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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

Dr. Eric Trexler, PhD – researcher, coach, and professional bodybuilder – recently appeared on the Renaissance Periodization podcast to share his evidence-based tier system for ranking muscle-building supplements. He emphasised that supplement rankings are goal-dependent, varying based on what you’re aiming to achieve with your training and supplementation.

Dr. Trexler then outlined his tiered approach specifically for those focused on gaining muscle and building strength, categorising supplements into five distinct tiers and providing examples of each along the way.

Tier-1 Supplements

‘Tier-1 basically means we have strong evidence. We know what this thing does, and what it does is good,’ says Dr. Trexler, who explains that for muscle-building, tier-1 supplements are in a class of their own. ‘It’s a short list – it’s creatine [assuming you’re not a non-responder] and it’s protein.’

Dr. Trexler caveats that protein supplements could be redundant if you’re able to get enough of the macronutrient from your diet. ‘If you’re eating enough from your food, who cares, forget it.’

Tier-2 Supplements

Dr. Trexler believes tier-2 supplements are the most interesting. ‘There is some evidence related to the supplement for the outcome we’re interested in, and it actually looks pretty good, but it’s not on tier-one because it has some shortcoming,’ he says. ‘Maybe the initial evidence is pretty good, but I’d like to see more of it before I get super stoked.’

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He adds that in some cases, the evidence for a supplement may be very strong, but in the real world, its effects are small and inconsistent, or only work in people with deficiencies. ‘You can have a really solid evidence-based justification for this. However, you’re likely going to have to acknowledge this is a really marginal effect. Maybe this only matters for a competitive athlete.’

The supplements Dr. Trexler would include in tier-2 are: sodium bicarbonate, citrulline malate and nitric oxide supplements.

Controversially, Trexler says he would also put caffeine, one of the most heavily relied-on ergogenic aids in existence, into tier-2. ‘There are meta-analyses and umbrella reviews indicating it should have a positive effect on things like strength, strength endurance, and power. But caffeine is probably better for endurance sport than it is for resistance exercise.’

He does point out the potential dark side of becoming too reliant on the pre-workout shot of espresso. ‘We don’t know when you get to that point when you say, “I wouldn’t dare work out without my pre-workout.” Is that because it’s still giving you an ergogenic [performance-enhancing] effect? Or is it because caffeine withdrawal gives you an ergolytic effect and your performance sucks?’

(Ergolytic is science-talk for something that negatively impacts your performance.)

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Tier-3 Supplements

‘Tier-3 is where the vast majority of supplements live’, Trexler says. ’It’s the tier where I tell someone I do not have enough evidence to say that there is a defensible use case for this but I also don’t have enough hard evidence to tell you there is no way this will work.’

So, if it’s not in any of the other tiers, with enough evidence for or against it’s use, consider it tier-3.

While Dr. Trexler doesn’t clearly define tier-3 supplements as he does with other tiers, examples might include Beta-alanine, which shows some promise for improving endurance but has inconsistent effects on muscle-building and strength, or Branched-chain amino acids (BCAAs). Once highly popular, recent research suggests their benefits are limited compared to complete proteins or essential amino acids, placing them in the tier-3 category.

Tier-4 Supplements

Dr. Trexler believes tier-4 is a tricky one – it’s the first category where we should consider actively swerving the compounds in question. ‘This is where we have evidence of a null effect. I can look at studies on it and say this is not going to achieve what you want it to achieve,’ says Dr. Trexler. His host, Dr. Mike Israetel, also an exercise scientist, offers a more concise and memorable definition: ‘It’s not hurting you; it just doesn’t do shit

When it comes to building strength and size, Trexler would include previously popular supplements like glutamine in tier-4. ‘For getting jacked and performing better, I think we’ve pretty much shut the book on glutamine.’

