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Electric bikepacking: lessons learned over four days and 250 miles

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Electric bikepacking: lessons learned over four days and 250 miles

“Electric bikes are for cheaters” is the refrain sung by cocksure men in lycra, worried their weekend hobbies will be invaded by unfit neophytes on battery-powered gravel, mountain, and road bicycles. 

It reminds me of the early internet when AOL users were considered inferior to the online elite who did the hard work of subscribing to a regional ISP. Back then, losing an argument with an aol.com email address was reason enough to sell your modem. Now, the ultimate humiliation is being overtaken by someone in street shoes casually pushing a throttle. 

But make no mistake, electric sport bikes are becoming increasingly common on trails and roads, just as electrics are slowly replacing regular bicycles in cities around the world.

To understand the appeal, I decided to pick just one electric sport bike — the Specialized Turbo Creo 2 Comp — to test on steep asphalt, rutted trails, loose gravel, mud, sand, and some green mushy stuff that smelled of doom. And to truly test its limits, I loaded the bike down with an absurd 50 pounds (23kg) of gear for a four day e-bikepacking trip.

And to test the performance of the e-bike, I was joined by an avid roadie who is currently training to ride over 800 miles (1,300km) from Amsterdam to Venice, Italy. He’s not only 10 years younger than me — he’s also fitter and carried just half the weight on his acoustic road bike.

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What follows is my e-bikepacking experience over nearly 150 miles (400km) and 4,265 feet (1,300m) of elevation change. It covers my evolving charging strategy, favorite gadgets and bike gear tested, and lessons learned from over 600 miles (1,000km) of in-the-saddle testing. 

Spoiler: I’m not a convert, but I can appreciate how e-bikes make cycling sports accessible to more people, even bikepacking if you live in the right places.

Charging

The Veluwe is a sprawling forest system in the heart of the Netherlands, rich in woodlands, heath, and wetlands divided by sandy hills cut by glaciers. It’s not a place you’d expect to find an extensive network of e-bike chargers. Yet, I found them to be so plentiful on my four-day trip that I was able to shed my initial range anxiety. 

There were more charging options available then you’d think.
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Each of the three campsites I stayed at cost around €10 to €15 (about $11 to $16) per night and offered free e-bike charging. The charging facilities ranged from a luxurious covered garage — important for keeping the charging brick dry when it rains — to a simple extension cord that snaked out of a solar-powered tent. 

Wild camping away from official sites — which isn’t allowed in the Netherlands — would have made the charging logistics more difficult. But it was certainly possible: three of the four cafes I randomly stopped at during the tour offered free public chargers run by companies like Ion and Laad. 

The Specialized e-bike I rode (more on that later) takes about 3.5 hours to fully charge both the main battery and one range extender using the included 164W (54.6V/3A) charging brick. My days would usually end with about 20 percent (out of 150 percent) of battery power remaining, which would have meant scheduling three hours of charging breaks along the route had I been wild camping. That’s certainly doable if spread over multiple food stops, especially on the long summer days found in Northern Europe. Nevertheless, charging in one go each night at a campsite was more convenient and required less planning.

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This random cafe along the way had a whole wall of e-bike chargers.
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Frankly, I was surprised by all the charging options I found along my route — but really, I shouldn’t have been. The Dutch are rightly lauded for their bicycling infrastructure. In the last few years, e-bikes have outsold regular bikes across the Netherlands, and a new survey suggests that electric bikes are now the majority of bikes ridden. But long before VanMoof helped make e-bikes trendy for young Dutch riders, it was the over-60s you’d see being propelled along bicycle paths. These are the same people who now strap a pair of e-bikes to RVs parked at campsites in the forests. I can only surmise that this remote charging infrastructure emerged in support of boomer demand.

You might not be able to replicate my multiday e-bikepacking experience where you live, but you will eventually, especially in Europe with its shorter distances and fast rate of e-bike adoption. It’ll take a bit longer in the US with its massive scale and dominating car culture.

The bike

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For this trip, I rode the $6,500 / €6,000 Specialized Turbo Creo 2 Comp drop-bar gravel / road e-bike. My European review bike was capped at a top speed of 15.5mph (25km/h) and 50Nm of torque from the company’s own 250W / 330W mid-drive motor. Buyers in the US will receive a faster Class-3 e-bike with a top speed of 28mph.

