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Use of Wegovy and other weight-loss drugs soars among kids and young adults

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Use of Wegovy and other weight-loss drugs soars among kids and young adults

At 17, Israel McKenzie was so burdened by obesity that he stopped going to high school in person and was embarrassed to speak to people at his restaurant job.

“I was in a really dark place,” says McKenzie, whose weight had climbed to 335 pounds on his 6-foot-1 frame, despite repeated efforts to diet and exercise. “I had given up hope.”

But last year, the weight-loss drug Wegovy helped him shed 110 pounds in nine months, making the rural Tennessee teen part of a surge of adolescents and young adults using diabetes and obesity medications known as GLP-1 receptor agonists, new research shows.

Even as millions of older adults clamor for drugs such as Ozempic and Wegovy, monthly use of the medications soared in people aged 12 to 25. That’s according to the new analysis of dispensing records from nearly 94% of U.S. retail pharmacies from 2020 to 2023.

The report, published in the journal JAMA on Wednesday, used the IQVIA prescription database to compile the first look at the national uptake of GLP-1 drugs among that age group. Nearly 31,000 children aged 12 to 17 and more than 162,000 people aged 18 to 25 used the medications in 2023 alone, said Dr. Joyce Lee, a University of Michigan pediatrician and diabetes expert who led the research.

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“What it’s suggesting is that it’s one of the tools in the toolbox and there are more providers prescribing this medication for the population,” she said.

The report shows that the number of 12- to 25-year-olds using any GLP-1 drug — including older medications first approved to treat diabetes in 2005 and for weight loss in 2014 — climbed from about 8,700 a month in 2020 to more than 60,000 a month in 2023, a nearly 600% increase. The rise occurred even as prescriptions of other drugs among those patients fell by about 3%.

Those who received the drugs were just a fraction of young people who struggle with obesity, Lee noted. About 20% of U.S. children and adolescents and about 42% of adults have the chronic disease, according to the U.S. Centers for Disease Control and Prevention.

In early 2023, the American Academy of Pediatrics recommended that children and teens with obesity be evaluated early and treated aggressively, including with surgery and medication if warranted.

McKenzie, the Tennessee teen, said he began gaining weight five years ago, during puberty.

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“I started turning to food for all of my problems,” he said.

The extra weight made his asthma worse and put him in danger of developing diabetes, his doctor said. He tried to follow medical advice by cutting out sugary soda and snack foods and exercising more, but the efforts failed to make a difference.

“My old doctor told me there was nothing he could do,” he said. “He told me it was my fault.”

In early 2023, McKenzie connected with Dr. Joani Jack, a pediatric obesity specialist at Children’s Hospital at Erlanger in Chattanooga, Tennessee, who regularly prescribes GLP-1 drugs for kids.

“I told him I’ve seen 10 other people just like you today and we have lots of tools and treatment options,” Jack said. Those typically include intensive behavioral and nutrition interventions combined with medication, if necessary.

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In McKenzie’s case, Jack prescribed the weight-loss drug Wegovy, which in late 2022 was approved for use in U.S. children over age 12. More than 6,000 kids in that age group received Wegovy in 2023, the new data show. More than 7,600 received Ozempic, which is approved to treat diabetes in adults, but can be used off-label in adolescents. Others received older GLP-1 drugs such as Saxenda and Trulicity.

McKenzie said he had no notable side effects from the medication, but Lee noted that some young people report nausea, vomiting or constipation, including symptoms so serious that they stop the drugs.

It’s important to understand the surging use of these medications in young people, Lee said. The drugs are meant for continuing use, so “we really need to think about the long-term safety and effectiveness of these medications for this population,” she said.

In addition, the drugs are expensive and often difficult to obtain, either because of supply problems or because they’re not covered by insurance.

Notably, government-run Medicaid plans paid for nearly half of the GLP-1 drugs prescribed to 12- to 17-year-olds and about a quarter of those used by people aged 18 to 25, the research found. Commercial insurance covered care for nearly 44% of the younger kids and about two-thirds of those who were older.

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Today, McKenzie says his asthma is better and he looks forward to interacting with co-workers and friends.

“I have a lot of self-confidence now, a lot more than I used to,” he said. “It has changed everything.”

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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Israel’s focus on political drama rather than Palestinian rape victim

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Israel’s focus on political drama rather than Palestinian rape victim

The revelation last week by Israel’s top military lawyer, Major General Yifat Tomer-Yerushalmi, that she leaked the footage of a gang rape of a Palestinian detainee at the Sde Teiman military detention centre in 2024 has shaken the country’s political and media establishment.

