Connect with us

Science

Do zinc products really help shorten a cold? It's hard to say

Published

on

Do zinc products really help shorten a cold? It's hard to say

You feel a cold coming on, or maybe it’s already upon you: the telltale cough, sore throat and stuffy head. You swing by the drugstore, where a shelf full of over-the-counter products containing the mineral zinc claim to be able to shorten the duration of your symptoms.

The promise of relief is tempting. But is it one these products can make good on?

A new analysis of studies published on zinc and cold viruses concludes that there isn’t enough evidence to say whether over-the-counter zinc treatments have any effect on preventing the common cold.

For those who pop lozenges or inhale nasal sprays once a cold has come on, the available research together indicates that the products may reduce the duration of symptoms by up to two days, said Daryl Nault, an assistant professor at Maryland University of Integrative Health and first author of the paper, published Wednesday by the nonprofit organization Cochrane.

Advertisement

But those studies are so inconsistent in terms of the dosage, type of zinc, patient population and definition of cold symptoms that “confidence in the evidence is mostly low to very low,” the review states. “It is likely that additional studies are required before any firm conclusions can be drawn.”

In other words: Nearly 30 years after zinc lozenges first hit the market, we still can’t say for sure if these things do what they say they do.

“We aren’t saying [zinc] does” have any effect on the common cold, Nault said. “We aren’t saying it doesn’t. We’re saying we need more consistent evidence that is replicable. That’s a cornerstone of good science.”

The age of zinc cold products dawned in 1996, when researchers from the Cleveland Clinic Foundation convinced 100 clinic employees to volunteer as research subjects within 24 hours of developing a cold.

Half were given placebos, and half were given lozenges containing 13.3 milligrams of zinc from zinc gluconate every two waking hours as long as their symptoms persisted. Those receiving the zinc got better after 4.4 days on average, while the placebo group felt sick for an average of 7.6 days.

Advertisement

Most people consume a sufficient amount of zinc, a vital nutrient, through a regular diet. The mineral is plentiful in red meat and poultry, and present in many grains and fruits. (Oysters contain more zinc per serving than any other known food, with a single serving containing nearly 300% of the daily recommended intake.)

Scientists aren’t exactly sure how the mineral works to alleviate cold symptoms. But the idea of an over-the-counter way to shorten the misery of a common cold has proved wildly popular.

Total U.S. sales of zinc products, such as Zicam and Cold-Eeze, were $340 million in 2023, said Hannah Esper, managing editor of the trade publication Nutrition Business Journal. Demand for zinc and other supplements exploded during the COVID-19 pandemic, with sales for zinc growing 168.3% during 2020.

Based in the U.K., Cochrane uses rigorous research methods to evaluate existing scientific evidence and produce reports to help people make decisions about their health, according to its website.

For this review, the Cochrane team looked at 34 studies conducted across 13 countries that examined zinc products and the treatment or prevention of the common cold.

Advertisement

Drawing strong conclusions from the available research is difficult, as the studies tend to measure different things, said author Susan Wieland, an assistant professor at the University of Maryland School of Medicine and director of the Cochrane Complementary Medicine Field.

The cold “is a very common condition that is a difficult one to study,” Wieland said. It comes and goes quickly, making it difficult to enroll research subjects. Dosages and the type of zinc administered to study subjects varied widely.

“The designs of each study are different. So different dosages, different dosage forms, different patient populations, different criteria of exclusion and inclusion, different outcomes [and] definitions of cold,” said Dr. Jason Yee, an antimicrobial stewardship pharmacist at Cedars Sinai Medical Center in Los Angeles who was not involved with the review. “It’s really hard to draw the same conclusion based on different studies.”

Physicians said they weren’t surprised by the findings.

“I agree with the study. … It is consistent with my clinical experience in the hospital,” said Dr. Samia Faiz, an internal medicine specialist at UC Riverside Health. “In general, healthy people may be able to take zinc supplements if they make them feel better or if they get some comfort. They should not take these supplements if they have distaste or stomach upset.”

Advertisement

While over-the-counter zinc products are generally harmless to patients battling colds, said Dr. Pritish Tosh, an infectious disease physician and researcher at the Mayo Clinic, popping lozenges “shouldn’t come at the expense of doing things that really matter, which is getting plenty of rest, plenty of fluids and taking care of yourself.”

So why do we continue to fork over our cash for these things when we don’t really have more than a hunch that they work?

When a cold hits, “it’s natural for consumers to just reach for anything that may help alleviate those symptoms. But average consumers aren’t really educated on the literature and studies that are out there showing that there’s limited evidence and efficacy with these products,” Yee said.

Buying the lozenges or huffing the nasal spray can make us feel like we have more agency in a situation where we’re at the mercy of time and our immune systems, Nault said.

“Having a sense of control makes a lot of people feel better, and feel like they’re doing something,” Nault said. “Even if they aren’t.”

Advertisement

Times researcher Scott Wilson contributed to this report.

Science

What’s in a Name? For These Snails, Legal Protection

Published

on

What’s in a Name? For These Snails, Legal Protection

The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.

Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.

Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.

The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.

A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.

Advertisement

Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.

Continue Reading

Science

Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

Published

on

Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order

Bruce, a disabled kea parrot, is missing his top beak. The bird uses tools to keep himself healthy and developed a jousting technique that has made him the alpha male of his group.

By Meg Felling and Carl Zimmer

April 20, 2026

Continue Reading

Science

Contributor: Focus on the real causes of the shortage in hormone treatments

Published

on

Contributor: Focus on the real causes of the shortage in hormone treatments

For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.

Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.

In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.

Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.

Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.

Advertisement

The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.

Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.

Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.

Meanwhile, there are a few strategies to cope.

  • Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
  • Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
  • Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
  • Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.

Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.

Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.

Advertisement

Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book When in Menopause: A User’s Manual & Citizen’s Guide. Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”

Continue Reading
Advertisement

Trending