Science
‘Memory manipulation is inevitable’: How rewriting memory in the lab might one day heal humans
We often think of memories like the contents of a museum: static exhibits that we view to understand the present and prepare for the future.
The latest research, however, suggests they are more like well-thumbed library books that wear and change a little bit every time they’re pulled off the shelf.
Think of one of your happiest memories. For real. Sit with the recollection. Let your mind’s eye wander around the scene. See if you can feel a spark of the joy or hope you felt at the time. Let a minute pass. Maybe two.
If you played along with this experiment, you are physically different now than you were a few minutes ago.
When you began to reminisce, brain cells dormant just seconds before began firing chemicals at one another. That action triggered regions of your brain involved in processing emotions, which is why you may have re-experienced some feelings you did at the time of the event.
Chemical and electrical signals shot out to the rest of your body. If you were stressed before you began this exercise, your heart rate probably slowed and stabilized as levels of cortisol and other stress hormones decreased in your blood. If you were already calm, your heart rate may have quickened with excitement.
In either case, regions of the brain that light up when you get a reward jittered with dopamine.
The memory changed you. But by pulling this memory to mind, neuroscientist Steve Ramirez says, you also changed the memory.
Some elements of the memory heightened in importance. Others receded. Your brain snipped out and inserted details without your conscious knowledge. The mood you were in at the time of reminiscence left emotional fingerprints on the memory, as neurons activated by your mental environment synced up with those activated by the recollection.
Every time you revisit this heartwarming scene you change it a little bit, both as a subjective experience and a physical network of cells.
Humans have engaged in this two-way operation of memory revision for as long as we’ve been conscious. But over the last two decades, neuroscientists have found mind-bending ways to control this process (in mice, at least): implanting false memories, deleting real ones, resurrecting memories thought lost to brain damage, detaching the memory of an emotional reaction to one event and attaching it to the memory of another.
“It is all part of a larger revolution brewing in science to make memory manipulation a commonplace practice in the lab,” Ramirez writes in his recent book, “How to Change a Memory: One Neuroscientist’s Quest to Alter the Past” (Princeton University Press). “A memory may transform me entirely, but I have the power to transform it as well — both with my mind and with my science.”
In movies about stuff like this, there’s often a sinister air around the memory-tweaking scientist character. Ramirez, a Boston University professor, is friendly, earnest and keeps a giant inflatable T-rex named Henry in his office.
He sees this research not as the next frontier of coercive mind control but as another way to alleviate mental suffering, alongside medications and cognitive therapies.
“It’s amazing that we can do these things in contemporary neuroscience,” Ramirez said recently from his lab in Boston. “But the real-life, overarching goal of all of this is to restore health and well-being to an organism. … Memory manipulation is another antidote [that] can be part of our toolkit in the clinic.”
Memory is the reason Ramirez exists at all.
His father was once kidnapped at gunpoint by soldiers in his native El Salvador and falsely accused of being a left-wing guerrilla. (Their “evidence”: He had a beard.) He was spared execution when one of his captors took a second look at his face and recognized him as the generous schoolmate who used to share his lunch.
Both of Ramirez’s parents emigrated to the U.S. before his birth, and raised him and his older siblings in Boston. Ramirez got a bachelor’s in neuroscience from Boston University in 2010 and his doctorate from MIT in 2017. As a graduate student he joined the lab of Nobel laureate Susumu Tonegawa, where he was paired with a postdoc fellow named Xu Liu.
Both Ramirez and Liu were drawn to the study of memory as a possible therapeutic tool, and instantly hit it off as friends and lab partners.
Their first major breakthrough together came in 2012.
Three years earlier, a University of Toronto team identified the neurons that lit up when a mouse was exposed to a scary stimulus — in this case, a sound that earlier accompanied a shock. The Toronto researchers then injected the mice with a toxin that killed only those brain cells that lit up when they heard the sound.
The result: The treated mice no longer demonstrated a fear response when the sound was played. Essentially, the scientists had erased a specific memory.
If a memory could be deleted in the lab, Ramirez and Liu reasoned, one could be implanted.
