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Cystic fibrosis patients are living much longer: Good news for patients revealed in new study

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Cystic fibrosis patients are living much longer: Good news for patients revealed in new study

A new study from Epic Research, a health analytics firm based in Verona, Wisconsin, detected some encouraging news for those who suffer from cystic fibrosis (CF). 

In 2008, the average life expectancy among CF patients was 26 years — 65% lower than those without the disease.

As of 2022, the life expectancy is 66 years — or just 12% lower than the non-CF population, the study found.

“This is an 82% reduction of the gap in life expectancy between patients with CF and those without,” the study said.

CYSTIC FIBROSIS PATIENTS, DOCTORS CELEBRATE FDA’S ‘LIFE-CHANGING’ APPROVAL OF NEW TREATMENT

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“These findings suggest that the advancements in cystic fibrosis treatment and therapies are associated with a substantial increase in life expectancy for patients diagnosed with cystic fibrosis,” the authors wrote in a discussion of the findings.

The reasons for the dramatic improvement include better diagnoses, treatments and comprehensive care programs for cystic fibrosis, said Jackie Gerhart, chief medical officer at Epic Research and a family medicine physician.

“A diagnosis (of CF) can now be made earlier due to advanced diagnostic testing,” a chief medical officer (not pictured) told Fox News Digital.  (iStock)

“A diagnosis can now be made earlier due to advanced diagnostic testing, and comprehensive care centers have allowed for individualized therapy for complications of cystic fibrosis and for complications of general aging in cystic fibrosis patients,” she told Fox News Digital. 

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“There are also new therapeutic options that not only help treat cystic fibrosis, but also treat infections that CF patients are more susceptible to, such as pneumonia,” she said. 

woman coughing

Cystic fibrosis is a “progressive, genetic disease that affects the lungs, pancreas and other organs,” according to the Cystic Fibrosis Foundation. (iStock)

In the study, investigators looked at the median age of death between 2008 and 2022 for 3,420 people with cystic fibrosis and 4.8 million people without the disease. 

The life expectancy remained “fairly consistent” for the latter group, according to a discussion of the study findings, with a median of 75 years in both 2008 and 2022. 

LOWER RESPIRATORY INFECTIONS WHEN YOUNG COULD BE LINKED TO EARLIER ADULT DEATHS: STUDY

Cystic fibrosis is a “progressive, genetic disease that affects the lungs, pancreas and other organs,” according to the Cystic Fibrosis Foundation.

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People with the disease have a genetic mutation that creates an abnormal protein, which causes a buildup of mucus in various organs. 

“New therapies called modulators help improve the symptoms of patients.”

When this mucus accumulates in the lungs, it makes it difficult to breathe and also traps germs that can lead to infections, inflammation and respiratory failure, CFF states on its website.

The disease can also hinder the functioning of the pancreas — leading to malnutrition and stunted growth — and the liver, which can cause liver disease.

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“New therapies called modulators help improve the symptoms of patients with this abnormal protein,” said Gerhart. “The most common cause for deaths in cystic fibrosis patients is respiratory failure, so many therapies are targeted to decrease that.”

With earlier diagnosis and new genetic advances for both diagnosis and treatment, the life expectancy for cystic fibrosis will continue to rise, Gerhart expects. 

Lung diagram

For patients with cystic fibrosis (CF), when mucus accumulates in the lungs, it makes it difficult to breathe — and also traps germs that can lead to infections, inflammation and respiratory failure. (iStock)

“There are now multiple genetic screening tests available for newborns to help diagnose cystic fibrosis,” she told Fox News Digital.

“Patients who are diagnosed should consider a comprehensive care program and take precautions against infections, including immunizations when appropriate.”

In the U.S., there are some 40,000 children and adults living with cystic fibrosis.

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Common symptoms of the disease include persistent coughing with phlegm, salty-tasting skin, frequent lung and sinus infections, wheezing or shortness of breath, stunted growth, trouble gaining weight, difficulty with bowel movements, the presence of nasal polyps and rectal prolapse, according to CFF. 

In men, the disease can cause infertility.

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).

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Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).

TO REDUCE CANCER RISK, SKIP THE ALCOHOL, REPORT SUGGESTS

“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research. (iStock)

“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”

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Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.

