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AI identified these 5 types of heart failure in new study: ‘Interesting to differentiate’

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AI identified these 5 types of heart failure in new study: ‘Interesting to differentiate’

“Heart failure” is a catch-all term used to describe any condition in which the organ doesn’t work as it’s supposed to — but one person’s experience with the disease can be very different from someone else’s.

Researchers from the University College London (UCL) recently used machine learning — a type of artificial intelligence — to pinpoint five distinct types of heart failure, with the goal of predicting the prognosis for the different kinds.

“We sought to improve how we classify heart failure, with the aim of better understanding the likely course of disease and communicating this to patients,” said lead author Professor Amitava Banerjee from UCL in a press release announcing the study.

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“Currently, how the disease progresses is hard to predict for individual patients,” he also said. “Some people will be stable for many years, while others get worse quickly.”

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The five types of heart failure identified were early onset, late onset, atrial fibrillation (which causes an irregular heart rhythm), metabolic (linked to obesity but with a low rate of cardiovascular disease) and cardiometabolic (linked to obesity and cardiovascular disease), according to a press release on UCL’s website.

For each type of heart failure, the researchers determined the likelihood of the person dying within a year of diagnosis. The prognosis varied widely for the five subtypes, they found. (iStock)

“The five types of heart failure were on the basis of common risk factors, such as age at onset of heart failure, history of cardiac disease, history of cardiac risk factors such as diabetes and obesity, or atrial fibrillation (the commonest heart rhythm problem),” explained Banerjee in a statement to Fox News Digital.

For the study, published in the journal Lancet Digital Health, the researchers analyzed data from more than 300,000 U.K. adults aged 30 and older who had experienced heart failure over a 20-year period.

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“Four methods of machine learning were used to cluster individuals with heart failure in electronic health data by their baseline characteristics,” said Banerjee. “The method and the number of clusters that ‘fit’ best to the data were selected.”

For each type of heart failure, the researchers determined the likelihood of the person dying within a year of diagnosis. The prognosis varied widely for the five subtypes, they found.

The five-year mortality risk was 20% for early onset, 46% for late onset, 61% for atrial fibrillation-related, 11% for metabolic and 37% for cardiometabolic, according to the press release.

Cardiac imaging

The main limitation of the new study from UCL was that the researchers didn’t have access to any imaging data, which is most commonly used to diagnose and predict risk in heart failure. (iStock)

For health professionals, Banerjee recommends that they ask their heart failure patients about common risk factors to help them understand the subtype they have. 

“Researchers also need to test how usable, generalizable and acceptable these subtypes defined in our study are in clinical practice,” he added. 

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“They should also consider whether studies such as ours, which use AI, can help inform a better understanding of disease processes and drug discovery.” 

The research team also developed an app for physicians that would enable them to determine which subtype of heart failure a patient has — with the goal of better predicting risk and keeping patients informed.

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Dr. Ernst von Schwarz, a triple board-certified clinical and academic cardiologist at UCLA in California, reviewed the results of UCL’s study.

“For clinicians, it is interesting to differentiate heart failure according to prognosis, which usually is not done in the clinical setting,” he told Fox News Digital. “Heart failure is generally seen as an incurable, chronic, progressive disease with poor long-term outcomes.” 

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“Heart failure is generally seen as an incurable, chronic, progressive disease with poor long-term outcomes.” 

“Studies like this might help clinicians make a more appropriate risk assessment according to the etiology of heart failure,” von Schwarz added. 

In particular, the very high mortality rate for atrial fibrillation-induced heart failure highlights the importance of aggressively managing this common arrhythmia, he said.

3D heart imaging

Researchers used machine learning — a type of artificial intelligence — to pinpoint five distinct types of heart failure. (iStock)

The mortality predictions for the five subtypes are “by far the most interesting part of this data,” according to Dr. Matthew Goldstein, a physician at Cardiology Consultants of Philadelphia, who also reviewed the study findings.

“This may help us guide who is at risk for dying suddenly, and thus, who needs protection with a defibrillator and who does not,” he added.

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AI shows promise, but limitations remain

While Goldstein recognizes that AI is becoming more common in general, he believes its application is medicine has shown “somewhat less success.”

He told Fox News Digital, “It is, however, good at looking for patterns that are too complicated for the human mind to see.”

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“Some of the more common utilizations are automatic readings of radiology studies to make sure that nothing is missed and emerging use in EKG interpretation to suggest underlying pathology,” he added.

