Montana
Path to a better TB vaccine runs through Montana
Jim Robbins
(KFF) A team of Montana researchers is playing a key role in the development of a more effective vaccine against tuberculosis, an infectious disease that has killed more people than any other.
The BCG (Bacille Calmette-Guérin) vaccine, created in 1921, remains the sole TB vaccine. While it is 40% to 80% effective in young children, its efficacy is very low in adolescents and adults, leading to a worldwide push to create a more powerful vaccine.
One effort is underway at the University of Montana Center for Translational Medicine. The center specializes in improving and creating vaccines by adding what are called novel adjuvants. An adjuvant is a substance included in the vaccine, such as fat molecules or aluminum salts, that enhances the immune response, and novel adjuvants are those that have not yet been used in humans. Scientists are finding that adjuvants make for stronger, more precise, and more durable immunity than antigens, which create antibodies, would alone.
Eliciting specific responses from the immune system and deepening and broadening the response with adjuvants is known as precision vaccination. “It’s not one-size-fits-all,” said Ofer Levy, a professor of pediatrics at Harvard University and the head of the Precision Vaccines Program at Boston Children’s Hospital. “A vaccine might work differently in a newborn versus an older adult and a middle-aged person.”
The ultimate precision vaccine, said Levy, would be lifelong protection from a disease with one jab. “A single-shot protection against influenza or a single-shot protection against covid, that would be the holy grail,” Levy said.
Jay Evans, the director of the University of Montana center and the chief scientific and strategy officer and a co-founder of Inimmune, a privately held biotechnology company in Missoula, said his team has been working on a TB vaccine for 15 years. The private-public partnership is developing vaccines and trying to improve existing vaccines, and he said it’s still five years off before the TB vaccine might be distributed widely.
It has not gone unnoticed at the center that this state-of-the-art vaccine research and production is located in a state that passed one of the nation’s most extreme anti-vaccination laws during the pandemic in 2021. The law prohibits businesses and governments from discriminating against people who aren’t vaccinated against covid-19 or other diseases, effectively banning both public and private employers from requiring workers to get vaccinated against covid or any other disease. A federal judge later ruled that the law cannot be enforced in health care settings, such as hospitals and doctors’ offices.
In mid-March, the Bill & Melinda Gates Medical Research Institute announced it had begun the third and final phase of clinical trials for the new vaccine in seven countries. The trials should take about five years to complete. Research and production are being done in several places, including at a manufacturing facility in Hamilton owned by GSK, a giant pharmaceutical company.
Known as the forgotten pandemic, TB kills up to 1.6 million people a year, mostly in impoverished areas in Asia and Africa, despite its being both preventable and treatable. The U.S. has seen an increase in tuberculosis over the past decade, especially with the influx of migrants, and the number of cases rose by 16% from 2022 to 2023. Tuberculosis is the leading cause of death among people living with HIV, whose risk of contracting a TB infection is 20 times as great as people without HIV.
“TB is a complex pathogen that has been with human beings for ages,” said Alemnew Dagnew, who heads the program for the new vaccine for the Gates Medical Research Institute. “Because it has been with human beings for many years, it has evolved and has a mechanism to escape the immune system. And the immunology of TB is not fully understood.”
The University of Montana Center for Translational Medicine and Inimmune together have 80 employees who specialize in researching a range of adjuvants to understand the specifics of immune responses to different substances. “You have to tailor it like tools in a toolbox towards the pathogen you are vaccinating against,” Evans said. “We have a whole library of adjuvant molecules and formulations.”
Vaccines are made more precise largely by using adjuvants. There are three basic types of natural adjuvants: aluminum salts; squalene, which is made from shark liver; and some kinds of saponins, which are fat molecules. It’s not fully understood how they stimulate the immune system. The center in Missoula has also created and patented a synthetic adjuvant, UM-1098, that drives a specific type of immune response and will be added to new vaccines.
One of the most promising molecules being used to juice up the immune system response to vaccines is a saponin molecule from the bark of the quillay tree, gathered in Chile from trees at least 10 years old. Such molecules were used by Novavax in its covid vaccine and by GSK in its widely used shingles vaccine, Shingrix. These molecules are also a key component in the new tuberculosis vaccine, known as the M72 vaccine.
But there is room for improvement.
“The vaccine shows 50% efficacy, which doesn’t sound like much, but basically there is no effective vaccine currently, so 50% is better than what’s out there,” Evans said. “We’re looking to take what we learned from that vaccine development with additional adjuvants to try and make it even better and move 50% to 80% or more.”
By contrast, measles vaccines are 95% effective.
According to Medscape, around 15 vaccine candidates are being developed to replace the BCG vaccine, and three of them are in phase 3 clinical trials.
One approach Evans’ center is researching to improve the new vaccine’s efficacy is taking a piece of the bacterium that causes TB, synthesizing it, and combining it with the adjuvant QS-21, made from the quillay tree. “It stimulates the immune system in a way that is specific to TB and it drives an immune response that is even closer to what we get from natural infections,” Evans said.
