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New cancer tech sends chemo straight to tumors

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New cancer tech sends chemo straight to tumors

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Chemotherapy can save lives, but anyone who has watched a loved one go through it knows how hard it can be. The nausea. The exhaustion. The infections. The days when even getting off the couch feels like too much.

That happens because standard chemotherapy travels through the bloodstream. It attacks cancer cells but can also harm healthy cells along the way. For some pancreatic cancer patients, that approach may be changing.

A targeted drug-delivery system from RenovoRx is designed to send chemotherapy directly near the tumor instead of through the entire body. The system, called Trans-Arterial Micro-Perfusion, or TAMP, is being studied in a Phase III clinical trial for locally advanced pancreatic cancer.

For 83-year-old Hernando Salcedo, who had been left weak, nauseous and overwhelmed by standard chemotherapy, the trial offered something he desperately needed: a reason to hope. He enrolled at Miami Cancer Institute and soon began to feel the shift in his own body. His appetite started coming back. His energy improved. He felt more like himself. “The difference was tremendous,” Hernando said. “I completed eight sessions, one every 15 days, and I felt dramatically better than I did with the original chemotherapy.”

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HIDDEN FACTOR IN CANCER TREATMENT TIMING MAY AFFECT SURVIVAL, RESEARCHERS SAY

Cancer patient Hernando Salcedo attended a family wedding after RenovoRx’s Trans-Arterial Micro-Perfusion system delivered chemotherapy directly near his tumor, helping him feel stronger during treatment. (Hernando Salcedo)

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How the RenovoRx drug-delivery device works

RenovoRx’s platform uses the FDA-cleared RenovoCath device to deliver chemotherapy through a catheter placed in an artery near the tumor. A physician guides the catheter into position using X-ray imaging.

Shaun Bagai, CEO of RenovoRx, said the platform is designed to localize chemotherapy delivery near the tumor instead of relying on the drug to travel through the whole body.

“Once in position, two small balloons on the catheter are inflated, and the system is adjusted to isolate a targeted segment of artery adjacent to a tumor,” Bagai said. “The chemotherapy drug is then infused between the balloons, creating pressure to push the drug across the vessel wall and near the tumor, directly bathing the target tumor.”

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That setup allows doctors to focus treatment in a specific area rather than exposing more of the body to chemotherapy. “The procedure itself is minimally invasive and is typically performed in an outpatient setting without the need for patients to be put under general anesthesia,” Bagai said.

For patients already dealing with pain, fatigue and fear, that outpatient approach may feel less overwhelming than a major hospital procedure.

 

How targeted chemotherapy for pancreatic cancer works

To understand why this approach matters, it helps to start with the problem doctors are trying to solve. Dr. Ripal Gandhi, a vascular interventional radiologist and interventional oncologist at Baptist Health Miami Cardiac & Vascular Institute and Miami Cancer Institute, explained why standard chemotherapy can be so hard on the body.

“With IV chemotherapy, the drug travels through the bloodstream, affecting both cancerous and healthy cells, which can lead to side effects,” Dr. Gandhi said. TAMP takes a more targeted route. A doctor places a catheter in an artery near the tumor, then delivers chemotherapy into that area instead of relying on the drug to circulate throughout the body.

Dr. Gandhi compared it to “a drip irrigation system for individual plants instead of watering an entire lawn.” For patients, that means doctors are trying to focus more of the treatment near the cancer while reducing how much chemotherapy reaches the rest of the body.

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Why pancreatic cancer is so difficult to treat

Pancreatic cancer has a reputation for being one of the hardest cancers to fight, partly because the tumor itself can block treatment from working the way doctors want it to.

Dr. Gandhi said that creates a major challenge for standard IV chemotherapy. “Studies have shown that less than 10% of chemotherapy administered intravenously actually reaches tumor cells due to the few blood vessels in the tumor as well as dense fibrous stroma, which serves as a physical barrier in the tumor microenvironment,” Dr. Gandhi said.

That helps explain why targeted delivery could play an important role. TAMP sends the drug closer to the tumor rather than depending on the bloodstream to do all the work.

