Science
‘Memory manipulation is inevitable’: How rewriting memory in the lab might one day heal humans
We often think of memories like the contents of a museum: static exhibits that we view to understand the present and prepare for the future.
The latest research, however, suggests they are more like well-thumbed library books that wear and change a little bit every time they’re pulled off the shelf.
Think of one of your happiest memories. For real. Sit with the recollection. Let your mind’s eye wander around the scene. See if you can feel a spark of the joy or hope you felt at the time. Let a minute pass. Maybe two.
If you played along with this experiment, you are physically different now than you were a few minutes ago.
When you began to reminisce, brain cells dormant just seconds before began firing chemicals at one another. That action triggered regions of your brain involved in processing emotions, which is why you may have re-experienced some feelings you did at the time of the event.
Chemical and electrical signals shot out to the rest of your body. If you were stressed before you began this exercise, your heart rate probably slowed and stabilized as levels of cortisol and other stress hormones decreased in your blood. If you were already calm, your heart rate may have quickened with excitement.
In either case, regions of the brain that light up when you get a reward jittered with dopamine.
The memory changed you. But by pulling this memory to mind, neuroscientist Steve Ramirez says, you also changed the memory.
Some elements of the memory heightened in importance. Others receded. Your brain snipped out and inserted details without your conscious knowledge. The mood you were in at the time of reminiscence left emotional fingerprints on the memory, as neurons activated by your mental environment synced up with those activated by the recollection.
Every time you revisit this heartwarming scene you change it a little bit, both as a subjective experience and a physical network of cells.
Humans have engaged in this two-way operation of memory revision for as long as we’ve been conscious. But over the last two decades, neuroscientists have found mind-bending ways to control this process (in mice, at least): implanting false memories, deleting real ones, resurrecting memories thought lost to brain damage, detaching the memory of an emotional reaction to one event and attaching it to the memory of another.
“It is all part of a larger revolution brewing in science to make memory manipulation a commonplace practice in the lab,” Ramirez writes in his recent book, “How to Change a Memory: One Neuroscientist’s Quest to Alter the Past” (Princeton University Press). “A memory may transform me entirely, but I have the power to transform it as well — both with my mind and with my science.”
In movies about stuff like this, there’s often a sinister air around the memory-tweaking scientist character. Ramirez, a Boston University professor, is friendly, earnest and keeps a giant inflatable T-rex named Henry in his office.
He sees this research not as the next frontier of coercive mind control but as another way to alleviate mental suffering, alongside medications and cognitive therapies.
“It’s amazing that we can do these things in contemporary neuroscience,” Ramirez said recently from his lab in Boston. “But the real-life, overarching goal of all of this is to restore health and well-being to an organism. … Memory manipulation is another antidote [that] can be part of our toolkit in the clinic.”
Memory is the reason Ramirez exists at all.
His father was once kidnapped at gunpoint by soldiers in his native El Salvador and falsely accused of being a left-wing guerrilla. (Their “evidence”: He had a beard.) He was spared execution when one of his captors took a second look at his face and recognized him as the generous schoolmate who used to share his lunch.
Both of Ramirez’s parents emigrated to the U.S. before his birth, and raised him and his older siblings in Boston. Ramirez got a bachelor’s in neuroscience from Boston University in 2010 and his doctorate from MIT in 2017. As a graduate student he joined the lab of Nobel laureate Susumu Tonegawa, where he was paired with a postdoc fellow named Xu Liu.
Both Ramirez and Liu were drawn to the study of memory as a possible therapeutic tool, and instantly hit it off as friends and lab partners.
Their first major breakthrough together came in 2012.
Three years earlier, a University of Toronto team identified the neurons that lit up when a mouse was exposed to a scary stimulus — in this case, a sound that earlier accompanied a shock. The Toronto researchers then injected the mice with a toxin that killed only those brain cells that lit up when they heard the sound.