The Specialized Turbo Creo 2 Comp ready to ride after packing up all the gear.

There are several reasons why I chose the Creo 2 Comp for my first e-bikepacking adventure. First, it’s lightweight for an e-bike at just 14.47kg (32 pounds) making it almost 5kg (11 pounds) lighter than DJI’s attention-grabbing electric mountain bike. Impressively, the Creo 2 Comp is just 1.3kg (almost 3 pounds) heavier than my own hardtail MTB.

The Creo 2 Comp also features multiple attachment points for all the cages and racks needed to haul lots of gear, and a front shock built into the handlebar stem that allows for 20mm of travel. That’s not a lot of dampening compared to mountain bikes, but my hands definitely benefited after several hours of daily riding over rough gravel, tree roots, and bumpy single track.

Specialized’s two-wheeler also supports healthy tire volumes, including the chunky 29 x 2.2-inch variety commonly fitted to mountain bikes. My review bike came with the company’s smaller 700 x 42 Pathfinder Pro tubeless tires. They proved to be smooth rollers on pavement and gravel and plenty capable in sections of sand and muck that stopped my friend who rode on thinner tires.

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My riding companion’s regular road bike, fitted with gravel tires.

But the main reason I selected the Creo 2 Comp was for its battery expansion. The electric gravel bike features a main 320Wh battery that can be easily supplemented with $450 160Wh range extenders. Specialized sent me two extenders for a total capacity of 640Wh. The company also sent me a Y-cable for dual-battery charging. 

Unfortunately, that main battery is fully integrated into the frame and can’t be removed for charging. Specialized did this to help keep the weight down. But the Y-cable can only charge the main battery and one range extender simultaneously — not two range extenders — ruining my plan to keep the bike securely by my tent while the two smaller batteries were charging elsewhere. That meant leaving Specialized’s very expensive bike and one range extender charging outside in the rain on three occasions — twice overnight, and a few hundred meters away — protected only by a lightweight lock and rain fly made from a trash bag. Not ideal.

Another intriguing feature of the Creo 2 Comp is Specialized’s smart battery control. In Smart Control mode, you can enter the distance and duration of your planned travel, and the bike will adjust the pedal assist to ensure you don’t run out of power. I ended up not using this mode for a few reasons. First, Smart Control requires tracking the ride in the Specialized app, and I didn’t want to drain my phone’s battery unnecessarily (the bike doesn’t have a USB charging port for bike computers and phones). The second reason I didn’t use Smart Control is that I was easily getting about 68 miles (110km) from the internal battery and range extender combo, even with all that gear and riding in Sport mode — Specialized’s medium setting, which nicely balances pedal assistance with battery conservation. Without all the gear, I was getting closer to 93 miles (150km) from the battery plus extender. 

And let’s face it: the real reason I chose the Specialized Creo 2 Comp for the trip is that it barely looks like an e-bike. But the motor’s audible whir made it obvious to anyone nearby that I was getting an electrical assist.

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Planning

For this tour, I upgraded to the Komoot Premium ($59 / year) service to access its multiday cycling trip planner. My plan started with a premade gravel tour called the Green Divide created by Erwin Sikkens, which I segmented into a custom four-day journey that extended to my home in Amsterdam. Komoot also helped me add cafes and campsites along the way. I then exported the maps to my old Garmin 530 bike computer. 

My modified Green Divide route on Komoot Premium.

When booking each campsite, I called ahead to confirm the availability of e-bike charging since I wanted to camp in the more isolated backpacking sections of the campsites, away from the busy charging poles used by all the parked RVs. Little did I know that this was a common amenity offered by every campsite I contacted in the area. 

Komoot Premium also displays detailed weather reports along the route. It showed mostly tailwinds for my dates of travel allowing me to plan a quicker-than-average pace, but the rain forecast meant packing additional protection. 

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I brought along a $270 Spinshift jacket from Gorewear to fight back the cold wind and rain. My review jacket kept me warm and completely dry and packed down small into the jacket’s zip pocket. It fit snuggly with my arms extended on the Creo 2 Comp e-bike, especially when fully stretched into the drop-bar position. But that also meant that the stiff (thin and lightweight) Gore-Tex fabric bunched up a bit when just standing around — a tradeoff I’m always happy to make in a cycling jacket. The Spinshift performed far better than my friend’s rain jacket, which quickly filled with air (slowing him down) and caused him to overheat more frequently. The Gorewear Spinshift jacket isn’t cheap, but it’s worth the price.