“This targeted approach via TAMP does not rely on chemotherapy circulating through the body to carry the drug to the tumor via tumor feeder vessels,” Dr. Gandhi said. “Trans-arterial micro-perfusion is a drug-delivery platform that delivers chemotherapy directly near the target tumor where it is needed most.”

NEW CANCER THERAPY HUNTS AND DESTROYS DEADLY TUMORS IN MAJOR BREAKTHROUGH STUDY 

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Chase McCann, associate director of the cell therapy lab core, demonstrates how cancerous T-cells from a child are used to develop an autoimmune treatment to fight cancer at Children’s National Hospital in Washington, D.C., on Aug. 26, 2025. (Marvin Joseph/The Washington Post/Getty Images)

 

Patient says targeted chemotherapy gave him hope

Hernando’s cancer journey began after he went to the doctor with a swollen stomach and hip pain. Doctors diagnosed him with locally advanced pancreatic cancer. When he started standard chemotherapy in August 2025, the side effects hit hard. “My body was going through an incredible amount of stress,” Hernando said. “My stomach was inflamed, I had persistent pain in my head, and I had almost no energy.”

He was also receiving chemotherapy and radiation at the same time. “It was a very difficult period, both physically and emotionally,” he said. “I remember feeling exhausted, overwhelmed and unsure of what the future would look like.”

When doctors presented the targeted treatment option, Hernando saw it as more than another medical procedure. “To me, it felt like a new opportunity to live,” he said. “It gave me hope at a time when my family and I really needed it.”

He credits Dr. Gandhi and the team at Miami Cancer Institute with helping him through it all. “From the beginning, he was honest, supportive and clear with my wife, my family and me,” Hernando said. “That meant everything.” 

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Fewer chemotherapy side effects changed daily life

“Before, I was losing weight, had no appetite and felt drained,” Hernando said. “After switching treatments, things began to change. I stopped losing weight, my appetite came back, my color improved and I had more energy.”

Cancer treatment can sometimes take over everyday life. When side effects ease, patients can get pieces of their normal life back. “After about eight weeks, we could see real progress,” Hernando said. “I was eating more, moving more and feeling excited about life again.”

One moment still stands out. Hernando was able to attend a family wedding and dance the entire night. “That moment meant everything to me,” he said. “After everything I had been through, being able to celebrate with my family in that way felt like a gift.” For Hernando, it was a chance to feel like himself again. “That night at the wedding, I was not thinking only about cancer or treatment,” Hernando said. “I was living.”

 

Early trial results show survival and quality-of-life signals

The early data from RenovoRx’s Phase III TIGeR-PaC trial suggest the targeted approach may offer both survival and tolerability benefits for some patients.

Dr. Gandhi said completed clinical studies with TAMP in pancreatic cancer showed “a potential for better outcomes and less side effects for patients.”

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“In the initial interim analysis of the TIGeR-PaC clinical trial, there was a trend towards improved overall survival by 6 months and improvement in the progression free survival by 8.1 months with 65% fewer adverse events in the TAMP arm of the study,” Dr. Gandhi said.

 

Who may benefit from targeted chemotherapy delivery?

This approach isn’t for every pancreatic cancer patient. Doctors still need to look at the cancer stage, tumor location, treatment history and whether the cancer has spread.

Dr. Gandhi said Hernando was the kind of patient who could be a strong fit. “He is precisely the type of patient who would benefit best from this approach because he has a tumor which is too far advanced to be treated surgically, but it has not spread to other organs,” Dr. Gandhi said.

He also pointed to clinical trials as an important option for pancreatic cancer patients.”I discussed with him that the recommendation of the National Comprehensive Cancer Network is that the best management for pancreatic cancer patients is participation in a clinical trial whenever possible and he was an ideal candidate,” Dr. Gandhi said.

He went on to say that TAMP may be an option for patients who are not candidates for surgery, patients who have failed chemotherapy or patients who no longer want to continue IV chemotherapy because of side effects.

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“TAMP can be used at any point within the treatment landscape, before, during or after other treatment modalities such as IV chemotherapy or radiation,” he said.

