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Why you should think twice before taking a daily multivitamin to ward off death

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Why you should think twice before taking a daily multivitamin to ward off death

If you’re taking a multivitamin to help you live longer, a new study by researchers at the National Cancer Institute may prompt you to reconsider.

After analyzing health and nutrition data from nearly 400,000 Americans, the researchers found that people who took multivitamins had a small but significantly greater risk of premature death than people who eschewed the supplements.

The findings, reported Wednesday in the journal JAMA Network Open, may seem baffling. Americans aren’t known for having the most balanced diets, and swallowing a pill to fill in our nutrition gaps is often touted as a sensible insurance policy.

Besides, vitamins are essential. It would stand to reason that the more you take, the better.

But like so many things regarding our health, the science is not so straightforward.

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As recently as 2022, the experts on the U.S. Preventive Services Task Force conducted a thorough review of the medical literature regarding the potential for multivitamins to help prevent cardiovascular disease and cancer. They concluded there was not enough reliable evidence to make a recommendation one way or the other.

Two things make it difficult to assess the value of multivitamins.

On the one hand, there’s the “healthy user effect.” This describes the fact that people who take multivitamins tend to do a lot of beneficial things, including eating fruits and vegetables, getting regular exercise and abstaining from smoking. When assessing the relationship between multivitamin use and longevity, these habits could make the pills or liquids seem more beneficial than they actually are.

On the other hand, there’s the “sick user effect.” People who are diagnosed with a chronic disease often respond by adding a multivitamin to their daily regimen. In real-world studies, this links the supplements to poorer health and tends to make them seem less helpful than they truly are.

To help fill the gaps left by prior research, a team led by epidemiologist Erikka Loftfield collected data from three large studies that tracked participants over decades — the National Institutes of Health-AARP Diet and Health Study; the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Agricultural Health Study. Anyone who had a chronic condition when they enrolled was excluded from the team’s analysis.

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A total of 390,124 people across the three studies shared information about their multivitamin use, and half of them were at least 61½ years old when they began being tracked. By the time the study period came to an end — December 2019 or December 2020, depending on which cohort they were in — 164,762 of them had died, including roughly 50,000 deaths from cancer and 35,000 deaths from heart disease.

There were some clear differences between those who took multivitamins and those who didn’t. For example, 49% of the people who took a multivitamin every day were women, compared with 39% of those who never took them. In addition, 42% of those with a daily multivitamin habit had gone to college, compared with 38% of those who hadn’t.

The health habits of vitamin users and nonusers were different as well. People who took multivitamins every day were less likely to smoke, more likely to exercise, had higher scores for diet quality and lower ones for body mass index, and were more likely to take individual vitamin and mineral supplements.

After accounting for those and other differences, the researchers calculated that the people who eschewed all multivitamins had the lowest risk of death during the first 12 years they were tracked. Compared to them, the mortality rate was 4% higher for those who took multivitamins daily and 9% higher for those who took them less often.

Younger vitamin users had the highest risk. Among those who joined one of the studies before their 55th birthday, the mortality rate for those who took the supplements every day was 15% higher than for those who didn’t take them at all.

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Loftfield and her team also compared the mortality risks during the following 15 years. Over that longer time horizon, there were no statistically significant differences between the three groups.

That may not be welcome news to the roughly 1 in 3 Americans who take a multivitamin at least once a month — and who do so despite the fact that researchers have been saying for years that vitamin supplements do not live up to their healthful reputation.

“Multiple vitamins overpromise and they underdeliver,” said Dr. Neal D. Barnard, president of the Physicians Committee for Responsible Medicine. “They took on this undeserved reputation as being an essential aspect of a healthy lifestyle.”

Barnard and two of his colleagues from PCRM explained how this came to be in a commentary that accompanies the study.

The importance of individual nutrients began to become apparent centuries ago, they wrote. For example, lime juice was found to cure sailors with scurvy long before anyone realized the juice was a delivery vehicle for vitamin C. Similarly, doctors were preventing beriberi by replacing white rice with brown rice before they understood that the polishing process removed the grain’s outer layers, which are rich in thiamine.

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Multivitamins divorced from foods became a commercial product in the 1940s, and Americans now spend $8 billion per year on the supplements.

There are some cases where vitamin pills can be helpful, Barnard and his colleagues wrote. People with age-related macular degeneration may slow the disease’s progression by taking a cocktail of beta carotene, zinc, and vitamins C and E. Multivitamin use by older adults has been linked with better memory and cognitive function. And people who’ve had bariatric surgery are advised to take multivitamins to make up for the fact that their bodies are no longer able to extract as many nutrients from food.

But those benefits don’t extend to staving off death. Indeed, taking the pills may backfire.

Multivitamins containing calcium and zinc can impede the body’s ability to absorb antibiotics. Multivitamins with vitamin K can counteract the blood-thinning benefits of warfarin, a drug taken by millions of Americans to prevent dangerous blood clots. The iron in multivitamins can result in hemochromatosis, which puts patients at risk for cardiovascular disease, liver failure and Alzheimer’s, among other problems.

“There’s a pretty big downside to all this,” said Barnard, who is also an adjunct professor at the George Washington University School of Medicine and Health Science. “They’re not just benign.”

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In most cases, if you want vitamins to help you, you’d be much better off getting them directly from food, Loftfield said. Barnard agreed.

“Taking a vitamin completely out of its context and ramping up the dosage to a formulation that nature never really saw is not necessarily a good idea,” he said. “Mortality is decreased by dietary patterns, not by pills.”

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What’s in a Name? For These Snails, Legal Protection

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What’s in a Name? For These Snails, Legal Protection

The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.

Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.

Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.

The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.

A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.

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Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.

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Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

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Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order

Bruce, a disabled kea parrot, is missing his top beak. The bird uses tools to keep himself healthy and developed a jousting technique that has made him the alpha male of his group.

By Meg Felling and Carl Zimmer

April 20, 2026

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Contributor: Focus on the real causes of the shortage in hormone treatments

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Contributor: Focus on the real causes of the shortage in hormone treatments

For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.

Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.

In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.

Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.

Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.

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The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.

Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.

Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.

Meanwhile, there are a few strategies to cope.

  • Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
  • Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
  • Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
  • Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.

Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.

Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.

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Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book When in Menopause: A User’s Manual & Citizen’s Guide. Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”

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