If you’re in the US, you’ll also want to check if the trails along your route allow for e-bikes, especially if you’re on a fast and powerful Class-3. Europe’s less powerful pedal-assisted e-bikes have fewer such restrictions. 

Baggage

The 14.47kg (32 pounds) Creo 2 Comp weighed a staggering 37kg (82 pounds) after loading it up with 1.5L of water and everything I needed for four days of camping in the rain and cold. For food, I only needed to pack breakfasts and energy snacks since lunches and dinners would be found at markets and cafes along the way. 

Ironically, the heaviest items were all related to keeping the e-bike’s motor running. This included the two external range extenders, the massive charging brick, and the heavy-duty Y charging cable. I also brought along a CEE-to-Schuko adapter cable just in case I needed to charge the e-bike from one of those blue charging poles at campsites (I never did). I also never used the second range extender battery, but I was happy to have it in reserve.

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The top bag and two panniers create 50L of quick-release and waterproof storage.

The AeroPack has a quick-release connection to the seat post with a safety to prevent accidental release.

I installed an extended rear axel to act as quick-release mounting points for the rack.

To support all that weight and volume, I had to fit the Creo 2 Comp with a rack and pannier bags. For this, I chose a carbon-fiber AeroPack rack and organization system from Tailfin to review. That 50 liters of waterproof on-bike storage proved to be fantastic, albeit expensive, at nearly €1,000 (almost $1,100). 

The AeroPack rack I reviewed attaches to the seat post and to an extended rear axle I had to install on the e-bike — a procedure that took about 30 minutes. Tailfin’s 16L Mini Panniers and the entire rear rack that includes an integrated 18L top bag are designed for quick attachment and detachment. That was super helpful since I wanted my gear at my tent while the bike was charging far away. 

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All my small gadgets and cables went into the smaller Tailfin Packing Cube that cinches shut, while most of my clothes went into the larger 6L Cube.

The big Cube is a perfect fit for the top bag. The other two Cubes are designed to fit on top.

I used Tailfin’s Packing Cubes to help keep things organized inside those deep storage bags. Most of my clothes went into the 6L Cube, which fit snugly into the AeroPack top bag. All my cables and small electronics went into the 2.5L Cube, and the toiletries and microfiber towel in the 3.5L Cube. Both of those organizers went into the waterproof panniers alongside items like my trusty JetBoil camping stove I’ve had for something like 15 years. All my stored gear stayed completely dry despite three days of on-and-off rain. 

The rest of the bags were my own, including two feed bags for quick access to snacks, my lock, and a water bottle; a partial frame bag for my tools and first aid kit; and a small top-tube bag for a USB battery pack, wallet, and miscellaneous items needed during the ride.

I’ve never carried so much gear on a bikepacking trip before, but I never had a motor to help carry the load, either. Still, the Tailfin bags remained firmly in place with zero sway, which has never been my experience when using those elongated saddle bags that often go limp after a bit of rough riding and end up dragging on the rear wheel. 

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Tailfin’s setup is totally worth the price, in my opinion.

Sleeping

The other star of the trip was the $500 Hubba Hubba Bikepack 1-Person Tent MSR sent me to review. It’s tiny and weighs only 2 pounds 1 ounce (0.9kg) but has a long list of very smart features for bikepackers. Notably, it comes in a waterproof handlebar bag / stuff sack with plenty of attachment points for add-ons. It features thick spacers that give room for the bike’s cables and a compartment for tent poles that are shorter than normal to not interfere with steering.

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The MSR Hubba Hubba opened up. It’s tall enough to sit upright and cook while still being sheltered from any rain.
Photo by Thomas Ricker / The Verge
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The waterproof and nicely ventilated tent and rainfly kept me completely dry in lots of rain, even a thunderstorm. The uniform rectangular shape made it easy to set up and provided plenty of headroom to sit upright. The Hubba Hubba tent also features plenty of internal pockets to store gear and a large vestibule outside the side entry to keep my shoes, helmet, bags, and other bits out of sight and dry while I slept. I also made good use of the internal and external clotheslines to dry my gear.

