Science
A life-saving transplant awaits Arthur Yu — if the U.S. government lets his donor into the country
Arthur Yu was exhausted, but he chalked it up to being a new father.
Usually active, Yu was finding himself winded by the afternoon. He negotiated with his wife Alice to get just a little bit more sleep, thinking his fatigue was just a passing phase.
But four months after the birth of their son Abel, Yu was diagnosed with acute myeloid leukemia, a genetic mutation that formed in his bone marrow and spread to his blood. Thanks to several rounds of chemotherapy, Yu is currently in remission, but his doctors say that status is temporary and his best chance for beating the cancer is a stem cell transplant from a suitable donor.
Yu found an ideal match in a distant cousin, only he now has to convince the U.S. government to let that person into the country. And so far, the feds said no twice to granting a visa to his potential donor.
After the media strategist was diagnosed with leukemia last March, doctors asked his family to take cheek-swab DNA samples to see whether there were any suitable candidates for the procedure. None of his immediate relatives were a match, but a distant cousin was: Noel Talania, who lives in the rural Philippines countryside.
The two had never met, and neither is fluent in Tagalog, the most common language spoken among the Filipino diaspora. (Talania speaks Ilocano, the third-most spoken language in the Philippines.) So the two connected over Facebook Messenger last year and translated their words into their respective languages over translation programs.
Talania agreed to become a donor and understood the severity of the situation. Yu was realistic about all that he was asking from his cousin, and he was gracious about it.
“I feel like I’m asking of you too much,” Yu would write to his cousin. “That’s when it turns into sort of like a reminder of gratitude.”
Talania spent an entire day traveling from his rural town to the U.S. embassy in Manila on Dec. 18, according to 41-year-old Yu, who thought that by the beginning of 2024 he would be in the process of receiving a stem cell transplant at Cedars-Sinai in Los Angeles.
At his embassy interview, Talania was provided an interpreter who spoke Tagalog, not Ilocano, Alice Yu said, which wasn’t ideal for making his case. It was a sign of things to come: At the end of the meeting, an embassy official made it clear that the U.S. government was denying Talania’s application for a tourist visa. The official reason was stated in a boilerplate letter handed to Talania: The government held that Talania could not prove that he would return back to his home country after arriving in the U.S., as required by section 2.14(B) of the Immigration and Nationality Act, despite the facts that his wife and children live in the Philippines and that he has an established business there.
“When we applied for this visa in December, no one warned me that this was going to be a problem,” Yu said. “Even my doctors were surprised.”
Citizens of 41 countries are allowed to travel to the U.S. without a visa for business or tourism purposes, but the Philippines is not one of those nations.
Talania appealed the denial, and Yu’s family and friends reached out to any available resources to find a workaround. Inquiries by aides to U.S. Sen. Alex Padilla (D-Calif.) expedited the application process, and Talania was granted a second interview on Jan. 10.
Talania arrived with documents showing that Yu could afford to house Talania while undergoing the transplant procedure, along with a doctor’s note detailing Yu’s diagnosis and proof that Yu’s family were in contact with Padilla’s office. He also brought his marriage certificate and proof that he wants to return to the Philippines after the procedure.
But he was stopped before he could present any of it.
“They told him, ‘Oh, we don’t need to see that,’” Alice Yu said, recounting what an embassy official told Talania.
This time the embassy didn’t provide an interpreter, and the interviewer spoke to him only in English, Alice Yu said. The official did not look at any of the documents Talania brought with him and told him that his application was denied — again. Talania text messaged his cousin a single screen shot with two words hastily written: “Humanitarian parole.”
The phrase filled Yu with despair.
“I started to ask him, ‘Why are you texting me this? What is this? I know what [parole] is? Are you telling me you got denied?’” Yu recalled asking his cousin.
Humanitarian parole allows foreign nationals to enter the U.S. on a temporary basis due to an ongoing conflict in their home country. The application process has been used recently by Ukrainians fleeing the Russian invasion, but the process can take up to two years, according to immigration attorney Sameen Ahmadnia with the law firm Fragomen, Del Rey, Bernsen & Loewy.
Yu will have to make a sympathetic case to the U.S. government to show why his cousin should be allowed to enter the country.
“Only, there are a lot of sympathetic cases,” Ahmadnia said. “The problem is trying to get your case to stand out to a government official.”
Ahmadnia, who offered to work with Yu pro bono after she heard about his case, helped him file the application for humanitarian parole, with a bolstered list of documents to support his case. The hope is that somewhere along the process, someone will expedite his case.
For Yu, “up to two years” is time he does not have.
“If there’s a word for a rage-infused optimism this is it, because I’m thankful that I have this option, but I’m also furious that I have to use it,” Yu said.
The U.S. State Department did not respond to requests for comment. Yu’s story was first reported by news station KABC 7.
