Science
Opinion: Surgeons give patients too many opioids. A few simple steps could curb excess prescribing
America’s opioid epidemic is as bad as it has ever been. Although the sharp increase in opioid overdose deaths over the last decade is largely attributed to the rise in fentanyl distributed through drug cartels, a startling number can be traced to prescriptions. In fact, the Centers for Disease Control and Prevention estimates that 45 people died each day in 2021 from a prescription opioid overdose — about one-fifth of all opioid-related deaths.
Some efforts to curb opioid prescribing have shown promise, including prescription drug monitoring programs, promotion of alternative analgesics, provider education and informing prescribing physicians when their patients die from opioid overdoses. But there is one medical specialty for which opioids are still a crucial part of most patients’ treatment plan: surgery. Nearly every patient discharged after surgery leaves the hospital in significant pain, which is why surgeons prescribe more opioids than almost any other specialty.
Most patients, however, do not use all the opioids they are prescribed after an operation. That leaves excess pills in circulation and helps fuel the epidemic. If we could get surgeons to prescribe only the number of pills patients need for their own use, this could greatly reduce the number of excess pills available for diversion and misuse, among patients, their families and members of their communities. This, in turn, could reduce addiction and overdoses.
Minimizing how often a surgery patient ends up with extra opioids would not solve the crisis, but it’s part of the solution — and it’s achievable.
Changing prescribers’ behavior is hard. They get set in their ways, moored by a strong belief that what they are doing is best for their patients. Moreover, they strenuously resist attempts to constrain their freedom to decide what is best. Our research team looked to behavioral science for ways to nudge providers to prescribe in accordance with best practices, while leaving them with full autonomy to choose what they think would be best.
Conventional strategies for curbing excessive opioid prescribing assume that surgeons are rational actors who, whenever they are informed about patient needs and incentivized to attend to them, will act to maximize the welfare of patients. If that were the case, simply educating doctors about the dangers of overprescribing might be sufficient.
However, numerous studies from experimental psychology and behavioral economics have shown that people are highly selective in the information they focus on and more socially minded than traditional models of rational self-interest would predict.
Such insights from behavioral science provide promising avenues for curtailing excessive opioid prescribing by surgeons. For instance, one group of researchers found that setting the default opioid quantity in the electronic health record system to match the amount patients actually use substantially reduces the amount of opioids prescribed. Apparently, busy surgeons tended to go with the flow when prescribing — presumably because the default number of pills became a salient reference point, was easiest to enter and suggested a norm of correct behavior.
Surgeons, like other humans, are social animals who are strongly motivated to adhere to the norms of good behavior endorsed by their peers. We capitalized on this for our recent study, a randomized trial to test two simple interventions across 19 hospitals in Northern California for a year.
In one version, the emails informed surgeons that they had prescribed more pills than other surgeons in their health system had been prescribing for the same procedure. This message highlighted “descriptive” norms of actual behavior. In a second, simpler version, whenever a surgeon prescribed opioid amounts that exceeded recommended quantities for the procedure they had performed, we sent the doctor an email notification informing them. This intervention highlighted “injunctive” norms of ideal behavior.
Surprisingly, both social norm interventions had the exact same impact on prescribing. Subsequent patients were about 25% less likely to receive an opioid prescription that exceeded the recommended amount. This resulted in about 42,000 fewer pills in the community for the 26,000 patients who were part of the intervention group.
Imagine how many fewer pills would be prescribed if this were scaled up nationwide, given that there are more than 50 million inpatient surgical procedures performed each year in the U.S. Surely this would lead to millions, if not tens of millions, fewer opioid pills circulating in the U.S. each year.
Inexpensive solutions grounded in evidence on human behavior can be powerful tools in our campaign against opioid addiction. Sometimes just a light touch — a tweak to the default settings in the electronic health system or an automated email to surgeons — can have an outsize effect on prescribing decisions with life-or-death consequences.
Zachary Wagner is a health economist at USC and Rand. Craig R. Fox is a professor of psychology and medicine at UCLA and chair of the Behavioral Decision Making Area at the UCLA Anderson School of Management.
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
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