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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

Dr. Eric Trexler, PhD – researcher, coach, and professional bodybuilder – recently appeared on the Renaissance Periodization podcast to share his evidence-based tier system for ranking muscle-building supplements. He emphasised that supplement rankings are goal-dependent, varying based on what you’re aiming to achieve with your training and supplementation.

Dr. Trexler then outlined his tiered approach specifically for those focused on gaining muscle and building strength, categorising supplements into five distinct tiers and providing examples of each along the way.

Tier-1 Supplements

‘Tier-1 basically means we have strong evidence. We know what this thing does, and what it does is good,’ says Dr. Trexler, who explains that for muscle-building, tier-1 supplements are in a class of their own. ‘It’s a short list – it’s creatine [assuming you’re not a non-responder] and it’s protein.’

Dr. Trexler caveats that protein supplements could be redundant if you’re able to get enough of the macronutrient from your diet. ‘If you’re eating enough from your food, who cares, forget it.’

Tier-2 Supplements

Dr. Trexler believes tier-2 supplements are the most interesting. ‘There is some evidence related to the supplement for the outcome we’re interested in, and it actually looks pretty good, but it’s not on tier-one because it has some shortcoming,’ he says. ‘Maybe the initial evidence is pretty good, but I’d like to see more of it before I get super stoked.’

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He adds that in some cases, the evidence for a supplement may be very strong, but in the real world, its effects are small and inconsistent, or only work in people with deficiencies. ‘You can have a really solid evidence-based justification for this. However, you’re likely going to have to acknowledge this is a really marginal effect. Maybe this only matters for a competitive athlete.’

The supplements Dr. Trexler would include in tier-2 are: sodium bicarbonate, citrulline malate and nitric oxide supplements.

Controversially, Trexler says he would also put caffeine, one of the most heavily relied-on ergogenic aids in existence, into tier-2. ‘There are meta-analyses and umbrella reviews indicating it should have a positive effect on things like strength, strength endurance, and power. But caffeine is probably better for endurance sport than it is for resistance exercise.’

He does point out the potential dark side of becoming too reliant on the pre-workout shot of espresso. ‘We don’t know when you get to that point when you say, “I wouldn’t dare work out without my pre-workout.” Is that because it’s still giving you an ergogenic [performance-enhancing] effect? Or is it because caffeine withdrawal gives you an ergolytic effect and your performance sucks?’

(Ergolytic is science-talk for something that negatively impacts your performance.)

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Tier-3 Supplements

‘Tier-3 is where the vast majority of supplements live’, Trexler says. ’It’s the tier where I tell someone I do not have enough evidence to say that there is a defensible use case for this but I also don’t have enough hard evidence to tell you there is no way this will work.’

So, if it’s not in any of the other tiers, with enough evidence for or against it’s use, consider it tier-3.

While Dr. Trexler doesn’t clearly define tier-3 supplements as he does with other tiers, examples might include Beta-alanine, which shows some promise for improving endurance but has inconsistent effects on muscle-building and strength, or Branched-chain amino acids (BCAAs). Once highly popular, recent research suggests their benefits are limited compared to complete proteins or essential amino acids, placing them in the tier-3 category.

Tier-4 Supplements

Dr. Trexler believes tier-4 is a tricky one – it’s the first category where we should consider actively swerving the compounds in question. ‘This is where we have evidence of a null effect. I can look at studies on it and say this is not going to achieve what you want it to achieve,’ says Dr. Trexler. His host, Dr. Mike Israetel, also an exercise scientist, offers a more concise and memorable definition: ‘It’s not hurting you; it just doesn’t do shit

When it comes to building strength and size, Trexler would include previously popular supplements like glutamine in tier-4. ‘For getting jacked and performing better, I think we’ve pretty much shut the book on glutamine.’