Yu’s survival rate with chemotherapy alone is minimal and comes with added risks to his health, according to his physician Dr. Ron Paquette, clinical director, Stem Cell and Bone Marrow Transplant Program with Cedars-Sinai Medical Center. Yu will need repeated chemotherapy treatments to keep his leukemia in remission, but every delay puts his life at risk.
Yu is in the “perfect place to proceed” with a transplant, Paquette said. There are some alternatives, like flying Talania to Mexico to donate his stem cells or using another donor who is not as close a match to Yu, but Paquette said the best chance is getting Talania to Cedars-Sinai.
While he’s unfamiliar with the visa process, Paquette urges government officials to “weigh the risks and benefits and read carefully” about Yu’s case.
“This is one person’s life on the line, where we can really make a difference in his long-term survival,” Paquette said.
Yu has “golden retriever energy” according to his wife Alice, even with his cancer diagnosis, chemotherapy treatment, the unexpected death of his father and the battle to get Talania a visa.
“If you just met him, you wouldn’t even know that he’s been through all of this in the past year,” Alice Yu said.
Alice Yu is a surgical nurse at Cedars-Sinai, and when she’s not raising their son with Yu, she’s taking care of her husband — when he lets her, that is, because he’s usually such an independent person. During his most recent chemotherapy treatment, Yu continued to clock into work, because he plans to save his remaining sick days for when he receives the stem cell transplant.
When that day comes, Alice Yu will become his caregiver 24/7 because it will take him more than a year for his immune system to recover.
But she’s also noticed her husband taking time to explain mundane tasks he usually tackled around the house, like paying their property taxes or working the remote controls in the home.
“It’s all to prepare me for when he’s not here,” she said, her voice breaking.
When Talania reported from Manila that he was denied a visa for the second time, it was late at night in Los Angeles. The message landed with a crash in the Yu home. Not knowing what to do, Alice and Arthur ate some strudels from Porto’s Bakery.
“We calmed down a bit, and then we went to sleep. There’s nothing else you can do at that point,” Yu said.
Without a transplant, his doctors arranged for another round of chemotherapy. Yu agreed, but before he went into the hospital he took his 14-month-old son to ride the trains at Griffith Park’s Travel Town just like he did when he was a child.
He also hastily arranged to baptize Abel at Cathedral Chapel of St. Vibiana, the same chapel where he married Alice.
Science
July Fourth fireworks may bring ‘hazardous’ air quality to Southern California. What you need to know
L.A.’s love of fireworks makes for a colorful Fourth of July, with dozens of official celebrations and countless illicit explosions expected for the holiday.
But as each sparkler, Roman candle, palm and peony dissipates, it leaves behind a cloud of noxious gases, soot and finely ground toxic metals — some of which ends up in the lungs of revelers and passersby below.
Hazardous levels of air pollution are expected across central and southern Los Angeles County, northern Orange County, and Riverside and San Bernardino counties from 5 p.m. Saturday evening through 3 p.m. Sunday, according to the South Coast Air Quality Management District. Unhealthy air quality is also expected in northern Los Angeles County and southern Orange County.
Pollution levels are expected to build from dusk onward Saturday, as light winds and increased firework activity lead to an increase in smoke, a South Coast AQMD advisory said. Soot and particulates will likely linger through Sunday afternoon before being dispersed by the wind.
Firework-related pollution can trigger coughs, breathing problems, asthma flares and heart attacks, according to Los Angeles County Public Health, and anyone experiencing severe or worsening cardiovascular symptoms like chest pain or difficulty breathing should seek medical attention immediately.
Pyrotechnics set off at home are even more likely to trigger cardiovascular problems, the American Lung Assn. says, as the burst of pollutants takes place closer to the ground.
July 4 and 5 are traditionally two of the worst days of the year for the region’s air quality, according to South Coast AQMD. This year’s celebration comes on the heels of a late June warehouse fire in Boyle Heights that released extraordinary amounts of soot and smoke across the county, on par with pollution generated by the previous year’s wildfires.
To limit negative health effects, the L.A. County public health department recommends avoiding strenuous physical activity and keeping doors and windows closed. As whole house fans and swamp coolers can suck additional pollutants inside, the department recommends using air purifiers or air conditioners as alternatives when possible.
Science
Contributor: Alcohol should be stigmatized like smoking
Few substances are as deeply woven into everyday life as alcohol. It is a fixture at holiday celebrations, work-related social gatherings, sporting events, airports, and brunch or dinner tables. All demonstrate how deeply alcohol has become embedded in social customs and cultural traditions.
Yet alcohol contributes to millions of deaths globally each year and is linked to cancer, liver disease, unintentional accidents, violence and, importantly, dependence and addiction. Despite this, the disconnect between alcohol’s cultural role and its serious health burden is striking. An estimated 2.3 billion people worldwide consume alcohol.
