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Covid May Cause Changes in the Brain, New Study Finds

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Covid May Cause Changes in the Brain, New Study Finds

Covid-19 might trigger better lack of grey matter and tissue injury within the mind than naturally happens in individuals who haven’t been contaminated with the virus, a big new research discovered.

The research, printed Monday within the journal Nature, is believed to be the primary involving individuals who underwent mind scans each earlier than they contracted Covid and months after. Neurological specialists who weren’t concerned within the analysis stated it was priceless and distinctive, however they cautioned that the implications of the adjustments had been unclear and didn’t essentially recommend that individuals might need lasting injury or that the adjustments would possibly profoundly have an effect on pondering, reminiscence or different capabilities.

The research, involving folks aged 51 to 81, discovered shrinkage and tissue injury primarily in mind areas associated to sense of odor; a few of these areas are additionally concerned in different mind capabilities, the researchers stated.

“To me, that is fairly convincing proof that one thing adjustments in brains of this general group of individuals with Covid,” stated Dr. Serena Spudich, chief of neurological infections and world neurology on the Yale College of Medication, who was not concerned within the research.

However, she cautioned: “To make a conclusion that this has some long-term medical implications for the sufferers I believe is a stretch. We don’t need to scare the general public and have them suppose, ‘Oh, that is proof that everybody’s going to have mind injury and never be capable to perform.’”

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The research concerned 785 contributors in UK Biobank, a repository of medical and different information from about half one million folks in Britain. The contributors every underwent two mind scans roughly three years aside, plus some primary cognitive testing. In between their two scans, 401 contributors examined constructive for the coronavirus, all contaminated between March 2020 and April 2021.

The opposite 384 contributors fashioned a management group as a result of they’d not been contaminated with the coronavirus and had comparable traits to the contaminated sufferers in areas like age, intercourse, medical historical past and socioeconomic standing.

With regular getting older, folks lose a tiny fraction of grey matter annually. For instance, in areas associated to reminiscence, the everyday annual loss is between 0.2 % and 0.3 %, the researchers stated.

However Covid sufferers within the research — who underwent their second mind scan a median of 4 and a half months after their an infection — misplaced greater than noninfected contributors, experiencing between 0.2 % and a pair of % extra grey matter loss in several mind areas over the three years between scans. Additionally they misplaced extra general mind quantity and confirmed extra tissue injury in sure areas.

“I discover it stunning within the sense of how rather more was misplaced and the way generalized it’s,” stated Dr. Spudich, who has studied the neurological results of Covid. She added, “I wouldn’t have anticipated to see fairly a lot proportion change.”

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The consequences could also be notably notable as a result of the research concerned largely individuals who — like nearly all of Covid sufferers within the basic inhabitants — had been mildly affected by their preliminary Covid an infection, not changing into sick sufficient to wish hospitalization.

The research’s lead creator, Gwenaëlle Douaud, a professor within the division of medical neurosciences on the College of Oxford, stated that though the variety of hospitalized sufferers within the research, 15, was too small to yield conclusive information, outcomes steered that their mind atrophy was worse than the mildly sufferers.

Individuals who had Covid additionally confirmed better decline than uninfected folks on a cognitive take a look at associated to consideration and effectivity in performing a posh activity. However exterior specialists and Dr. Douaud famous that the cognitive testing was rudimentary, so the research may be very restricted in what it will possibly say about whether or not the grey matter loss and tissue injury the Covid sufferers skilled affected their cognitive expertise.

“None of them obtained thorough sufficient cognitive testing to know if they’d vital deficits in these many areas the place they discovered these adjustments in quantity,” stated Dr. Benedict Michael, an affiliate professor of neurological infections on the College of Liverpool, who’s researching the neuropsychiatric results of Covid and was not concerned within the research. “We don’t know that it truly means something for the affected person’s high quality of life or perform.”

For instance, though among the largest grey matter loss was in areas associated to odor, together with the orbitofrontal cortex and parahippocampal gyrus, these areas are additionally concerned in reminiscence and different capabilities. However the Covid sufferers didn’t carry out worse than noninfected contributors on reminiscence exams, Dr. Douaud stated, though she added that the reminiscence exams they took had been transient and primary.

The primary cognitive evaluation the place Covid sufferers confirmed a deficit was the trail-making take a look at, a connect-the-dots kind of train involving alternating letters and numbers. Covid sufferers took longer to finish the duty, which could recommend weaknesses in focus, processing velocity and different expertise.

