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Contributor: Animal testing slows medical progress. It wastes money. It’s wrong

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Contributor: Animal testing slows medical progress. It wastes money. It’s wrong

I am living with ALS, or amyotrophic lateral sclerosis, often called Lou Gehrig’s disease. The average survival time after diagnosis is two to five years. I’m in year two.

When you have a disease like ALS, you learn how slowly medical research moves, and how often it fails the people it is supposed to save. You also learn how precious time is.

For decades, the dominant pathway for developing new drugs has relied on animal testing. Most of us grew up believing this was unavoidable: that laboratories full of caged animals were simply the price of medical progress. But experts have known for a long time that data tell a very different story.

The Los Angeles Times reported in 2017: “Roughly 90% of drugs that succeed in animal tests ultimately fail in people, after hundreds of millions of dollars have already been spent.”

The Times editorial board summed it up in 2018: “Animal experiments are expensive, slow and frequently misleading — a major reason why so many drugs that appear promising in animals fail in human trials.”

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Then there’s the ethical cost — confining, sickening and killing millions of animals each year for a system that fails 9 times out of 10. As Jane Goodall put it, “We have the choice to use alternatives to animal testing that are not cruel, not unethical, and often more effective.”

Despite overwhelming evidence and well-reasoned arguments against animal-based pipelines, they remain central to U.S. medical research. Funding agencies, academic medical centers, government labs, pharmaceutical companies and even professional societies have been painfully slow to move toward human- and technology-based approaches.

Yet medical journals are filled with successes involving organoids (mini-organs grown in a lab), induced pluripotent stem cells, organ-on-a-chip systems (tiny devices with human cells inside), AI-driven modeling and 3D-bioprinted human tissues. These tools are already transforming how we understand disease.

In ALS research, induced pluripotent stem cells have allowed scientists to grow motor neurons in a dish, using cells derived from actual patients. Researchers have learned how ALS-linked mutations damage those neurons, identified drug candidates that never appeared in animal models and even created personalized “test beds” for individual patients’ cells.

Human-centric pipelines can be dramatically faster. Some are reported to be up to 10 times quicker than animal-based approaches. AI-driven human biology simulations and digital “twins” can test thousands of drug candidates in silico, with a simulation. Some models achieve results hundreds, even thousands, of times faster than conventional animal testing.

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For the 30 million Americans living with chronic or fatal diseases, these advances are tantalizing glimpses of a future in which we might not have to suffer and die while waiting for systems that don’t work.

So why aren’t these tools delivering drugs and therapies at scale right now?

The answer is institutional resistance, a force so powerful it can feel almost god-like. As Pulitzer Prize–winning columnist Kathleen Parker wrote in 2021, drug companies and the scientific community “likely will fight … just as they have in past years, if only because they don’t want to change how they do business.”

She reminds us that we’ve seen this before. During the AIDS crisis, activists pushed regulators to move promising drugs rapidly into human testing. Those efforts helped transform AIDS from a death sentence into a chronic condition. We also saw human-centered pipelines deliver COVID vaccines in a matter of months.

Which brings me, surprisingly, to Robert F. Kennedy Jr. In December, Kennedy told Fox News that leaders across the Department of Health and Human Services are “deeply committed to ending animal experimentation.” A department spokesperson later confirmed to CBS News that the agency is “prioritizing human-based research.”

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Kennedy is right.

His directive to wind down animal testing is not anti-science. It is pro-patient, pro-ethics and pro-progress. For people like me, living on borrowed time, it is not just good policy, it is hope — and a potential lifeline.

The pressure to end animal testing and let humans step up isn’t new. But it’s getting new traction. The actor Eric Dane, profiled about his personal fight with ALS, speaks for many of us when he expresses his wish to contribute as a test subject: “Not to be overly morbid, but you know, if I’m going out, I’m gonna go out helping somebody.”

If I’m going out, I’d like to go out helping somebody, too.

Kevin J. Morrison is a San Francisco-based writer and ALS activist.