The University of Montana center is researching the treatment of several problems not commonly thought of as treatable with vaccines. They are entering the first phase of clinical trials for a vaccine for allergies, for instance, and first-phase trials for a cancer vaccine. And later this year, clinical trials will begin for vaccines to block the effects of opioids like heroin and fentanyl. The University of Montana received the largest grant in its history, $33 million, for anti-opioid vaccine research. It works by creating an antibody that binds with the drug in the bloodstream, which keeps it from entering the brain and creating the high.
For now, though, the eyes of health care experts around the world are on the trials for the new TB vaccines, which, if they are successful, could help save countless lives in the world’s poorest places.
Montana
Montana Vista residents confront ‘Pecos West’ developers in tense meeting
EL PASO, Texas (KTSM) — Following widespread neighborhood concerns first reported by KTSM 9 News on Friday, residents of the Montana Vista area came face-to-face with developers of the proposed “Pecos West” transmission line project on Saturday morning, May 9 during a community meeting held at the Montana Vista Community Center.
The multi-million dollar project, spearheaded by power grid developer Grid United, aims to build a massive transmission line connecting the El Paso area to southeastern New Mexico.
While developers tout the project as a crucial link to prevent grid bottlenecks, families living in the path of the proposed line continue to voice mounting frustration and distrust over how the land acquisition is being handled.
On Friday, Grid United released a statement to KTSM insisting their one-on-one land negotiations were conducted out of respect for private property rights. But at Saturday’s community gathering, residents and advocates made it clear they aren’t buying it.
“People are afraid. I’m not afraid. I’m angry,” said Armando Rodriguez, president of the Union of Montana Vista Landowners, who previously said that developers had been quietly approaching his neighbors for months with varying buyout offers.
Only about a dozen residents and advocates attended the weekend meeting, but they loudly questioned why the company spent the past year approaching landowners individually rather than addressing the community as a whole.
During the exchange, project officials admitted they have already acquired about 50 percent of the properties in the impacted area. Grid United later clarified to KTSM that the exact number fluctuates frequently, just like the proposed route.
Community organizers argued that the company’s isolated approach leaves residents vulnerable and misinformed.
“When a company like this turns up and says, ‘We’re going to buy your property.’ We must ensure that community members understand that they have the right to say no, or that they have the right to negotiate a higher value,” said Veronica Carbajal, an organizer with the Sembrando Esperanza Coalition.
Carbajal highlighted that the lack of widespread notification and a standardized compensation formula is creating deep unease.
“They’ve already bought properties, but they have not established notification to every resident that will be impacted, nor have they set up a formula for compensation,” Carbajal said. “So what we can see online through the title transfers is that there is a very wide distinction between how much people are being paid. We don’t want the community to be divided. We also want people to understand that this is voluntary. They do not have to sell if they don’t want to.”
A major point of contention at Saturday’s meeting was the threat of eminent domain. Grid United explained that, as a private company, they do not possess eminent domain authority, insisting that if a landowner refuses to sell, the company will simply find an alternative route.
“At Pecos West we’re very landowner-first approach,” said Alexis Marquez, Pecos West community relations manager. “So if a landowner does not want (the transmission line) on the property, then we would find alternative routes.”
But Rodriguez remains highly skeptical that the developers would simply walk away from targeted plots.
“A corporation as big as you, a multi-million dollar corporation, I find it hard to believe that you would invest money into something this big and just walk away if the family said, ‘No, I don’t want to sell it,’” Rodriguez told officials during the meeting. “The question is: Are you really serious about what you’re saying here? Or is this just another dog and pony show?”
Project leaders conceded they need to adjust their efforts in engaging and informing the community, promising more meetings to come. However, residents emphasized that trust is currently broken and will only be rebuilt with concrete action.
El Paso County Commissioner Jackie Butler, who helped organize the meeting, said the County has no power to halt the proposed project, but she said she has been communicating with project officials and is trying to connect them with community advocacy organizations.
“I learned very quickly that the County does not have any authority or permitting process to stop these kinds of projects. And so that’s when I started connecting Pecos West to community members so that they could get directly involved,” Butler said. “My questions to Pecos West have been, Why do you have to come through our community? And even if you have to build through our region, you should go around it.”
Moving forward, the residents in attendance made it clear they do not intend to sell their property. They are demanding Grid United bring all impacted neighbors to the table as a collective before any more land is purchased.
If the project continues to move forward, construction is not expected to begin until the mid-2030s.
Montana
Montana Lottery Mega Millions, Big Sky Bonus results for May 8, 2026
The Montana Lottery offers multiple draw games for those aiming to win big.
Here’s a look at May 8, 2026, results for each game:
Winning Mega Millions numbers from May 8 drawing
37-47-49-51-58, Mega Ball: 16
Check Mega Millions payouts and previous drawings here.
Winning Big Sky Bonus numbers from May 8 drawing
09-14-18-20, Bonus: 16
Check Big Sky Bonus payouts and previous drawings here.