The Hubba Hubba Bikepack tent is hands down the best lightweight tent of the dozens I’ve tried over the last three decades. It’s clearly been designed by people who spend a ton of time cycling away from civilization. Still, $500 is very expensive. My friend’s $110 NatureHike Cloud tent (which I also own) is only slightly heavier, and he seemed just as comfortable and dry. You don’t absolutely need the Hubba Hubba for bikepacking — but you’re right to want it.

Rounding out my sleep gear was a very comfortable and warm $200 NeoAir XLite NXT four-season air mattress that Thermarest sent me to test. And despite measuring a thick three inches (7.6cm), it packs down small and light at 13 ounces (370g). I appreciated the WingLock Valve that let me inflate (and deflate) it quickly without exhausting myself using the included pump sack and some good ol’ Bernoulli physics. 

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Thermarest also sent me a down-filled Vesper 32F/0C Quilt to review; $400 for a trail blanket is expensive, but it weighs just 15 ounces (425g) and packs down into an impossibly small ball. Despite being lightweight, it was a bit too warm when falling asleep in 64 degrees Fahrenheit (18 degrees Celsius), but I was happy to have it when temps dropped down to 48F (9C) a few nights — Thermarest says the quilt’s sweet spot is around 41F (5C). It’s silky soft to the touch and stretches around the NeoAir XLite NXT to prevent slippage and drafts.

I slept reasonably well with this setup or at least as well as I do at home. But I just can’t get comfortable with any inflatable pillow I’ve tried. Someday, I’ll find the perfect pillow, but the Trekology Aluft Pro I bought on Amazon isn’t it.

Gadgets

As a nerd, I brought far more gadgets than a typical person would. That meant bringing several USB power banks along to keep everything charged over a period of four days: two 10,000mAh (40Wh) batteries and one 27,000mAh (100Wh) behemoth. That’s far more than I’d normally bring, but again, I had a motor and tons of storage. 

Some gadgets I always bring with me on bikepacking trips. These include my iPhone in a QuadLock bike-mount case and my Apple Watch — both set to low-power modes. I also brought a GoPro with extra batteries that I never even used. My aging but formidable Garmin 530 bike computer provided turn-by-turn navigation. To my delight, it was able to read power, cadence, and speed data off the Specialized Turbo Creo 2 Comp after I manually added each bike sensor.

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I also had to bring the little SRAM AXS battery charger that came with the bike just in case its wireless electronic shifter died. Something that nearly happened to me earlier during 370 miles (about 600km) of preparation for the trip.

Naturally, I also brought along plenty of gadgets to review.

The Baseus over-the-ear slug let me hear sounds around me while also providing better quality than bone-conduction units favored by many cyclists.

I tested a pair of $60 Baseus Eli Sport 1 open-ear Bluetooth headphones to be sure that I could still hear everything around me. Most riders prefer bone-conducting headphones for this purpose, but I’ve never been a fan of the flat sound. With the rain-proof Eli Sport 1, I could slip on just one of the two over-the-ear slugs for the duration of the ride to hear the navigation. They’re so lightweight and comfortable that I’d forget I was wearing one by the end of the day, and it never fell off my ear, even on the roughest trails or when taking off my helmet and sunglasses. At night, I could pop on the second slug and listen to music or watch videos with real bass, though anyone nearby could hear the audio bleed into the quiet even at modest volumes. The case also kept the headphones charged for the duration of the trip despite heavy all-day usage. For the price, they proved to be outstanding, but I should note that Amazon says it’s a frequently returned product. 

The Milo communicator mounted to the top tube where it didn’t perform as well as I had hoped — probably too far from my mouth. Will try on an arm band and handlebar mount next time.
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I also tested a pair of Milo Communicators. I’ll have a full review coming later, as these need to be tested in a few more scenarios. My first impressions are mixed. They were invaluable in finding out that my friend had fallen off his bike in a gnarly sand patch a few hundred meters behind me, but they frequently failed to clearly deliver insults and warnings when both of us were riding full out over noisy gravel, wind, grunts, and woo-hooing. We had the Milos mounted on the bikes, and that might have been too far away to properly isolate our voices (the company offers several mounting options). It’s promising tech, so more on this later. 

