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Study shows dramatic decline in effectiveness of all three COVID-19 vaccines over time

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Study shows dramatic decline in effectiveness of all three COVID-19 vaccines over time

Because the Delta variant turned the dominant pressure of the coronavirus throughout the US, all three COVID-19 vaccines obtainable to People misplaced a few of their protecting energy, with vaccine efficacy amongst a big group of veterans dropping between 35% and 85%, in response to a brand new examine.

Researchers who scoured the information of practically 800,000 U.S. veterans discovered that in early March, simply because the Delta variant was gaining a toehold throughout American communities, the three vaccines had been roughly equal of their potential to stop infections.

However over the subsequent six months, that modified dramatically.

By the top of September, Moderna’s two-dose COVID-19 vaccine, measured as 89% efficient in March, was solely 58% efficient.

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The effectiveness of pictures made by Pfizer and BioNTech, which additionally employed two doses, fell from 87% to 45% in the identical interval.

And most strikingly, the protecting energy of Johnson & Johnson’s single-dose vaccine plunged from 86% to only 13% over these six months.

The findings had been revealed Thursday within the journal Science.

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The three vaccines held up higher of their potential to stop COVID-19 deaths, however by July — because the Delta variant started to drive a three-month surge of infections and deaths — the pictures’ effectiveness on that rating additionally revealed extensive gaps.

Amongst veterans 65 and older who had been inoculated with the Moderna vaccine, those that developed a so-called breakthrough an infection had been 76% much less prone to die of COVID-19 in contrast with unvaccinated veterans of the identical age.

Older veterans who received the Pfizer-BioNTech vaccine and subsequently skilled a breakthrough an infection had been 70% much less prone to die than had been their unvaccinated friends.

And when older vets who received a single jab of the J&J vaccine suffered a breakthrough an infection, they had been 52% much less prone to die than their friends who didn’t get any pictures.

For veterans youthful than 65, the Pfizer-BioNTech and Moderna vaccines supplied one of the best safety in opposition to a deadly case of COVID-19, at 84% and 82%, respectively. When youthful veterans inoculated with the J&J vaccine suffered a breakthrough an infection, they had been 73% much less prone to die of COVID-19 than had been their unvaccinated friends.

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Johnson & Johnson representatives didn’t instantly reply to requests to debate the examine’s findings.

The Facilities for Illness Management and Prevention has advisable booster pictures for everybody who received the Johnson & Johnson vaccine at the very least two months earlier.

Boosters are additionally advisable six months after a second dose of the Moderna or Pfizer vaccines for everybody 65 and older; these with medical circumstances that make them extra weak to a severe case of COVID-19; those that dwell in nursing houses or different group settings; and those that dwell or work in high-risk settings equivalent to hospitals or prisons.

As well as, all individuals with compromised immune programs are suggested to get a booster shot if it’s been at the very least 28 days since their vaccine took full impact.

With thousands and thousands of vaccinated People pondering whether or not they want a lift, the brand new examine affords essentially the most complete comparability but of how the three vaccines have carried out throughout the nation this yr.

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It tracked 780,225 veterans of the U.S. armed forces from Feb. 1 to Oct. 1. Near 500,000 of them had been vaccinated, whereas just below 300,000 had not.

Hailing from throughout the nation, all had been cared for by the Division of Veterans Affairs’ unified system, which offers healthcare to 2.7% of the U.S. inhabitants. Whereas the group beneath examine was ethnically and racially various, the record-keeping that researchers relied upon was uniform.

As a result of these had been veterans, the examine inhabitants comprised six occasions as many males as girls. They usually skewed older: about 48% had been 65 or older, 29% had been between 50 and 64, and 24% had been youthful than 50.

Although older veterans had been extra prone to die than youthful vets all through the examine interval, the decline of the vaccines’ safety in opposition to sickness and dying was seen in each younger and outdated.

The examine was performed by a staff from the Public Well being Institute in Oakland, the Veterans Affairs Medical Middle in San Francisco, and the College of Texas Well being Science Middle.