In terms of using AI to classify heart failure, Goldstein noted that this is only a retrospective study and will need to be proven for future cases in order to be truly useful. 

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Looking ahead

The main limitation of the new study was that the researchers didn’t have access to any imaging data, which is most commonly used to diagnose and predict risk in heart failure.

“However, imaging markers alone do not predict mortality and other outcomes,” Banerjee said. 

“The fact that we were able to use routinely collected data without this imaging data to predict subtypes and outcomes relatively well suggests that the imaging biomarkers alone may not be the best way to characterize and study heart failure at population scale.”

Heart doctor with patient

Using these findings as a foundation, Professor Banerjee of UCL said the next step is to determine whether these heart failure classifications can make a practical difference to patients. (iStock)

The next step, Banerjee said, is to determine whether classifying various heart failures can make a practical difference to patients — “whether it improves predictions of risk and the quality of information clinicians provide, and whether it changes patients’ treatment.” 

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Cost-effectiveness is another consideration, he added.

The UCL research team previously used similar methods to identify subtypes in chronic kidney disease.

Looking ahead, Banerjee expects that machine learning will be used to analyze many types of routinely collected medical data and to identify subtypes of different diseases.

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First case of human bird flu diagnosed without exposure to infected animals, CDC says

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First case of human bird flu diagnosed without exposure to infected animals, CDC says

A patient in Missouri was hospitalized with bird flu despite having no known contact with animals.

The Centers for Disease Control and Prevention (CDC) confirmed the positive case of avian influenza A (H5) on Friday.

The patient, who had underlying medical conditions, was successfully treated with antiviral medications at the hospital and has since been discharged, according to the Missouri Department of Health and Senior Services (DHSS).

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This marks the 14th person (in three states) to contract bird flu in the U.S. this year — and the first infection to occur without any reported exposure to sick or infected animals, the CDC alert stated.

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The prior 13 cases came after exposure to dairy cows or poultry.

The CDC has confirmed the positive case of avian influenza A (H5) without any known exposure to animals. (iStock)

Dr. Benjamin Anderson, assistant professor in the Department of Environmental and Global Health at the University of Florida, said the fact that an individual has tested positive for H5 without any reported animal exposure is “very concerning,” but noted that very little is known about the case.

“We don’t know if the individual had indirect exposure to people or products from agricultural settings,” he told Fox News Digital. 

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“We also do not yet know the sequence of the virus to determine if it is related to the strains circulating in dairy cattle or not.”

A full epidemiological investigation is necessary to determine all potential paths of exposure, Anderson said.

“If our cases of influenza A spike, we need to test more samples to see if some are avian influenza.”

“This is definitely something we need to pay very close attention to.”

Dr. Edward Liu, chief of infectious diseases at Hackensack Meridian Jersey Shore University Medical Center in New Jersey, echoed the concern about human-to-human spread. 

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“When that happens, you won’t see an animal vector or source,” he told Fox News Digital.

"Bird flu"-labeled test tubes

A full epidemiological investigation is necessary to determine all potential paths of exposure, said an infectious disease expert. (REUTERS/Dado Ruvic/Illustration/File Photo)

“One of the underlying concerns is that the avian influenza will adapt itself to be more efficient at replicating in humans and better at spreading in respiratory droplets and secretions.”

Liu also emphasized that current testing for avian influenza is limited. 

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“Knowing it is influenza A doesn’t mean it is avian influenza,” he said. 

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“The confirmation of avian influenza requires another step to send it to the state health department or CDC — so we may be measuring the tip of an iceberg. If our cases of influenza A spike, we need to test more samples to see if some are avian influenza.”

Split image of cows and bird flu vial

This marks the 14th person to contract bird flu in the U.S. this year. The prior 13 cases came after exposure to dairy cows or poultry. (iStock)

Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, noted that while there hasn’t been evidence of animal exposure, “most likely there was.”

“There has been no evidence of any human-to-human spread at this point,” he told Fox News Digital. 

“Surveillance, wastewater analysis and control in animals are key.”

Risk factors

The biggest concern for bird flu right now, according to Anderson, is the potential for it to evolve and gain human-to-human transmission ability. 

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“Influenza viruses can evolve over time through the accumulation of small point mutations in their genetic sequence,” he said. “However, they can also evolve very rapidly through what is called recombination — when two or more influenza viruses infecting the same host exchange their genetic material and make a new strain of virus.”

