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Can toxic algae blooms be predicted? La Jolla scientists think so

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Can toxic algae blooms be predicted? La Jolla scientists think so


A harmful algae bloom off the California coast created a neurotoxin called domoic acid that killed hundreds of sea lions and about 60 dolphins in a short period last year.

Soon after, scientists at UC San Diego’s Scripps Institution of Oceanography in La Jolla started studying the process of how such masses of algae develop so researchers, industries, officials and communities can be better prepared for future outbreaks.

As part of a study funded by the National Oceanic and Atmospheric Administration, Bradley Moore, a professor of marine biology, marine chemistry and geochemistry at Scripps Oceanography, worked to determine how domoic acid is produced with the hope of creating a predictive model.

Now, a team of researchers from SIO, La Jolla’s J. Craig Venter Institute and other organizations appear to have done it.

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In September, the group published a study on predicting harmful algae blooms that contain high levels of domoic acid by tracking a single gene that serves like a canary in a coal mine — an early detector of danger.

The study provides new insights into the mechanisms that drive harmful blooms and offers potential ways to forecast and mitigate their effects.

“We are witnessing a barrage of highly toxic and impactful domoic acid events in California, creating an urgent need for better predictions and forewarning that a harmful algal bloom is imminent,” said Clarissa Anderson, director of the Southern California Coastal Ocean Observing System at Scripps Oceanography and a co-author of the study.

Moore said that while blooms happen nearly annually, not all of them become toxic. According to NOAA, rapid growth of an algae called pseudo-nitzschia causes the production of domoic acid.

“In the last several years, we have had these harmful events in Santa Barbara, which is very disturbing,” Moore said. “Some years it happens, other years it is really minor. The vast majority are not toxic, but some are. And when they are, they really are.

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“So we sought out to use our knowledge to make that kind of prediction … so industries and communities that would be affected can prepare accordingly. If there is a bloom coming, will it be toxic? And can I prepare? Because these events can be devastating to fishing industries and communities.”

The minor type of blooms, he said, are needed to produce phytoplankton that serve as part of the ocean food web.

To explore what makes some algae blooms toxic, scientists started studying water conditions before, during and after a harmful bloom. In pouring through tens of thousands of genes and cells appearing in the ocean, they found one — dubbed dabA — that was “highly expressed” about a week before the neurotoxin appeared.

“It was the telltale signal,” Moore said. “We could measure that and there was no toxin in the water, and a week later the toxin would appear. It was a one-week look ahead.”

Armed with that knowledge, “having the ability to forecast these harmful algal blooms is going to happen,” Moore said. “These toxic blooms are global events. We think this … will be impactful.”

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Work to develop such a model has been going on since 2015, when the largest recorded harmful algae bloom occurred in the northeast Pacific, causing nearly $100 million in damage to fisheries and killing many marine mammals.

During such blooms, shellfish such as clams, mussels and scallops filter-feed on algae and accumulate the toxin in their tissue.

Contaminated shellfish are dangerous to humans when consumed, often causing vomiting, diarrhea, headache, abdominal cramps, dizziness and disorientation, and in more severe cases, difficulty breathing, seizures, loss of short-term memory, irregular heartbeat and more. The toxin cannot be detected by sight or taste.

Following the 2015 bloom, researchers collected water samples from Monterey Bay nearly every week for a year, recording available nutrients and domoic acid concentrations.

Three years later, a published study first implicated the dabA gene in the production of domoic acid. Though scientists discovered the genetic mechanism for production, they didn’t understand the biological or environmental drivers involved.

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With the role of dabA now better understood, and with data from the past three years of water samples, Moore and his collaborators are now working to create a test kit that can identify the gene.

“It is expensive and time-consuming to find the dabA signal, so we are looking to … make diagnostic kits that would simplify things tremendously,” Moore said.

The team also is looking to test the model in other areas of the world.

The issue is important for sea animals that frequent the waters off California.

In 2023, NOAA Fisheries reported that the Channel Islands Marine & Wildlife Institute fielded more than 1,000 reports of sick or dead marine mammals between June 8 and 14 that were thought to have been exposed to the toxic algae bloom.

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“Responders believe domoic acid is behind the deaths, given the neurological symptoms exhibited by the animals,” NOAA said. Tissue samples were collected for testing to confirm.

Because the toxin may cause animals to experience seizures, disorientation and hyper-reactivity, the bloom also led to a surge of sick and potentially aggressive sea lions onshore, including in San Diego.

During that time, sea lions sickened by the algae bit and injured at least two people at beaches in Orange County. The Channel Islands institute, which serves Santa Barbara and Ventura counties, recorded five incidents of marine animals biting beach-goers both in the water and on land. ♦



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San Diego, CA

Constitutional amendment needed to curb influence of money in politics

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Constitutional amendment needed to curb influence of money in politics


This year marks the 50th anniversary of Buckley v. Valeo, the Supreme Court ruling that first equated campaign spending with “free speech.” Sixteen years ago, Citizens United extended similar rights to corporations and unions.