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He’d also place arginine – an amino acid that was once popular in pre-workout mixtures and touted as a ‘pump enhancer’ – in tier-4, alongside some testosterone boosters and modern ‘new-and-improved’ creatines like ethyl ester and alkaline varieties, saying they don’t justify their cost when tier-1’s cheaply available creatine monohydrate is an option.

Tier-5 Supplements

Tier-5 is the group that Dr. Trexler strongly advises you avoid. ‘[These are] supplements where we have evidence that one of two things is going to happen – either this is going to literally harm your performance, or it is going to harm you.’

Trexler says he would include compounds like DMAA, a chemical extract previously included in now-banned pre-workout supplements such as the highly-memed JACK-3D. He jokes that although these compounds were widely available and not previously banned, the aim of manufacturers at the time seemed to be to get as close as possible to the effects of methamphetamine.

Another tier-5 chemical that was once the stimulant of choice for many bodybuilders is ephedrine. ‘It was the era of [high stimulant] pre-workouts. However, there were serious adverse events reported. I believe that there were a couple of deaths.’ Thankfully, sporting organisations and federations have helped to pave the way to a slightly safer supplement industry. ‘Once it’s banned by all the big federations, I say all right, we’re going to tier-5…’

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With almost 18 years in the health and fitness space as a personal trainer, nutritionist, breath coach and writer, Andrew has spent nearly half of his life exploring how to help people improve their bodies and minds.    

As our fitness editor he prides himself on keeping Men’s Health at the forefront of reliable, relatable and credible fitness information, whether that’s through writing and testing thousands of workouts each year, taking deep dives into the science behind muscle building and fat loss or exploring the psychology of performance and recovery.   

Whilst constantly updating his knowledge base with seminars and courses, Andrew is a lover of the practical as much as the theory and regularly puts his training to the test tackling everything from Crossfit and strongman competitions, to ultra marathons, to multiple 24 hour workout stints and (extremely unofficial) world record attempts.   

 You can find Andrew on Instagram at @theandrew.tracey, or simply hold up a sign for ‘free pizza’ and wait for him to appear.

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‘WH’ Editors Put These Fitness Gifts On Their Wishlist

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‘WH’ Editors Put These Fitness Gifts On Their Wishlist

For The Runner Who Loves Music

SHOKZ OpenRun Headphones

OpenRun Headphones

Sweat-proof, waterproof, and featherweight, these wireless headphones for working out are a runner’s dream. “These allow me to hear oncoming traffic, people, and other outside noise with their wrap-around, open-ear design while delivering feel-good jams,” says Nicolette Accardi, WH’s fitness commerce editor, who loves using ‘em on her runs.

For The Friend Who’s Always At Barre

Gaiam Yoga Barre Socks

Black Friday/Cyber Monday Sale

Yoga Barre Socks

If your friend lives at barre class, snag them a few pairs of these non-slip barre socks. Machine-washable and grippy, these socks come in a variety of cute colors, including mulberry and sky blue. Isabel McMahon, WH’s assistant social media editor, loves that they have crisscross straps to help keep her feet steady during her yoga and Pilates classes. “I wouldn’t mind finding a few more in my stocking this year!”

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For The Traveling Fitness Lover

TheraBody TheraGun Mini

TheraGun Mini

With its compact size, ergonomic grip, and 150 minutes of charge time, the Theragun Mini is the ideal gift for that person who’s always traveling around the world to run marathons (or just makes really good use of the hotel gym).

Accardi loves hers, keeping it handy in her gym bag for on-the-go muscle relief. “It works wonders at alleviating my muscle soreness during tough training cycles,” she says.

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For The Friend Who Needs A New Gym Bag

BALEINE Gym Bag

Black Friday/Cyber Monday Sale

Gym Bag

Soft, machine-washable, and waterproof, your gym-going pal will love this bag. It’s a bestseller among WH readers. From toting it to dance class to carrying all their pickleball essentials, they’ll appreciate its separate compartment to store things like shoes and wet swimsuits, as well as its additional storage pockets for all their other workout accessories. Plus, they’ll look super stylish wearing it in this gorgeous bubblegum pink color.