Yes, that’s a HoverAir X1 drone in my mouth, something I wouldn’t try with a DJI.

I’ve also been testing a HoverAir X1 drone for the past few weeks. And honestly, I think I love it. It’s so easy to grab and set aloft without needing any type of controller. And like they say, the best drone is the drone you have with you, and I wasn’t about to bring a DJI drone on this trip. A full review is coming.

The FlexTail Tiny Repeller S kept my tent lit and free of mosquitos, but more testing is required.

Last but not least is the Flextail Tiny Repeller S combination bug repellent and lantern. It kept my tent mosquito-free and well-lit at night, but I need to test it in a few more scenarios, which requires a full review. That one is coming later this summer after I test it in an RV, but so far, so good.

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Truthfully, if this hadn’t been a work assignment I would have left most of my electronic devices at home. I love technology’s ability to bend nature to my will, but it can be very distracting from just living in the moment and creates a lot of charging stress where no stress should be.

E-bikepacking is indeed, a thing.

Conclusion

Let’s be clear: the vast majority of people don’t need to spend nearly $10,000 on an electric bike, top-of-the-line camping gear, and premium bike bags to go bikepacking. 

If you’re already moderately fit, then you’d be amazed at what you can do with a bunch of bungee cords strapped to a regular ol’ second-hand mountain or gravel bike — and you’ll never need to worry about finding a charger. You can even splurge a little on inexpensive bikepacking gear from brands I’ve used, like Naturehike and Rhinowalk. 

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But e-bikepacking is most definitely a thing and will become more popular as the charging infrastructure spreads to more wilderness areas around the world. That motor is a game changer, allowing for heavier loads to be carried (even trailers with pets and small kids), tall mountain passes to be flattened, and for people with lesser abilities to get outside and do more.

Notably, e-bikes can help recreational riders join their hardcore cycling partners and friends on their long weekend rides. After which, they’ll be regaled with stories full of grit, cadence, and power stats while gobbling back all those spent calories.

My e-bike allowed me to keep up with my younger and fitter riding mate — basically leveling the field. He got his training sessions in, and I got the camaraderie I was seeking. I got a solid workout in myself since European pedal assist cuts out at 15.5mph (25km/h), and we’d regularly be traveling at speeds above 19mph (30km/h) whenever things flattened out.

Despite the immense amount of fun I had on the very capable Specialized Turbo Creo 2 Comp, I won’t be trading in my trusty hardtail mountain bike for an electrified version any time soon. I still enjoy the exercise and simplicity of conquering terrain with a pure mechanical assist. 

I get the urge for gravel, road, and mountain bikers to dunk on e-bike riders, but let’s not reflexively call them all cheaters. Cheating is an act of dishonesty to unfairly gain an advantage over another, and plenty of people buy electric sport bikes after an honest assessment of their own limited abilities. They give people new options for enjoying the benefits of being active and upright on two wheels, even as they get older. And that’s something we should be celebrating.

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But I was definitely cheating, and I will miss listening to my friend’s exclamations anytime he fell behind on long climbs or found his little baby tires stuck in the mud or sand that I had already traversed. 

To everyone else: apologies if I knocked you off the Strava segment leaderboard — you should try harder.

All photography by Thomas Ricker / The Verge

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Honda’s hybrid future starts with new Accord and RDX prototypes

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Honda’s hybrid future starts with new Accord and RDX prototypes

Honda revealed prototypes of two new hybrid models, an Accord sedan and the Acura RDX SUV, during its annual business briefing this week, built on a platform that it says will begin launching next year. The RDX was announced earlier this year as Honda’s first SUV to feature the next-gen version of its two-motor hybrid system.

In March, Honda announced it would take a writedown of up to 2.5 trillion yen ($15.7 billion) on its EV investments. Now Honda says its EV-related losses will be “resolved” by 2029, and that it will reevaluate its EV plans in 2030.

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New cancer tech sends chemo straight to tumors

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New cancer tech sends chemo straight to tumors

NEWYou can now listen to Fox News articles!

Chemotherapy can save lives, but anyone who has watched a loved one go through it knows how hard it can be. The nausea. The exhaustion. The infections. The days when even getting off the couch feels like too much.