As a physician working in addiction medicine, I regularly care for patients whose alcohol use affects nearly every organ system. It is often not until these patients end up admitted to the hospital that they learn the effects of alcohol on various parts of their body besides their liver.
Newer evidence challenges assumptions about what was long considered “safe drinking.” Even moderate drinking carries risk and is not as harmless as people, including experts, once thought.
Many people associate alcohol risk primarily with addiction or dangerous behaviors such as driving while intoxicated. However, its effects extend far beyond this, into nearly every aspect of a person’s well-being.
While alcohol may transiently improve mood and ease social anxiety, long-term alcohol use can lead to a worsening of mood, cognition and sleep, which can further compound use.
A 2021 literature review found that consuming approximately two standard drinks roughly doubles the odds of sustaining injuries — with or without a vehicle involved. The review also found that heavy episodic (binge) drinking can increase the risk of injury by 50-fold, depending on the amount of alcohol consumed and the type of injury. While alcohol’s effects on the liver are well known, it can also lead to gastrointestinal complications and heart disease
The World Health Organization estimates that 2.6 million deaths each year are attributable to alcohol, accounting for nearly 1 in every 20 deaths worldwide.
While many people recognize the risks of alcohol addiction, people are generally much less aware of the links between alcohol use and cancer risk.
The World Health Organization classifies alcohol as a Group 1 carcinogen — the same category as tobacco and asbestos. In 2025, the U.S. surgeon general emphasized that alcohol increases the risk of at least seven cancers, including cancers of the breast, colorectal, liver, oral, esophagus and larynx. An advisory called for updated warning labels.
Yet fewer than half of Americans recognize alcohol as a risk factor for cancer, particularly for cancers such as breast cancer that are not commonly associated with alcohol use.
Throughout the 1990s and early 2000s, observational studies suggested that moderate alcohol consumption might offer cardiovascular benefits. Over the past decade, however, higher-quality studies have challenged these findings, suggesting that much of the apparent benefit may have reflected differences in the health and lifestyles of moderate drinkers rather than a protective effect of alcohol itself.
Current evidence increasingly suggests that even low levels of alcohol may increase cancer risk.
Federal guidelines acknowledge that adults should “consume less alcohol for better overall health.” However, the most recent version of the “Dietary Guidelines for Americans,” updated in January, removed the previous recommendation to limit intake to no more than one drink per day for women and two for men. It also omitted explicit discussion of alcohol’s links to cancer.
These changes have drawn criticism from public health experts, who argue that the revised language plays down the growing evidence of alcohol-related harms and provides less specific guidance to consumers. The current administrator of the Centers for Medicare & Medicaid Services characterized alcohol as a “social lubricant” that brings people together, rather than emphasizing its well-established health risks.
This may be true physiologically, at least temporarily, but obscures the fact that relying on it as a social lubricant can lead to chemical and psychological dependency. In my view, statements to that effect are shortsighted, prioritizing short-term social effects over more insidious and long-term issues, including addiction.
While many dangerous mind-altering substances are hidden from public perception, alcohol is often placed at the center of it – a trend that shows no sign of changing imminently.
Further, large companies often profit from ads that appeal to young people.
Looking back at the history of tobacco smoking provides some helpful insights. In 1965, 42.4% of the U.S. population smoked. By 2022, that figure had dropped to 11.6%.
This steep decline did not happen because of a single intervention, but through decades of accumulating scientific evidence, public education campaigns, warning labels, restrictions on advertising, smoke-free policies, higher tobacco taxes and shifts in social norms. Together, these efforts transformed smoking from a widely accepted social behavior into one broadly recognized as a major health risk and correspondingly, less socially accepted.
Although alcohol consumption has modestly declined in recent years, it remains deeply embedded in social life in ways cigarette smoking no longer is.
People often assume that if a substance is legal, common and widely socially accepted — even encouraged — it must also be safe. But public health history suggests those assumptions can and should change.
Emma Fenske is an addiction medicine fellow and internal medicine physician at Oregon Health & Science University. This article was produced in partnership with the Conversation.
Science
Boyle Heights blaze choked L.A. with astronomical soot pollution
The air near the Lineage refrigerated warehouse fire in Boyle Heights carried astronomically high levels of smoke and soot, surpassing some of the worst air pollution during the Los Angeles County fires in January 2025, according to preliminary data from air officials.
The fire spewed thick black smoke for days. From downtown Los Angeles to the San Gabriel Valley, tens of thousands were enveloped in unhealthful levels of smoke, even as some local officials told residents that the air posed no danger.