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Diablo Canyon nuclear power plant gets final go-ahead to run through 2030

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Diablo Canyon nuclear power plant gets final go-ahead to run through 2030

The federal Nuclear Regulatory Commission on Thursday renewed Diablo Canyon’s license to operate, ensuring that California’s last remaining nuclear facility will continue to run through at least 2030.

The plant was originally slated to close in 2025, but lawmakers extended the deadline by five years in 2022, citing ongoing need for power from a plant that provides more than 8% of the state’s electricity.

The approval from the body that regulates nuclear reactors and waste marks the final hurdle in Pacific Gas & Electric’s multiyear journey to gather the necessary state and federal permits to keep its facility online.

In December, PG&E received a key permit from the California Coastal Commission by agreeing to give up 12,000 acres of nearby land for conservation in exchange for the loss of marine life caused by the plant’s operations.

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Another key step took place in February when the Central Coast Regional Water Board approved waste discharge permits for the plant and granted a certification under the Clean Water Act, the last step required before the Nuclear Regulatory Commission could issue its final approval.

The license renewal from the commission allows the plant to remain running for 20 years, although extending it past 2030 would require additional action from the California Legislature.

“Today’s milestone reminds us that when discipline, science, responsibility and vision all come together, we can build an energy future that is both sustainable and secure,” said NRC Office of Nuclear Reactor Regulation acting Director Jeremy Groom at a signing ceremony.

Already this year some lawmakers and regulators have expressed interest in extending the plant’s life through 2045, citing growing electricity demand and the plant’s central role in helping the state meet its climate goals by providing carbon-free power to the grid.

Groups that oppose the plant want to make sure that doesn’t happen. Last week, the California Coastkeeper Alliance filed a petition asking the State Water Resources Control Board to throw out the facility’s water discharge permit. The group alleged that the Central Coast Regional Water Board illegally allowed the facility to continue operating without technology required under the federal Clean Water Act to protect marine life.

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Other groups have petitioned the board to limit Diablo Canyon’s Clean Water Act certificate to 2030, rather than 2045.

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Video: How the Artemis Astronauts Plan to Live in Space for 10 Days

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Video: How the Artemis Astronauts Plan to Live in Space for 10 Days

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How the Artemis Astronauts Plan to Live in Space for 10 Days

On the Artemis II mission, four astronauts will work, exercise and sleep in a capsule that is about the size of two minivans for 10 days. In April 2025, National Geographic worked with NASA to film the astronauts at an Orion space capsule model in Houston.

“Did y’all really get dibs on spots?” “She thinks.” “I know.” “Shotgun.” “Yeah, I basically called shotgun.” “We’re thinking maybe one of the sleeping bags will be kind of laid out, like, around this bend right here. So somebody’s going to have a head maybe over here, and then the feet all the way down there by the ECLSS wall.” “And Dre, don’t forget that I’ve already claimed the tunnel here. Except you’re not supposed to sleep with your head in there because of carbon dioxide. So I’m going to be hanging like a bat, is my plan. But I won’t even know it because there’s no gravity.” “Here, we’ve got both the toilet area and the exercise device on Orion. So this is the flywheel exercise device. We’ll start here. The toilet is right below it. So underneath me right now is the hygiene bay. And then it kind of looks like a rower. So you have a strap here and a hand-held bar or a harness, depending on what type of exercise you’re doing, and the way you use it is actually in this direction. So this is one of the things that we have to think in a 0g environment for, that the person who’s exercising on this will have their head coming up in the direction of the docking tunnel. And if you’re a really tall person — let’s say, the largest Canadian that we have — and you’re assigned to this mission, your head is going to extend all the way toward the docking hatch.” “That space is going to feel bigger on orbit when we’re floating. And then going up to the, again, the forward portion is what’s up now. But going forward and looking down to the deck, while this may be an awkward space to talk about here on Earth, where we have the normal pull of gravity, when we get into weightlessness, those two walls are going to be spaces that we work in, and that we use more than we do here when we’re on Earth.”

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On the Artemis II mission, four astronauts will work, exercise and sleep in a capsule that is about the size of two minivans for 10 days. In April 2025, National Geographic worked with NASA to film the astronauts at an Orion space capsule model in Houston.

