Health
Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic.
With approximately 70% of American adults meeting the criteria for being obese or overweight, more people are turning to weight loss medications to help them shed pounds.
Ozempic is approved for type 2 diabetes, while its counterpart, Wegovy, is approved for treating obesity. Both are made by Novo Nordisk.
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Eli Lilly also offers a diabetes medication, Mounjaro, as well as a version for weight loss, Zepbound.
In a new trend, some people are using smaller daily “microdoses” of Ozempic, doctors report. (iStock)
“Ozempic is the only version among the weekly injectables — Ozempic, Wegovy, Zepbound and Mounjaro — that has the option to ‘hack’ the pen for a smaller dose,” Dr. Alexandra Sowa, an obesity medicine specialist and founder of SoWell in New York, told Fox News Digital.
She is also the author of the book “The Ozempic Revolution” that is set to be released on Jan. 7.
Fox News Digital spoke to the experts to get the skinny on this latest trend.
What is microdosing?
Microdosing Ozempic refers to using smaller amounts compared to the standard therapeutic doses that are traditionally prescribed for managing type 2 diabetes and aiding weight loss, experts say.
This practice is not approved by the U.S. Food and Drug Administration (FDA).
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“Health care clinicians do not typically recommend this approach, as the standard dosing regimen is based on clinical trials determining the most effective and safe amount for these conditions,” noted Dr. Fatima Cody Stanford, obesity medicine physician at Massachusetts General Hospital and Harvard Medical School.
There are no established guidelines for microdosing – although there are reports on social media of using 10 to 100 times lower than standard prescriptions, added Dr. Christopher McGowan, a gastroenterologist and obesity specialist who runs True You Weight Loss in Cary, North Carolina.
“Health care clinicians do not typically recommend this approach.”
Some people get confused by the terminology, the doctors noted.
“I think there’s a little bit of a misconception, as some people say ‘I’m microdosing’ when they’re just on the starting doses or don’t go all the way up in the escalation titration dosing of the medication,” Sowa said.
Benefits of microdosing
The primary reason for microdosing is to reduce costs, according to McGowan.
For example, he said, a patient might think that if a full prescription costs over $250 per week, they may be able to achieve some benefit with just $25 worth of the medication.
With approximately 70% of American adults meeting the criteria for being obese or overweight, more people are turning to weight loss medications to help them shed pounds. (iStock)
The average monthly retail price of Ozempic ranges from $1,000 or more without insurance, per GoodRx.
People may also pursue microdosing to reduce the incidence or severity of side effects such as nausea, vomiting or stomach discomfort, according to Stanford.
“Some individuals might start with microdoses to gradually acclimate their body to the medication, potentially easing into the full therapeutic dose over time,” she said.
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Any potential benefit of the medication, however, will likely wane proportionally with lower doses, experts noted.
Individuals may also microdose due to supply challenges, according to Dr. Amy Rothberg, clinical professor of medicine in the Division of Metabolism, Endocrinology & Diabetes at the University of Michigan.
“Some individuals might start with microdoses to gradually acclimate their body to the medication, potentially easing into the full therapeutic dose over time.” (iStock)
“Some feel they may derive a benefit from microdosing by being able to extend their supply and may perceive an effect,” Rothberg, who is also the medical director of Rewind, a lifestyle program for type 2 diabetes patients, told Fox News Digital. “As we know, the placebo effect may have a strong impact.”
Potential risks of the practice
The most likely risk of microdosing is a lack of effectiveness, McGowan noted.
“Microdosing Ozempic or other [weight-loss] medications is entirely off-label and unproven, with no supporting clinical studies,” he cautioned.
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Stanford also warned that smaller doses may not provide adequate blood sugar management, leading to uncontrolled diabetes and associated complications.
It can also lead to suboptimal weight loss and unpredictable results, as well as the potential for misuse, she added.
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People who microdose often use a “compounded” version of the medication, which the FDA does not regulate.
“This introduces risks such as contamination, inconsistent formulations and uncertainty about the actual strength of the product being injected,” McGowan stated.
Without changes to diet and physical activity patterns, the long-term benefits will disappear once the drug is stopped, one doctor noted. (iStock)
Additionally, these compounded versions are usually dispensed in vials, which requires a syringe to draw it up, in contrast to the FDA-approved versions that are simpler to use.
Using the compounded versions through vials runs the risk of drawing up too much medication — so instead of microdosing, it’s possible to macrodose, Sowa warned.
Medical supervision is key
Some providers are still comfortable offering microdosing for select patients with one caveat — that people should always consult a health care clinician before altering their medication regimen.