The result: The treated mice no longer demonstrated a fear response when the sound was played. Essentially, the scientists had erased a specific memory.
If a memory could be deleted in the lab, Ramirez and Liu reasoned, one could be implanted.
For their experiment, the pair identified brain cells in a mouse hippocampus that activated when the animal received a startling shock. Then they took the mouse out of the enclosure where the shock occurred and placed it in a new box with no sights or other sensory cues associated with the memory of its old environment. Next, using millisecond-long pulses of light, they activated those same brain cells — without the physical shock of the earlier stimulus.
The mouse acted exactly as it had when the shock happened, even though no shock occurred.
You can’t interview a mouse about its memories. Researchers base their conclusions on the animal’s behavior. And in this case, it appeared that they’d turned a memory on.
“It just blew everyone away,” said Sheena Josselyn, a University of Toronto neuroscientist who led the 2009 work on erasing fear memories. “When you can do those sorts of things to memories, you know you have found the neural basis of a memory.”
In 2013, Ramirez and Liu set a mouse loose in a box — let’s call it, as Ramirez does in his book, Box A — and took note of the brain cells that activated as it explored the environment.
They then scooped it up and placed it in a second box, Box B. With minuscule pulses of light, they reactivated the cells that lit up in Box A, triggering a memory of that earlier environment as it explored the new one. At the same time, they gave the mouse a shock.
When they put the mouse back in Box A, a place where it had never been harmed, it froze in fear.
The mouse’s negative memory of being shocked in Box B had, essentially, been remapped to what was previously a neutral memory of Box A. The scientists had created a false memory, another seminal feat.
For their final project together, they put a mouse in an enclosure with other mice and took note of the neurons that fired as it responded positively to the social interaction.
Then they moved that mouse to a smaller cage than usual, where it was alone.
At first, this rodent equivalent of downsizing dimmed the mouse’s mood.
Given the choice between plain and sugary water, healthy mice prefer the latter. But when stressed or depressed, mice show no preference. That’s how Ramirez and Liu’s lonely mouse acted initially.
But when the scientists activated neurons associated with the memory of hanging out with other mice, the mouse’s behavior suddenly changed. It enthusiastically slurped the sweet water. Remembering better times had changed its behavior to resemble that of a healthy mouse.
The paper was published in 2015 in the prestigious journal Nature. But unlike their past shared achievements, this one couldn’t be celebrated together. As it was going through the review process, Liu died suddenly at the age of 37.
Grief, Ramirez writes, is not so different from memory: “Both endure across the entire lifespan, forever changing us, helping us to decide what matters most.”
Ramirez, now 37, opened his own lab at Boston University in 2017. In the years since, memory researchers have made impressive strides: restoring memories lost to amnesia, activating a memory while suppressing the emotions attached to it, detaching the emotional reaction to one memory and attaching it to another. The tools now exist to erase whole events and corresponding emotions from mouse brains, or to artificially jump-start memories and all the feelings that go with them.
But there is no expectation in the research community that laser-wielding doctors will one day artificially reshape human patients’ memories.
For one, these experiments are possible only with mice that have been genetically modified to have brain cells that light up when exposed to lasers. Genetically altering a human in this manner, researchers interviewed for this story said, is neither ethical nor practical.
It’s also not necessary.
“We don’t need to generate technophobic fears of a digital future where our memories will be distorted — our memories can already be distorted very effectively by nondigital means,” memory scientists Ciara Greene and Gillian Murphy wrote in “Memory Lane: The Perfectly Imperfect Ways We Remember,” published earlier this year.
Humans are suggestible creatures with extremely pliable memories. Armed with little more than a few leading questions, researchers have found that most humans can be easily manipulated into believing that they did or saw something they didn’t. We don’t need lasers to activate our memories, which can be summoned at will or triggered by any number of sensory cues, or to edit their contents, which our brains do constantly without any conscious input from us.
The real goal of research like his, Ramirez said, is to establish the biological mechanisms of memory and apply that knowledge to noninvasive therapies.