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Dr. Barbara Cohn, the examine’s lead writer, stated along with its comparability of COVID-19 vaccines, the group’s evaluation offers “a lens for making knowledgeable selections round major vaccination, booster pictures, and different a number of layers of safety.” That features masks mandates, coronavirus testing and different public well being measures geared toward countering viral unfold.

Robust proof of the vaccines’ declining energy ought to immediate even states and locales with extremely vaccinated populations to think about retaining masks mandates, the authors stated. And the findings strongly help the CDC’s latest suggestion that every one recipients of the J&J vaccine get a booster.

The examine concluded that the Delta variant, which drove a wave of infections and deaths throughout the nation over the spring and summer time, was in all probability the issue that the majority eroded the safety of vaccines.

Different researchers have discovered related proof of declining vaccine effectiveness. However they’ve prompt that the immune system’s defenses in opposition to SARS-CoV-2 merely fade with time, and that waning vaccine effectiveness would in all probability have been seen with or with out the arrival of a brand new, extra transmissible pressure.

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.

Across the water, cargo ships made dark shapes as they slid between the seas.

The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.

But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.

The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.

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Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.

In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.

Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.

Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”

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Sitting hurts. Train for your desk job with these 5 easy exercises for your head and neck

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Sitting hurts. Train for your desk job with these 5 easy exercises for your head and neck

It’s Monday morning, the start of your work week. You’ve put the finishing touches on that big report, prepared for that imminent presentation. But it’s likely that there’s one aspect of the job you’re not ready for: the marathon of sitting at your desk all day.

Time to start training. Because while it might not be earthshaking news, it bears repeating: Prolonged desk work can lead to a host of musculoskeletal issues, from annoying aches and pains to injuries.

Even if your work space is ergonomically correct — and even if you exercise regularly in your free time — excessive desk work (considered three or four continuous hours) can lead to weakened, tight muscles, joint stiffness, inflammation in the muscles and tendons and tight fascia (connective tissue). Add it all up, and the result is typically some level of discomfort.

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Left untreated, muscles that are stressed and deconditioned can lead to painful soft tissue problems, such as tendonitis and carpal tunnel syndrome, as well as chronic lower back pain. You can also become at risk for bulging or herniated discs, pinched nerves and other issues.

Desk work can also lead to biomechanical imbalances. Weakened glutes from sitting, for example, can lead to stress on the knees and lower back; tired hip flexors can alter pelvic movement, leading to lower back pain.

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Which is concerning seeing as sitting for work is both on the rise and can put us at risk for other serious health issues, says Stella Volpe, president of the American College of Sports Medicine.

“We know that there are more Americans now that have sedentary jobs than ever in the past,” Volpe says. “The more we sit, the greater risk we have of diabetes, obesity and cardiovascular disease.”

Blame our sitting-related woes on the advent of furniture, says David Raichlen, a USC evolutionary biologist who studies sedentary behavior and exercise.

Before chairs with a back and arm rests debuted as a status symbol among ancient Egyptians about 5,000 years ago, he says that humans mostly kneeled or squatted for about 2 million years. Those resting postures require light muscle activity, but when the body is fully supported by a chair or a couch, it turns off that activity in the body parts being supported by the furniture, Raichlen says. Prolonged inactivity can then lead to muscle atrophy and other problems.

“From an evolutionary standpoint, the human body hasn’t yet adapted to furniture,” Raichlen says. “It never had to deal with completely inactive muscles for long periods of time until very recently.”

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But the good news is you can train for long-distance sessions at your desk by working out your neck, your wrists, your lower back, even your feet and toes. These “exercise snacks,” as trainers call them, don’t require a trip to the gym, or equipment, or even much time.

They’re not meant to replace regular exercise, but they will — if done regularly — prepare your body for the challenge that is desk work by stretching and strengthening your muscles, taking pressure off your joints and reducing stiffness and inflammation in the area — all of which may alleviate pain and prevent new injuries.