For their experiment, the pair identified brain cells in a mouse hippocampus that activated when the animal received a startling shock. Then they took the mouse out of the enclosure where the shock occurred and placed it in a new box with no sights or other sensory cues associated with the memory of its old environment. Next, using millisecond-long pulses of light, they activated those same brain cells — without the physical shock of the earlier stimulus.
The mouse acted exactly as it had when the shock happened, even though no shock occurred.
You can’t interview a mouse about its memories. Researchers base their conclusions on the animal’s behavior. And in this case, it appeared that they’d turned a memory on.
“It just blew everyone away,” said Sheena Josselyn, a University of Toronto neuroscientist who led the 2009 work on erasing fear memories. “When you can do those sorts of things to memories, you know you have found the neural basis of a memory.”
In 2013, Ramirez and Liu set a mouse loose in a box — let’s call it, as Ramirez does in his book, Box A — and took note of the brain cells that activated as it explored the environment.
They then scooped it up and placed it in a second box, Box B. With minuscule pulses of light, they reactivated the cells that lit up in Box A, triggering a memory of that earlier environment as it explored the new one. At the same time, they gave the mouse a shock.
When they put the mouse back in Box A, a place where it had never been harmed, it froze in fear.
The mouse’s negative memory of being shocked in Box B had, essentially, been remapped to what was previously a neutral memory of Box A. The scientists had created a false memory, another seminal feat.
For their final project together, they put a mouse in an enclosure with other mice and took note of the neurons that fired as it responded positively to the social interaction.
Then they moved that mouse to a smaller cage than usual, where it was alone.
At first, this rodent equivalent of downsizing dimmed the mouse’s mood.
Given the choice between plain and sugary water, healthy mice prefer the latter. But when stressed or depressed, mice show no preference. That’s how Ramirez and Liu’s lonely mouse acted initially.
But when the scientists activated neurons associated with the memory of hanging out with other mice, the mouse’s behavior suddenly changed. It enthusiastically slurped the sweet water. Remembering better times had changed its behavior to resemble that of a healthy mouse.
The paper was published in 2015 in the prestigious journal Nature. But unlike their past shared achievements, this one couldn’t be celebrated together. As it was going through the review process, Liu died suddenly at the age of 37.
Grief, Ramirez writes, is not so different from memory: “Both endure across the entire lifespan, forever changing us, helping us to decide what matters most.”
Ramirez, now 37, opened his own lab at Boston University in 2017. In the years since, memory researchers have made impressive strides: restoring memories lost to amnesia, activating a memory while suppressing the emotions attached to it, detaching the emotional reaction to one memory and attaching it to another. The tools now exist to erase whole events and corresponding emotions from mouse brains, or to artificially jump-start memories and all the feelings that go with them.
But there is no expectation in the research community that laser-wielding doctors will one day artificially reshape human patients’ memories.
For one, these experiments are possible only with mice that have been genetically modified to have brain cells that light up when exposed to lasers. Genetically altering a human in this manner, researchers interviewed for this story said, is neither ethical nor practical.
It’s also not necessary.
“We don’t need to generate technophobic fears of a digital future where our memories will be distorted — our memories can already be distorted very effectively by nondigital means,” memory scientists Ciara Greene and Gillian Murphy wrote in “Memory Lane: The Perfectly Imperfect Ways We Remember,” published earlier this year.
Humans are suggestible creatures with extremely pliable memories. Armed with little more than a few leading questions, researchers have found that most humans can be easily manipulated into believing that they did or saw something they didn’t. We don’t need lasers to activate our memories, which can be summoned at will or triggered by any number of sensory cues, or to edit their contents, which our brains do constantly without any conscious input from us.
The real goal of research like his, Ramirez said, is to establish the biological mechanisms of memory and apply that knowledge to noninvasive therapies.
If researchers understand exactly how to retrieve a memory from a mouse hippocampus that brain damage has rendered inaccessible, for example, that information could be the basis for a drug that helps preserve or strengthen certain types of memory in people suffering from dementia or other cognitive disorders.
Understanding how an animal brain encodes memories and the emotional responses they evoke could lead to better cognitive therapies for post-traumatic stress disorder.
The obvious dark side of this line of research is that someone who understands how to boost well-being through memory manipulation could just as easily use the same knowledge for pernicious ends.