PANCREATIC CANCER PATIENT SURVIVAL DOUBLED WITH HIGH DOSE OF COMMON VITAMIN, STUDY FINDS

The RenovoCath device uses a catheter-based system to deliver chemotherapy near the tumor instead of through the whole body. (RenovoRx)

 

What comes next for RenovoRx’s cancer treatment platform

RenovoRx says the RenovoCath catheter is already FDA-cleared for general therapy and chemotherapy delivery. The company is also nearing the end of enrollment in its Phase III TIGeR-PaC trial.

That trial is evaluating intra-arterial gemcitabine (IAG) delivered through RenovoCath for locally advanced pancreatic cancer. Bagai said enrollment is expected to be completed in mid-2026, with final results expected in 2027.

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“If positive, data generated from this trial could potentially support a new drug application for this combination product to the FDA for IAG,” Bagai said. RenovoRx also sees potential beyond pancreatic cancer. “The challenge we are addressing is not unique to pancreatic cancer,” Bagai said.

He said the platform could apply to other solid tumors with limited blood supply, including bile duct cancer, certain lung cancers and sarcomas. “The platform is designed to work with different types of therapies, not just one drug,” Bagai said. “That opens the door to future combinations and potential partnerships, with the goal of expanding options for patients who have limited treatment choices.” 

 

What this means to you

If you or someone you love has pancreatic cancer, this story is worth paying attention to. Clinical trials can open up options when standard treatment feels too hard to tolerate or stops working.

Drug delivery matters, too. The medicine itself is only part of the story. Where it goes inside the body can affect side effects, energy levels and quality of life. Targeted chemotherapy delivery remains a specialized treatment approach. Some cancer centers may not offer it, and every diagnosis will not be a fit. Your care team can review imaging, staging, prior treatments and overall health to see whether it makes sense.

Start with direct questions. Ask whether a clinical trial makes sense. You can also ask about targeted delivery options or a second opinion from a pancreatic cancer specialist. Hernando’s advice to other patients is simple. “I would tell them not to lose hope and not to wait to ask questions,” he said. 

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Kurt’s key takeaways

Pancreatic cancer has a way of turning normal life upside down fast. One day, a family is making plans. The next, they are trying to understand scans, treatment choices and side effects that no one feels ready for. That is what makes Hernando’s story so powerful. The part that stays with you isn’t only the technology. It is the fact that he started eating again. He had more energy. He felt more like himself. And he got to dance at a wedding after wondering what the future would look like. The final Phase III trial results will be important. Doctors still need to see how widely this approach could help patients. But the promise is easy to understand. If chemotherapy can get closer to the tumor while taking less of a toll on the rest of the body, patients may get something that matters just as much as treatment itself: more good days.

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Technology

The best Apple deals you can get during Prime Day

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The best Apple deals you can get during Prime Day

Amazon’s Prime Day is now in its second day, and whether you’re looking for a new pair of wireless earbuds or a smartwatch, there’s a good chance you’ll find a discount. The Apple Watch Series 11 has already dropped to a new low price, while the AirPods Pro 3 are discounted to $179. With Tim Cook warning that price hikes are coming, now may be the moment if you’ve been eyeing one of the company’s devices.

Below are the best Apple deals currently available. Some are exclusive to Prime Day, while others are simply great discounts we think are worth highlighting. We’ll continue updating this guide throughout Prime Day, highlighting more deals as they become available.

Earbud and headphone deals

Update, June 24th: Adjusted prices and availability, and added deals for Apple’s MagSafe Charger as well as the Apple Magic Keyboard.

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A new paper argues Microsoft exaggerated its quantum claims a year ago

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A new paper argues Microsoft exaggerated its quantum claims a year ago

A critique published in Nature Wednesday calls the basic technology behind Microsoft’s “breakthrough” quantum computing chip the Majorana 1 into question. Microsoft unveiled the chip in February 2025 and said it featured a brand-new technology known as a topological qubit. Topological qubits, they said, would be the “building blocks” for their future quantum computer. Microsoft announced the next generation chip Majorana 2 at Build earlier this month.

But in a peer-reviewed article, Henry Legg, a physicist at the University of St Andrews, reanalyzed Microsoft’s data on their device and argued that the company’s researchers did not conclusively demonstrate a working topological qubit in the first place.