That happens because standard chemotherapy travels through the bloodstream. It attacks cancer cells but can also harm healthy cells along the way. For some pancreatic cancer patients, that approach may be changing.

A targeted drug-delivery system from RenovoRx is designed to send chemotherapy directly near the tumor instead of through the entire body. The system, called Trans-Arterial Micro-Perfusion, or TAMP, is being studied in a Phase III clinical trial for locally advanced pancreatic cancer.

For 83-year-old Hernando Salcedo, who had been left weak, nauseous and overwhelmed by standard chemotherapy, the trial offered something he desperately needed: a reason to hope. He enrolled at Miami Cancer Institute and soon began to feel the shift in his own body. His appetite started coming back. His energy improved. He felt more like himself. “The difference was tremendous,” Hernando said. “I completed eight sessions, one every 15 days, and I felt dramatically better than I did with the original chemotherapy.”

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HIDDEN FACTOR IN CANCER TREATMENT TIMING MAY AFFECT SURVIVAL, RESEARCHERS SAY

Cancer patient Hernando Salcedo attended a family wedding after RenovoRx’s Trans-Arterial Micro-Perfusion system delivered chemotherapy directly near his tumor, helping him feel stronger during treatment. (Hernando Salcedo)

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How the RenovoRx drug-delivery device works

RenovoRx’s platform uses the FDA-cleared RenovoCath device to deliver chemotherapy through a catheter placed in an artery near the tumor. A physician guides the catheter into position using X-ray imaging.

Shaun Bagai, CEO of RenovoRx, said the platform is designed to localize chemotherapy delivery near the tumor instead of relying on the drug to travel through the whole body.

“Once in position, two small balloons on the catheter are inflated, and the system is adjusted to isolate a targeted segment of artery adjacent to a tumor,” Bagai said. “The chemotherapy drug is then infused between the balloons, creating pressure to push the drug across the vessel wall and near the tumor, directly bathing the target tumor.”

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That setup allows doctors to focus treatment in a specific area rather than exposing more of the body to chemotherapy. “The procedure itself is minimally invasive and is typically performed in an outpatient setting without the need for patients to be put under general anesthesia,” Bagai said.

For patients already dealing with pain, fatigue and fear, that outpatient approach may feel less overwhelming than a major hospital procedure.

 

How targeted chemotherapy for pancreatic cancer works

To understand why this approach matters, it helps to start with the problem doctors are trying to solve. Dr. Ripal Gandhi, a vascular interventional radiologist and interventional oncologist at Baptist Health Miami Cardiac & Vascular Institute and Miami Cancer Institute, explained why standard chemotherapy can be so hard on the body.

“With IV chemotherapy, the drug travels through the bloodstream, affecting both cancerous and healthy cells, which can lead to side effects,” Dr. Gandhi said. TAMP takes a more targeted route. A doctor places a catheter in an artery near the tumor, then delivers chemotherapy into that area instead of relying on the drug to circulate throughout the body.

Dr. Gandhi compared it to “a drip irrigation system for individual plants instead of watering an entire lawn.” For patients, that means doctors are trying to focus more of the treatment near the cancer while reducing how much chemotherapy reaches the rest of the body.

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Why pancreatic cancer is so difficult to treat

Pancreatic cancer has a reputation for being one of the hardest cancers to fight, partly because the tumor itself can block treatment from working the way doctors want it to.

Dr. Gandhi said that creates a major challenge for standard IV chemotherapy. “Studies have shown that less than 10% of chemotherapy administered intravenously actually reaches tumor cells due to the few blood vessels in the tumor as well as dense fibrous stroma, which serves as a physical barrier in the tumor microenvironment,” Dr. Gandhi said.

That helps explain why targeted delivery could play an important role. TAMP sends the drug closer to the tumor rather than depending on the bloodstream to do all the work.

“This targeted approach via TAMP does not rely on chemotherapy circulating through the body to carry the drug to the tumor via tumor feeder vessels,” Dr. Gandhi said. “Trans-arterial micro-perfusion is a drug-delivery platform that delivers chemotherapy directly near the target tumor where it is needed most.”