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He’d also place arginine – an amino acid that was once popular in pre-workout mixtures and touted as a ‘pump enhancer’ – in tier-4, alongside some testosterone boosters and modern ‘new-and-improved’ creatines like ethyl ester and alkaline varieties, saying they don’t justify their cost when tier-1’s cheaply available creatine monohydrate is an option.

Tier-5 Supplements

Tier-5 is the group that Dr. Trexler strongly advises you avoid. ‘[These are] supplements where we have evidence that one of two things is going to happen – either this is going to literally harm your performance, or it is going to harm you.’

Trexler says he would include compounds like DMAA, a chemical extract previously included in now-banned pre-workout supplements such as the highly-memed JACK-3D. He jokes that although these compounds were widely available and not previously banned, the aim of manufacturers at the time seemed to be to get as close as possible to the effects of methamphetamine.

Another tier-5 chemical that was once the stimulant of choice for many bodybuilders is ephedrine. ‘It was the era of [high stimulant] pre-workouts. However, there were serious adverse events reported. I believe that there were a couple of deaths.’ Thankfully, sporting organisations and federations have helped to pave the way to a slightly safer supplement industry. ‘Once it’s banned by all the big federations, I say all right, we’re going to tier-5…’

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With almost 18 years in the health and fitness space as a personal trainer, nutritionist, breath coach and writer, Andrew has spent nearly half of his life exploring how to help people improve their bodies and minds.    

As our fitness editor he prides himself on keeping Men’s Health at the forefront of reliable, relatable and credible fitness information, whether that’s through writing and testing thousands of workouts each year, taking deep dives into the science behind muscle building and fat loss or exploring the psychology of performance and recovery.   

Whilst constantly updating his knowledge base with seminars and courses, Andrew is a lover of the practical as much as the theory and regularly puts his training to the test tackling everything from Crossfit and strongman competitions, to ultra marathons, to multiple 24 hour workout stints and (extremely unofficial) world record attempts.   

 You can find Andrew on Instagram at @theandrew.tracey, or simply hold up a sign for ‘free pizza’ and wait for him to appear.

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I’m a fitness writer and these are the 44 best deals I’ve found in the Amazon Big Spring Sale

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I’m a fitness writer and these are the 44 best deals I’ve found in the Amazon Big Spring Sale

Lou Mudge is a Health Writer at Future Plc, working across Fit&Well and Coach. She previously worked for Live Science, and regularly writes for Space.com and Pet’s Radar. Based in Bath, UK, she has a passion for food, nutrition and health and is eager to demystify diet culture in order to make health and fitness accessible to everybody.

Multiple diagnoses in her early twenties sparked an interest in the gut-brain axis and the impact that diet and exercise can have on both physical and mental health. She was put on the FODMAP elimination diet during this time and learned to adapt recipes to fit these parameters, while retaining core flavors and textures, and now enjoys cooking for gut health.

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Exercise scientist reveals the strength training mistake many women make, even after lifting for years

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Exercise scientist reveals the strength training mistake many women make, even after lifting for years

Wondering how much weight you should be lifting in the gym to build strength? Dr Stacy Sims says that not going heavy enough could be the biggest mistake women are making in their workouts.

What strength training looks like might differ (for example, some prefer callisthenics over classic weight training) for some, but one thing is clear – it needs to be a challenge.

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Jogging 101: Benefits for Your Body and Mind

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Jogging 101: Benefits for Your Body and Mind

Walking and running share a number of benefits — but what about that sweet middle ground between the two?

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“Jogging is about creating a steady pace,” says sports and exercise medicine specialist Leonardo Oliveira, MD. “Instead of focusing on speed, you’re focused more on endurance with good, quality steps.”

Before your next jaunt, Dr. Oliveira shares the many benefits of jogging and how it can help improve your overall health and wellness.

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9 benefits of jogging

Unlike running, where you’re focused on targeting different heart rate zones, jogging involves keeping a more stable and persistent pace. If you’re jogging at a moderate intensity, for example, your target heart rate will usually fall into zone 2, at 60% to 70% of your max heart rate.