Theory predicts that the electrons in this wire behave in a collective pattern known as a Majorana particle, for which the chip is named.

Proponents of quantum computing predict that the technology’s computational abilities will advance new medicine discovery, encryption, and machine learning. Companies like Google and IBM have already demonstrated more advanced machines than Majorana 1 or 2, although presently, no one has conclusively gotten any quantum computer to perform anything useful. But Microsoft claimed that Majorana 1, and subsequently Majorana 2, paved their path toward a practical quantum computer.

Microsoft’s design, unique among quantum computing companies, involves a tiny wire, thinner than a human hair, made of the semiconductor indium arsenide stuck to a superconductor. Theory predicts that the electrons in this wire behave in a collective pattern known as a Majorana particle, for which the chip is named. Microsoft wants to encode information in the properties of the Majorana particle. (A topological qubit is to a Majorana particle as a transistor is to silicon.)

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Proponents of the Majorana particle think it is promising qubit material because theory predicts that when formed into topological qubits, the Majorana should compute with fewer errors than competing materials, such as superconducting circuits pursued by IBM. This suggests that ultimately, fewer topological qubits are needed to scale up to a useful quantum computer.

That is, if Microsoft has actually made a Majorana particle. “They haven’t convincingly shown that they have Majoranas,” Legg told The Verge. “You can’t make a qubit if you don’t have the Majoranas.”

In Legg’s critique, he writes that what Microsoft claims as a signature of the Majorana particle could actually be from the formation of quantum dots, which are electron-containing structures, in the device. Quantum dots would not be useful for building the quantum computer. He also writes that Microsoft cherry-picked their data.

“You can’t make a qubit if you don’t have the Majoranas.”

Microsoft’s team published a rebuttal in Nature disputing Legg’s interpretation of their data. Legg’s critique “does not constitute a substantial scientific challenge to our findings,” the Microsoft team wrote. Legg has not “proposed an alternative model that fits all of our data,” Chetan Nayak, a physicist leading Microsoft’s quantum team, told The Verge.

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Legg first posted his critique on the online physics repository arXiv on February 26, 2025, within a week of Microsoft’s Majorana 1 announcement. It took a year for Nature to conduct a peer review and publish his article.

Meanwhile, on June 2, Microsoft announced a new chip, the Majorana 2, featuring what they claimed was the next generation of their topological qubits. The company says they can build a “scalable quantum computer” by 2029. “We 100% stand behind our results,” Nayak told The Verge. “We stand by our roadmap. We stand behind our long-standing commitment to scientific rigor and dialogue.”

Legg says the company’s characterization of Majorana 2, which Microsoft wrote in a non-peer reviewed manuscript, suffers from similar problems he pointed out a year ago. “Nothing in this [manuscript] resolves the fundamental issues that so many scientists have with this company’s previous claims,” Legg told The Verge.

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FCC phone ID plan could end burner phones

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FCC phone ID plan could end burner phones

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Buying a phone without tying it directly to your identity could get much harder. The Federal Communications Commission (FCC) is considering tougher “know your customer” rules for voice providers.

The proposal would push phone companies to collect and keep more personal information before giving many new or renewing customers access to service. That could include your name, physical address, government-issued identification number and an alternate phone number.

The FCC says the goal is to make life harder for scammers, robocallers and criminals who abuse phone networks. That sounds reasonable at first. Nobody wants more fake bank calls, Medicare scam texts or urgent messages from crooks pretending to be family members. Yet this proposal raises a much bigger question. How much personal privacy should we give up to fight scam calls?

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GOOGLE SEARCH LED TO A COSTLY SCAM CALL

The FCC is considering tougher phone identity checks that could require more personal information before service begins. (Kurt “CyberGuy” Knutsson)

What the FCC phone ID proposal would require

The FCC phone ID proposal focuses on identity checks for originating voice providers. Those are the companies that allow calls to enter the phone network. Right now, the FCC already expects providers to take steps to know their customers and stop illegal calls. The new proposal would make those duties more specific. The FCC is asking whether providers should be required to obtain and retain certain customer information before granting service. At a minimum, that could include:

  • Name
  • Physical address
  • Government-issued identification number
  • Alternate telephone number

The FCC is also asking how these rules should apply to “new and renewing” customers. That phrase is important. A narrow version could focus on people opening new accounts. A broader version could reach people who switch plans or renew service with a current provider. For high-volume customers, including some business and foreign customers, the FCC is also asking whether providers should collect more information. That could include the intended use of the service and the IP address used to place calls, when applicable.