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For The Fitness Lover Always On The Go

Tower 28 SOS Daily Rescue Facial Spray

SOS Daily Rescue Facial Spray

Is your friend constantly squeezing in workouts between WFH meetings, or maybe doesn’t always have enough time to shower post-sweat? Gift them this facial toner to keep their skin issues at bay and prevent breakouts. Fitness editor Talene Appleton always keeps a bottle in her gym bag so she can spray it on her face and chest after every workout.

For The Friend Who Doesn’t Like To Wear Fitness Watches

Oura Ring Gen 3

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Ring Gen 3

The Oura ring isn’t just a buzzy wellness product—WH editors love this smart ring to help them monitor their sleep, activity, stress, heart rate, and more. Better yet, it’s lightweight, comfortable to wear, water-resistant, and has a stylish design that’ll seamlessly blend in with your friend’s aesthetic. It also boasts a great battery life—WH’s executive health and fitness director Jacqueline Andriakos says hers generally lasts a whole week.

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For The Friend Who Lives In Leggings

Lululemon Align Pant

Align Pant

It’s no secret that WH editors are obsessed with these Lululemon leggings. They’re awesome for any sort of workout—HIIT, yoga, boxing, you name it—with their buttery-soft fabric, weightless fit, and high-rise waistband. Your friend will adore these leggings so much, they’ll even wear them on their recovery days relaxing at home or running errands around town. Better yet, they come in an assortment of colors, including espresso, teal, and raspberry.

For The Fashion-Forward Fitness Girly

Vuori Halo Slim Flare

Halo Slim Flare

Flared leggings are so in right now, says assistant fashion editor Rose Lauture. “They elevate every look, are super flattering, and versatile.” Style and comfort combine in this pair from Vuori, making them the perfect fit for every activity—from lounging at home to grabbing breakfast with your girls. “Not only do flared leggings make great yoga pants, but you can also wear them out and about paired with a boot or a sneaker,” Lauture adds.

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For The Friend Who Loves The Outdoors

Homesick Scented Gone Hiking Candle

Scented Gone Hiking Candle

Your loved one is sure to appreciate this WH-favorite candle that’s specifically designed to smell like hiking (yup, that’s a thing), with refreshing top notes of pine, cassis, and fresh waters. They’ll appreciate being able to experience (kinda) the great outdoors while they’re stuck inside working this winter.

For The Yogi

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Manduka The Pro Yoga Mat

The Pro Yoga Mat

Dubbed the best overall thick yoga mat by WH, this mat is a game-changer for your yogi friend with bad knees or wrists. Featuring ultra-dense cushioning and a supportive grip, it provides comfort and stability for even the toughest poses.

Available in a wide range of colors, you can pick out your friend’s favorite hue. “I never slide when busting challenging moves and also love it for mat pilates workouts,” says Accardi. Plus, with a lifetime warranty, your friend is all set for countless yoga seshes to come.

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For The Fitness Lover Who Works From Home

Merach Walking Pad

Black Friday/Cyber Monday Sale

Walking Pad

Got a pal who’s always trying to hit their step goal? Gift them this walking pad (aka an under-desk treadmill) so they can strut their stuff while crunching numbers or typing away on their computer. “I love using it while working at my desk—it easily rolls right underneath!” says Accardi. It’s the perfect present to help them stay active throughout the day without interrupting their workflow.

For The Woman Who Wants To Get Into Strength-Training

Women’s Health The Woman’s Guide To Strength Training: Dumbbells

The Woman's Guide To Strength Training: Dumbbells

This new Women’s Health guide, designed by trainer Nellie Barnett, CPT, is packed with 12 weeks of dumbbell-only strength-training routines that can be done in just 30 minutes. It’s the perfect gift for any woman looking to improve muscle mass or just experience the benefits of regular movement.