Israeli Prime Minister Benjamin Netanyahu – whose leadership of the genocidal war on Gaza has drawn global condemnation – called the leak “perhaps the most severe public relations attack that the State of Israel has experienced”. Critics of Netanyahu’s view come from establishment voices desperate to defend the judiciary and state institutions, which they believe Netanyahu and his allies are exploiting the leak to undermine.

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Lost amid headlines fuelled by the leak’s admission is the gang rape of the Palestinian prisoner at Sde Teiman on July 5, 2024. The attack was so brutal that the man was admitted to hospital with what the Israeli daily Haaretz revealed was a ruptured bowel, severe anal and lung injuries, and broken ribs – injuries that later required surgery.

“It’s a huge story in Israel, but you won’t see the word ‘rape’ anywhere in it,” Orly Noy, editor of the Hebrew language Local Call, told Al Jazeera. “The contextualisation of the story is entirely different here than anything you or I might see.”

Instead of focusing on the rape and the ongoing legal proceedings against the five suspects, the story has instead centred on Tomer-Yerushalmi and those accused of helping her cover up the leak.

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Speaking on Israeli television on Saturday night, a member of Netanyahu’s Likud Party, Energy Minister Eli Cohen, told viewers that Tomer-Yerushalmi was “supposed to be the bulletproof vest, the protector, of the [Israeli military] soldiers”.

“Instead of that, she stabbed them in the back,” he said about the lawyer who leaked footage of soldiers appearing to rape a prisoner. “In this case, we are talking about treason.”

Defence Minister Israel Katz was no less damning, releasing at least seven statements targeting the military attorney in a week and accusing her of participating in “blood libel” against the five alleged rapists.

The politicisation of rape

Focusing on Tomer-Yerushalmi, rather than the alleged rapists, is nothing new.

The former chief military advocate had been the subject of political pressure and accusations of covering up the source of the leak since the first reports of the rape emerged in August 2024. That pressure continued to build, culminating in the announcement from Attorney General Gali Baharav-Miara in early October of an investigation into the source of the leak.

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On Friday, November 1, Tomer-Yerushalmi resigned and admitted that she had been the source of the leak. Two days later, she was reported missing for several hours following the discovery of what friends and family worried was a suicide note, which prompted a large-scale search.

Israel’s Defence Minister Israel Katz said the leaked footage showing the alleged rape of a Palestinian prisoner by soldiers was ‘blood libel’ against the attack’s perpetrators [Ronen Zvulun/Reuters]

Within hours of being found safe, Tomer-Yerushalmi was arrested, and the suicide note was dismissed by Israeli prosecutors as a ploy. She has been charged with multiple offences, including fraud, breach of trust, obstruction of justice, and abuse of office.

Since Sunday, police have also arrested the military’s former chief prosecutor, Colonel Matan Solomosh, on suspicion of helping Tomer-Yerushalmi cover up the leak. There have also been suggestions that the attorney general and her staff may have been involved.

“Rape doesn’t matter,” said political analyst Ori Goldberg, referring to how Israeli authorities are responding to news of the leak. “What matters is the woman who leaked the tape and what they want to call the deep state.”

“For Netanyahu and others, this is evidence that the deep state has gotten too big for its britches and that, by accusing Tomer-Yerushalmi of collaborating with the attorney general, they have evidence of the treachery and a further means of undermining any civilian oversight there may be over their workings.”

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The ‘deep state’

Netanyahu and his allies’ fight with the judiciary dates back to what his critics call the “judicial coup” of 2023, when he proposed a sweeping legislative overhaul of Israel’s judicial system. He has also faced multiple charges of corruption since 2019.

The prime minister’s proposed judicial reforms would grant his right-wing coalition the freedom to act without the check of the Supreme Court, potentially leading to a further crackdown on dissent and the rights of Palestinians.

Israel's Attorney General Gali Baharav-Miara listens on as she attends a cabinet meeting at the Bible Lands Museum in Jerusalem on June 5, 2024. GIL COHEN-MAGEN/Pool via REUTERS
Israel’s Attorney General Gali Baharav-Miara listens on as she attends a cabinet meeting at the Bible Lands Museum in Jerusalem [Gil Cohen-Magen/Reuters]

Attorney General Baharav-Miara has found herself in the firing line for resisting those reforms. In 2023, she issued legal guidance opposing the proposed judicial overhaul, writing that it would undermine Israel’s checks and balances, and that it was “a sure recipe for harming human rights and clean governance”. She also told the prime minister to distance himself from the judicial reforms, noting that it would be a conflict of interest amid his own corruption trial.