Addiction expert warns of risks

There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.

“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.

‘DOES SMARTPHONE EXPOSURE CAUSE BRAIN CANCER?’: ASK A DOCTOR

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli. 

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The more someone drinks — both in volume and frequency — the higher the risk, he warned.

Doctor holding lung x-ray and woman smoking

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%). (iStock)

“Alcohol is a toxin,” Scioli said. 

“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”

Is there a ‘safe’ amount?

Moderate alcohol use is defined as one drink or less in one day for women. 

For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).

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“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”

“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.

“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”

      

Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”

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“The line between safety and danger is debatable, and is different for each person.”

While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.

alcoholic beverages

Moderate alcohol use is defined as one drink or less in one day for women, and two drinks or fewer for men, per the CDC. (iStock)

Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.

“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.

What needs to change?

The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk. 

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As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.

cancer patient looks out window

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, an expert said. (iStock)

“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said. 

“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”

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To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”

Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight


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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

A new drug has been approved for the treatment of schizophrenia in adults.

On Thursday, the U.S. Food and Drug Administration (FDA) approved COBENFY (xanomeline and trospium chloride), an oral medication that is manufactured by Bristol Myers Squibb in New Jersey.

This marks the first new class of medications for the brain disorder in several decades, according to a press release.

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COBENFY is expected to be available in the U.S. in late October, the company noted.

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A new drug has been approved for the treatment of schizophrenia in adults. (iStock)

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb, in the press release.

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Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors.

It often causes hallucinations, delusions, disordered speech and loss of touch with reality, Mayo Clinic states on its website.

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COBENFY

COBENFY (xanomeline and trospium chloride) is an oral medication that is manufactured by Bristol Myers Squibb in New Jersey. (Bristol Myers Squibb)

The disorder can also lead to lack of emotional expression, lack of motivation, cognitive dysfunction and social withdrawal.

Approximately 2.8 million people in the U.S. and 24 million people globally are living with schizophrenia.

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The disorder has traditionally been treated with antipsychotic medications, but around 40% of patients do not respond to treatments and 60% experience “inadequate improvement” in symptoms or “intolerable side effects,” studies have shown.

COBENFY

COBENFY is expected to be available in the U.S. in late October, the company noted. (Bristol Myers Squibb)

COBENFY works differently than the currently available schizophrenia medications.

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“Due to its heterogeneous nature, schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies,” said Rishi Kakar, MD, chief scientific officer and medical director at Segal Trials and investigator in the drug’s clinical trials, in the release. 

“Schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies.”

“The approval of COBENFY is a transformative moment in the treatment of schizophrenia because, historically, medicines approved to treat schizophrenia have relied on the same primary pathways in the brain.”

“By leveraging a novel pathway, COBENFY offers a new option to manage this challenging condition.”

Bristol Myers Squibb

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb. (iStock)

Sam Clark, founder and CEO at Terran Biosciences — a biotech company that develops treatments and technologies for neurological and psychiatric diseases in New York City — commented on the new approval in a statement sent to Fox News Digital.

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“I am excited that the FDA has just approved [COBENFY] as a treatment for patients with schizophrenia, marking a big leap forward in the psychiatry space,” he said. 

      

“These patients live with a difficult disease, and this drug with a novel mechanism of action will surely make a significant impact,” Clark continued. 

“We look forward to seeing the renaissance continue as this approval paves the way for future breakthroughs and novel patient-focused therapeutics.”

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The approval follows three phases of clinical trials in which COBENFY was shown to result in a “statistically significant improvement in illness.”

schizophrenia split

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors and often causes hallucinations and delusions. (iStock)

In terms of safety, the medication’s most common side effects during clinical trials were nausea, indigestion, vomiting, diarrhea, constipation, hypertension, abdominal pain, accelerated heart rate, dizziness and gastroesophageal reflux disease, the release stated.

Patients with certain existing medical conditions may experience other, more serious risks.

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People should discuss potential complications with a doctor before starting the medication.

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Fox News Digital reached out to Bristol Myers Squibb and the Schizophrenia & Psychosis Action Alliance requesting comment.

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