North Carolina
North Carolina Vaccine Facility Certified for the Next Pandemic
.jpg "North Carolina Vaccine Facility Certified for the Next Pandemic")
If the U.S. authorities declares an influenza pandemic, a brand new vaccine manufacturing facility situated in Holly Springs, North Carolina, is licensed and able to go.
New Jersey-based Seqirus introduced at the moment that the corporate’s progressive manufacturing facility has efficiently achieved all standards required to ascertain home manufacturing functionality for cell-based seasonal and pandemic influenza vaccines as outlined by the Biomedical Superior Analysis and Improvement Authority (BARDA).
The Holly Springs manufacturing facility, the biggest cell-based influenza vaccine producer globally and the primary of its sort within the USA was purpose-built by means of this public-private partnership with BARDA.
With this recognition, the U.S. authorities confirms that Seqirus has established and can preserve the required pandemic readiness to ship 150 million doses of cell-based pandemic influenza vaccines inside six months of an influenza pandemic declaration within the U.S.
This Seqirus website maintains ongoing seasonal vaccine manufacturing and supply of pre-pandemic annual heaps to the U.S. authorities. It’s geared up to shortly transition from seasonal to pandemic vaccine manufacturing to answer an influenza pandemic.
A substitute for egg-based manufacturing, cell-based manufacturing avoids egg-adapted modifications, one supply of pressure mismatch between vaccines and circulating pandemic influenza virus.
“Serving as a major accomplice to the U.S. authorities in help of its pandemic preparedness plans is each an honor and an incredible accountability,” said Marc Lacey, Govt Director, Pandemic Response Options, Seqirus, in a press launch issued on June 2, 2022.
“Now we have particularly designed our platform applied sciences to be scalable, supporting our seasonal and pandemic vaccine manufacturing wants. We stay up for a continued productive partnership for a few years to come back.”
To help speedy response to public well being emergencies, Seqirus is ready to produce the U.S. authorities with influenza vaccines and adjuvants, together with:
- AUDENZ™ is the first-ever adjuvanted, cell-based influenza vaccine designed to assist defend people six months of age and older towards influenza A(H5N1) within the occasion of a pandemic. Audenz’s preliminary U.S. FDA Approval was in January 2020 and acquired a supplemental FDA approval in 2021.
- The MF59® adjuvant, when added to an influenza vaccine, is designed to boost and broaden the physique’s immune response by creating broad, cross-reactive antibodies.
Past pandemic preparedness, the joint funding allows Seqirus to maintain the manufacturing of differentiated seasonal influenza vaccines, together with:
- FLUCELVAX® QUADRIVALENT is the primary and solely cell-based quadrivalent influenza vaccine for people six months of age and older with out contraindication.
- FLUAD® QUADRIVALENT is the primary and solely adjuvanted quadrivalent seasonal influenza vaccine for adults 65 years of age and older.
In line with the U.S. CDC, Seqirus’s new capabilities are important to defending the USA from ‘viruses of particular concern.’
The CDC web site says ‘some novel influenza A viruses are believed to pose a better pandemic menace than others and are extra regarding to public well being officers as a result of they’ve induced severe human sickness and loss of life.’
‘Novel influenza A viruses are of additional concern due to the potential affect they might have on public well being in the event that they achieve the flexibility to unfold simply from individual to individual, which could trigger the following influenza pandemic.’
In 2022, the Eurasian H5N1 pressure first appeared in North American wild birds in January 2022. Since then, it has affected poultry/birds in 36 states and led to the lack of about 38 million birds as of June 1, 2022.
The U.S. CDC says these are the primary detections of HPAI A(H5) viruses within the U.S. since 2016.
In April 2022, the state of Colorado reported the primary influenza A (H5) virus an infection in an individual. The CDC says this ‘Colorado affected person is the primary human detection of any influenza A(H5) virus within the USA.’
BARDA is a division of the Workplace of the Assistant Secretary for Preparedness and Response throughout the U.S. Division of Well being and Human Companies (HHS).
As well as, pandemic influenza information is posted at PrecisionVaccinations.com/Avian.
PrecisionVaccinations publishes fact-checked, research-based vaccine information curated for cell readership.
The 24th-ranked Cal women’s basketball team defeated a ranked opponent for the second time this season on Thursday night when the Bears knocked off No. 21 North Carolina State 78-71 at Haas Pavilion.
“I think this was one of the biggest wins for Cal women’s basketball in some time,” Cal coach Charmin Smith.
The Bears defeated then-No. 19 Alabama back on December 5 at Haas Pavilion, and on Thurday Cal beat a team that reached the Final Four last season.
Marta Suarez scored 17 points for Cal (15-2, 3-1 ACC.), and 14 of those points came in the first half when Cal took control late in the second quarter. Ioanna Krimili, Michelle Onyiah and Kayla Williams added 15 points apeice to help the Bears end the Wolfpack’s seven-game winning streak while keeping Cal unbeaten at home (11-0).
Krimili was just 6-for-18 from the the field, including 3-for-12 on three-pointers, but she hit one of the biggest shots of the game when she nailed a three-point shot with 4:57 left, 21 seconds after the Wolfpack had scored six straight points to close Cal’s nine-point lead to three points.
“She made it when we needed it, and we have a habit of doing that,” Smth said.