The results are clear: an explosion of campaign spending and growing concern that our democracy is being dominated by a small, wealthy few. In California, outside money plays an outsized role, causing our elections to be among the most expensive in the nation.

Polling shows broad, bipartisan agreement that money has too much influence in politics.

Americans want voters and elected officials — not the courts — to set the rules.

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The solution is a constitutional amendment to restore the authority of Congress and the states to regulate campaign spending. We have amended the Constitution before to correct our nation’s course. It’s time to do it again and put “We the People” back in charge.

— Rosalind Hirst, Normal Heights



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Border Patrol agent indicted in San Diego for 2022 shooting of unarmed teen driver

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Border Patrol agent indicted in San Diego for 2022 shooting of unarmed teen driver


A federal grand jury in San Diego has indicted a U.S. Border Patrol agent on a civil rights violation for shooting an unarmed 19-year-old U.S. citizen in 2022 in Calexico, according to an indictment unsealed Thursday.

Marcos Javier Andrade faces one count of deprivation of rights under color of law and one count of use and discharge of a firearm during and in relation to a crime of violence. He is scheduled to be arraigned on the charges next week in U.S. District Court in San Diego.

The indictment alleges that on July 11, 2022, Andrade tried to stop a minivan that he suspected of smuggling undocumented immigrants on a highway in Calexico, in Imperial County. The van was being driven by a teen “who was unarmed and was not engaged in smuggling activity,” according to the indictment, which identifies the teen only by his initials, A.F.

After the teen failed to pull over and then became stuck in traffic, Andrade allegedly pulled up next to the van, exited his Border Patrol SUV and fired eight shots at the driver, striking him in his neck, hip, shoulder and hand, according to the indictment. The teen survived after undergoing surgery for his injuries.

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The indictment alleges that after the shooting, Andrade “refused to answer basic safety questions that all Border Patrol agents are required to answer on scene when they discharge their firearms.” It also alleges that Andrade had been disciplined previously for firing his gun “at civilians” in 2012 and 2017.

Andrade could not immediately be reached for comment Thursday, and it was unclear if he had an attorney who could comment on his behalf.

Officials from the Border Patrol, as well as its parent agency, U.S. Customs and Border Protection, did not immediately respond to messages seeking comment late Thursday afternoon.

The indictment against Andrade comes at a time when Border Patrol agents and other immigration officers have faced increased scrutiny for shooting U.S. citizens. In October, a Border Patrol agent shot and wounded Marimar Martinez in Chicago, and in January, a Border Patrol agent fatally shot Alex Pretti in Minneapolis just weeks after an Immigration and Customs Enforcement officer fatally shot Renée Good in the same city.

Gregory Bovino, the Border Patrol’s former “commander at large” who spearheaded the Trump administration’s immigration operations in Chicago and Minneapolis, and who sent an email to the Chicago agent just hours after he shot Martinez praising his “excellent service,” was the chief of the El Centro sector in 2022 when Andrade allegedly shot the teen driver.

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Border Patrol officials had previously released few details about the shooting in Calexico, which occurred in the middle of the day near a busy intersection. Andrade’s name was never publicly linked to the shooting before Thursday.

The indictment alleges that when Andrade tried to pull over the driver, the teen continued along state Route 98, driving at the speed limit until he came to a stop behind a line of cars at a stoplight. Andrade allegedly pulled his SUV partially in front of the minivan on the left side, exited his SUV and pointed his gun at the teen.

At that point, both the teen and the driver of a semi in the lane to his right began to pull forward “with the stop-and-go pace of traffic,” traveling between 1 and 5 mph, according to the indictment. The teen then steered his minivan slightly to the right, away from Andrade’s vehicle, in an effort to get around, the indictment alleges.

“At no time did A.F.’s vehicle pose a threat to defendant Marcos Javier Andrade or anyone else,” the indictment alleged. “Nevertheless … Andrade fired eight shots at A.F.”

The indictment alleges that one shot struck the hood, three pierced the windshield and four went through the driver’s side window. In addition to the gunshot wounds the teen suffered, he also sustained injuries from shattered glass that lodged in his right eye, according to the indictment. Six of the eight shots allegedly traveled through the van and also struck the tractor-trailer.

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A photo published by the Calexico Chronicle the day of the shooting showed a Border Patrol agent taking cover behind an SUV and pointing his gun at the van, which at that time was riddled with bullet holes.

Andrade is facing the same two charges that federal prosecutors in San Diego brought against a sheriff’s deputy who fatally shot an unarmed, fleeing man in downtown San Diego in 2020. An initial jury in that case deadlocked after being unable to reach a unanimous verdict, but a second jury convicted the deputy last month on both counts.



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I-805 fatal crash snarls traffic at Murray Ridge Road

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I-805 fatal crash snarls traffic at Murray Ridge Road


Several lanes are closed on the northbound Interstate 805 due to a fatal crash on Thursday morning.

The crash was reported at around 5:30 a.m. at Murray Ridge Road and closed all lanes, but by 6 a.m., two lanes reopened while three lanes remained closed, according to Caltrans.

By 8 a.m., all lanes had reopened to traffic.

Heavy traffic is reported in that area.





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