“We’re designed to be hunter-gatherers, not to wiggle our fingers on a keyboard for eight hours straight,” says Dr. Joshua T. Goldman, a UCLA sports medicine physician. “We need to build up strength, for endurance purposes, to help those body parts tolerate that activity.”

“The human body hasn’t yet adapted to furniture. It never had to deal with completely inactive muscles for long periods of time until very recently.”

— David Raichlen, USC evolutionary biologist

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We spoke to exercise physiologists, sports medicine physicians, personal trainers, physical therapists and others to devise a short, five-minute exercise routine for six key regions of the body. We’ll roll out one routine a week — starting with the head and neck area — for six weeks, until you have a complete full-body workout.

Each exercise is purposefully simple, meant to take 30-60 seconds. And each routine lasts about five minutes or less in total. They’re ideally done throughout the day, so as to promote mobility and circulation, bringing blood flow and nutrients to the muscles and tendons, and increasing lubrication in the joints. Set a timer. Take a five-minute break to execute one routine. Then get back to work.

Still too busy? Do just one exercise, for 30-60 seconds, then continue working. If you get through one routine by day’s end, consider it a win. Focus on a different routine the next day.

“It all adds up,” Volpe says. “Our society often thinks that if you’re not running a marathon, you’re not doing enough. But the additive effect is still good for you.”

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A routine for your head and neck

The neck is a common area in which to develop pain from desk work. Looking at a computer monitor, we often jut our neck forward rather than tucking in our chin, as we should. That pushes our cervical column out of alignment and creates excess stress on the bones and discs of the cervical spine. It shortens and tightens muscles in the neck, which can lead to pain and cause tension headaches.

Do these exercises to help stretch and strengthen the muscles that support your head and neck. They’re demonstrated by trainer Melissa Gunn, of Pure Strength LA, whose team trains desk workers on how to protect their bodies through exercise.

  1. Clasp your hands behind your head and gently tuck your chin down toward your chest. Hold 10 seconds. Do five times.
  1. Slowly tilt your head to the left, bringing your ear toward your shoulder. Hold for 10 seconds, then raise it slowly back up to the starting point. Switch sides. Do three times on each side. To increase the stretch, after bringing your ear to your shoulder and holding, turn your head and look down toward your armpit on the same side, then return to starting position.
  1. Place your back flat against a wall and stand with your feet about eight inches from the wall, with knees slightly bent. Your arms should be flush against the wall, with palms facing outward. Tuck your chin slightly and push your head gently against the wall. Slide your arms up the wall, as if doing a snow angel. Go as far as you can with your arms and hands flush against wall. Stop when they begin to pull away from the wall — typically when palms are between shoulder height and head height. Do 10 times.
  1. Stand up straight and align your head, shoulders, hips and ankles — most people jut their neck forward without knowing it, creating static tension there, so consciously move your head back so it’s above your shoulders. Slowly roll your head in a circle, first to the left, clockwise, all the way around; then to the right, counter-clockwise. Do 3 times on each side.
  1. Stand up straight and align your head, shoulders, hips and ankles. Your arms should be beside you and your palms facing outward. Then pull your arms back but no further than the back pockets of your pants — without lifting your shoulders — and draw your shoulder blades together. Hold for 2-5 seconds. Do 5-10 times.

(Exercises came from Dr. Joshua T. Goldman, UCLA sports medicine; Melissa Gunn, Pure Strength LA; Tom Hendrickx, Pivot Physical Therapy; Vanessa Martinez Kercher, Indiana University-Bloomington, School of Public Health; Nico Pronk, Health Partners Institute; Niki Saccareccia, Light Inside Yoga.)

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Lead Poisoning May Have Made Ancient Romans a Bit Less Intelligent

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Lead Poisoning May Have Made Ancient Romans a Bit Less Intelligent

Roughly 2,000 years ago, the Roman Empire was flourishing. But something sinister was in the air. Literally.

Widespread pollution in the form of airborne lead was taking a toll on health and intelligence, researchers reported on Monday in the journal Proceedings of the National Academy of Sciences.

