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How Patient Data Brings Life-Changing Medicine to Central Pennsylvania – UPMC & Pitt Health Sciences News Blog

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How Patient Data Brings Life-Changing Medicine to Central Pennsylvania – UPMC & Pitt Health Sciences News Blog


Each year, thousands of patients visit UPMC hospitals, outpatient centers and specialty and primary care offices – generating thousands of datasets in the process. Whether it’s demographic information, imaging, lab results, signs and symptoms, family histories or treatment outcomes, there are countless stories for the masses of de-identified data to tell – and physicians like Hemal Gada, M.D., president, UPMC Heart and Vascular Institute in Central Pa., are using artificial intelligence to unravel those narratives.  

“Applying machine learning and artificial intelligence to big datasets is a burgeoning field of medical research. In the next five years, we’ll use predictive modeling to precisely define the progression of diseases like cancer and heart disease,” Dr. Gada said.  

Certain geographic, demographic, cultural, genetic and generational factors contribute to how diseases develop, progress and affect our bodies. For example, the social and environmental factors that drive the development and progression of heart disease will vary between someone living in rural Appalachia and someone living in an urban or suburban environment.  

According to Dr. Gada, machine learning, a type of computer program, allows researchers to identify patterns in vast amounts of patient data. By identifying these trends in a specific subset of de-identified patient data from central Pennsylvania, Dr. Gada hopes to identify the precise factors that drive disease progression in the region – which could someday lead to specialized clinical trials and treatment approaches.  

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Dr. Gada and his colleagues published a study in The American Journal of Cardiology that utilized this machine learning approach to understand more about the characteristics of the stages of aortic stenosis for people living in central Pennsylvania. Patients with this condition have a heart valve that doesn’t open fully, which reduces blood flow from the heart to the aorta and to the rest of the body. If left untreated, chest pain and shortness of breath can develop, along with a host of other cardiac challenges – including clotting, heart failure, and stroke.  

Historically, aortic stenosis patients have typically been assigned to three categories – mild, moderate, and severe. Severe patients typically undergo transcatheter aortic valve replacement (TAVR), but milder severity patients do not. Cardiologists have debated whether moderate aortic stenosis might benefit from a TAVR procedure due to their higher risk for poor outcomes. 

Using echocardiograms and patient data from more than 61,000 aortic stenosis (AS) patients at UPMC Heart and Vascular Institute in Central Pa, Dr. Gada and his colleagues developed an algorithm to study the medical histories of these patients over time — How long after diagnosis before they were readmitted to the hospital? What other co-occurring diseases did they have? What signs did the body give to signal that a poor outcome or hospital readmission could be imminent?  

The research team determined that moderate AS patients living in central Pennsylvania who have end-stage kidney disease or atrial fibrillation were at the highest risk for poor outcomes. According to Dr. Gada, these patients could need an intervention like the TAVR procedure, sooner rather than later.  

While these findings are intriguing, Dr. Gada said this research is hypothesis-generating, meaning it will lead to the development of clinical trials – some of which are already underway.  

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Artificial intelligence-driven research often leads to more questions than it does answers, but the next time you’re at the doctor’s office and answering questions about your symptoms and health history, remember that you could shape the future of medicine simply by showing up and getting the care you need.  

“Your data, which is de-identified in the research process, is just one piece of a much larger puzzle,” Dr. Gada said. “This data doesn’t have to be stagnant; it can help us develop personalized approaches to medicine in our community and determine what health challenges the citizens of our region face. We’re just beginning to scratch the surface of how artificial intelligence can transform health care in central Pennsylvania.”   

 





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Pennsylvania

Pennsylvania Gov Josh Shapiro’s neighbor accuses him of stealing land in ‘outrageous abuse of power’

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Pennsylvania Gov Josh Shapiro’s neighbor accuses him of stealing land in ‘outrageous abuse of power’


Pennsylvania Gov. Josh Shapiro’s neighbors are suing the Democrat, accusing him of stealing a slice of their land to erect an eight-foot-high security fence around his private residence in an “outrageous abuse of power.”

The neighbors, Jeremy and Simone Mock, are currently duking it out with the governor in court over a 2,900 square foot parcel of land located between their two homes in Abington, Montgomery County, court papers show.

The Mocks alleged in a lawsuit filed last month that Shapiro and his wife, Lori, unlawfully seized the stretch of land after initial negotiations to buy it from them went up in flames.