As the days wore on, worst off were communities nearest the blaze. On June 19, three days after the facility ignited, a temporary air quality monitoring station at Eastman Elementary in unincorporated East Los Angeles measured an extremely hazardous 755 micrograms per cubic meter of fine particles for more than an hour, according to the South Coast Air Quality Management District.
For comparison, a Caltech air monitor in Pasadena recorded about 650 micrograms per cubic meter during the Eaton fire.
These high levels of fine particles, known as PM 2.5, probably resulted in the surge of residents into local emergency rooms during the fire, according to local health officials. But even now with the smoke gone, people still have not been told what chemicals they were breathing in during the weeklong ordeal.
Michael Jerrett, an environmental health professor at the UCLA Fielding School of Public Health, said his concern is the composition of materials emitted when the building burned.
“These contain many particularly toxic components,” Jerrett said, “and we know little about how these mixtures affect health.”
There is no completely safe level of fine particulate pollution, he noted, meaning higher concentrations are always worse.
During the 2025 L.A. County fires, local air officials announced that several monitors downwind had detected elevated levels of brain-damaging lead and cancer-causing arsenic from toxic paint and construction materials used in older homes.
The Lineage warehouse, built in 2018, is likely to contain different materials of concern. Thick insulation foam required for a massive refrigeration operation, solar panels and refrigerants were burned, leaving many residents on edge.
Even though three public agencies conducted air monitoring, the picture is still murky.
“[Public officials] are speaking with a lot of confidence but not a lot of information,” said mark! Lopez, a community organizer with East Yard Communities for Environmental Justice. “We’ve gotten in the room with folks to discuss where the gaps lie and where assumptions are being made. And I think they are realizing these agencies supposed to protect our air and our health aren’t as reliable as they thought they were.”
In response to the Boyle Heights fire, the South Coast air district deployed a mobile monitoring vehicle to screen for toxic substances in the community near the fire, according to Nahal Mogharabi, a spokesperson for the air district. It found increased levels of bromine, a chemical commonly found in fire retardant, and chlorine, often released from burning plastic. Both were below short-term health-based exposure thresholds.
Toxic metals, including lead and arsenic, were not elevated, according to air district data.
“That was the reassuring piece, that they were not picking up any of the metals,” said Dr. Nichole Quick, chief medical advisor for the Los Angeles County Department of Public Health. “But … that smoke is unhealthy. “You don’t want to be breathing it, regardless.”
The U.S. Environmental Protection Agency set up air monitors around the perimeter of the facility to test for toxic air contaminants, has the results and has not made them public. Julia Giarmoleo, an EPA spokesperson, said the monitors did not detect elevated metals, but would not provide a copy of the data without a federal records request.
The Los Angeles Fire Department’s hazardous material team also tested for ammonia, which is used in refrigeration, and hydrogen fluoride, a toxic chemical that could be released by burning lithium-ion batteries and solar panels.
Fire officials previously said they measured low levels of hydrogen fluoride on the second day of the fire. But the department would not answer questions about its air monitoring. It also told a reporter to submit a public records request.
It remains unclear whether any agency has tested for hydrogen cyanide or isocyanates, highly toxic gases that could be released from burning chemical-laden insulating foam inside the building.
“The real issue is what monitoring has not been done to protect the fence-line community from the air toxics,” said Jane Williams, executive director of California Communities Against Toxics.
Without the EPA or LAFD data, what is known of the smoke’s toxicity rests on the air district’s mobile monitoring.
Jerrett, the UCLA researcher, said that is not ideal for understanding the kind of plume released by the Boyle Heights fire, which rapidly changed direction with the wind.
“This can in some instances lead to levels that look low, but they are resulting from a mismatch between the location of the vehicle and the plume,” he said.
The Boyle Heights blaze, similar to the Eaton and Palisades fires, has revealed the region’s air monitoring can’t always tell people what they’ve been exposed to in a disaster.
“We do need a better monitoring system in place,” he said.
Local officials are now shifting their focus to the rancid odors from millions of pounds of rotting food in the ruined wing of the warehouse. Decomposing food can release hydrogen sulfide, a toxic gas synonymous with landfills and garbage. Lineage hired contractors who are measuring this noxious gas and other pollution. Their data indicate they have not detected hydrogen sulfide.
As Lineage workers haul the rotting food to local landfills, they are using deodorizing mist and have discussed using shrink wrapping to suppress the stench and minimize issues for nearby homes.
At this point, the odors are believed to be an inconvenience rather than a public health threat, according to Quick, the county medical advisor. She said running air purifiers may help to reduce odors indoors.
“It’s very important for folks to understand that the odors themselves do not indicate any dangerous levels of toxins, mold, bacteria, and so forth,” Quick said. “But the odors are a public nuisance.”
The air district is still encouraging residents to report odors to its online complaint system or by calling (800) 288-7664.
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