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For Cold-Weather Workout Warriors

Smartwool Merino 150 Wool Top

Merino 150 Wool Top

A WH reader-favorite, the merino wool material on this long-sleeve base layer shirt makes it both moisture-wicking and odor-resistant. The fitted silhouette is uber-flattering while offering unrestricted movement in the arms and chest. They’ll love sporting this cozy shirt on the slopes (or just at home) all day. A bonus? It comes in several cute colors, like fuchsia and rose.

For The Avid Runner

On Cloudmonster

Cloudmonster

Experts say regular runners are supposed to replace their running shoes every four to six months. Gift your friend who’s overdue for a replacement a brand new pair from cult-favorite brand On. Extra cushiony, bouncy, and airy, this running shoe is built for long-lasting comfort and performance. Accardi felt unstoppable wearing them during her half marathon, appreciating their breathability, secure fit, and durability.

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For The Tech-Savvy Exerciser

Apple Watch Series 10

Black Friday/Cyber Monday Sale

Watch Series 10

If they’ve been eyeing the newest Apple Watch, there’s no better time than the holidays to splurge and treat them to one—because they deserve it! WH readers love using this waterproof smartwatch for optimizing workouts, monitoring sleep, tracking their heart rates, and so much more. Your fittech-loving friend will never want to take it off.

For The Friend Who Wants To Level Up Their Hot Girl Walk

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Bala Bangles

Bangles

These wrist weights from Bala went viral on TikTok for their sleek design and ability to elevate any workout. Whether your friend is walking or doing pilates, these stylish wrist weights will add light resistance to tone arms and enhance muscle endurance. Flexible and comfortable, they make a thoughtful gift for anyone looking to level up their fitness routine. An added pro: They come in several cute colors, like blush and sage.

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For The Friend Who Loves To Track Their Training

Cossac Fitness Log Book & Workout Planner

Fitness Log Book & Workout Planner

Practical gifts are always appreciated. Designed by experts to help exercisers track progress and stay motivated, this WH reader-topselling workout journal will become your friend’s ultimate gym companion. It offers structured pages to log exercises, sets, reps, goals, and even diet preferences and nutrition. Compact and sleek, they can easily toss it in their gym bag and even travel with it to keep themselves accountable.

For The Friend Who Loves A Multipurpose Fitness Gift

Trigger Point Therapy Grid Foam Roller

Black Friday/Cyber Monday Sale

Therapy Grid Foam Roller

Accardi has tried her fair share of foam rollers over the years but always returns to this one. Known for its firm yet flexible design, this roller targets deep tissue to help relieve soreness and improve flexibility. Plus, with free online instructional videos, your friend can learn the best techniques for effective muscle recovery. Whether they’re prepping for a race or recovering after a tough workout, this foam roller is a must-have.

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For The Acupuncture Enthusiast

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ProsourceFit Acupressure Mat and Pillow Set

Acupressure Mat and Pillow Set

WH readers and editors say that this cult-favorite acupressure mat is great for soothing stiff muscles, relaxation, and general pain relief. If the person in your life is into all things recovery, there’s no doubt they’ll love testing this tool out. While it’s TBD if the physical benefits aren’t just a placebo effect, studies have found that taking the time to use one and relax can lead to a reduction in stress levels.

For The Fitness Lover Who Adores A Matching Set

Beyond Yoga Spacedye Slim Racerback Cropped Tank

Spacedye Slim Racerback Cropped Tank

Matching sets are *so* in. Buttery soft, comfortable, and ultra-flattering, your friend will love unwrapping this matching set from Beyond Yoga. The pieces are sold separately so be sure to grab the matching leggings. Perfect for yoga class, cardio workouts (hello, built-in bra!), or even just strolling around, McMahon loves that this set comes in a wide range of colors, too—like ruby red, mocha, and deep moss—so you’re sure to find one your friend will love.

