Connect with us

Health

MD: You Can Get the Weight Loss Benefits of Injectables *Without* the Side Effects

Published

on

MD: You Can Get the Weight Loss Benefits of Injectables *Without* the Side Effects

Whether you’re searching for a way to outsmart diabetes or seeking a solution for stubborn weight gain, look no further: A hormone called GLP-1 (glucagon-like peptide 1) has a powerful ability to lower blood sugar and melt unwanted pounds. In fact, it’s the reason “miracle” drugs like Ozempic and Wegovy have skyrocketed in popularity.

But taking the medications — if you can even get them amid shortages — can run you up to $2400 a month. Plus, they can trigger unwelcome side effects such as nausea, diarrhea and fatigue. And, if you’re a food lover, it’s tough to take a medication that robs you of the pleasure of eating. The good news: Experts say people who prefer drug-free GLP-1 alternatives have plenty of natural options that deliver all the benefits without the GI upset.

The benefits of increasing GLP-1 levels

Produced primarily in the intestines, GLP-1 is a hormone that prods the pancreas to produce blood sugar-balancing insulin. That’s a clear benefit when it comes to outsmarting diabetes. Indeed, findings from the National Research Institute reveal lifting levels of GLP-1 can lower A1C readings (a measurement of average blood glucose levels) by nearly two points. It’s also a boon for weight loss, since excess blood glucose gets stored as fat. Plus, by preventing the blood sugar spikes and swings that trigger food cravings, GLP-1 helps dieters stay on track.

Designua/Shutterstock

That’s not all GLP-1 does. It also safeguards against blood sugar surges and the dips that follow. How? It suppresses release of glucagon, a hormone that signals the liver to send the glucose it contains into circulation. In addition, GLP-1 slows the rate at which food moves through the stomach and intestines. The result: you feel fuller and more satisfied after eating. What’s more, a study in the journal Molecular Psychiatry reveals GLP-1 sends hunger-taming signals to the hypothalamus, the brain region that’s been dubbed the “master regulator” of satiety.

Finally, GLP-1 increases production of brown fat (also known as brown adipose tissue) in the body, say researchers reporting in the journal Diabetes. That’s key, since brown fat boosts fat-burning and metabolism. This makes it markedly easier to melt stubborn pounds. (Click through for more ways to activate your body’s brown fat.)

Why GLP-1 boosters have taken the weight-loss world by storm

The active ingredient in both Ozempic and Wegovy is called semaglutide and belongs to a class of drugs known as GLP-1 agonists. Similar in chemical structure to the GLP-1 produced in the body, it was originally approved by the FDA as Ozempic, an injectable diabetes treatment. But people who used it enjoyed more than blood sugar reductions: They experienced weight loss on par with bariatric surgery. And in a New England Journal of Medicine study, adults on the drug dropped 489% more weight than those who received placebo injections.

Advertisement

Following Ozempic’s success, the FDA approved semaglutide for weight loss under a second brand name (and a higher dose). Called Wegovy, it quickly soared in popularity. But the drug’s manufacturer had supply-chain issues, so people stared slimming with “off-label“Ozempic instead. Hollywood A-listers were rumored to use it to stay trim, and demand skyrocketed. In fact, people with diabetes struggled to find Ozempic due to the weight loss craze.

Those who should consider GLP-1 injectables

Semaglutide isn’t for everyone. According to Katrina Ubell, MD, host of the podcast Weight Loss for Busy Physicians, it can be a “godsend” or some, “but it’s not meant for someone who just has those last 20 pounds to lose.” And as Amy Shah, MD, points out, the drugs aren’t intended for people who can lose weight by adopting healthy lifestyle and diet measures.

So who is semuglutide designed for? People with a body mass index (BMI) of greater than 30, or a BMI of 27 or more plus a weight-related health issue such as type 2 diabetes, high blood pressure or high cholesterol. Those criteria are set for health insurance purposes. (Click through to discover small lifestyle tweaks that help reverse prediabetes.)