North Carolina State (11-4, 3-1 ACC) never got closer than four points the rest of the way and suffered its first conference loss despite 21 points from Aziaha James and 19 from Tilda Trygger.
Cal took the lead for good with 1:01 left in the third quarter, then held off every North Carolina State surge after that.
An important reason for Cal’s consistency throughout the game was the play of point guard Kayla Williams, who played all 40 minutes, shot 7-for-13 from the field and added six assists with just two turnovers while doing all the ball-handling chores and driving the lane to create opportunities for herself or others.
“I thought Williams killed us off the bounce,” North Carolina State coach Wes Moore said.
Williams may be the key to Cal’s success this season, because her strong play has come as a surprise to casual observers. She did not start any games for USC last season when she averaged 10.8 minutes, 2.6 points and 0.6 assists per game. After transferring to Cal, Williams has started every game for the Bears this season while averaging 33 minutes, 12.2 points and 4.6 assists to go along with 44.5% three-point shooting.
Thursday was the first time two top-25 women’s teams played a game at Haas Pavilion since Dec. 22, 2018, when 14th-ranked Cal lost to No. 1 UConn.
Cal led by eight points entering the fourth quarter, and the Wolfpack got as close as three points, but the Bears maintained the lead throughout. Cal had scored the final eight points of the third quarter to break away from a 52-52 tie to grab that 60-52 advantage after three quarters.
Cal held a 39-33 lead at halftime, thanks in large part to a one-minute shooting spree by Suarez. She hit three-pointers on three consecutive Cal possessions over a span of 56 seconds to cap a 16-0 Bears run that took Cal from a 22-14 deficit to a 30-22 lead with 5:22 left in the first half.
Suarez’s one-minute shooting spree seemed to change the complexion of the game. Cal never trailed after that.
“I was feeling it,” Suarez said.
Suarez was 4-for-4 from long range in the first half and had 14 points and 10 rebounds at intermission. The rest of the Cal team was just 3-for-12 on three-pointers, and Krimili was 1-for-7 from beyond the arc at halftime. Her one made three-pointer came from well behind the line with the shot clock running down.
Cal shot 44.4% from the field in the first half, while the Wolfpack made just 35.3% of its shots. Cal attempted just one free throw in the first half, and missed it.
NOTES: The top two scorers from North Carolina State’s Final Four team of last season are starters on this season’s Wolfpack squad – Aziaha James and Saniya Rivers.
Heading into Thursday’s action, Cal was averaging 10.1 made three-pointers per game, sixth-most in the country, and were making 37.8% of its three-point shots, which is 12th-best in the nation.
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A man who fired an assault rifle inside a Washington, D.C., restaurant in December 2016 while claiming to investigate the “pizzagate” hoax died this week after being fatally shot by police during a traffic stop in Kannapolis, North Carolina.
On the night of Jan. 4, Edgar Welch was a passenger in a 2001 GMC Yukon that was stopped by officers, Kannapolis police said Thursday in a news statement.
The traffic stop was conducted after officers linked the vehicle to Welch, who was wanted at the time on an outstanding arrest warrant, police said.
When officers recognized Welch and moved to arrest him, he produced a handgun from his jacket and pointed it at one of the officers, police said, and after refusing commands to drop the gun, two officers opened fire on him.
He died of his wounds at an area hospital two days later, on Jan. 6, police said.
The three officers involved in the traffic stop and the two other occupants in Welch’s vehicle were uninjured, police said.
The North Carolina State Bureau of Investigation confirmed to CBS News Thursday Welch’s identity as the “pizzagate” shooter.
Welch fired his weapon inside the Comet Ping Pong restaurant on Dec. 4, 2016, after he drove there from North Carolina to investigate a false far-right conspiracy theory claiming that Democrats were running a child sex ring out of the restaurant, a claim that had garnered numerous threats against the eatery.
After he entered the crowded restaurant with an AR-15 assault rifle and a revolver, he fired the rifle into a door, authorities said at the time. No one was hurt.
He later pled guilty to one federal count each of interstate transportation of a firearm and assault with a dangerous weapon. In June 2017 he was sentenced by Supreme Court Justice Ketanji B. Jackson, then a U.S. district judge, to four years in prison.
The North Carolina Department of Transportation is expected to give an update Thursday morning on their plans to protect people from this weekend’s winter storm.
UPDATES: School & Business Closings
Several roads across Charlotte have already been treated.
NCDOT said its workers will be on 12-hour shifts to respond to any issues once the storm starts.
>> CLICK HERE for the latest forecast from Severe Weather Center 9
Charlotte Douglas International Airport has airport workers and about 40 trucks on standby to de-ice planes and remove snow from runways.
Channel 9 is monitoring impacts at Charlotte Douglas. You can also check the status of your flight, or visit your airline’s website, on FlightAware.
ALSO READ: Duke Energy preparing for winter storm
Across the Charlotte metro, Channel 9′s Eli Brand reports people are stocking up on essentials at grocery stores.
Duke Energy suggested you get bottled water and nonperishable food, and charge devices just in case ice knocks the power out.
Winter Weather Guide:
Stay with Channel 9 for the latest winter storm coverage.
(WATCH BELOW: Winter weather preparations underway in western North Carolina)
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