“When you’re jogging, you should be able to carry on a conversation as you breathe through your nose,” says Dr. Oliveira. “If you’re doing just 15 minutes of jogging three times a week, you’re already going to notice the benefits.”

Here’s how you can benefit from jogging.

1. Reduces stress

Jogging, like other exercises, can help decrease your stress levels. As an aerobic exercise, it helps release endorphins, which can boost your mood and create feelings of euphoria or satisfaction. Not only does it provide an outlet for pent-up energy, but jogging outside also allows you to spend more time in nature, which provides even more mental health benefits.

“Research shows exercise can be as effective as medication when treating depression because of its wide-ranging benefits,” says Dr. Oliveira.

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2. Burns calories

Jogging is a full-body exercise that offers a higher calorie burn than some other aerobic exercises. According to the widely used Compendium of Physical Activities, jogging burns about 7.5 calories per kilogram of body weight each hour. That means you can burn about:

  • 8 times as many calories as sitting quietly
  • 4 times as many calories as walking
  • 2.6 times as many calories as stationary cycling

“Jogging will burn more calories in a shorter period of time than cycling, especially if you’re not used to exercising,” reports Dr. Oliveira.

3. Improves insulin resistance and boosts metabolism

Insulin resistance is one of the biggest barriers to having a healthy metabolism. Insulin helps your body break down glucose for energy. But if your body can’t do that, your metabolism slows down, leading to:

  • Lower energy levels
  • Weight gain
  • An inability to burn fat

“Exercising at higher intensities helps increase metabolism and insulin resistance,” says Dr. Oliveira. “But researchers have also found that even lower-intensity exercises, like jogging, for longer periods of time can have the same effect.”

4. Strengthens your heart

Jogging also has positive impacts on your heart and its ability to pump blood to the rest of your body. That’s because it contributes to hypertrophy, or the strengthening of your heart’s muscle tissues.

“As you develop endurance, the amount of blood in one pump increases,” explains Dr. Oliveira. “When your heart gets stronger, it contracts more efficiently, which decreases your resting heart rate.”

5. Improves lung expansion and gas exchange

The more you work on building endurance and stamina, the more likely it is that you’ll improve your overall ability to breathe — both at rest and while jogging.

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“Consistent aerobic exercise helps your lungs get stronger and more efficient,” says Dr. Oliveira. “Over time, you won’t need to breathe as often because each breath brings in more oxygen than before.”

6. Activates muscles

Jogging activates major muscle groups, including your:

  • Quads
  • Hamstrings
  • Glutes
  • Core
  • Back

“Strength training is a good complement to jogging because it can help strengthen all the areas of your body,” says Dr. Oliveira. “This can help you handle longer distances.”

7. Reduces stiffness

“Jogging is one of those activities where once you get going, you start to feel better,” notes Dr. Oliveira. “It’s an exercise that helps warm up your muscles and lubricate your joints, which can help with the overall sense of stiffness that comes with age.”

That said, jogging is still a high-impact exercise because it forces you to bear down weight as your feet hit the pavement. Consider working with a physical therapist or athletic trainer to reduce the risk of further injury if you:

  • Have arthritis
  • Have an active injury
  • Had previous sprains or fractures in your lower body

8. Improves endurance

“The more you jog, the more you’ll increase your functional aerobic capacity,” says Dr. Oliveira. “Someone who jogs regularly will have better physical fitness that will help them last longer on a bike or a walk than someone who’s just getting started.”

Your ability to breathe and move also extends to other daily activities that demand cardiovascular strength and endurance, like climbing stairs.

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9. Provides better quality of life and other mental health benefits

Research shows that any amount of jogging — even just once a week — can improve your quality of life and lower your risk of dying from cancer and cardiovascular-related issues.

“Jogging is a great form of exercise, but it’s not the only one,” notes Dr. Oliveira. “The most important thing is to work on being healthy and strong. And for a lot of people, if you’re looking to advance your physical fitness, jogging is a good place to start.”

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