The Missouri Department of Health and Senior Services (DHSS) has issued an advisory regarding 7-hydroxymitragynine, also known as 7-hydroxy and 7-OH.

It’s an extract of the kratom plant and it’s being marketed as a “natural remedy” for pain relief and brain stimulation. But 164 people in Missouri have died from using Kratom products since 2019, including those containing 7-OH.

Dr. Heidi Miller, Chief Medical Officer for DHSS compares 7-OH to an opioid, saying it can be up to 13 times stronger than morphine.

“Nationally, we have seen patients who have died from overdose have had kratom-type substances in their blood,” she told Missourinet. “Unfortunately, it’s very hard to distinguish between whether or not someone has taken the kratom leaf versus this concentrated 7-OH substance.”

Miller also said the Missouri Poison Center has seen a rise in 7-OH reported cases.

“You know, two years ago, we only had about 19 reports, and then the year after that (2024), we had 25 reports. And this year, 2025 – the year isn’t even done – and we already have 47 reports.”

Miller said 7-OH is unregulated, and products containing the compound can easily be purchased online or at convenience stores, without age restrictions.

“Seven-hydroxy products are sold as, like, little energy shots or powders that can be mixed into drinks,” she said. “There are also versions that can be dissolved in the mouth. There are versions that can be inhaled. There are gummies.”

Symptoms of 7-OH exposure may include:

• Nausea, vomiting and gastrointestinal distress.
• Anxiety, agitation, confusion and insomnia.
• Rapid heart rate, high blood pressure and trouble breathing.
• Seizures, unconsciousness and withdrawal symptoms.
• Risk of overdose, especially when combined with alcohol or other sedatives.

Miller said anyone experiencing symptoms or is suspected of overdosing should call 911, and to administer naloxone (Narcan) if any is available.

Copyright © 2025 · Missourinet

The Texas A&M Aggies are one of the undefeated teams left in the college football Top 25 and they’re hoping to stay that way after facing another ranked opponent when the Aggies travel to Missouri.

The Aggies have not lost in the 2025 season, including securing two wins over ranked opponents including Notre Dame and, most recently, LSU. Missouri has won three of their last five games, but is coming off a loss to a climbing Vanderbilt Commodores team.

Here’s everything you need to know to buy Missouri vs. Texas A&M tickets:

Missouri vs. Texas A&M college football tickets

No. 17 Missouri will host No. 3 Texas A&M at Memorial Stadium in Columbia, Missouri on Saturday, Nov. 8 at 3:30 p.m. ET.

Tickets are available now, starting at $166.

Missouri vs. Texas A&M game information