Headshot of Jasmine Gomez

Jasmine Gomez is the Commerce Editor at Women’s Health, where she cover the best product recommendations across beauty, health, lifestyle, fitness, and more. When she’s not shopping for a living, she enjoys karaoke and dining out more than she cares to admit. Follow her @JazzeGomez.  

Lettermark

Mark Stock is a food, drink, and outdoors writer from Portland, Oregon. He spent years making, selling, and sipping Pinot Noir in the Dundee Hills before a full return to his journalistic roots in 2016. In addition to Men’s Health, he writes for SevenFifty Daily, Sip Northwest, The Somm Journal, The Drake, Willamette Week, Travel Oregon, and more.  

 
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This type of exercise suppresses hunger in women more than men, study proves

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This type of exercise suppresses hunger in women more than men, study proves

Find yourself with a bigger appetite on rest days than after logging your hardest workout of the week? Same. It usually takes me an hour or two to feel hunger after an intense session, and while there are plenty of existing studies that have attributed this to a decrease in the hunger hormone grehlin and an increase in the hormone peptide YY, which helps you feel fuller for longer, new research suggests women are more susceptible to this response than men.

Granted, the study was conducted on only a small sample of participants (eight males and six females), but this is the first review to have included women at all, and the findings were notable.

The method was pretty straightforward: participants were asked to fast overnight, before completing bouts of cycling at varying levels of intensity the next morning. These were then followed up with blood tests (to measure amounts of lactate) and self-reports to analyse appetite levels.

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Science shows that high-intensity exercise suppresses appetite more in women than men

Results showed that the females had higher levels of total ghrelin (the hormone that makes you feel hunger) at baseline compared to the males, while they also had ‘significantly reduced levels’ of acylated (AG) ghrelin after intense exercise compared to males. Ghrelin levels were, in fact, much lower in both males and females after intense exercise compared to moderate exercise, meaning that all participants felt ‘less hungry’ after high-intensity exercise compared to after moderate exercise, but this was even more significant for women.

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‘We found that moderate intensity exercise either did not change ghrelin levels or led to a net increase,’ the study noted. The authors added that exercise above your lactate threshold may be necessary to elicit a suppression in grehlin. Lactate threshold is the point at which lactate builds up in your bloodstream faster than your body can remove it – it occurs during high-intensity exercise.

Why is this useful to know? The author of the study, Kara Anderson, PhD, says: ‘Our research suggests that high-intensity exercise may be important for appetite suppression, which can be particularly useful as part of a weight loss programme. Exercise should be thought of as a “drug”, where the “dose” should be customised based on an individual’s personal goals.’


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Lettermark

Bridie is Fitness Director at Women’s Health UK. She spends her days sweating over new workouts, fitness launches and the best home gym kit so you have all that you need to get fit done. Her work has been published in Stylist, Glamour, Cosmopolitan and more. She’s also a part-time yoga teacher with a habit of nodding off mid savasana (not when she’s teaching, promise).

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Working out but not seeing results? A PT confirms whether 30-minute workouts are top-tier for boosting fitness

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Working out but not seeing results? A PT confirms whether 30-minute workouts are top-tier for boosting fitness

While some of you have your healthy lifestyle down to a tee – balanced nutrition, adequate sleep and a finely tuned workout regime incorporating strength, cardio and flexibility training – others struggle to know where to start when it comes to fitness. And with Google searches for “Is 30 minutes of exercise a day enough?” spiking, it seems that many of you aren’t sure about the length of time or number of workouts to aim for weekly.

And to make matters even more confusing, knowing how often you should workout isn’t always as simple as it should be. You see, your progress will depend on a combination of factors which might seem unconnected to exercise but still have an impact. Sleep, for example, has been shown in various studies (like this one, published in the European Journal of Applied Physiology) to affect physical performance, while research also shows a bi-directional relationship between exercise and stress.

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