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New MRI brain scan predicts Alzheimer's risk years before symptoms develop

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New MRI brain scan predicts Alzheimer's risk years before symptoms develop

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Levels of iron in the brain could be a warning sign of future Alzheimer’s disease, a new study suggests.

High levels of the chemical element have been shown to increase brain toxins and trigger neurodegeneration, resulting in cognitive decline — especially when they interact with the abnormal amyloid and tau proteins that are the hallmark pathologies of Alzheimer’s disease.

Researchers at Johns Hopkins University found that a special MRI technique called quantitative susceptibility mapping (QSM) can measure levels of brain iron.

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“QSM is an advanced MRI technique developed over the last decade to measure tissue magnetic susceptibility with good precision,” the study’s senior author, Xu Li, associate professor of radiology at Johns Hopkins University in Baltimore, said in a press release. 

“QSM can detect small differences in iron levels across different brain regions, providing a reliable and non-invasive way to map and quantify iron in patients, which is not possible with conventional MR approaches.”  

Levels of iron in the brain could be a warning sign of future Alzheimer’s disease, a new study suggests. (iStock)

Compared to traditional imaging options for Alzheimer’s diagnosis, including PET scans, QSM MRI is “non-invasive and much more affordable,” according to the researchers. 

This measurement could help predict the likelihood of mild cognitive impairment (MCI) and cognitive decline, even if the person has shown no symptoms.

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In the study, which was published in the journal Radiology, the researchers tested the MRI technique on 158 cognitively unimpaired participants from a previous research project.

After a follow-up period of 7½ years, the team concluded that higher iron levels in two key parts of the brain were linked to a higher risk of mild cognitive impairment, which is typically a precursor to the development of Alzheimer’s dementia.

“Brain iron changes may be measured years before memory loss, when the participants are still cognitively normal.”

“The key takeaway of our study is that higher brain iron levels, especially in some critical brain regions related to memory and learning (entorhinal cortex and putamen, as shown in our study), are linked to a two to four times higher risk of developing MCI and faster cognitive decline,” Li told Fox News Digital. 

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“And such brain iron changes may be measured years before memory loss, when the participants are still cognitively normal.

“Using QSM, we found higher brain iron in some memory-related regions that are linked to a higher risk of developing cognitive impairment and faster cognitive decline,” Li said. “This risk is even higher when the participants have higher levels of amyloid pathologies.”

High levels of the chemical element have been shown to increase brain toxins and trigger neurodegeneration. (iStock)

The study did have some limitations, Li noted, including the smaller group of participants.

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“The study population is from a specialized cohort consisting of mainly White, highly educated participants with a strong family history of Alzheimer’s disease,” the researcher noted.

If larger, more diverse studies confirm these findings, it could support the use of this MRI technique for patients at a higher risk of dementia, the release stated.

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“I think we should be hopeful,” Li said. “We can use this kind of tool to help identify patients at higher risk of developing Alzheimer’s disease and potentially guide early interventions as new treatments become available. Also, besides serving as a biomarker, brain iron may become a future therapeutic target.”  

The researchers also hope to make the QSM technology more standardized, faster and more widely accessible in clinical practice, he added.

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While brain iron is associated with neurodegeneration and could lead to faster cognitive decline, it is also an important element for cognitive health, the researcher said. (iStock)

Li noted that while brain iron is associated with neurodegeneration and could lead to faster cognitive decline, it is also an important element for cognitive health and neurodevelopment at a young age. 

“While iron chelation therapies (to remove iron) for Alzheimer’s are currently explored, their effect is still not very clear and much more research is needed,” he said.

For more Health articles, visit www.foxnews.com/health

The study was supported by the National Institute of Biomedical Imaging and Bioengineering, National Institute on Aging and the National Institutes of Health.

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

SIMPLE NIGHTLY HABIT LINKED TO HEALTHIER BLOOD PRESSURE, STUDY SUGGESTS 

“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism


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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.

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