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The more this strain of influenza virus circulates, the greater the potential for recombination to occur, the doctor said. 

“Right now, the highest-risk human groups are individuals with dairy cow and poultry exposure in areas where spillovers of bird flu have been documented,” Anderson said.

Woman getting vaccine

Bird flu is not currently in the seasonal influenza vaccine, although the immunization may still provide some protection, one expert said. (iStock)

So far, those who have contracted the dairy cow strain of influenza virus have mostly had mild infections, the doctor noted. 

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“However, we know these viruses change quickly, so we need to continue to be vigilant in monitoring their circulation.”

      

Another risk is that avian influenza may cause more severe disease than regular influenza, Liu cautioned. 

“It is not currently in our seasonal influenza vaccine, although the vaccine may still provide some protection,” he said. 

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“Luckily, current prescription antivirals, like Tamiflu, still can treat avian influenza.”

As with other flu strains, avian influenza will likely pose a greater risk to older patients, young children, immunocompromised patients, and those with chronic lung, cardiac or kidney disease, the doctor added.

“If it starts to pass from human to human, it could be a huge problem, but we aren’t there.”

Overall, Siegel said, bird flu poses “no current concern unless it mutates further.”

“It needs to be monitored closely,” he added. “If it starts to pass from human to human, it could be a huge problem, but we aren’t there.”

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The CDC stated on Friday that the public risk for bird flu infection remains low.

The agency will continue to investigate the specimen from the human patient, and the Missouri DHSS is looking into potential means of exposure.

Fox News Digital reached out to the Missouri DHSS for comment.

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'Six-pack surgery' gaining popularity among men, say plastic surgeons

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'Six-pack surgery' gaining popularity among men, say plastic surgeons

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Move over, “Dad bod” — more men are seeking “six-pack abs” with the help of a surgical procedure called high-definition liposuction, according to plastic surgeons. 

This type of “ab-etching” technique is gaining popularity among men who can’t get rid of stubborn belly fat with exercise alone, according to members of the American Society of Plastic Surgeons (ASPS).

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The method targets removal of stubborn fat much like traditional liposuction, but it also creates defined lines across the stomach muscles to create the illusion of “chiseled” abdominals.

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What is high-definition liposuction?

Dr. Josef Hadeed, MD, a board-certified plastic surgeon at the Hadeed Plastic Surgery practice in Beverly Hills, California, and Miami, Florida, described the procedure during an interview with Fox News Digital.

“It is more like creating that six-pack and creating the ‘V lines,’ and giving somebody that more athletic, toned physique that traditional liposuction can’t really achieve,” he said.

More men are seeking “six-pack abs” with the help of a surgical procedure called high-definition liposuction, according to plastic surgeons.  (iStock)

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Traditional liposuction focuses on removing fat, volume and bulk, but doesn’t address the specifics of the “underlying anatomy,” according to the surgeon.

High-definition liposuction is more detailed, Hadeed said. 

“We remove a little more fat from that vertical line above the belly button, and also those horizontal lines above the belly button,” he said. 

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“We also remove a little more fat in those areas to create the illusion or appearance of somebody having a six-pack.”

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In some cases, fat is redistributed to other areas to help create a bulkier, more muscular abdominal appearance, the surgeon added.

A growing trend

There has been an uptick in men undergoing this liposuction procedure, according to members of the ASPS.

“I’m definitely seeing an increase in high-definition liposuction requests for men,” ASPS member Dr. Joubin Gabbay, MD, the medical director at Gabbay Plastic Surgery in Beverly Hills, California, told Fox News Digital. 

Surgeon marking man

“It is more like creating that six-pack and creating the ‘V lines,’ and giving somebody that more athletic, toned physique that traditional liposuction can’t really achieve,” a plastic surgeon said. (iStock)

“They are coming in with specific requests for a defined, chiseled contour.”

Dr. Finny George, MD, a board-certified plastic surgeon and partner at New York Plastic Surgical Group, a division of Long Island Plastic Surgical Group, has also seen more male patients looking to improve their muscle definition.

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“It is becoming more socially acceptable for men to have plastic surgery.”

“There is definitely a growing desire among men [for] alternate means of achieving an athletic physique for two main reasons,” George told Fox News Digital.

“First, it is becoming more socially acceptable for men to have plastic surgery — and second, many have already tried and failed with conventional diet and exercise,” she added.

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High-definition liposuction isn’t the only procedure growing in popularity among men.

