicare fraud not only harms the federal budget and steals from taxpayers, but exposes seniors to identity theft, unnecessary care, higher premiums and reduced access, Oz cautioned.

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Removing corruption from the healthcare system will have the greatest impact among seniors, since “so much of the fraud is perpetrated against them,” the administrator said.

“I’m talking about people tricking seniors to give up their Medicare beneficiary numbers, which is like a credit card basically,” he said. “These scammers can take those numbers and use them for all kinds of illegitimate purposes.”

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz. (Fox News Digital)

“People are stealing from you by pretending to send you drugs you don’t want, wheelchairs you don’t need, [and] services you never asked for or don’t benefit from,” Oz added.

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To prevent this, he shared his top advice for seniors: Do not give your Medicare beneficiary number to anybody, do not answer questions on a phone call from an unknown person and do not give away personal information.

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“These scammers are calling seniors, tricking them, and once they have key information, they can steal it,” he said. “And I won’t know it and you won’t know it.”

“We want to protect people who need these programs the most,” Oz went on. “You do that by making sure scoundrels don’t corrupt the systems and steal money out of the till that is designed to help folks in dire straits when they’re vulnerable and in need of services.”

Seniors should never share their Medicare information with unknown people, the administrator advised. (iStock)

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Removing fraud could “double the life expectancy of the trust fund that makes all this possible,” Oz predicted.

“If you’re worried about Medicare being there when you’re ready to retire in a couple decades, depending on how old you are, and you’re concerned that it might not last because of all the fraud that’s hitting it … you’ve got a good [reason to] worry,” he said.

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“If we take the fraud out, we could double the life expectancy, which means you, your kids, your kids’ kids … they could all benefit from this beautiful safety net program.”

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