Winning Millionaire for Life numbers from May 8 drawing
14-16-21-43-51, Bonus: 03
Check Millionaire for Life payouts and previous drawings here.
Feeling lucky? Explore the latest lottery news & results
When are the Montana Lottery drawings held?
- Powerball: 8:59 p.m. MT on Monday, Wednesday, and Saturday.
- Mega Millions: 9 p.m. MT on Tuesday and Friday.
- Lucky For Life: 8:38 p.m. MT daily.
- Lotto America: 9 p.m. MT on Monday, Wednesday and Saturday.
- Big Sky Bonus: 7:30 p.m. MT daily.
- Powerball Double Play: 8:59 p.m. MT on Monday, Wednesday, and Saturday.
- Montana Cash: 8 p.m. MT on Wednesday and Saturday.
- Millionaire for Life: 9:15 p.m. MT daily.
Missed a draw? Peek at the past week’s winning numbers.
This results page was generated automatically using information from TinBu and a template written and reviewed by a Great Falls Tribune editor. You can send feedback using this form.
Montana
“It’s Life Alert or rent”: Montana trailer park tenants are on rent strike
Mobile home residents in Bozeman, Montana, say they’re being forced to choose between paying rent and paying medical costs.Courtesy of Jered McCafferty
35-year-old Benjamin Moore has lived in Mountain Meadows Mobile Home Park, outside Bozeman, Montana, since he was 17. This month, for the first time, he’s withholding his rent.
On May 1, Moore received a rent bill for $947, up 11 percent from the month before, and the second hike in nine months—the product of the park’s sale to an undisclosed buyer.
Moore hung a sign on his trailer that says “RENT STRIKE.” He and his neighbors in Mountain Meadows and nearby King Arthur Park, organized with the citywide group Bozeman Tenants United, are collectively withholding over $50,000 a month from their landlord.
Historically, trailer parks have been a relatively affordable housing option—a third of trailer park residents in America live below the poverty line. But on average, their cost of living has risen 45 percent over the past decade. By unionizing, the Bozeman trailer park tenants believe they might be able to fight the most recent rent hike—especially given the state of their housing.
For years, tenants say, the maintenance hasn’t been attended to: tree limbs hang perilously over trailers, and water shutoffs are a regular occurrence. “I cannot recall a time in the past 20 years where we had three straight months of water and power working all day, every day,” Moore said.
Shauna Thompson, another resident, calls the water “atrocious…like a Milky Way, like you’re drinking skim milk. It’s very nasty and turned off all the time, without any notice.” And tenants allege that they’ve experienced retribution for maintenance requests, punitive eviction attempts, and unsafe conditions.
“It’s really hard on people here,” Moore said. Some residents are “already paying their entire Social Security check for rent. It’s a very poor neighborhood. We’ve got old folks. We’ve got young families. We’ve got working-class people who can’t afford anything else.”
For the past four decades, a group called Oakland Properties has owned both trailer parks. When they learned about the sale, tenants were scared that their parks would be bulldozed, or that their rent would be increased even further, forcing them to move.
The tenants attempted to buy the parks themselves, but were decisively outbid. The winning bidder demanded an NDA. The transaction should be finalized next month, park owner Gary Oakland said, but residents still don’t know who’s going to own the land they live on.
This month’s rent hike, Oakland acknowledged, was “part and parcel” of the sale. But for tenants, it’s a catastrophe. On top of the $947 lot rent—more than double the national average—many residents also pay off home loans on their trailers, as well as insurance and utilities costs.
Oakland calls claims of broken utilities “nonsense”: “If it was such a bad place to live, why would the homes be selling for such high dollars?” he said. The rent strike, Oakland points out, is “just a group of people not paying their rent.”
Some people are rationing their medication to make ends meet, Moore said. “There’s one person who canceled Life Alert. It’s either Life Alert or rent, and if you don’t pay rent, they evict you and throw you in the streets.”
Tenant organizers across the nation have found a foothold in recent years organizing against individual landlords, and Bozeman’s tenant union, situated in one of the fastest-growing communities in the state, is no exception. Tenant unions from Los Angeles to Kansas City to New York have organized to win rent freezes, maintenance, and security in their homes.
Mobile home parks—increasingly private-equity-owned and uniquely at-risk in the face of climate disasters—are organizing, too: a group of trailer park residents in Columbia, Missouri, unionized in February. In Montana, as Rebecca Burns recently wrote for In These Times, mobile homes were already once a site of tenant organizing: buoyed by the state’s miners unions, the first Bozeman-area mobile home tenants’ union won an agreement with their landlord in 1978.
Oakland says park residents “have been terrorized by the union,” and plans to evict the strikers. The strikers say they’ve retained a lawyer and will fight to stay in their homes.
“I wish none of this was happening,” Moore said. “Your utilities should work. Your place should be safe. You should be able to get in and out of it. These are the absolute basics, and they just haven’t kept them up. And if you call them on it, they threaten you.”
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