“They want to cover up the rape,” Aida Touma-Suleiman, a member of the Israeli parliament representing the left-wing Hadash-Ta’al faction, told Al Jazeera. “That’s why they’re dealing with the prosecutors and not the crime itself.”

“Benjamin Netanyahu is using this, just like the right wing is using this. They’ve been repeating the same messaging ever since the story broke. This is how the judiciary works. These are your so-called checks and balances. Look at them, they’re criminals.”

Justice lost

Amid the political furore, the likelihood of prosecuting the alleged rapists appears to be diminishing.

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On Monday, it emerged that the rape victim had been returned to Gaza in October as part of the exchange of captives, leading to speculation that he might not appear in proceedings against his alleged attackers.

Five of those indicted for the assault saw their charges downgraded to “severely abusing” the detainee on Sunday, when they appeared outside Israel’s Supreme Court wearing balaclavas to hide their identity.

A lawyer for the suspects, Moshe Polsky, told journalists that his clients could not expect a fair trial due to the leak, saying “the wheel cannot be turned back” and that, consequently, the indictment process had been tainted.

One suspect, who declined to be identified, described himself and his fellow suspects as loyal patriots wrongfully targeted by a legal system they see as undermining their service. “We knew we had to defend the country [following the October 7 attack],” he said.

“Since that day, dozens of fighters are still fighting for justice not on the battlefield, but in courtrooms.”

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For observers such as journalist Noy, however, there is little to do with justice in the saga of accusation, counter-accusation and cover-up that has come to overshadow the brutal rape of a prisoner in Israeli custody.

“For the two sides, this is all about the system and nothing to do with the Palestinian victim,” she reflected.

“One side sees it as [about] the old elite protecting itself, and the other about safeguarding the institutions of the state,” Noy said. “But don’t forget, these are the same institutions they need to protect to continue the abuse of Palestinians. These are the defences they offer up whenever they’re criticised from overseas.”

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UPS distribution hub in Louisville has 300 flights per day. What to know

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UPS distribution hub in Louisville has 300 flights per day. What to know

LOUISVILLE, Ky. (AP) — A UPS cargo plane crashed Tuesday at an airport in Louisville, Kentucky, where the company operates its largest package delivery hub.

UPS calls the giant center Worldport.

Here’s what to know about its enormous scale:

Processes 2 million packages per day

The facility at Muhammad Ali International Airport sprawls across an area the size of 90 football fields.

It processes 2 million packages per day, but has the ability to handle even more. It has the capacity to process 416,000 packages and documents per hour if needed.

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The Louisville airport ranks third among U.S. airports for cargo as measured by weight, after Memphis, Tennessee, and Anchorage, Alaska, according to Airports Council International World.

A UPS town

Some 20,000 people work at the center, making UPS the largest employer in the Louisville area, the company said on its website.

Louisville Metro Council member Betsy Ruhe said everyone in town knows someone who works at UPS.

“My heart goes out to everybody at UPS because this is a UPS town,” Ruhe said. “My cousin’s a UPS pilot. My aide’s tennis partner is a UPS pilot. The intern in my office works overnight at UPS to pay for college.”

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Hundreds of flights per day

More than 300 flights take off and land from the facility each day..

A time-lapse video UPS posted on YouTube shows planes taxiing to and from special cargo gates. Workers unload containers packed with cardboard boxes. Other employees load the boxes onto a conveyor belt, which delivers packages to workers who load them into other containers.

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The center has room for 125 aircraft to park.

Louisville’s location in Kentucky puts it within four hours of flight time to 95% of the U.S. population. It serves 200 countries around the world.

UPS flies six different types of planes in the U.S.

It has 27 MD-11s, which is the model that crashed on Tuesday. It also flies the Airbus A300-600 and four different types of Boeing jets: the 757-200, 767-300, 747-400 and 747-8.

Expansions in Louisville

UPS made Louisville an air cargo hub starting in the 1980s. It opened the package sorting center it calls Worldport in 2002. The public media outlet Marketplace reported UPS picked the city because it doesn’t get a lot of extreme heat or snow and because it’s centrally located.