If researchers understand exactly how to retrieve a memory from a mouse hippocampus that brain damage has rendered inaccessible, for example, that information could be the basis for a drug that helps preserve or strengthen certain types of memory in people suffering from dementia or other cognitive disorders.
Understanding how an animal brain encodes memories and the emotional responses they evoke could lead to better cognitive therapies for post-traumatic stress disorder.
The obvious dark side of this line of research is that someone who understands how to boost well-being through memory manipulation could just as easily use the same knowledge for pernicious ends.
“The idea of artificially changing our own memories might elicit uneasy feelings of a dystopic future where relationships are erased, identities are replaced, and governmental powers implant thoughts in our heads to mind-control society,” Ramirez writes in his book. But, he said, any tool in existence can be used to harm or help, and he’d rather make well-intended progress than none at all.
“The idea of memory manipulation, to me, makes sense if we have an ethically bounded goal, and that ethically bounded goal is to restore health and nourish human well being,” he said. “Exercise is an antidote for the brain, and social enrichment is an antidote [and] a good night’s sleep is an antidote. What if toggling with memories in a therapeutic manner can also be an antidote? Then we’re in business.”
Science
Video: How the Artemis Astronauts Plan to Live in Space for 10 Days
new video loaded: How the Artemis Astronauts Plan to Live in Space for 10 Days
transcript
transcript
How the Artemis Astronauts Plan to Live in Space for 10 Days
On the Artemis II mission, four astronauts will work, exercise and sleep in a capsule that is about the size of two minivans for 10 days. In April 2025, National Geographic worked with NASA to film the astronauts at an Orion space capsule model in Houston.
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“Did y’all really get dibs on spots?” “She thinks.” “I know.” “Shotgun.” “Yeah, I basically called shotgun.” “We’re thinking maybe one of the sleeping bags will be kind of laid out, like, around this bend right here. So somebody’s going to have a head maybe over here, and then the feet all the way down there by the ECLSS wall.” “And Dre, don’t forget that I’ve already claimed the tunnel here. Except you’re not supposed to sleep with your head in there because of carbon dioxide. So I’m going to be hanging like a bat, is my plan. But I won’t even know it because there’s no gravity.” “Here, we’ve got both the toilet area and the exercise device on Orion. So this is the flywheel exercise device. We’ll start here. The toilet is right below it. So underneath me right now is the hygiene bay. And then it kind of looks like a rower. So you have a strap here and a hand-held bar or a harness, depending on what type of exercise you’re doing, and the way you use it is actually in this direction. So this is one of the things that we have to think in a 0g environment for, that the person who’s exercising on this will have their head coming up in the direction of the docking tunnel. And if you’re a really tall person — let’s say, the largest Canadian that we have — and you’re assigned to this mission, your head is going to extend all the way toward the docking hatch.” “That space is going to feel bigger on orbit when we’re floating. And then going up to the, again, the forward portion is what’s up now. But going forward and looking down to the deck, while this may be an awkward space to talk about here on Earth, where we have the normal pull of gravity, when we get into weightlessness, those two walls are going to be spaces that we work in, and that we use more than we do here when we’re on Earth.”

By Jamie Leventhal
April 2, 2026
Science
Federal health and environmental agencies to study microplastics and pharmaceuticals in drinking water
U.S. Secretary of Health and Human Services Robert F. Kennedy Jr. and Environmental Protection Agency Administrator Lee Zeldin announced new initiatives to tackle microplastics in the human body and drinking water on Thursday.
Kennedy said the government will create a $144-million program called STOMP, for the systematic targeting of microplastics.
“We are focusing on three questions, what is in the body, what’s causing harm, and how do we remove it?” Kennedy said.
Zeldin said the environmental agency will add microplastics and pharmaceuticals to its list of concerning chemicals in drinking water.
“For the first time in the program’s history, EPA is designating both microplastics and pharmaceuticals as priority contaminant groups,” he said.