Dr. Douaud stated this diminished capacity correlated with lack of grey matter in a particular area of the mind’s cerebellum. However the research doesn’t show trigger and impact, stated Dr. Spudich, who additionally stated that the cerebellum, primarily related to stability, coordination and motion, “isn’t the primary mind construction you consider” to elucidate adjustments in capacity on the trail-making take a look at.

One vital limitation to the research, Dr. Douaud stated, is that researchers didn’t have details about folks’s signs, together with whether or not they misplaced their sense of odor. The researchers additionally couldn’t establish whether or not any sufferers had lengthy Covid, so it’s unclear if the findings relate to that long-term situation.

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Variations between contaminated and uninfected folks elevated with age. On the trail-making take a look at, for instance, efficiency was comparable in each teams for folks of their 50s and early 60s, however the hole widened considerably after that. “I don’t know if that’s as a result of youthful folks get better sooner or they weren’t as affected to start out with,” Dr. Douaud stated. “Might be both or it may very well be each.”

Dr. Michael cautioned that the findings couldn’t be extrapolated to the numerous youthful folks experiencing post-Covid mind fog and different cognitive points. And since grey matter and tissue injury had been measured at just one time-point after an infection, “we don’t know if it’s only a transient change that will get higher with restoration,” he stated.

Outdoors specialists and the research’s authors stated the vary of mind areas the place Covid sufferers expertise extra grey matter loss raised intriguing questions.

“There’s nobody a part of the mind that does one factor,” Dr. Douaud stated. “There are components of the mind within the contaminated contributors with extra grey matter loss that don’t have anything to do with the odor, and those which are associated to odor are also concerned in different mind capabilities.”

The reason for the mind adjustments is unclear. The authors talked about theories together with irritation, proof of which has been present in different research, and “sensory deprivation” from disrupted sense of odor.

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Dr. Avindra Nath, chief of the part on infections of the nervous system on the Nationwide Institute of Neurological Problems and Stroke, who was not concerned within the research, stated one other “essential query” was whether or not the mind adjustments may make Covid sufferers extra liable to dementia or different deficits sooner or later.

And whereas the researchers didn’t discover the identical mind adjustments in sufferers with non-Covid pneumonia, Dr. Nath really helpful learning sufferers with different coronaviruses or the flu “to see if these findings are distinct for Covid-19 or extra generalizable.”

Dr. Spudich stated the research’s best worth could also be its indication that “there’s been one thing that’s occurred within the mind in these folks,” including that “I believe folks have felt that it’s so imprecise, so laborious to measure.”

Different scientists can now construct on these findings, she and others stated.

“It’s an vital research, they’ve finished good work,” Dr. Michael stated, including, “now we have to do the research to take a look at cognition and psychiatric signs and behavioral stuff and neurological stuff and discover out what does this imply for sufferers.”

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.

Across the water, cargo ships made dark shapes as they slid between the seas.

The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.

But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.

The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.

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Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.

In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.

Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.

Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”

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Sitting hurts. Train for your desk job with these 5 easy exercises for your head and neck

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Sitting hurts. Train for your desk job with these 5 easy exercises for your head and neck

It’s Monday morning, the start of your work week. You’ve put the finishing touches on that big report, prepared for that imminent presentation. But it’s likely that there’s one aspect of the job you’re not ready for: the marathon of sitting at your desk all day.

Time to start training. Because while it might not be earthshaking news, it bears repeating: Prolonged desk work can lead to a host of musculoskeletal issues, from annoying aches and pains to injuries.

Even if your work space is ergonomically correct — and even if you exercise regularly in your free time — excessive desk work (considered three or four continuous hours) can lead to weakened, tight muscles, joint stiffness, inflammation in the muscles and tendons and tight fascia (connective tissue). Add it all up, and the result is typically some level of discomfort.

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Left untreated, muscles that are stressed and deconditioned can lead to painful soft tissue problems, such as tendonitis and carpal tunnel syndrome, as well as chronic lower back pain. You can also become at risk for bulging or herniated discs, pinched nerves and other issues.

Desk work can also lead to biomechanical imbalances. Weakened glutes from sitting, for example, can lead to stress on the knees and lower back; tired hip flexors can alter pelvic movement, leading to lower back pain.

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Which is concerning seeing as sitting for work is both on the rise and can put us at risk for other serious health issues, says Stella Volpe, president of the American College of Sports Medicine.

“We know that there are more Americans now that have sedentary jobs than ever in the past,” Volpe says. “The more we sit, the greater risk we have of diabetes, obesity and cardiovascular disease.”

Blame our sitting-related woes on the advent of furniture, says David Raichlen, a USC evolutionary biologist who studies sedentary behavior and exercise.