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The hub has steadily grown over the decades. Last year, UPS opened a new $220 million aircraft hangar in Louisville large enough to park two 747 planes side by side. The investment tripled the company’s maintenance footprint for the plane at the airport.

In 2022 it announced plans to add eight new flight simulators.

UPS Healthcare, which provides shipments for clinical trials, shipments to medical care patients and other services, was due to get two new buildings in the expansion.

UPS gets permission to fly its own planes in 1988

UPS got its start in Seattle in 1907, when two teenagers started American Messenger Co. The name United Parcel Service debuted in 1919.

The company won Federal Aviation Administration approval to operate its own aircraft in 1988.

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Headquartered in Atlanta, UPS today employs about 490,000 people worldwide.

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This story has been corrected to show that the facility is equivalent in size to 90 football fields, not 10.

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Hegseth applauds South Korea’s plan to take larger role in defense against North Korean aggression

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Hegseth applauds South Korea’s plan to take larger role in defense against North Korean aggression

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U.S. Pentagon chief Pete Hegseth on Tuesday lauded South Korea’s plans to boost its military spending and take on a larger role in defending itself from North Korea’s aggression.

The U.S. has wanted South Korea to increase its conventional defense capabilities so that Washington can center its attention on China.

Hegseth spoke to reporters after annual security talks with South Korean Defense Minister Ahn Gyu-back in Seoul, where he said he was “greatly encouraged” by Seoul’s commitment to raising defense spending and making greater investments in its own military capabilities.

He said the two allies agreed that the investments would boost South Korea’s ability to lead its conventional deterrence against its northern foe.

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US, CHINA AGREE TO OPEN DIRECT MILITARY HOTLINE AFTER XI-TRUMP SUMMIT

U.S. Defense Secretary Pete Hegseth, left, looks on as South Korean Defense Minister Ahn Gyu-back, right, speaks during a joint press conference following the 57th Security Consultative Meeting at the Defense Ministry in Seoul, South Korea, Tuesday, Nov. 4, 2025. (AP)

South Korean President Lee Jae Myung, in a speech to parliament Tuesday, asked lawmakers to approve an 8.2% increase in defense spending next year. The president said the increase in spending would help modernize the military’s weapons systems and reduce its reliance on the U.S.

Hegseth noted defense cooperation on repairing and maintaining U.S. warships in South Korea, stressing that the activities harness South Korea’s shipbuilding capabilities and “ensure our most lethal capabilities remain ready to respond to any crisis.”

“We face, as we both acknowledge, a dangerous security environment, but our alliance is stronger than ever,” Hegseth said.

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TRUMP ARRIVES IN SOUTH KOREA FOR KEY TALKS AHEAD OF APEC SUMMIT, XI MEETING — NO KIM JONG UN REUINION

Pete Hegseth in South Korea

U.S. Defense Secretary Pete Hegseth, second from left, and South Korean Defense Minister Ahn Gyu-back, center, visit the Observation Post Ouellette near the border village of Panmunjom, South Korea, Monday, Nov. 3, 2025. (AP)

Hegseth said the South Korea-U.S. alliance is primarily meant to respond to potential North Korean aggression, but other regional threats must also be addressed.

“There’s no doubt flexibility for regional contingencies is something we would take a look at, but we are focused on standing by our allies here and ensuring the threat of the [Democratic People’s Republic of Korea] is not a threat to the Republic of Korea and certainly continue to extend nuclear deterrence as we have before,” he said.

In recent years, the U.S. and South Korea have discussed how to integrate U.S. nuclear weapons and South Korean conventional weapons.

Hegseth visits South Korea

U.S. Defense Secretary Pete Hegseth, left, shakes hands with South Korean Defense Minister Ahn Gyu-back for a photo at the 57th Security Consultative Meeting at the Defense Ministry in Seoul, South Korea, Tuesday, Nov. 4, 2025. (AP)

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South Korea has no nuclear weapons, and Ahn denied speculation that it could eventually seek its own nuclear weapons program or that it is pushing for redeployment of U.S. tactical weapon weapons that were removed from South Korea in the 1990s.

Earlier Tuesday, South Korea’s Joint Chiefs of Staff said the country detected North Korea test-firing around 10 rounds of artillery toward its western waters on Monday, shortly before Hegseth arrived at an inter-Korean border village with Ahn to begin his two-day visit to South Korea.

Hegseth visited the Demilitarized Zone on the border with North Korea earlier in the week.

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