The two Cabinet members sat a table before a crowded room at EPA headquarters in Washington, flanked by microplastic researchers, including Marcus Ericsson, an environmental scientist and co-founder of the antiplastic Five Gyres Institute; Matthew Campin, a biomedical scientist at the University of New Mexico; and Leo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service.
On either side of the table were two large posters that read “Confronting Microplastics” in capital letters.
Zeldin had been under fire by the movement known as MAHA, or Make America Health Again, in recent months over federal plans to loosen restrictions on harmful chemicals, and approve new pesticides — including two that contain what are internationally recognized as “forever chemicals,” linked to serious health risks.
Kennedy, who is the political face of the MAHA movement, has also been criticized for capitulating on issues he once embraced. In February, President Trump signed an executive order to shore up production of the herbicide glyphosate, for “national security and defense reasons.”
Kennedy publicly supported that decision and in a social media post said that while herbicides and pesticides were “toxic by design” and “put Americans at risk,” the food supply depends on them.
Glyphosate, known commercially as Roundup, has long been a target of the MAHA movement. Produced by Bayer, which acquired the original manufacturer, Monsanto, in 2018, the herbicide has been the subject of tens of thousands of lawsuits, many from users who claim to have developed non-Hodgkins lymphoma as a result of exposure.
Antiplastic advocates applauded Thursday’s announcement.
“The U.S. Environmental Protection Agency has taken an important first step to regulate microplastics in drinking water,” said Judith Enck, a former regional director of the agency and the founder of Beyond Plastics, an antiplastic waste environmental group based in Bennington, Vt. She urged the regulators to “move rapidly,” not only to regulate the plastic in drinking water, but also prevent it from getting into drinking water.
So, too, did Kimberly Wise White, vice president of regulatory and scientific affairs at the American Chemistry Council, the trade group for the chemical industry.
“We support science-driven monitoring of microplastics in drinking water and research to better understand potential impacts,” White said in a statement.
Others, however, seemed dubious.
There is reason to be concerned about microplastics in drinking water, said Erik Olson, strategic director of health for the Natural Resources Defense Council, “but the EPA’s actions speak louder than its words. The Trump EPA is trying to scrap key PFAS standards and just two weeks ago said it wouldn’t issue any new protections for toxins in drinking water. So, which is it?”
In 2022, California became the first government in the world to require microplastics testing for drinking water. The state has not yet begun reporting its results.
Blair Robertson, a spokesman for the State Water Resources Control Board, said regulators are “working on it and being very deliberate as they proceed and try to quantify how microplastics are impacting drinking water.”
A report was expected in 2025, but has not yet been issued.
Micro- and nanoplastics have been found everywhere scientists have looked. They’ve been found in human organs and tissue, such as brains, livers, placentas and testicles. They’ve also been detected in blood, breast milk and even meconium — an infant’s first stool. In addition, they are prevalent throughout the environment — in alpine snow, deep sea sediment and drinking water.
On March 31, a coalition of MAHA groups associated with Kennedy sent a letter to Zeldin requesting the Trump administration halt permitting for new plastics manufacturing plants and step up monitoring of microplastics in drinking water.
In December, Zeldin told MAHA groups he would include measures on plastics as part of the agency’s agenda, after several prominent MAHA groups called for him to be fired. They said he was too close to chemical companies.
Science
NASA launches humans to moon for first time in half-century
For the first time in more than 50 years, astronauts are on their way to the moon.
NASA’s colossal Space Launch System rocket lifted off at 3:35 p.m. Pacific time from the Kennedy Space Center in Florida, marking the start of the 10-day Artemis II mission.
In the hours and minutes leading up to launch, as the astronauts waited aboard, NASA engineers troubleshooted minor issues with the 30-story-tall rocket. First, the teams identified an issue with the hardware that communicates with a system designed to detonate the rocket to protect public safety if the rocket veers off course. Next, there was a fluke temperature reading on the Launch Abort System, designed to pull the crew to safety during such an event. Finally, they managed a brief telemetry issue with the capsule.