Before chairs with a back and arm rests debuted as a status symbol among ancient Egyptians about 5,000 years ago, he says that humans mostly kneeled or squatted for about 2 million years. Those resting postures require light muscle activity, but when the body is fully supported by a chair or a couch, it turns off that activity in the body parts being supported by the furniture, Raichlen says. Prolonged inactivity can then lead to muscle atrophy and other problems.

“From an evolutionary standpoint, the human body hasn’t yet adapted to furniture,” Raichlen says. “It never had to deal with completely inactive muscles for long periods of time until very recently.”

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But the good news is you can train for long-distance sessions at your desk by working out your neck, your wrists, your lower back, even your feet and toes. These “exercise snacks,” as trainers call them, don’t require a trip to the gym, or equipment, or even much time.

They’re not meant to replace regular exercise, but they will — if done regularly — prepare your body for the challenge that is desk work by stretching and strengthening your muscles, taking pressure off your joints and reducing stiffness and inflammation in the area — all of which may alleviate pain and prevent new injuries.

“We’re designed to be hunter-gatherers, not to wiggle our fingers on a keyboard for eight hours straight,” says Dr. Joshua T. Goldman, a UCLA sports medicine physician. “We need to build up strength, for endurance purposes, to help those body parts tolerate that activity.”

“The human body hasn’t yet adapted to furniture. It never had to deal with completely inactive muscles for long periods of time until very recently.”

— David Raichlen, USC evolutionary biologist

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We spoke to exercise physiologists, sports medicine physicians, personal trainers, physical therapists and others to devise a short, five-minute exercise routine for six key regions of the body. We’ll roll out one routine a week — starting with the head and neck area — for six weeks, until you have a complete full-body workout.

Each exercise is purposefully simple, meant to take 30-60 seconds. And each routine lasts about five minutes or less in total. They’re ideally done throughout the day, so as to promote mobility and circulation, bringing blood flow and nutrients to the muscles and tendons, and increasing lubrication in the joints. Set a timer. Take a five-minute break to execute one routine. Then get back to work.

Still too busy? Do just one exercise, for 30-60 seconds, then continue working. If you get through one routine by day’s end, consider it a win. Focus on a different routine the next day.

“It all adds up,” Volpe says. “Our society often thinks that if you’re not running a marathon, you’re not doing enough. But the additive effect is still good for you.”

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A routine for your head and neck

The neck is a common area in which to develop pain from desk work. Looking at a computer monitor, we often jut our neck forward rather than tucking in our chin, as we should. That pushes our cervical column out of alignment and creates excess stress on the bones and discs of the cervical spine. It shortens and tightens muscles in the neck, which can lead to pain and cause tension headaches.

Do these exercises to help stretch and strengthen the muscles that support your head and neck. They’re demonstrated by trainer Melissa Gunn, of Pure Strength LA, whose team trains desk workers on how to protect their bodies through exercise.

  1. Clasp your hands behind your head and gently tuck your chin down toward your chest. Hold 10 seconds. Do five times.
  1. Slowly tilt your head to the left, bringing your ear toward your shoulder. Hold for 10 seconds, then raise it slowly back up to the starting point. Switch sides. Do three times on each side. To increase the stretch, after bringing your ear to your shoulder and holding, turn your head and look down toward your armpit on the same side, then return to starting position.
  1. Place your back flat against a wall and stand with your feet about eight inches from the wall, with knees slightly bent. Your arms should be flush against the wall, with palms facing outward. Tuck your chin slightly and push your head gently against the wall. Slide your arms up the wall, as if doing a snow angel. Go as far as you can with your arms and hands flush against wall. Stop when they begin to pull away from the wall — typically when palms are between shoulder height and head height. Do 10 times.
  1. Stand up straight and align your head, shoulders, hips and ankles — most people jut their neck forward without knowing it, creating static tension there, so consciously move your head back so it’s above your shoulders. Slowly roll your head in a circle, first to the left, clockwise, all the way around; then to the right, counter-clockwise. Do 3 times on each side.
  1. Stand up straight and align your head, shoulders, hips and ankles. Your arms should be beside you and your palms facing outward. Then pull your arms back but no further than the back pockets of your pants — without lifting your shoulders — and draw your shoulder blades together. Hold for 2-5 seconds. Do 5-10 times.

(Exercises came from Dr. Joshua T. Goldman, UCLA sports medicine; Melissa Gunn, Pure Strength LA; Tom Hendrickx, Pivot Physical Therapy; Vanessa Martinez Kercher, Indiana University-Bloomington, School of Public Health; Nico Pronk, Health Partners Institute; Niki Saccareccia, Light Inside Yoga.)