(For more information on injectables, click through our sister publication’s story: Ozempic for Women Over 50? 5 Doctors Weigh In on the New Weight-Loss Injectables)

The downsides of weight loss injectables

For all that semuglutide can do, the drug does have its downsides. Wegovy and Ozempic have to be injected on a regular basis. And while costs (usually around $1,200 per month) are covered by most insurance plans for diabetes, you may have to pay out-of-pocket for weight loss purposes. Same goes for Rybelsus, a pill form of semuglutide that’s approved for treating diabetes but can be used off-label for weight loss. (For more on Rybelsus, click through Rybelsus vs Ozempic.)

Advertisement

The medications can also trigger side effects that include nausea, diarrhea and fatigue. Plus, they carry potential risks of thyroid tumors, cancer, pancreatitis and gallbladder and kidney problems. What’s more, the weight you’ve lost can come back when you stop taking the drug. Researchers reporting in Diabetes, Obesity and Metabolism found people who discontinued Wegovy regained two-thirds of lost weight within one year.

The best natural GLP-1 alternatives

GLP-1 agonists can be an inspiration for anyone hoping to drop excess pounds, notes Columbia University–trained nutrition expert Fred Pescatore, MD. And in welcome news, he adds, “It’s easy to mimic the effects of the medications without their drawbacks.” Here, the simple strategies that boost GLP-1 naturally.

Make breakfast your biggest meal of the day

Love indulging in a hearty breakfast? Go ahead and enjoy! A study in the journal Diabetologia found that when people consumed a generous breakfast and a light dinner, their GLP-1 levels were 30% higher than when they reversed the pattern. The body’s circadian clock triggers a natural GLP-1 uptick in the morning. That means eating ample morning calories optimizes GLP-1 release all day by working in sync with your internal timekeeper. (Click through to see how a protein-rich breakfast like proffee speeds weight loss.)

Big breakfast as a natural alternative to GLP-1
Elena Veselova/Shutterstock

Switch up your sweetener

Sure, sipping beverages that contain “fake sugars” such as sucralose and acefsulfame-K will save you some calories . But as Dr. Pescatore points out, it will also block your body’s ability to produce GLP-1. In fact, one study found ingesting the artificial sweeteners daily lowered folks’ GLP-1 levels by 35% within two weeks. Instead, Dr. Pescatore recommends stirring a low-calorie option called allulose into lemonade, coffee and tea. Experts reporting in Food Science and Technology Research found the sweetener lifted women’s GLP-1 by 70% in 1 hour. One to try: Rx Sugar Allulose (Buy from Walgreens.com, $9.99). (Click through to see how woman made weight loss effortless by switching to allulose sweetener.)

Drizzle EVOO over your favorite dishes

Using olive oil in marinades, dressings and veggie dishes boosts more than flavor: Researchers reporting in the American Journal of Clinical Nutrition found enjoying 3 to 4 Tbs. of the oil in place of butter increased GLP-1 43% within a single day. The monounsaturated fatty acids found in olive oil spur an uptick in GLP-1 release. And the polyphenol compounds it contains blunt the breakdown of the hormone in the body. Tip: Opt for extra virgin olive oil whenever possible. In a study published in the journal Nutrients, it proved 63% higher in polyphenols than refined olive oil.

Challenge friends to a game of pickleball

Or dance in your living room. Moving your muscles activates the sympathetic nervous system to stimulate GLP-1 release. And in an International Journal of Preventive Medicine study, folks who got three hours of exercise weekly for 12 weeks experienced increases in GLP-1 that were 733% greater than their less-active counterparts. Dr. Pescatore advises engaging in fun activities like dancing, bicycling, badminton or pickleball for 20 to 30 minutes daily. “The key is to choose something you enjoy — that way, you’ll do it gladly rather than dreading it,” he says. (Click through to see why fitness legend Denise Austin loves pickleball.)

Advertisement
Woman playing pickleball as a natural GLP-1 alternative
Natali Kuzina/Shutterstock

Make green veggies your go-to

Vegetables such as broccoli, Brussels sprouts and cabbage activate bitter taste receptors in the gut, which stimulates GLP-1 release. Plus, the veggies’ natural fiber slows stomach emptying , another way drugs such as Ozempic support slimming. Dr. Shah says, “If you eat these vegetables with two meals a day, you’ll change your body in ways you’d never imagine.”