Pennsylvania Gov. Josh Shapiro’s neighbors have accused the Democrat of stealing a slice of their land to erect an eight-foot-high security fence around his private residence. Josh Shapiro / Facebook

Shapiro claimed in a countersuit that he owns the disputed land due, citing an “adverse possession” loophole that makes it his because he has maintained the sliver of property for decades.

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The land-grab tit-for-tat kicked off last year when the Shapiros first sought to erect the huge fence and upgrade security following an arson attack on the governor’s official residence in Harrisburg while they were all sleeping inside on April 13.

Shapiro initially offered to pay the Mocks for the 2,900-square-foot section of land, which he for decades had believed was his, to be able to build the fence, the suit said.

The negotiations, however, fell through when the neighbors couldn’t agree on a price.

The Mocks allege that’s when Shapiro and his wife unlawfully claimed ownership of the property — even planting trees and having State Troopers stationed there.

“What followed was an outrageous abuse of power by the sitting Governor of Pennsylvania,” the Mocks’ lawsuit argues.

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The neighbors claim Shapiro had State Troopers stationed on the property after unlawfully claiming ownership, the lawsuit states. Eastern District of Pennsylvania
Shapiro initially offered to pay the Mocks for the 2,900 square foot section of land, which he had believed for decades was actually part of his own property, but the negotiations fell through, according to the suit. Eastern District of Pennsylvania

“To begin, the Shapiros suddenly claimed, without evidence, they owned the Mock Property through ‘adverse possession’ despite their previous acknowledgments that the Mock Property was owned by no one other than the Mocks and despite having never been awarded the Mock Property through adverse possession by a court,” the court filing states.

The law allows for an occupant to legally acquire the title of someone else’s property if they’ve occupied the area for over 21 years.

The Shapiros purchased their home in 2003 and long believed the disputed 2,900 square foot section of land was part of their property, meaning they had maintained it for more than the required 21 years, their countersuit claims.

As the issue continues to play out in court, Shapiro’s office suggested the entire saga was a political stunt.

“The Governor looks forward to a swift resolution and will not be bullied by anyone trying to score cheap political points, especially at the expense of his family’s safety and wellbeing,” his office told NBC when the dueling suits were filed.

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Funeral arrangements set for Pa. state trooper shot and killed in Chester County

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Funeral arrangements set for Pa. state trooper shot and killed in Chester County


The funeral arrangements for Corporal Timothy O’Connor, who was shot and killed in Chester County on Sunday, have been announced.

The viewing for O’Connor will be Tuesday, March 17, from 4:30 p.m. to 8 p.m. at St. Joseph’s Church located at 338 Manor Avenue in Downingtown, Pa., according to the Parkesburg Police Department.

The funeral will be held at the same location on Wednesday, March 18, at 11 a.m., police said.

O’Connor was shot and killed during a traffic stop in Honey Brook on Sunday night. The suspect, Jesse Nathan Elks, took his own life after shooting O’Connor.

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O’Connor was a 15-year veteran of the Pennsylvania State Police who leaves behind a wife, Casey, and a 6-year-old daughter, according to police.

Pennsylvania State Police

Pennsylvania State Police



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Fire crews try moving burning barge to shallow water in Delaware Bay

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Fire crews try moving burning barge to shallow water in Delaware Bay


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Delaware, Pennsylvania, and federal agencies have been responding to a barge fire in the Delaware Bay. 

The barge, which is carrying salvage metal, is being moved to shallow water so it can be secured, allowing on-scene responders to extinguish the fire and complete salvage operations, according to a March 10 statement from the Delaware Emergency Management Agency.

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No injuries have been reported as of 1:15 p.m.

The Delaware Department of Natural Resources and Environmental Control (DNREC) is on scene to perform air monitoring, the statement said.

Responding agencies include the Wilmington Fire Department, Good Will, Leipsic Volunteer, Bowers and South Bowers fire companies. Also there are Delaware State Police, DNREC, New Castle County Office of Emergency Management, Kent County Department of Public Safety, the Delaware Emergency Management Agency and the U.S. Coast Guard Sector Delaware Bay.

The Philadelphia Fire Department was enroute.

This is a developing story. Check back with delawareonline.com for more information.

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Send tips or story ideas to Esteban Parra at (302) 324-2299 or eparra@delawareonline.com.



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