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There has been a 207% rise in total cosmetic procedures among males since 2019, according to the 2022 ASPS report.  

One reason may be that men are looking for a more youthful appearance to “maintain career vitality,” the report said. 

Man sit-ups

This type of “ab-etching” technique is gaining popularity among men who can’t get rid of stubborn belly fat with exercise alone, according to members of the American Society of Plastic Surgeons. (iStock)

Social media influencers and male celebrities have also created an open dialogue about male cosmetic surgery, making it more acceptable for men to seek such enhancement treatments, the ASPS also noted.

“It actually has been very common in Brazil and South America for quite some time now, and it’s slowly been migrating to the United States,” Hadeed told Fox News Digital.

What to know before seeking surgery

If an individual is considering undergoing high-definition liposuction, they should examine their reasons for doing so, said Hadeed.

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“They should do it for themselves, not because their spouse or partner is pressuring them to do it,” he advised.

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When a person is seeking those “perfect six-pack abs,” Hadeed said, the surgeon will typically look at the individual’s lifestyle behaviors, such as diet and exercise. 

For example, if someone is sedentary and eats fast food every day, “maybe this isn’t for you,” according to the doctor. 

Man meeting surgeon

It is important to research the credentials of the plastic surgeon who will perform the procedure and make sure they are certified by the American Board of Plastic Surgery, an expert advised. (iStock)

Patients should have realistic expectations of what can be achieved rather than trying to look like a certain fitness model or social media influencer, Hadeed cautioned.

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In some situations, he said, “we have to lower the expectations a little bit and say, ‘I can’t make you look like this other person who’s completely ripped and shredded, but I can help you look like a more refined version of yourself.’”

“Having elective surgery is a very major decision, and not something that people should take lightly.”

If the individual were to gain or lose a significant amount of weight after the surgery, that could affect the results, leading to the need for a revision or touch-up, Hadeed said — which is why he screens his patients to identify their lifestyle habits and make sure they can maintain the results.

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Gabbay also emphasized the importance of following a good regimen to maintain the benefits of the surgery.

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“I think the treatment is certainly effective at helping many achieve the six-pack look, but it requires work and maintenance to maintain,” he told Fox News Digital.

Man six-pack abs

Experts emphasized the importance of following a good regimen to maintain the benefits of the surgery. (iStock)

“It is important to maintain a healthy, active lifestyle and avoid major weight fluctuations after the procedure,” he went on. 

“Unintended weight gain after a high-definition procedure can exaggerate the look of the six-pack, making it look a little less natural.” 

Potential risks

Hadeed, who also serves as chair of the Patient Safety Committee for the ASPS, said it is important for patients to understand the risks involved with the procedure.

      

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“Having elective surgery is a very major decision, and not something that people should take lightly,” he said.

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Hadeed agreed that while the surgery is typically safe, there are risks involved. 

“In particular, there could be skin necrosis, where some of the skin dies,” he warned. “There could also be fat necrosis, where some of the fatty tissue that’s left behind dies.”

Man working out

“It is important to maintain a healthy, active lifestyle and avoid major weight fluctuations after the procedure,” a doctor advised. (iStock)

Other potential complications may include blood clots and intestinal perforation.

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It is also important to research the credentials of the plastic surgeon who will perform the procedure and make sure they are certified by the American Board of Plastic Surgery, Hadeed said.

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The doctor warned, “There are a lot of physicians out there who are not plastic surgeons who are doing these procedures.”

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Alzheimer’s risk may increase with light pollution, new study finds

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Alzheimer’s risk may increase with light pollution, new study finds

Exposure to outdoor light at night could put people at a higher risk of developing Alzheimer’s disease (AD), according to a new study published in Frontiers in Neuroscience.

“We show that, in the U.S., there is a positive association between AD prevalence and exposure to light at night, particularly in those under the age of 65,” first author Dr. Robin Voigt-Zuwala, an associate professor at Rush University Medical Center in Chicago, said in a press release.

“Nightly light pollution, a modifiable environmental factor, may be an important risk factor for AD.”

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Some common sources of artificial light include streetlamps, vehicles, illuminated signs, office buildings and other lighted structures.

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Exposure to outdoor light at night could put people at a higher risk of developing Alzheimer’s disease, according to a new study. (iStock)

In the study, researchers analyzed light pollution maps across the country, ranking each state’s “nighttime intensity data.” They then looked at the corresponding levels of Alzheimer’s disease.