During the roughly two centuries starting in 27 B.C., a period of relative stability and prosperity known as the Pax Romana, the empire extended throughout Europe, the Middle East and North Africa. Its economy relied on silver coinage, which required huge mining operations.

But extracting silver from the Earth creates a whole lot of lead, said Joseph McConnell, an environmental scientist at the Desert Research Institute, a nonprofit group based in Nevada, and the lead author of the new research. “If you produce an ounce of silver, you’d have produced something like 10,000 ounces of lead.”

And lead has a host of negative effects on the human body. “There is no such thing as any safe level of lead exposure,” said Deborah Cory-Slechta, a neurotoxicologist at the University of Rochester Medical Center who was not involved in the research.

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Dr. McConnell and his colleagues have now detected lead in layers of ice collected in Russia and Greenland that date to the time of the Roman Empire. Lead entered the atmosphere from Roman mining operations, hitched a ride on air currents and eventually fell out of the atmosphere as snow in the Arctic, the team surmised.

The levels of lead that Dr. McConnell and his collaborators measured were extremely low, roughly one lead-containing molecule per trillion molecules of water. But the ice samples were collected thousands of miles from southern Europe, and lead concentrations would have been highly dispersed after such a long journey.

In order to estimate the amount of lead originally emitted by Roman mining operations, the researchers worked backward: Using powerful computer models of the planet’s atmosphere and making assumptions about the location of the mining sites, the team varied the amount of lead emitted to match the concentrations they measured in the ice. In one case, they assumed that all silver production took place at a historically important mining site in southwestern Spain known as Rio Tinto. In another case, they presumed that silver mining was equally spread out across dozens of sites.

The team calculated that anywhere from 3,300 to 4,600 tons of lead were being emitted into the atmosphere each year by Roman silver-mining operations. The researchers then estimated how all that lead would be scattered across the Roman Empire.

“We ran the model in the forward direction to see how those emissions would be distributed,” Dr. McConnell said.

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With those atmospheric-lead concentrations in hand, the researchers next used modern-day data to estimate how much lead would have entered the bloodstreams of people in ancient Rome.

Dr. McConnell and his colleagues focused on infants and children. Young people are particularly susceptible to taking up lead from their environment via ingestion and inhalation, said Dr. Bruce Lanphear, a public heath physician at Simon Fraser University in British Columbia who was not involved in the research. “Pound for pound, children, particularly infants, eat more and breathe more.”

In recent decades, lead levels in children’s blood have been correlated with a slew of physical and mental health metrics, including I.Q., Dr. Cory-Slechta said. “We have actual data on I.Q. scores in kids with different blood-lead concentrations.”

Using those modern-day relationships, Dr. McConnell and his team estimated that children across much of the Roman Empire would have had around 2 to 5 additional micrograms of lead, per deciliter of blood. Such levels correspond to I.Q. declines of roughly 2 or 3 points.

For comparison, American children in the 1970s had average blood-lead-level enhancements of around 15 micrograms more lead per deciliter of blood before the phasing out of leaded gasoline and leaded paints. Their corresponding average I.Q. decline was about 9 points.

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But lead exposure would have had other negative effects on Romans as well. Higher levels of lead in the blood have also been linked to higher incidences of preterm births and reduced cognitive functioning in old age. “It follows you throughout life,” Dr. Lanphear said.

Some scholars have hypothesized that lead poisoning played an important role in the decline of the Roman Empire. But that idea has been called into question, at least when it comes to water contaminated by lead pipes. A 2014 study showed that, while the pipes used to distribute water in Rome increased lead levels, the water was unlikely to be truly harmful.

These new findings make sense, said Hugo Delile, a geoarchaeologist at the French National Centre for Scientific Research, who was not involved in the research. “They confirm the extent of lead pollution resulting from Roman mining and metallurgical activities.”

According to Dr. McConnell, the research also confers a dubious honor on Roman mining. “To my knowledge, it’s the earliest example of widespread industrial pollution,” he said.

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