NEW CANCER THERAPY HUNTS AND DESTROYS DEADLY TUMORS IN MAJOR BREAKTHROUGH STUDY 

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Chase McCann, associate director of the cell therapy lab core, demonstrates how cancerous T-cells from a child are used to develop an autoimmune treatment to fight cancer at Children’s National Hospital in Washington, D.C., on Aug. 26, 2025. (Marvin Joseph/The Washington Post/Getty Images)

 

Patient says targeted chemotherapy gave him hope

Hernando’s cancer journey began after he went to the doctor with a swollen stomach and hip pain. Doctors diagnosed him with locally advanced pancreatic cancer. When he started standard chemotherapy in August 2025, the side effects hit hard. “My body was going through an incredible amount of stress,” Hernando said. “My stomach was inflamed, I had persistent pain in my head, and I had almost no energy.”

He was also receiving chemotherapy and radiation at the same time. “It was a very difficult period, both physically and emotionally,” he said. “I remember feeling exhausted, overwhelmed and unsure of what the future would look like.”

When doctors presented the targeted treatment option, Hernando saw it as more than another medical procedure. “To me, it felt like a new opportunity to live,” he said. “It gave me hope at a time when my family and I really needed it.”

He credits Dr. Gandhi and the team at Miami Cancer Institute with helping him through it all. “From the beginning, he was honest, supportive and clear with my wife, my family and me,” Hernando said. “That meant everything.” 

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Fewer chemotherapy side effects changed daily life

“Before, I was losing weight, had no appetite and felt drained,” Hernando said. “After switching treatments, things began to change. I stopped losing weight, my appetite came back, my color improved and I had more energy.”

Cancer treatment can sometimes take over everyday life. When side effects ease, patients can get pieces of their normal life back. “After about eight weeks, we could see real progress,” Hernando said. “I was eating more, moving more and feeling excited about life again.”

One moment still stands out. Hernando was able to attend a family wedding and dance the entire night. “That moment meant everything to me,” he said. “After everything I had been through, being able to celebrate with my family in that way felt like a gift.” For Hernando, it was a chance to feel like himself again. “That night at the wedding, I was not thinking only about cancer or treatment,” Hernando said. “I was living.”

 

Early trial results show survival and quality-of-life signals

The early data from RenovoRx’s Phase III TIGeR-PaC trial suggest the targeted approach may offer both survival and tolerability benefits for some patients.

Dr. Gandhi said completed clinical studies with TAMP in pancreatic cancer showed “a potential for better outcomes and less side effects for patients.”

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“In the initial interim analysis of the TIGeR-PaC clinical trial, there was a trend towards improved overall survival by 6 months and improvement in the progression free survival by 8.1 months with 65% fewer adverse events in the TAMP arm of the study,” Dr. Gandhi said.

 

Who may benefit from targeted chemotherapy delivery?

This approach isn’t for every pancreatic cancer patient. Doctors still need to look at the cancer stage, tumor location, treatment history and whether the cancer has spread.

Dr. Gandhi said Hernando was the kind of patient who could be a strong fit. “He is precisely the type of patient who would benefit best from this approach because he has a tumor which is too far advanced to be treated surgically, but it has not spread to other organs,” Dr. Gandhi said.

He also pointed to clinical trials as an important option for pancreatic cancer patients.”I discussed with him that the recommendation of the National Comprehensive Cancer Network is that the best management for pancreatic cancer patients is participation in a clinical trial whenever possible and he was an ideal candidate,” Dr. Gandhi said.

He went on to say that TAMP may be an option for patients who are not candidates for surgery, patients who have failed chemotherapy or patients who no longer want to continue IV chemotherapy because of side effects.

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“TAMP can be used at any point within the treatment landscape, before, during or after other treatment modalities such as IV chemotherapy or radiation,” he said.

PANCREATIC CANCER PATIENT SURVIVAL DOUBLED WITH HIGH DOSE OF COMMON VITAMIN, STUDY FINDS

The RenovoCath device uses a catheter-based system to deliver chemotherapy near the tumor instead of through the whole body. (RenovoRx)

 

What comes next for RenovoRx’s cancer treatment platform

RenovoRx says the RenovoCath catheter is already FDA-cleared for general therapy and chemotherapy delivery. The company is also nearing the end of enrollment in its Phase III TIGeR-PaC trial.