For people 65 and older, light pollution was a greater risk factor than obesity, depression, alcohol abuse and chronic kidney disease, the researchers found.

Other risk factors, however — such as high blood pressure, diabetes and stroke — outweighed the risk of light pollution for that age group.

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Those under 65 years old, however, appeared to be more sensitive to nighttime lighting exposure, which increased their Alzheimer’s risk more than any other risk factor.

“Certain genotypes,  which influence early-onset AD, impact the response to biological stressors, which could account for increased vulnerability to the effects of nighttime light exposure,” Voigt-Zuwala said in the release. 

City lights

Previous studies have shown that light pollution is increasing by around 10% each year, causing the night sky to become brighter and reaching approximately 80% of the global population. (iStock)

“Additionally, younger people are more likely to live in urban areas and have lifestyles that may increase exposure to light at night.”

Risks of light pollution

Previous studies have shown that light pollution is increasing by around 10% each year, causing the night sky to become brighter and reaching approximately 80% of the global population.

Light pollution has been shown to disrupt the circadian rhythm and reduce production of the hormone melatonin, which can lead to sleep problems.

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ALZHEIMER’S AND OTHER DEMENTIA DIAGNOSES CAN VARY BY ZIP CODE, NEW STUDY FINDS

Insufficient sleep, in turn, is a proven risk factor for neurodegenerative diseases like Alzheimer’s.

One recent study published in the American Journal of Preventive Medicine found that getting only five hours of sleep per night can raise the risk of dementia by 30% for people 50 and older.

Among adults who have sleep-related movement disorders, the likelihood of dementia is nearly four times higher, the same study found.

“Constant light exposure disrupts the circadian rhythm and limits the amount of time the brain is in the deeper, restorative stages of sleep.”

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Dr. Earnest Lee Murray, a board-certified neurologist at Jackson-Madison County General Hospital in Jackson, Tennessee, was not involved in the study, but spoke with Fox News Digital about the environmental factors that can affect the prevalence of dementia like Alzheimer’s. 

“We have known for some time that the lack of quality sleep has detrimental health effects, and this includes an increased risk of developing cognitive difficulties later in life,” he said.

City map lights

Researchers analyzed light pollution maps across the country, ranking each state’s “nighttime intensity data.” They then looked at the corresponding levels of Alzheimer’s disease. (iStock)

The brain relies on a circadian rhythm to restore itself during sleep, the doctor added.

“Constant light exposure disrupts this circadian rhythm and limits the amount of time the brain is in the deeper, restorative stages of sleep,” Murray said.

Ways to reduce light exposure

Based on the findings, the researchers recommend people take steps to reduce their exposure to light pollution.

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“Awareness of the association should empower people — particularly those with risk factors for AD — to make easy lifestyle changes,” said Voigt-Zuwala. 

Sleep mask

“Easy-to-implement changes include using blackout curtains or sleeping with eye masks,” the researchers said. “This is useful especially for those living in areas with high light pollution.” (iStock)

“Easy-to-implement changes include using blackout curtains or sleeping with eye masks. This is useful especially for those living in areas with high light pollution.”

Although the study only examined outdoor light exposure, the researchers also suggested making changes indoors, such as installing dimmers, using blue light filters and swapping to warm lightbulbs instead of cool.

Some have pushed for regulations to control outdoor lighting exposure.

      

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“The legislation against light pollution is usually very weak and/or not well implemented,” Fabio Falchi, Ph.D., a researcher at the Light Pollution Science and Technology Institute in Italy, told Fox News Digital.

“It is time to start putting limits on this pollutant, too, as with the rest of the other common pollutants.”

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The study did have some limitations, the researchers acknowledged.

The data was gathered from a subset of the U.S. population, they stated, and individual outcomes may vary based on how long someone lived in an area with high light exposure.

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Man sleeping at computer

“It can clearly be implied that exposure to constant light from devices can lead to cognitive issues later in life,” a neurologist told Fox News Digital. (iStock)

“The study only looked at outdoor light pollution and did not include any type of data from indoor light pollution, such as from cellphones or televisions,” Murray noted.

“However, it can clearly be implied that exposure to constant light from devices can lead to cognitive issues later in life, reinforcing the importance of limiting nocturnal light exposure from cell phones and other devices.”

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The researchers called for more studies into the association between light pollution and Alzheimer’s.

Fox News Digital reached out to the study authors requesting comment.

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