By Jamie Leventhal

April 2, 2026

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Federal health and environmental agencies to study microplastics and pharmaceuticals in drinking water

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Federal health and environmental agencies to study microplastics and pharmaceuticals in drinking water

U.S. Secretary of Health and Human Services Robert F. Kennedy Jr. and Environmental Protection Agency Administrator Lee Zeldin announced new initiatives to tackle microplastics in the human body and drinking water on Thursday.

Kennedy said the government will create a $144-million program called STOMP, for the systematic targeting of microplastics.

“We are focusing on three questions, what is in the body, what’s causing harm, and how do we remove it?” Kennedy said.

Zeldin said the environmental agency will add microplastics and pharmaceuticals to its list of concerning chemicals in drinking water.

“For the first time in the program’s history, EPA is designating both microplastics and pharmaceuticals as priority contaminant groups,” he said.

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The two Cabinet members sat a table before a crowded room at EPA headquarters in Washington, flanked by microplastic researchers, including Marcus Ericsson, an environmental scientist and co-founder of the antiplastic Five Gyres Institute; Matthew Campin, a biomedical scientist at the University of New Mexico; and Leo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service.

On either side of the table were two large posters that read “Confronting Microplastics” in capital letters.

Zeldin had been under fire by the movement known as MAHA, or Make America Health Again, in recent months over federal plans to loosen restrictions on harmful chemicals, and approve new pesticides — including two that contain what are internationally recognized as “forever chemicals,” linked to serious health risks.

Kennedy, who is the political face of the MAHA movement, has also been criticized for capitulating on issues he once embraced. In February, President Trump signed an executive order to shore up production of the herbicide glyphosate, for “national security and defense reasons.”

Kennedy publicly supported that decision and in a social media post said that while herbicides and pesticides were “toxic by design” and “put Americans at risk,” the food supply depends on them.

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Glyphosate, known commercially as Roundup, has long been a target of the MAHA movement. Produced by Bayer, which acquired the original manufacturer, Monsanto, in 2018, the herbicide has been the subject of tens of thousands of lawsuits, many from users who claim to have developed non-Hodgkins lymphoma as a result of exposure.

Antiplastic advocates applauded Thursday’s announcement.

“The U.S. Environmental Protection Agency has taken an important first step to regulate microplastics in drinking water,” said Judith Enck, a former regional director of the agency and the founder of Beyond Plastics, an antiplastic waste environmental group based in Bennington, Vt. She urged the regulators to “move rapidly,” not only to regulate the plastic in drinking water, but also prevent it from getting into drinking water.

So, too, did Kimberly Wise White, vice president of regulatory and scientific affairs at the American Chemistry Council, the trade group for the chemical industry.

“We support science-driven monitoring of microplastics in drinking water and research to better understand potential impacts,” White said in a statement.

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Others, however, seemed dubious.

There is reason to be concerned about microplastics in drinking water, said Erik Olson, strategic director of health for the Natural Resources Defense Council, “but the EPA’s actions speak louder than its words. The Trump EPA is trying to scrap key PFAS standards and just two weeks ago said it wouldn’t issue any new protections for toxins in drinking water. So, which is it?”

In 2022, California became the first government in the world to require microplastics testing for drinking water. The state has not yet begun reporting its results.

Blair Robertson, a spokesman for the State Water Resources Control Board, said regulators are “working on it and being very deliberate as they proceed and try to quantify how microplastics are impacting drinking water.”

A report was expected in 2025, but has not yet been issued.

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Micro- and nanoplastics have been found everywhere scientists have looked. They’ve been found in human organs and tissue, such as brains, livers, placentas and testicles. They’ve also been detected in blood, breast milk and even meconium — an infant’s first stool. In addition, they are prevalent throughout the environment — in alpine snow, deep sea sediment and drinking water.

On March 31, a coalition of MAHA groups associated with Kennedy sent a letter to Zeldin requesting the Trump administration halt permitting for new plastics manufacturing plants and step up monitoring of microplastics in drinking water.

In December, Zeldin told MAHA groups he would include measures on plastics as part of the agency’s agenda, after several prominent MAHA groups called for him to be fired. They said he was too close to chemical companies.

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