Structures called thylakoids found in leafy greens also have a study backed ability to lift GLP-1. In fact, findings in the journal Appetite suggest enjoying ½ cup of leafy greens such as spinach, kale and collards increases GLP-1 by 250% within 30 minutes. And as a result, cravings for sweets drop by 93% for up to three hours . Experts explain thylakoids inhibit the activity of pancreatic lipase, an enzyme that blunts GLP-1 release. (Click through to learn more about the health benefits of leafy greens.)

Savor a cheeseburger for dinner

Or enjoy chicken parm. “Protein-rich foods such as beef and chicken nourish intestinal cells that produce GLP-1, as does the calcium in cheese,” explains Dr. Pescatore. That’s why research in Advances in Nutrition suggests eating meat and cheese raises GLP-1 by 300% in just 90 minutes. The tasty way to get the benefits: Aim for at least two servings of beef, poultry, fish and eggs paired with two servings of cheese daily.

Boosting GLP-1 naturally with a cheeseburger
Olga Miltsova/Shutterstock

Consider a berberine boost

Experts have long known that berberine, a compound derived from plants such as Indian barberry, goldenseal, and Oregon grape, has an impressive ability to balance blood sugar. And findings in the journal Nutrition and Diabetes suggest supplementing with berberine can optimize GLP-1 levels within 8 weeks. The compound defends cells that secrete GLP-1 against damage that can sabotage production of the hormone. The dose Dr. Pescatore recommends: 500 mg., three times daily. One to try: Solaray Vital Extracts Berberine 500 mg. (Buy from iHerb.com, $19.99). (Click through to learn more about berberine, which has been dubbed “nature’s Ozempic”.)

Add a dash of cinnamon to desserts

Good news for cinnamon lovers: Enjoying 1 tsp. of the spice can lift GLP-1 levels by 89% for 2 1/2 hours. So say researchers reporting in The American Journal of Clinical Nutrition, who note cinnamon stimulates L-cells in the gut that produce the hormone. Folks in the study stirred cinnamon into rice pudding, but it also makes a great addition to fresh fruit and yogurt parfaits.

Read on to learn more about weight loss injectables and if they’re right for you:

This content is not a substitute for professional medical advice or diagnosis. Always consult your physician before pursuing any treatment plan.

Advertisement

A version of this article originally appeared in our print magazine, Woman’s World.

Woman’s World aims to feature only the best products and services. We update when possible, but deals expire and prices can change. If you buy something via one of our links, we may earn a commission.

Questions? Reach us at shop@womansworld.com

Advertisement
Continue Reading
Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Health

Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

Published

on

Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

Join Fox News for access to this content

Plus special access to select articles and other premium content with your account – free of charge.

By entering your email and pushing continue, you are agreeing to Fox News’ Terms of Use and Privacy Policy, which includes our Notice of Financial Incentive.

Please enter a valid email address.

Having trouble? Click here.

It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).

Advertisement

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).

TO REDUCE CANCER RISK, SKIP THE ALCOHOL, REPORT SUGGESTS

“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research. (iStock)

“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”

Advertisement

Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.

Addiction expert warns of risks

There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.

“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.

‘DOES SMARTPHONE EXPOSURE CAUSE BRAIN CANCER?’: ASK A DOCTOR

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli. 

Advertisement

The more someone drinks — both in volume and frequency — the higher the risk, he warned.

Doctor holding lung x-ray and woman smoking

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%). (iStock)

“Alcohol is a toxin,” Scioli said. 

“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”

Is there a ‘safe’ amount?

Moderate alcohol use is defined as one drink or less in one day for women. 

For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).

Advertisement

“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”

“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.

“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”

      

Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”

Advertisement

“The line between safety and danger is debatable, and is different for each person.”

While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.

alcoholic beverages

Moderate alcohol use is defined as one drink or less in one day for women, and two drinks or fewer for men, per the CDC. (iStock)

Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.

“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.

What needs to change?

The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk. 

Advertisement

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.

cancer patient looks out window

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, an expert said. (iStock)

“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said. 