The FCC is also asking whether providers should retain KYC records for four years after the customer relationship ends, tied to the statute of limitations for certain illegal calling violations.

Why the FCC wants stronger phone identity checks

The FCC says scammers hide behind phone calls and texts to rip people off, then disappear before anyone can track them down. Anyone with a phone knows this problem has gotten out of hand. Most of us now look at an unknown number and assume trouble before we even answer.

The agency believes tougher identity checks could make it harder for bad actors to get onto phone networks in the first place. It also says better customer records could help investigators connect the dots after a scam call or text causes harm.

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Here is where the proposal gets bigger. The FCC also asks whether stronger records could help law enforcement investigate crimes that go beyond scam calls, including national security threats and abuse in text messaging networks. So while robocalls are the headline, this proposal reaches much further. It could move phone service closer to an identity-check model that goes well beyond robocalls.

Why burner phones could become harder to buy

The FCC proposal does not specifically say it will ban burner phones. Still, the practical impact could be significant.  A burner phone usually refers to a prepaid phone or phone line with no clear identity link at the point of purchase. TV shows often connect burner phones with criminals. Real life is more complicated.

People use prepaid or private phone lines for plenty of lawful reasons. A domestic abuse survivor may need a safe phone that an abuser cannot easily trace through shared accounts. A journalist may need to protect a source. A whistleblower may need to call without exposing a personal number. Someone without a stable address may rely on prepaid service because it is easier to obtain.

If phone companies must collect a government ID number and physical address before service begins, anonymous or lightly identified prepaid service could become far harder to access. That is why privacy advocates see this as more than a robocall rule. They see it as a potential shift in how Americans get basic phone service.

HOW SCAMMERS BUILD A PROFILE ON YOU USING DATA BROKERS

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Prepaid phones could face closer scrutiny if the FCC moves ahead with stricter “know your customer” rules. (Photographer: Brent Lewin/Bloomberg via Getty Images)

The FCC proposal could affect prepaid phone plans

Prepaid phones are a big part of this story. Some people use them to save money. Others use them because they want more control over what they spend or because a traditional phone plan creates hurdles they would rather avoid.

The FCC is now asking whether prepaid and postpaid customers should face different identity checks. That question is important because prepaid service has long been one of the easiest ways to get a working phone without a lengthy signup process.

A strict final rule could make prepaid service feel a lot more like opening a bank account. For some people, that may only mean another form to fill out. For others, especially someone trying to stay safe or keep a phone line private, it could be a much bigger deal.

The privacy risk behind a phone ID database

The most obvious concern is privacy. The quieter concern is cybersecurity. Phone companies already hold sensitive customer information. Adding government ID numbers, physical addresses and alternate phone numbers would make those records even more valuable to hackers.

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If a telecom database gets breached, criminals may use stolen customer data for phishing, identity theft, SIM-swap attacks or stalking. A rule meant to stop scammers could create a richer target for scammers to steal. That to me is scary.

The FCC does ask how providers should protect customer information and how long records should be retained. Those are important questions. Still, better security rules would need real teeth. Sensitive data becomes a liability the moment it gets collected.

What “physical address” could mean for phone customers

The FCC is also asking whether P.O. boxes, shared office locations and similar addresses should count as a customer’s physical address. That detail could create real problems.

Some people do not have a traditional home address. Others may avoid sharing one because of safety concerns. A domestic abuse survivor may use a mailing address that keeps a home location private. A small business owner may use a shared office or mail service. If the final rule limits what counts as a valid address, some people could face a harder path to phone service. That may sound like a compliance detail. For someone trying to stay safe, it could matter a lot.