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Lead Poisoning May Have Made Ancient Romans a Bit Less Intelligent

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Lead Poisoning May Have Made Ancient Romans a Bit Less Intelligent

Roughly 2,000 years ago, the Roman Empire was flourishing. But something sinister was in the air. Literally.

Widespread pollution in the form of airborne lead was taking a toll on health and intelligence, researchers reported on Monday in the journal Proceedings of the National Academy of Sciences.

During the roughly two centuries starting in 27 B.C., a period of relative stability and prosperity known as the Pax Romana, the empire extended throughout Europe, the Middle East and North Africa. Its economy relied on silver coinage, which required huge mining operations.

But extracting silver from the Earth creates a whole lot of lead, said Joseph McConnell, an environmental scientist at the Desert Research Institute, a nonprofit group based in Nevada, and the lead author of the new research. “If you produce an ounce of silver, you’d have produced something like 10,000 ounces of lead.”

And lead has a host of negative effects on the human body. “There is no such thing as any safe level of lead exposure,” said Deborah Cory-Slechta, a neurotoxicologist at the University of Rochester Medical Center who was not involved in the research.

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Dr. McConnell and his colleagues have now detected lead in layers of ice collected in Russia and Greenland that date to the time of the Roman Empire. Lead entered the atmosphere from Roman mining operations, hitched a ride on air currents and eventually fell out of the atmosphere as snow in the Arctic, the team surmised.

The levels of lead that Dr. McConnell and his collaborators measured were extremely low, roughly one lead-containing molecule per trillion molecules of water. But the ice samples were collected thousands of miles from southern Europe, and lead concentrations would have been highly dispersed after such a long journey.

In order to estimate the amount of lead originally emitted by Roman mining operations, the researchers worked backward: Using powerful computer models of the planet’s atmosphere and making assumptions about the location of the mining sites, the team varied the amount of lead emitted to match the concentrations they measured in the ice. In one case, they assumed that all silver production took place at a historically important mining site in southwestern Spain known as Rio Tinto. In another case, they presumed that silver mining was equally spread out across dozens of sites.

The team calculated that anywhere from 3,300 to 4,600 tons of lead were being emitted into the atmosphere each year by Roman silver-mining operations. The researchers then estimated how all that lead would be scattered across the Roman Empire.

“We ran the model in the forward direction to see how those emissions would be distributed,” Dr. McConnell said.

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With those atmospheric-lead concentrations in hand, the researchers next used modern-day data to estimate how much lead would have entered the bloodstreams of people in ancient Rome.

Dr. McConnell and his colleagues focused on infants and children. Young people are particularly susceptible to taking up lead from their environment via ingestion and inhalation, said Dr. Bruce Lanphear, a public heath physician at Simon Fraser University in British Columbia who was not involved in the research. “Pound for pound, children, particularly infants, eat more and breathe more.”

In recent decades, lead levels in children’s blood have been correlated with a slew of physical and mental health metrics, including I.Q., Dr. Cory-Slechta said. “We have actual data on I.Q. scores in kids with different blood-lead concentrations.”

Using those modern-day relationships, Dr. McConnell and his team estimated that children across much of the Roman Empire would have had around 2 to 5 additional micrograms of lead, per deciliter of blood. Such levels correspond to I.Q. declines of roughly 2 or 3 points.

For comparison, American children in the 1970s had average blood-lead-level enhancements of around 15 micrograms more lead per deciliter of blood before the phasing out of leaded gasoline and leaded paints. Their corresponding average I.Q. decline was about 9 points.

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But lead exposure would have had other negative effects on Romans as well. Higher levels of lead in the blood have also been linked to higher incidences of preterm births and reduced cognitive functioning in old age. “It follows you throughout life,” Dr. Lanphear said.

Some scholars have hypothesized that lead poisoning played an important role in the decline of the Roman Empire. But that idea has been called into question, at least when it comes to water contaminated by lead pipes. A 2014 study showed that, while the pipes used to distribute water in Rome increased lead levels, the water was unlikely to be truly harmful.

These new findings make sense, said Hugo Delile, a geoarchaeologist at the French National Centre for Scientific Research, who was not involved in the research. “They confirm the extent of lead pollution resulting from Roman mining and metallurgical activities.”

According to Dr. McConnell, the research also confers a dubious honor on Roman mining. “To my knowledge, it’s the earliest example of widespread industrial pollution,” he said.

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