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“As long as it is being dispensed and monitored by a physician, I don’t see how anybody is going to overdose, especially when we are giving such small amounts,” Dr. Suzanne A. Trott, a double board-certified plastic and general surgeon in Beverly Hills, told Fox News Digital.
“I have seen a lot of patients who are given metformin for weight loss — I don’t see how this is any different,” said Trott, who runs her own microdosing clinic.
Trott pointed out that there are many “off-label” practices offered to patients.
“Botox and fillers are not even FDA-approved for most of the places we use them,” she noted.
“Some individuals might start with microdoses to gradually acclimate their body to the medication.”
Experts agree that sustained weight loss will not occur with medication alone.
“I think people find that it’s easier to take a drug, but neglect concomitant behavioral changes,” Rothberg said.
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In the absence of changes to diet and physical activity patterns, the long-term benefits will disappear once the drug is stopped, she noted.
Trott also recommends maintaining consistent exercise, strength training, hydration and high protein intake to maintain muscle mass.
Fox News Digital reached out to Novo Nordisk, the maker of Ozempic, for comment.
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One woman’s uncomfortable reaction to alcohol led to a grave discovery.
Hollie Thursby, 28, a mother of two from the U.K., told Kennedy News and Media that after giving birth to her second son, Jack, she began experiencing unusual symptoms.
At a checkup for her son, who was a couple of months old, Thursby mentioned that she was experiencing “unbearably itchy skin,” which is known to be a post-partum symptom. The doctor suggested it was due to changing hormones.
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Thursby added that she occasionally drank a couple glasses of wine. Although she kept the drinking to a minimum, she described having “a lot of pain” down the side of her neck.
“Really quite painful and uncomfortable,” she said, according to the report.
A U.K. mom reported experiencing pain in her neck after drinking a glass or two of wine, which turned out to be one of the first signs that she had cancer. (Kennedy News and Media)
The mother also reported feeling extremely exhausted, which she assumed was due to caring for her children throughout the day.
“I also felt like when I got to bed that someone was sitting on my chest,” she shared.
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In July 2025, Thursby discovered a lump on the side of her neck that she described as “really quite big,” but wasn’t painful, Kennedy News and Media reported.
“It was hard, it didn’t move, but it was there,” she said. “When I turned my neck to the side, you could see it.”
Thursby reportedly began chemotherapy for Stage 2 Hodgkins lymphoma. (Kennedy News and Media)
Thursby’s symptoms turned out to be a form of blood cancer — Stage 2 Hodgkins lymphoma, which means it is in two or more lymph nodes, according to Cancer Research U.K.
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Common symptoms include swelling of the lymph nodes, heavy sweating, weight loss, itching, persistent cough or shortness of breath, high temperatures, and pain in the stomach or lymph nodes after drinking alcohol.
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“Pain when you drink alcohol is actually a known side effect of Hodgkin lymphoma,” she said, per the report. “It’s something about the acidity in the wine and not when you drink other alcohol.”
While alcohol-related pain in Hodgkins lymphoma patients has been “an accepted scientific consensus” since the 1950s, cases are rare, Healthline confirmed.
Hollie Thursby, 28, and her two sons are pictured above. The mother reported feeling extremely exhausted, which she assumed was due to caring for her children throughout the day. (Kennedy News and Media)
Thursby reportedly began chemotherapy in November, noting that the hardest part is not being able to care for her kids after losing her own mother to a blood disorder called myelodysplasia.
“I grew up without a mum, and it was horrendous. I can’t do that to the boys,” she told Kennedy News and Media. “We’re all devastated, but we all know now, and we’ve got a treatment plan, which is what we need.”
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“I’m just doing everything I can to get better for them. I keep telling myself this is only temporary, I just need to keep going.”
Anyone experiencing pain or other concerning symptoms after consuming alcohol should consult a doctor for guidance.
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Red light therapy has been shown to reduce brain inflammation, protecting people who experience head trauma from long-term health consequences, a University of Utah study has shown.
Brain damage from repeated impact over the years is known to cause cognitive symptoms, ranging from memory issues to full-blown dementia, particularly affecting soldiers and athletes.
Chronic traumatic encephalopathy (CTE) is a progressive, degenerative brain disease linked to repeated head impacts rather than a single injury, according to Mayo Clinic.
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More than 100 former NFL football players have been posthumously diagnosed with CTE, according to the new study, which was published in the Journal of Neurotrauma.
Other research has shown that military personnel in active combat suffer from similar issues, as do first responders and veterans.
The treatment was administered three times a week for 20 minutes using specialized headsets and intranasal devices designed to penetrate the skull. (iStock)
In the new study, the researchers recruited 26 current football players to understand more about the impact of red-light therapy on brain injuries.