TOP 10 ROBOCALL HOT SPOTS IN AMERICA

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Privacy advocates warn that stronger identity checks could make private phone access harder for people with legitimate safety concerns. (Kurt “CyberGuy” Knutsson)

What happens next with the FCC phone ID proposal

The FCC is taking public comments on the proposal through June 25, 2026. Reply comments are due July 27, 2026. After that, the agency can review feedback from phone companies, law enforcement, privacy groups, consumer advocates and the public.

The final rule could change. The FCC could narrow the requirements, add privacy safeguards, create exceptions or revise major parts of the proposal. For now, this is one to watch closely.

We reached out to the FCC for comment, but did not hear back before our deadline. 

How to reduce scam calls and texts now

You do not need to wait for a new FCC rule to protect yourself.

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1) Let unknown calls go to voicemail

Do not feel pressured to answer every unknown number. A real caller can leave a message. A scammer wants you on the line fast, before you have a chance to slow down and think.

2) Turn on phone spam protections

On iPhone, go to Settings, tap Apps, scroll down and tap Phone, then go to the unknown caller settings. Choose Silence to send calls from unsaved numbers to voicemail, or choose Ask Reason for Calling if you want unsaved callers to provide more information before your iPhone rings. You can also look under Call Filtering and toggle on Unknown Callers and Spam

On many Samsung phones, open the Phone app, tap the three dots, tap Settings, tap Caller ID and spam protection and turn it on. Then, scroll down and make sure Block all spam and scam calls is toggled on. Settings may vary depending on your phone model.

3) Avoid links in unexpected texts

Go directly to the company’s app or website instead. That habit can help stop fake toll texts, bank scams and delivery alerts.

4) Reduce the personal info scammers can use against you

Scammers often sound convincing because they already know something about you. That information can come from people-search sites, data brokers, old breaches or public records. Consider using a data removal service to reduce how much of your personal information is floating around online. Check out my top picks for data removal services and get a free scan to find out if your personal information is already out on the web by visiting Cyberguy.com

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5) Block and report suspicious messages

Do not just delete scam texts. On iPhone, open Messages. If you have not opened the message, swipe left on it, tap the Delete button, then tap Delete and Report Spam. If you have already opened it, tap Report Spam at the bottom of the message, then tap Delete and Report Spam. To block the sender, open the conversation, tap the sender’s icon at the top, tap Info, scroll down and tap Block Contact. Apple says reporting spam does not block the sender. Settings and carrier support may vary.

On many Samsung Galaxy phones using Google Messages, open the message, tap the three dots and choose Block and report spam, if requested confirm your decision by tapping Yes.  If you use Samsung Messages, touch and hold the conversation, tap More, then tap Block. Settings may vary depending on your phone model and messaging app.

6) Use antivirus software and a password manager

Strong antivirus software can help block phishing links and malicious websites before they cause damage. A password manager can also help you avoid reusing passwords if a scammer tricks you into entering login details on a fake page. Get my picks for the best 2026 antivirus protection winners for your Windows, Mac, Android & iOS devices at Cyberguy.com

7) Turn on account alerts

Turn on bank, credit card and phone carrier alerts so you know quickly if someone tries to make a charge, move money or change your account. Fast alerts can help you stop damage before it spreads.

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Kurt’s key takeaways

The FCC wants to stop scammers before they ever get onto the phone network. I get that. Scam calls and texts are out of control, and they have cost too many people real money. At the same time, the way the FCC is looking at this raises a real privacy concern. Asking phone companies to collect a government ID number, physical address and alternate phone number could change what it takes to get basic phone service in America. The FCC believes stronger customer records could help investigators track scammers after illegal calls happen. The question is whether scammers would still find ways around the rules while people with legitimate privacy needs face new hurdles. A domestic abuse survivor, journalist, whistleblower or person without a stable address may have a much harder time getting a private phone line. That is why any scam-fighting plan needs strong privacy safeguards. Before asking phone customers to hand over more personal information, the FCC should show how this data would reduce scams and how it would be protected.

Would you give your phone carrier a government ID number and physical address if it meant fewer scam calls, or does that go too far? Let us know by writing to us at CyberGuy.com.Cyberguy.com

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