“The idea of artificially changing our own memories might elicit uneasy feelings of a dystopic future where relationships are erased, identities are replaced, and governmental powers implant thoughts in our heads to mind-control society,” Ramirez writes in his book. But, he said, any tool in existence can be used to harm or help, and he’d rather make well-intended progress than none at all.
“The idea of memory manipulation, to me, makes sense if we have an ethically bounded goal, and that ethically bounded goal is to restore health and nourish human well being,” he said. “Exercise is an antidote for the brain, and social enrichment is an antidote [and] a good night’s sleep is an antidote. What if toggling with memories in a therapeutic manner can also be an antidote? Then we’re in business.”
Science
Video: NASA Announces Artemis III Crew
new video loaded: NASA Announces Artemis III Crew
transcript
transcript
NASA Announces Artemis III Crew
NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.
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“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”
By Alisa Shodiyev Kaff
June 9, 2026
Science
Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies
Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.
But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.
“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.
That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.
The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.
(RCDSMM Stream Team)
The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.
Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.
Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.
Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.
But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.
“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”
Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.
“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”
The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.
Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.
Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.
She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.
The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.
(RCDSMM Stream Team)
Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.
There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.
For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.
Science
Pacifica pier cracks, another coastal casualty as seas continue to rise
The Pacifica Municipal Pier was shut down and taped off Thursday after city workers noticed cracks running through the landmark structure and concrete chunks falling into the ocean.
It’s just one of many coastal California structures that have recently crumbled under pressure from a rising and relentless ocean.
Officials from the small, beach city south of San Francisco said the pier was closed due to “cracking, separation, and displacement of the concrete walkway and structural elements.”
It will stay closed while structural engineers asses its safety.
Photos taken by city employees show a wide crack that runs from top to bottom and across the structure as well. Other photos show a large horizontal crack under the foundation of a small restaurant on the pier, the Chit Chat Cafe.
The cafe was also shut down.
This is not the first time the 53-year-old pier has shown signs of stress. In 2021, part of it was shut down after handrails along the edge collapsed. And in 2023, after a series of storms pummeled the Central California coast, damaging parts of the pier, the structure was partially closed for more than year.
Those same storms caused extensive damage in Aptos and Capitola, 70 miles south, where piers and waterfront infrastructure were swept away or damaged.
In 2024, a 150- to 180- foot section of the Santa Cruz wharf was ripped off by powerful waves.
At least 10 of the state’s dozens of coastal public piers were closed for part or all of 2024 due to structural damage sustained in winter storms since 2022. At least five others have longer-term upgrades planned to address structural issues.
“These things are costly to maintain,” said Zach Plopper, senior environmental director at Surfrider. “They are a part of our California coastal culture in many ways, but we’re going to need to reckon with, one, the state that they’re in, and two, the continuous and worsening threats they’re going to experience,”
He said most of the piers were constructed in the early 1900s, and they weren’t built to withstand decades of rough seas, storms and rising sea level.
“With this incoming El Niño, which is forecasted to be significant, and this marine heat wave we’re in the midst of, we’re kind of in uncharted waters as far as what this winter could bring in terms of storms and swells to the California coast, and we’re likely going to see a lot more damage,” he said. “Not just piers, but roads and other coastal infrastructure up and down the state.”
There was no storm in Pacifica earlier this week, so no single event could be blamed for the destruction.
However, a 2025 report from an outside engineering firm, GHD, found that several sections of the pier were in “poor” or “serious” condition, and they recommended closure before anticipated storms or events that could “subject the piles to high winds, swells and large waves.”
The firm found several areas of the pier where concrete was missing and rebar was exposed and corroding.
“The pier has continued to experience high winds and large waves in a harsh marine environment,” the engineers wrote in the report, noting that continuous exposure to seawater or marine spray was “detrimental” to the structure.
A 2023 city report estimated it would cost $19 million to repair.
That same year, a state law was enacted to require local governments along the California coast to plan for sea level rise in the coming decades.
Sea level has risen some 8 inches, on average, along the coast in the past 150 years, Plopper said, and researchers anticipate another foot in the next 25 years.
“We’re going to see profound shifts on our coastline, none that we have ever experienced before, and building static structures on the coast just doesn’t work all that well,” he said. “We’re going to have to make some really hard decisions.”
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