That trial is evaluating intra-arterial gemcitabine (IAG) delivered through RenovoCath for locally advanced pancreatic cancer. Bagai said enrollment is expected to be completed in mid-2026, with final results expected in 2027.

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“If positive, data generated from this trial could potentially support a new drug application for this combination product to the FDA for IAG,” Bagai said. RenovoRx also sees potential beyond pancreatic cancer. “The challenge we are addressing is not unique to pancreatic cancer,” Bagai said.

He said the platform could apply to other solid tumors with limited blood supply, including bile duct cancer, certain lung cancers and sarcomas. “The platform is designed to work with different types of therapies, not just one drug,” Bagai said. “That opens the door to future combinations and potential partnerships, with the goal of expanding options for patients who have limited treatment choices.” 

 

What this means to you

If you or someone you love has pancreatic cancer, this story is worth paying attention to. Clinical trials can open up options when standard treatment feels too hard to tolerate or stops working.

Drug delivery matters, too. The medicine itself is only part of the story. Where it goes inside the body can affect side effects, energy levels and quality of life. Targeted chemotherapy delivery remains a specialized treatment approach. Some cancer centers may not offer it, and every diagnosis will not be a fit. Your care team can review imaging, staging, prior treatments and overall health to see whether it makes sense.

Start with direct questions. Ask whether a clinical trial makes sense. You can also ask about targeted delivery options or a second opinion from a pancreatic cancer specialist. Hernando’s advice to other patients is simple. “I would tell them not to lose hope and not to wait to ask questions,” he said. 

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Kurt’s key takeaways

Pancreatic cancer has a way of turning normal life upside down fast. One day, a family is making plans. The next, they are trying to understand scans, treatment choices and side effects that no one feels ready for. That is what makes Hernando’s story so powerful. The part that stays with you isn’t only the technology. It is the fact that he started eating again. He had more energy. He felt more like himself. And he got to dance at a wedding after wondering what the future would look like. The final Phase III trial results will be important. Doctors still need to see how widely this approach could help patients. But the promise is easy to understand. If chemotherapy can get closer to the tumor while taking less of a toll on the rest of the body, patients may get something that matters just as much as treatment itself: more good days.

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If you or someone you loved needed chemo, would targeted delivery change how you think about treatment? Let us know by writing to us at Cyberguy.com

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Technology

Use this map to find the data centers in your backyard

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Use this map to find the data centers in your backyard

When Oregon resident Isabelle Reksopuro heard Google was gobbling up public land to fuel its data centers in her home state, she didn’t initially know what to believe. “There’s a lot of misinformation about data centers,” she said. “Google has denied taking that land.”

Technically, she explains, The Dalles, a city near the Washington state border, sought to reclaim that land, “and Google is just a big, unnamed power user.” The city had in fact asked for ownership of a 150-acre portion of Mount Hood National Forest, claiming it needs access to Mount Hood’s watershed to meet municipal needs as its population — 16,010 as of the 2020 census — grows. But critics, including environmentalists, say the city is trying to secure more water for Google, which has a sprawling data center campus in The Dalles that already consumes about one-third of the city’s water supply.

This controversy made Reksopuro curious about the backlash to data centers being built in other communities. So Reksopuro, a student at the University of Washington who studies the connections between tech and public policy, decided to map it out. Using information collected by Epoch AI and data scraped from legislation on data centers, she built an interactive map tracking AI policy around the world. She designed it to be simple enough for anyone to use. “I wanted it to be something that my younger sisters could play through and explore to understand what are the data centers in the area and what’s actually being done about it,” Reksopuro said. She hoped to shift their opinions that way, “instead of like, through TikTok.”

Four times a day, the map searches for new sources and checks them against the existing database Reksopuro built out. “Once it does that, it will write a new summary, add it to the news feed, and populate it on the sidebar,” she said. “I wanted it to be self-updating, since I’m also a student.”

Reksopuro isn’t against data centers, but she thinks tech giants benefit from a lack of transparency around data center policies. “Right now, it’s this really opaque thing — and all of a sudden, there’s a facility,” she said. “I think that if people knew about data centers beforehand, it would give them leverage. They would be able to negotiate: ask for job training programs, tax revenue, environmental monitoring, things to improve their community.”

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