All were ultimately resolved, and the agency proceeded.
“On this historic mission, you take with you the heart of this Artemis team, the daring spirit of the American people and our partners across the globe, and the hopes and dreams of a new generation,” Artemis II launch director Charlie Blackwell-Thompson said to the crew minutes before launch. “Good luck. Godspeed, Artemis II. Let’s go.”
In a few days’ time, the four astronauts aboard will perform a flyby of the moon — they will not land on the surface nor will they enter the moon’s orbit. Instead, the flyby is designed as an essential stepping-stone mission to test the rocket, human life support systems and flight procedures ahead of a lunar landing, which NASA hopes to pull off in 2028.
NASA’s Artemis II moon rocket lifts off from the Kennedy Space Center on Wednesday in Cape Canaveral, Fla.
(Joe Raedle / Getty Images)
This includes studies on the astronauts’ sleep and mental health, as well as how deep-space radiation and microgravity affect organs and immune system. The crew will also practice manually piloting the spacecraft while still close to Earth.
NASA expects the crew to reach the moon Monday morning, around 10 a.m. Pacific time. As the astronauts pass the far side of the moon, NASA expects to temporarily lose communication with the crew, who will focus on documenting and analyzing the rugged lunar surface. Around this point, NASA anticipates the crew will break the Apollo 13 crew’s record for the farthest distance any human has traveled from Earth.
The crew will then begin their four-day return. The crew capsule is set to slam into the Earth’s atmosphere at roughly 30 times the speed of sound — potentially making it the fastest reentry of a crewed capsule in history — on April 10. NASA anticipates the crew will splash down off the coast of San Diego around 5 p.m. Pacific time.
The mission, made possible by scientists, engineers and support crews across the country and world, has a touch of Southern California, too.
Victor Glover, the astronaut piloting the mission, was once a kid in the Pomona Valley, watching the space shuttle launch on TV and dreaming of driving the thing. He cut his teeth as a test pilot out in the Mojave, attending test pilot school at Edwards Air Force Base and serving on a Navy test pilot squadron in China Lake, Calif.
If the mission is successful, Glover will become the first Black person to travel to the moon. With him will be the first woman to do so, NASA astronaut Christina Koch, and the first non-American to do so, Jeremy Hansen of the Canadian Space Agency. Not to be outdone by his crewmates, mission commander Reid Wiseman, at 50, will be the oldest to do so.
NASA’s Armstrong Flight Research Center inside Edwards Air Force Base is also conducting critical research and testing for the mission. They supported two tests of the rocket’s Launch Abort System — designed to accelerate from 0 to 500 mph in just two seconds to literally outrun the debris of an exploding rocket — in the 2010s. (The rocket discarded the abort system after the crew safely escaped the majority of Earth’s atmosphere.)
During reentry, the center will participate in a high-speed relay of military and civilian planes to chase the capsule and measure how the heat shield performs with high-tech telescopes and sensors. Artemis II is testing out a new reentry trajectory after an uncrewed test mission in 2022 resulted in unexpected damage to the heat shield.
Finally, once the capsule safely splashes down off San Diego, NASA and U.S. Navy divers will secure the capsule, with medical staff from both on standby. A Navy ship will then bring the capsule back to Naval Base San Diego, right next to the city’s downtown.
The Artemis program ultimately aims to land humans back on the moon, help the space agency establish a lunar base and serve as the testing grounds for future missions to Mars.
NASA plans to launch Artemis III, a mission in Earth’s orbit to test docking the NASA spacecraft with SpaceX’s and Blue Origin’s lunar landers, in 2027. It aspires to launch Artemis IV, which would put humans on the surface of the moon, in 2028.
“Artemis II is the opening act,” said NASA Administrator Jared Isaacman shortly before launch. “We’re going into the golden age of science and discovery right now.”
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