The participants received either red light therapy delivered by a light-emitting headset and a device that clips into the nose, or a placebo treatment with an identical device that doesn’t produce light. Players self-administered the therapy three times a week, 20 minutes each time, for 16 weeks.
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“My first reaction was, ‘There’s no way this can be real,’” said first author Hannah Lindsey, Ph.D., in the university press release. “That’s how striking it was.”
Specific wavelengths of light are believed to enter the brain and reduce molecules that trigger inflammation, potentially halting the path toward dementia and other cognitive conditions. (iStock)
Players using the placebo treatment experienced increased brain inflammation over the course of the season. Magnetic resonance imaging (MRI) scans taken at the end of the season showed significantly more signs of inflammation than at the beginning of the season, the study found.
For players who used red-light therapy during the season, their brain inflammation didn’t increase at all.
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Previous studies have shown that red light, if powerful enough, can penetrate the skull and reach the brain, where it may reduce inflammation-related molecules.
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“When we first started this project, I was extremely skeptical,” said Elisabeth Wilde, Ph.D., the senior author on the study. “But we’ve seen consistent results across multiple of our studies, so it’s starting to be quite compelling.”
Study limitations
The study was conducted using a small sample size, which led to different levels of inflammation in the treatment and control groups, the researchers acknowledged.
While the placebo group showed increased brain inflammation during the football season, those receiving red light therapy showed no increase in inflammatory markers. (iStock)
Future large randomized clinical trials will be “crucial to back up the results” in larger populations, they noted.
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“We’ve been trying to figure out how to make sports safer, so that our kids, friends and family can participate in sports safely for the long term while they’re involved in activities that give them happiness and joy,” Carrie Esopenko, Ph.D., second author of the study, said in the release.
“And this really feels like part of the hope for protecting the brain that we’ve been searching for.”
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The team plans to recruit 300 people with persistent symptoms from TBI or concussion for a randomized controlled trial in 2026, with a focus on first responders, veterans and active-duty service members.
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Drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer, according to a study published in the journal Cancer by the American Cancer Society (ACS).
The study analyzed 20 years of data from more than 88,000 U.S. adults to determine how long-term drinking impacted the risk of developing colorectal cancer (CRC) or precancerous colorectal adenomas (polyps).
The participants reported their average weekly intake of beer, wine and liquor intake during four age periods — 18 to 24, 25 to 39, 40 to 54, and 55 and older.
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“Heavy drinkers” were identified as having more than 14 drinks per week and “moderate drinkers” had between seven and 14 drinks per week.
The observational research revealed that consistent heavy drinking over adulthood was linked to a higher risk of colorectal cancer, especially rectal cancer.
Researchers found a major association between colorectal cancer diagnosis and heavy lifetime drinking. (iStock)
Heavy lifetime drinking was associated with a 25% higher overall CRC risk and nearly double the risk of rectal cancer. Moderate lifetime drinking had a lower overall CRC risk.
Compared to light drinkers, the consistently heavy drinkers had about a 91% higher risk of CRC.
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For colorectal adenomas (precancerous polyps), higher current lifetime drinking did not show a strong pattern, although former drinkers showed a significantly lower risk of non-advanced adenoma compared to current light drinkers.
Out of the 88,092 participants, 1,679 were diagnosed with colorectal cancer.
Out of the 88,092 participants in the study, 1,679 were diagnosed with colorectal cancer. (iStock)
The authors noted that the research was limited, as it was observational and not based on a clinical trial. It also hinged on self-reported alcohol use.
The findings suggest that consistently heavy alcohol intake and higher average lifetime consumption “may increase CRC risk, whereas cessation may lower adenoma risk,” the researchers stated. Associations “may differ by tumor site,” they added.
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The link between drinking alcohol and cancer is not a new discovery, according to health experts.
In a recent episode of the podcast “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health in California, detailed how even moderate drinking can impact “nearly every organ system in the body,” due to metabolic stress, inflammation, impaired detoxification and its effect on hormones.
The link between drinking alcohol and cancer is not a new discovery, according to health experts. (iStock)
Drinking has been found to increase the risk of many cancers, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins, Hyman said.
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“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” he warned.
Reducing or eliminating alcohol can lower the risk of several cancers, according to medical experts. (Getty Images)
In a previous interview with Fox News Digital, Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, shared that taking a break from drinking alcohol for longer periods of time can “reshape health more profoundly.”
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“Over months to a year, we see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”
Chiang added, “Reducing or eliminating alcohol lowers the risk of several cancers, including breast and colorectal, over time.”
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Fox News Digital reached out to the study researchers for comment.
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