“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”

For more Health articles, visit www.foxnews.com/health

Advertisement

To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”

Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”

Continue Reading

Health

Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight

Published

on

Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight


Advertisement


Intermittent Fasting Weight Loss Results: A Grandma’s Fat Burn Success | Woman’s World




















Advertisement













Advertisement


Use left and right arrow keys to navigate between menu items.

Advertisement


Use escape to exit the menu.

Continue Reading

Health

New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

Published

on

New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

A new drug has been approved for the treatment of schizophrenia in adults.

On Thursday, the U.S. Food and Drug Administration (FDA) approved COBENFY (xanomeline and trospium chloride), an oral medication that is manufactured by Bristol Myers Squibb in New Jersey.

This marks the first new class of medications for the brain disorder in several decades, according to a press release.

5 MYTHS ABOUT SCHIZOPHRENIA, ACCORDING TO A MENTAL HEALTH EXPERT: ‘HUGE STIGMA’

COBENFY is expected to be available in the U.S. in late October, the company noted.

Advertisement

A new drug has been approved for the treatment of schizophrenia in adults. (iStock)

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb, in the press release.

STUDY REVEALS HEAVY MARIJUANA USE IS LINKED TO SCHIZOPHRENIA

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors.

It often causes hallucinations, delusions, disordered speech and loss of touch with reality, Mayo Clinic states on its website.

Advertisement
COBENFY

COBENFY (xanomeline and trospium chloride) is an oral medication that is manufactured by Bristol Myers Squibb in New Jersey. (Bristol Myers Squibb)

The disorder can also lead to lack of emotional expression, lack of motivation, cognitive dysfunction and social withdrawal.

Approximately 2.8 million people in the U.S. and 24 million people globally are living with schizophrenia.

AI-DISCOVERED DRUG SHOWS ‘ENORMOUS POTENTIAL’ TO TREAT SCHIZOPHRENIA: ‘REAL NEED FOR BETTER TREATMENT’

The disorder has traditionally been treated with antipsychotic medications, but around 40% of patients do not respond to treatments and 60% experience “inadequate improvement” in symptoms or “intolerable side effects,” studies have shown.

COBENFY

COBENFY is expected to be available in the U.S. in late October, the company noted. (Bristol Myers Squibb)

COBENFY works differently than the currently available schizophrenia medications.

Advertisement

“Due to its heterogeneous nature, schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies,” said Rishi Kakar, MD, chief scientific officer and medical director at Segal Trials and investigator in the drug’s clinical trials, in the release. 

“Schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies.”

“The approval of COBENFY is a transformative moment in the treatment of schizophrenia because, historically, medicines approved to treat schizophrenia have relied on the same primary pathways in the brain.”

“By leveraging a novel pathway, COBENFY offers a new option to manage this challenging condition.”

Bristol Myers Squibb

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb. (iStock)

Sam Clark, founder and CEO at Terran Biosciences — a biotech company that develops treatments and technologies for neurological and psychiatric diseases in New York City — commented on the new approval in a statement sent to Fox News Digital.

Advertisement

“I am excited that the FDA has just approved [COBENFY] as a treatment for patients with schizophrenia, marking a big leap forward in the psychiatry space,” he said. 

      

“These patients live with a difficult disease, and this drug with a novel mechanism of action will surely make a significant impact,” Clark continued. 

“We look forward to seeing the renaissance continue as this approval paves the way for future breakthroughs and novel patient-focused therapeutics.”

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Advertisement

The approval follows three phases of clinical trials in which COBENFY was shown to result in a “statistically significant improvement in illness.”

schizophrenia split

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors and often causes hallucinations and delusions. (iStock)

In terms of safety, the medication’s most common side effects during clinical trials were nausea, indigestion, vomiting, diarrhea, constipation, hypertension, abdominal pain, accelerated heart rate, dizziness and gastroesophageal reflux disease, the release stated.

Patients with certain existing medical conditions may experience other, more serious risks.

For more Health articles, visit www.foxnews.com/health

People should discuss potential complications with a doctor before starting the medication.

Advertisement

Fox News Digital reached out to Bristol Myers Squibb and the Schizophrenia & Psychosis Action Alliance requesting comment.

Continue Reading

Trending